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1. 发明申请

WO2016113731A1 SELF-CURVING STENT-GRAFT 审中-公开
标题翻译：自弯曲钢筋
公开(公告)号：WO2016113731A1
公开(公告)日：2016-07-21
申请号：PCT/IL2016/050014
申请日：2016-01-06
申请人： ENDOSPAN LTD.
发明人： MARMUR, Yaniv , TZILER, Tzachi
IPC分类号： A61F2/07
CPC分类号： A61F2/07 , A61F2210/0014 , A61F2250/0006 , A61F2250/0012 , A61F2250/0029 , A61F2250/0039
摘要： An endovascular self-curving stent-graft (20) includes a self-curving longitudinal portion (22), which is curved so as to define an innermost curve (26) and an outermost curve (28), when the stent-graft (20) is unconstrained in a radially-expanded state. The stent-graft (20) includes a plurality of circumferential strut members (30); a compression-generation spring (40), which (a) is in an elongated configuration when the stent-graft (20) is in a radially-compressed state, and (b) overlaps respective first portions (44) of at least two of the circumferential strut members (30); and an anti-buckling spring (50), which overlaps respective second portions (54) of at least two of the circumferential strut members (30). The anti-buckling spring (50) and the compression-generation spring (40) are together configured to curve the self-curving longitudinal portion (22) when the stent-graft (20) is unconstrained in the radially-expanded state, such that a lesser length of the self-curving longitudinal portion (22), measured along the innermost curve (26), is less than 80% of a greater length of the self-curving longitudinal portion (22), measured along the outermost curve (28).
摘要翻译：一种血管内自弯曲支架移植物（20）包括自弯曲纵向部分（22），其弯曲以便当支架移植物（20）处于最内侧曲线（26）和最外侧曲线（28）时）在径向展开状态下是不受约束的。支架移植物（20）包括多个圆周支柱构件（30）; 压缩发生弹簧（40），其中（a）当所述支架移植物（20）处于径向压缩状态时处于细长结构，并且（b）与相应的第一部分（44）重叠至少两个周向支柱构件（30）; 以及与所述周向支柱构件（30）中的至少两个的相应的第二部分（54）重叠的抗弯曲弹簧（50）。当抗弯曲弹簧（50）和压缩发生弹簧（40）一起被配置成当支架移植物（20）在径向展开状态下受约束时弯曲自弯曲纵向部分（22），使得沿着最内曲线（26）测量的自弯曲纵向部分（22）的较小长度小于沿着最外曲线（28）测量的自弯曲纵向部分（22）的较大长度的80％）。

2. 发明申请

WO2016125137A1 SELF-ORIENTING ENDOVASCULAR DELIVERY SYSTEM 审中-公开
标题翻译：自主性内分泌系统
公开(公告)号：WO2016125137A1
公开(公告)日：2016-08-11
申请号：PCT/IL2016/050049
申请日：2016-01-14
申请人： ENDOSPAN LTD.
发明人： MARMUR, Yaniv , ZIGELBOIM, Or , SHALEV, Alon
IPC分类号： A61F2/966 , A61F2/07
CPC分类号： A61F2/962 , A61F2/07 , A61F2/856 , A61F2/966 , A61F2230/008
摘要： An elongate delivery shaft assembly (30) includes an outer covering shaft (38) and an inner support shaft (40). When the delivery shaft assembly (30) is unconstrained and a stent-graft (20) is removably constrained in a radially-compressed delivery state along a distal end portion (34) of the delivery shaft assembly (30), radially between the outer covering shaft (38) and the inner support shaft (40): (a) the delivery shaft assembly (30) is shaped so as to define a self-orienting portion (50), which (i) is shaped so as to define at least proximal and distal curved portions (52A, 52B), the proximal curved portion (52A) disposed more proximal than the distal curved portion (52B), and (ii) at least one point of inflection (53) on a central longitudinal axis (36) of the delivery shaft assembly (30) longitudinally between the proximal and the distal curved portions (52A, 52B), and (b) respective smallest radii of curvature of the proximal and the distal curved portions (52A, 2B), measured at the central longitudinal axis (36), are each between 2.5 and 12 cm.
摘要翻译：细长输送轴组件（30）包括外覆盖轴（38）和内支撑轴（40）。当输送轴组件（30）不受约束并且支架移植物（20）沿着输送轴组件（30）的远端部分（34）以径向压缩的输送状态可拆卸地约束时，径向地在外覆盖物轴（38）和内支撑轴（40）：（a）输送轴组件（30）成形为限定自取向部分（50），（i）成形为至少限定近端和远端弯曲部分（52A，52B），近端弯曲部分（52A）远离远侧弯曲部分（52B）设置，以及（ii）至少一个拐点（53）在中心纵向轴线（52A，52B）之间纵向布置的输送轴组件（30）的远端弯曲部分（52A，2B）的近似和远端弯曲部分（52A，2B）的最小曲率半径中心纵向轴线（36）各自在2.5和12厘米之间。

3. 发明申请

WO2014141232A1 MULTI-COMPONENT STENT-GRAFT SYSTEM FOR AORTIC DISSECTIONS 审中-公开
标题翻译：用于动态断开的多组分STEG-GRAFT系统
公开(公告)号：WO2014141232A1
公开(公告)日：2014-09-18
申请号：PCT/IL2014/050174
申请日：2014-02-18
申请人： ENDOSPAN LTD.
发明人： SHALEV, Alon , MARMUR, Yaniv
IPC分类号： A61F2/07
CPC分类号： A61F2/856 , A61F2/07 , A61F2/89 , A61F2002/061 , A61F2002/075 , A61F2230/0013 , A61F2230/0069 , A61F2250/0039 , A61F2250/006
摘要： A generally tubular stent-graft has distal and proximal stent-graft ends and includes a generally tubular support element and a covering element. When the stent-graft is unconstrained in a radially-expanded state: the covering and support elements are shaped so as to together define a lateral fenestration having distal and proximal fenestration ends, a perimeter of the distal stent-graft end equals at least 200% of a perimeter of the proximal stent-graft end, and the stent-graft includes a dissection-reinforcement axial portion, which (a) has a proximal dissection-reinforcement end that is disposed no more than 20 mm proximal to the proximal fenestration end, extends along the stent-graft for a distance equal to between 5% and 32% of a greatest perimeter of the stent-graft distally to the distal fenestration end, and (c) has a radial strength that is at least 10% greater than an average radial strength of the entire stent-graft.
摘要翻译：通常管状的支架移植物具有远端和近端的支架移植物端部，并且包括大致管状的支撑元件和覆盖元件。当支架移植物在径向扩张状态下不受约束时：覆盖和支撑元件成形为一起限定具有远端和近端开窗端的侧向开窗，远侧支架移植端的周边等于至少200％近端支架移植端的周边，并且支架移植物包括解剖 - 加强轴向部分，其（a）具有近端解剖加强端，其近端开口端不超过20毫米，沿着支架移植物延伸一段距离等于支架移植物远端远端开窗端的最大周长的5％至32％之间的距离，以及（c）具有至少10％的径向强度整个支架移植物的平均径向强度。

4. 发明申请

WO2016098113A1 ENDOVASCULAR STENT-GRAFT WITH FATIGUE-RESISTANT LATERAL TUBE 审中-公开
标题翻译：具有耐疲劳侧管的内部支架
公开(公告)号：WO2016098113A1
公开(公告)日：2016-06-23
申请号：PCT/IL2015/051221
申请日：2015-12-16
申请人： ENDOSPAN LTD.
发明人： MARMUR, Yaniv , NAE, Nir Shalom , SHALEV, Alon
IPC分类号： A61F2/07
CPC分类号： A61F2/91 , A61F2/07 , A61F2/848 , A61F2/89 , A61F2002/061
摘要： A stent-graft (20) comprises strut members (30) and a graft member (32), which is fixed to the strut members (30). The strut members (30) and the graft member (32) are arranged so as to define, when the stent-graft (20) is in a radially-expanded state: a main tube (40), which is shaped so as to define a main lumen (42); and a lateral tube (50), which (a) has (i) a distal end (52) and (ii) a proximal end (54) that is joined to a lateral wall (56) of the main tube (40) at a junction (60), (b) is shaped so as to define a lateral lumen (62) that is in fluid communication with the main lumen (42), and (c) defines a central longitudinal axis (64). The strut members (30) that define the lateral tube (50) are shaped so as to define two to four non-contiguous arcuate members (70), which (a) are centered around the central longitudinal axis (64), and (b) collectively subtend at least 150 degrees around the central longitudinal axis (64).
摘要翻译：支架移植物（20）包括固定到支柱构件（30）上的支柱构件（30）和移植构件（32）。支架构件（30）和移植构件（32）布置成当支架移植物（20）处于径向展开状态时限定：主管（40），其被成形为限定主管腔（42）; 和侧管（50），其中（a）具有（i）远端（52）和（ii）接近主管（40）的侧壁（56）的近端（54）（60），（b）成形为限定与主腔（42）流体连通的侧腔（62），（c）限定中心纵向轴线（64）。限定侧管（50）的支柱构件（30）成形为限定两个至四个不连续的弓形构件（70），其中（a）围绕中心纵向轴线（64）居中，并且（b ）围绕中心纵向轴线（64）共同对向至少150度。

5. 发明申请

WO2018173056A1 STENT-GRAFTS FOR SEALING AROUND EXTERNAL DISTURBANCES 审中-公开
公开(公告)号：WO2018173056A1
公开(公告)日：2018-09-27
申请号：PCT/IL2018/050325
申请日：2018-03-21
申请人： ENDOSPAN LTD.
发明人： ZIGELBOIM, Or , MARMUR, Yaniv , SHALEV, Alon
IPC分类号： A61F2/07
摘要： An endovascular stent-graft (10, 110, 210, 310) is provided that includes elastic struts (20) and a fluid flow guide (30) that is fixed to first and second subsets (32, 34) of the struts (20). The struts (20) of the first subset (32) are arranged as circumferential cells (80) in circumferentially-continuous rings (56), which cause the fluid flow guide (30) to define substantially cylindrical tubular portions (40). The struts (20) of the second subset (34) cause the fluid flow guide (30) to define a bulge (42) having a greatest bulge radius from a central longitudinal axis (38) that is at least 5% greater than an average radius of the substantially cylindrical tubular portions (40) proximally and distally adjacent the bulge (42). The struts (20) of the second subset (34) define tip portions (50). The number of the tip portions (50) of the struts (20) of the second subset (34) that define the bulge (42) is at least 50% greater than the average number of circumferential cells (80) in the two circumferentially-continuous rings (56) proximally and distally adjacent the bulge (42).

6. 发明申请

WO2015075708A1 STENT SYSTEM WITH RADIAL-EXPANSION LOCKING 审中-公开
标题翻译：具有径向膨胀锁定的STENT系统
公开(公告)号：WO2015075708A1
公开(公告)日：2015-05-28
申请号：PCT/IL2014/050973
申请日：2014-11-06
申请人： ENDOSPAN LTD.
发明人： MARMUR, Yaniv , ZIGELBOIM, Or , NAE, Nir Shalom
IPC分类号： A61F2/95
CPC分类号： A61F2/966 , A61F2/07 , A61F2002/061 , A61F2002/065 , A61F2002/9517 , A61F2002/9665 , A61F2250/006
摘要： A deployment system (10, 410) includes an inner shaft (36, 436), removably disposed in a self-expanding stent-graft (40), and shaped so as to define (a) at least one conduit therealong (50, 450), which is (i) not coaxial with the inner shaft (36, 436), and (ii) shaped so as to define at least first (52, 452) and second enclosed longitudinal segments (54, 454), and (b) a restraining longitudinal portion (56, 456) that is longitudinally disposed between the first (52, 452) and second enclosed longitudinal segments (54, 454). The deployment system (10, 410) is configured such that (a) when a restraining wire (60, 460) thereof is removably disposed in the first (52, 452) and second enclosed longitudinal segments (54, 454), a portion (62, 463) of the restraining wire (60, 460) disposed alongside the restraining longitudinal portion (56, 456) prevents full radial expansion of a longitudinal portion (70, 470) of the stent-graft (40) by physically engaging the stent-graft longitudinal portion (70, 470), and (b) when the restraining wire (60, 460) has been withdrawn from at least the first enclosed longitudinal segment (52, 452), the restraining wire (60, 460) does not prevent the full radial expansion of the stent-graft longitudinal portion (70, 470).
摘要翻译：展开系统（10,410）包括可拆卸地设置在自膨胀支架移植物（40）中的内轴（36,463），并且成形为限定（a）至少一个导管（50,450）），其是（i）不与内轴（36,436）同轴，和（ii）成形为至少限定第一（52,452）和第二封闭纵向段（54,454），并且（b））纵向设置在第一（52,452）和第二封闭纵向段（54,454）之间的约束纵向部分（56,456）。配置系统（10,410）被构造成使得（a）当限制线（60,460）可拆卸地设置在第一（52,452）和第二封闭的纵向段（54,454）中时，一部分沿着限制纵向部分（56,456）设置的约束线（60,460）的62,663,462,463,462,462,462,462,462,462,462,462,462,462,462,462,462,462,462,462,462,462,462,462,462,462,462,462,462,462,462,462,462,462,462,462,462,462,462,462,462,462,462,4 移动纵向部分（70,470），和（b）当约束线（60,460）至少从第一封闭纵向段（52,452）撤回时，限制线（60,460）不防止支架 - 移植物纵向部分（70,470）的完全径向膨胀。

7. 发明申请

WO2017081679A1 STENT-GRAFTS SYSTEMS WITH SKIRT 审中-公开
标题翻译：带裙边的扶手系统
公开(公告)号：WO2017081679A1
公开(公告)日：2017-05-18
申请号：PCT/IL2016/051207
申请日：2016-11-09
申请人： ENDOSPAN LTD.
发明人： ZIGELBOIM, Or , MARMUR, Yaniv , SHALEV, Alon
IPC分类号： A61F2/07 , A61F2/962 , A61F2/06
CPC分类号： A61F2/07 , A61F2/962 , A61F2002/061 , A61F2002/075 , A61F2002/077 , A61F2230/0093 , A61F2250/0039
摘要： An endovascular prosthesis (200) includes a stent-graft (240) and an external coagulation inducer (750). The stent-graft (240) includes a first portion (734A) of structural strut members (730) and a first portion (736A) of a graft member (732), which, when the endovascular prosthesis (200) is unconstrained in a radially-expanded state, together are shaped so as to define a blood-carrying tubular structure defining a lumen. The external coagulation inducer (750) includes an extra-luminal skirt (760), which includes a second portion (734B) of the structural strut members (730) and a second portion (736B) of the graft member (732), and is configured to assume: (i) when the endovascular prosthesis (200) is removably disposed in a delivery sheath, a radially- compressed delivery state, in which the structural strut members (730) of the first portion (734A) do not coincide with the structural stent members (730) of the second portion (734B), and (ii) when the endovascular prosthesis (200) is unconstrained, a radially- expanded state, in which the extra-luminal skirt extends (760) radially outward from an external surface (252) of the stent-graft (240).
摘要翻译：血管内假体（200）包括支架移植物（240）和外部凝血诱导物（750）。支架移植物（240）包括结构支柱构件（730）的第一部分（734A）和移植物构件（732）的第一部分（736A），当血管内假体（200）不径向约束时膨胀状态一起成形为限定限定内腔的携血管状结构。外部凝血诱导器750包括包括结构支柱构件730的第二部分734B和移植构件732的第二部分736B的外腔裙部760，被构造成假设：（i）当血管内假体（200）被可移除地设置在输送护套中时，径向压缩输送状态，其中第一部分（734A）的结构支柱构件（730）不与当所述血管内假体（200）不受约束时，所述第二部分（734B）的结构支架构件（730）和所述血管外假体（200）不受约束的径向扩张状态（其中所述腔外裙部从外部支架移植物（240）的表面（252）。

8. 发明申请

WO2014108895A2 MINIMIZATION OF STENT-GRAFT MIGRATION DURING IMPLANTATION 审中-公开
标题翻译：植被过程中最小化移植骨移植
公开(公告)号：WO2014108895A2
公开(公告)日：2014-07-17
申请号：PCT/IL2014/050019
申请日：2014-01-07
申请人： ENDOSPAN LTD.
发明人： SHALEV, Alon , MARMUR, Yaniv , NISSAN, Ori , NAE, Nir Shalom
IPC分类号： A61F2/966
CPC分类号： A61F2/962 , A61F2/07 , A61F2/966 , A61F2002/061 , A61F2002/067 , A61F2002/075 , A61F2002/9665 , A61F2230/0069
摘要： An endovascular system (10) includes an endovascular implant (20) and a delivery tool (30). The implant (20) is configured to assume a radially-compressed delivery state, and a radially-expanded deployment state. The delivery tool (30) includes a proximal main delivery catheter (36), having a distal portion (46) in which the implant (20) is disposed while in the radially-compressed delivery state; and a distal restraining assembly (50), which includes a restraining-assembly tubular shaft (52) disposed distal to the proximal main delivery catheter (36). The distal restraining assembly (50) is configured to assume an engaged state, in which the distal restraining assembly (50) prevents proximal displacement of the implant (20) relative to the distal restraining assembly (50), and a disengaged state, in which the distal restraining assembly (50) allows proximal displacement of the implant (20) relative to the distal restraining assembly (50). Other embodiments are also described.
摘要翻译：血管内系统（10）包括血管内植入物（20）和递送工具（30）。植入物（20）构造成呈现径向压缩的递送状态和径向展开的展开状态。输送工具（30）包括近端主输送导管（36），其具有远端部分（46），植入物（20）在径向压缩输送状态下设置在其中; 和远端约束组件（50），其包括远离所述近侧主输送导管（36）设置的限制组件管状轴（52）。所述远端约束组件（50）构造成呈现接合状态，其中所述远侧限制组件（50）防止所述植入物（20）相对于所述远侧约束组件（50）的近侧位移以及脱离状态，其中远侧约束组件（50）允许植入物（20）相对于远侧约束组件（50）近端移位。还描述了其它实施例。

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