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1. 发明申请

WO2013030818A3 STENT-GRAFTS WITH POST-DEPLOYMENT VARIABLE AXIAL AND RADIAL DISPLACEMENT 审中-公开
标题翻译：具有后置部分可变轴向和径向位移的STENT-GRAFTS
公开(公告)号：WO2013030818A3
公开(公告)日：2015-06-18
申请号：PCT/IL2012000148
申请日：2012-04-04
申请人： ENDOSPAN LTD , SHALEV ALON
发明人： SHALEV ALON
IPC分类号： A61F2/82
CPC分类号： A61F2/07 , A61F2/82 , A61F2/89 , A61F2002/065 , A61F2002/075 , A61F2210/0057 , A61F2210/0066 , A61F2220/0075 , A61F2230/0078 , A61F2250/0007 , A61F2250/001 , A61F2250/0013 , A61F2250/0039
摘要： An endovascular stent-graft (20) includes a generally tubular body (22), which is configured to assume a radially-compressed delivery state and a radially-expanded deployment state. The body (22) includes a flexible stent member (24), and a tubular fluid flow guide (26) attached to the stent member (24). The body (22) includes a compliance-restoration body portion (34), which extends axially along a portion of the body, and which comprises a portion of the stent member (24) and a portion of the fluid flow guide (26). When the body (22) is in the radially-expanded deployment state, the compliance-restoration body portion (34) is (a) characterized by a greatest diastolic outer radius (RD) when the body (22) is internally pressurized by fluid having a pressure of 80 mmHg, and (b) radially expandable to a greatest systolic outer radius (RS) when the body (22) is internally pressurized by fluid having a pressure of 120 mmHg. The greatest systolic outer radius (RS) is at least 5% greater than the greatest diastolic outer radius (RD).
摘要翻译：血管内支架移植物（20）包括大致管状体（22），其构造为呈现径向压缩的递送状态和径向扩张的展开状态。主体（22）包括柔性支架构件（24）和连接到支架构件（24）的管状流体流动引导件（26）。主体（22）包括顺应性恢复主体部分（34），其沿主体的一部分轴向延伸，并且包括支架构件（24）的一部分和流体流动引导件（26）的一部分。当身体（22）处于径向展开的展开状态时，柔顺修复体部分（34）的特征在于当身体（22）被内部加压时具有最大的舒张外半径（RD） 80mmHg的压力，以及（b）当身体（22）由压力为120mmHg的流体内部加压时，径向可扩张至最大的收缩外半径（RS）。最大的收缩期外半径（RS）比最大舒张外半径（RD）至少大5％。

2. 发明申请

WO2012104842A3 IMPLANTABLE MEDICAL DEVICES CONSTRUCTED OF SHAPE MEMORY MATERIAL 审中-公开
标题翻译：构造形状记忆材料的可植入医疗器械
公开(公告)号：WO2012104842A3
公开(公告)日：2012-11-22
申请号：PCT/IL2012000060
申请日：2012-02-02
申请人： ENDOSPAN LTD , SHALEV ALON , BERNARY RAPHEL
发明人： SHALEV ALON , BERNARY RAPHEL
IPC分类号： A61F2/95 , A61F2/97
CPC分类号： A61F2/82 , A61F2/07 , A61F2/95 , A61F2/97 , A61F2002/9511
摘要： Medical apparatus (100) is provided for insertion into a mammalian body. The apparatus (100) includes structural stent elements (110), at least a portion of which are shaped so as to define (a) at least one generally circumferential band (112), and (b) a plurality of engagement members (114) that are joined to and extend radially inwardly from the band (112). The apparatus (100) further includes an elongated latch member (118) which is threaded through the engagement members (114), thereby physically latching the engagement members (114). The band (112) and the engagement members (114) are configured such that (a) when the latch member (118) is threaded through and thus physically latches the engagement members (114), the engagement members (114) retain the band (112) in a radially-compressed state, and (b) when the latch member (118) is removed from the engagement members (114), the band (112) assumes a radially-expanded state. Other embodiments are also described.
摘要翻译：提供医疗装置（100）用于插入哺乳动物体内。装置（100）包括结构性支架元件（110），其至少一部分成形为限定（a）至少一个大致圆周的带状物（112），和（b）多个接合构件（114）其从带（112）接合并径向向内延伸。装置（100）还包括细长的闩锁构件（118），其穿过接合构件（114），从而物理地锁定接合构件（114）。带（112）和接合构件（114）构造成使得（a）当闩锁构件（118）穿过并因此物理地闩锁接合构件（114）时，接合构件（114）保持带 112）处于径向压缩状态，和（b）当闩锁构件（118）从接合构件（114）移除时，带（112）呈放射状膨胀状态。还描述了其他实施例。

3. 发明申请

WO2011064782A3 MULTI-COMPONENT STENT-GRAFT SYSTEM FOR IMPLANTATION IN A BLOOD VESSEL WITH MULTIPLE BRANCHES 审中-公开
标题翻译：用于在具有多个分支的血管中植入的多组分STEG-GRAFT系统
公开(公告)号：WO2011064782A3
公开(公告)日：2011-10-06
申请号：PCT/IL2010000999
申请日：2010-11-30
申请人： ENDOSPAN LTD , SHALEV ALON , RAZ SAGI , BENARY RAFI
发明人： SHALEV ALON , RAZ SAGI , BENARY RAFI
IPC分类号： A61F2/06 , A61F2/07
CPC分类号： A61F2/07 , A61F2/90 , A61F2002/061 , A61F2250/0039 , A61F2250/006 , A61F2250/0065
摘要： A multi-component stent-graft system (10) comprises first, second, and third generally tubular stent-grafts (20, 22, 24), which are configured to assume radially-expanded states. The first (20) is shaped so as to define a first lateral opening (34) when radially-expanded. The second (22) is shaped so as to define a second lateral opening (44) when radially-expanded. The first and second (20, 22) are configured such that the second (22) forms a blood-impervious seal with the first (20) around the first lateral opening (34) when the second stent-graft (22) is disposed therethrough, and the first and the second (20, 22) are radially-expanded. The second and the third (22, 24) are configured such that the third (24) forms a blood-impervious seal with the second (22) around the second lateral opening (44) when the third (24) is disposed therethrough, and the second and third (22, 24) are radially-expanded. Other embodiments also described.
摘要翻译：多组分支架移植物系统（10）包括第一，第二和第三大体管状支架移植物（20,22,24），其构造成呈放射状扩张状态。第一（20）成形为当径向展开时限定第一侧向开口（34）。第二（22）成形为当径向展开时限定第二侧向开口（44）。第一和第二（20,22）构造成使得当第二支架移植物（22）穿过其中时，第二（22）在第一侧向开口（34）周围形成具有第一（20）的不透血性密封件，并且第一和第二（20,22）径向展开。第二和第三（22,24）被构造成使得当第三（24）穿过其中时，第三（24）在第二侧开口（44）周围形成具有第二（22）的不透血的密封，以及第二和第三（22,24）径向展开。还描述了其它实施例。

4. 发明申请

WO2013084235A3 BRANCHED STENT-GRAFT SYSTEM 审中-公开
标题翻译：分支式支架系统
公开(公告)号：WO2013084235A3
公开(公告)日：2013-08-29
申请号：PCT/IL2012050506
申请日：2012-12-04
申请人： ENDOSPAN LTD , BENARY RAPHAEL , SHALEV ALON , NAE NIR SHALOM
发明人： BENARY RAPHAEL , SHALEV ALON , NAE NIR SHALOM
IPC分类号： A61F2/06
CPC分类号： A61F2/82 , A61F2/07 , A61F2/856 , A61F2/89 , A61F2/915 , A61F2002/061 , A61F2002/067 , A61F2002/075 , A61F2002/91508 , A61F2002/9511 , A61F2220/0075 , A61F2230/0078 , A61F2250/0039 , A61F2250/0098
摘要： An endovascular stent-graft (10) includes a generally tubular hourglass-shaped body (22), which is configured to assume a radially-compressed delivery configuration and a radially-expanded deployment configuration. The hourglass -shaped body (22) includes a flexible stent member (26), which includes a plurality of structural stent elements (28); and a tubular fluid flow guide (24), which includes a fabric (29), and is attached to the structural stent elements (28). The hourglass- shaped body (22) is shaped so as to define a narrow waist portion (32) longitudinally surrounded by and adjacent to wider first and second longitudinal portions (30, 34). The fabric (29) along the waist portion (32) is shaped so as to define at least first and second lateral apertures (36, 38). Other embodiments are also described.
摘要翻译：血管内支架 - 移植物（10）包括大致管状的沙漏形主体（22），该沙漏形主体构造成呈现径向压缩递送构型和径向扩张展开构型。沙漏形本体（22）包括柔性支架构件（26），柔性支架构件（26）包括多个结构支架元件（28）; 和包括织物（29）并且附接到结构支架元件（28）的管状流体流动引导件（24）。沙漏形主体（22）成形为限定由较宽的第一纵向部分（30）和第二纵向部分（34）纵向地围绕并邻近的窄腰部分（32）。沿着腰部（32）的织物（29）成形为至少限定第一和第二横向孔（36,38）。还描述了其他实施例。

5. 发明申请

WO2012104842A8 IMPLANTABLE MEDICAL DEVICES CONSTRUCTED OF SHAPE MEMORY MATERIAL 审中-公开
标题翻译：构造形状记忆材料的可植入医疗器械
公开(公告)号：WO2012104842A8
公开(公告)日：2013-02-21
申请号：PCT/IL2012000060
申请日：2012-02-02
申请人： ENDOSPAN LTD , SHALEV ALON , BENARY RAPHAEL
发明人： SHALEV ALON , BENARY RAPHAEL
IPC分类号： A61F2/06 , A61F2/95 , A61F2/97
CPC分类号： A61F2/82 , A61F2/07 , A61F2/95 , A61F2/97 , A61F2002/9511
摘要： Medical apparatus (100) is provided for insertion into a mammalian body. The apparatus (100) includes structural stent elements (110), at least a portion of which are shaped so as to define (a) at least one generally circumferential band (112), and (b) a plurality of engagement members (114) that are joined to and extend radially inwardly from the band (112). The apparatus (100) further includes an elongated latch member (118) which is threaded through the engagement members (114), thereby physically latching the engagement members (114). The band (112) and the engagement members (114) are configured such that (a) when the latch member (118) is threaded through and thus physically latches the engagement members (114), the engagement members (114) retain the band (112) in a radially-compressed state, and (b) when the latch member (118) is removed from the engagement members (114), the band (112) assumes a radially-expanded state. Other embodiments are also described.
摘要翻译：提供医疗装置（100）用于插入哺乳动物体内。装置（100）包括结构支架元件（110），其至少一部分成形为限定（a）至少一个大致圆周的带状物（112），和（b）多个接合构件（114）其从带（112）接合并径向向内延伸。装置（100）还包括细长的闩锁构件（118），其穿过接合构件（114），从而物理地锁定接合构件（114）。带（112）和接合构件（114）被构造成使得（a）当闩锁构件（118）被穿过并因此物理地闩锁接合构件（114）时，接合构件（114）保持带 112）处于径向压缩状态，和（b）当闩锁构件（118）从接合构件（114）移除时，带（112）呈放射状膨胀状态。还描述了其它实施例。

6. 发明申请

WO2012049679A2 ACCELERATED BENCH-TESTING OF MEDICAL DEVICES 审中-公开
标题翻译：加速医疗器械的测试
公开(公告)号：WO2012049679A2
公开(公告)日：2012-04-19
申请号：PCT/IL2011000801
申请日：2011-10-10
申请人： ENDOSPAN LTD , RAZ SAGI , BENARY RAPHAEL , SHALEV ALON
发明人： RAZ SAGI , BENARY RAPHAEL , SHALEV ALON
IPC分类号： G01D5/242
CPC分类号： G01F17/00 , A61F2/2472 , A61F2240/008 , G01M99/007 , G01N3/32
摘要： A biomedical tester (10) includes a fluid-control container (101), shaped to define a fluid-control container port (102) and a first interface surface (24) defining fluid-control container apertures (103). A fluid controller (22) is shaped to define a second interface surface (26) defining controller ports (28). These elements (101, 22) and a motor (151) are arranged to relative translation between the first and second interface surfaces (24, 26), thereby effecting a time-varying overlap between subgroups of the system. Fixtures (1 12) allow disposition therewithin of respective medical devices (100). Each of the fixtures (112) includes one or more fixture first ports (1 16) and fixture second ports (1 17). The fixture first ports (116) are mounted in fluid communication respective with the controller ports (28). A fluid pump (121) includes first and second pump ports (122, 123) in fluid communication with the fixture second ports (1 17) and the fluid-control container port (102), respectively.
摘要翻译：生物医学测试器（10）包括流体控制容器（101），其被成形为限定流体控制容器端口（102）和限定流体控制容器孔口（103）的第一界面表面（24）。流体控制器（22）成形为限定限定控制器端口（28）的第二接口表面（26）。这些元件（101,22）和马达（151）被布置成在第一和第二接口表面（24,26）之间的相对平移，从而实现系统的子组之间的时变重叠。夹具（112）允许在各自的医疗装置（100）内进行配置。每个固定装置（112）包括一个或多个夹具第一端口（116）和夹具第二端口（17）。固定装置第一端口（116）分别与控制器端口（28）流体连通地安装。流体泵（121）包括分别与夹具第二端口（17）和流体控制容器端口（102）流体连通的第一和第二泵口（122,123）。

7. 发明申请

WO2010150208A2 VASCULAR PROSTHESES FOR TREATING ANEURYSMS 审中-公开
标题翻译：用于治疗神经系统的血管扩张
公开(公告)号：WO2010150208A2
公开(公告)日：2010-12-29
申请号：PCT/IB2010052861
申请日：2010-06-23
申请人： ENDOSPAN LTD , SHALEV ALON , BENARY RAFI
发明人： SHALEV ALON , BENARY RAFI
IPC分类号： A61M25/01 , A61F2/06
CPC分类号： A61F2/07 , A61F2/06 , A61F2/848 , A61F2/856 , A61F2/89 , A61F2/954 , A61F2/958 , A61F2002/061 , A61F2002/065 , A61F2002/068 , A61F2002/075 , A61F2002/8483 , A61F2220/0016 , A61F2220/0075 , A61F2230/001 , A61F2230/005 , A61F2230/0054 , A61F2230/0067 , A61F2230/0093 , A61F2250/0062
摘要： An endovascular stent-graft (5) is configured to initially be positioned in a delivery catheter (30) in a radially-compressed state, and to assume a radially-expanded state upon being deployed from the delivery catheter (30). The stent-graft (5) includes a structural member (10), including a plurality of structural stent elements (15), at least a portion of which structural stent elements (15) define a stent body (8) when the stent-graft (5) assumes the radially-expanded state. The stent-graft (5) further includes a fluid flow guide (16), including at least one biologically-compatible substantially fluid-impervious flexible sheet, and coupled to the stent body (8). When the stent-graft (5) assumes the radially-expanded state, the fluid flow guide (16) is shaped so as to define radially- diverging and radially-converging portions (13, 19), which together define a bulge (20) that extends radially outward, and has a greatest cross-sectional area that is equal to at least 120% of a cross-sectional area of a narrowest portion (17) of the stent-graft (5) rostral to the bulge (20). Other embodiments are also described.
摘要翻译：血管内支架移植物（5）构造成最初以径向压缩状态定位在输送导管（30）中，并且在从输送导管（30）展开时呈现径向展开状态。支架移植物（5）包括结构构件（10），其包括多个结构性支架元件（15），其中至少一部分结构性支架元件（15）限定支架主体（8），当支架移植物（5）呈放射状膨胀状态。支架移植物（5）还包括流体流动引导件（16），其包括至少一个生物相容的基本上不透液体的柔性片，并且联接到支架主体（8）。当支架移植物（5）呈现径向扩张状态时，流体导流器（16）成形为限定径向扩张和径向会聚的部分（13,19），它们共同限定凸起（20）其径向向外延伸，并且具有最大的横截面面积，该横截面面积等于支架移植物（5）的隆起（20）的最窄部分（17）的横截面面积的至少120％。还描述了其它实施例。

8. 发明申请

WO2009116047A3 SOLID DOSAGE FORM FOR TREATING HEADACHES 审中-公开
标题翻译：用于治疗头痛的固体剂型
公开(公告)号：WO2009116047A3
公开(公告)日：2010-03-11
申请号：PCT/IL2009000314
申请日：2009-03-19
申请人： PAINDURE LTD , SHALEV ALON , LAMNSDORF ITSCHAK
发明人： SHALEV ALON , LAMNSDORF ITSCHAK
IPC分类号： A61K9/22
CPC分类号： A61K9/0024 , A61K9/0043 , A61K9/0085 , A61K31/167 , A61K31/245 , A61K47/34
摘要： A retrievable, sustained release, solid dosage form is provided for implanting into cranial bony canals and for prolonged release of an anesthetic, whereby treating neurovascular conditions, such as migraine. The dosage comprises an anesthetic contained in a polymeric carrier, and a retrieval member, the anesthetic being gradually released from the carrier.
摘要翻译：提供可回收，持续释放的固体剂型用于植入颅骨通道和延长释放麻醉剂，从而治疗神经血管病症，例如偏头痛。剂量包括聚合物载体中含有的麻醉剂和回收构件，麻醉剂逐渐从载体释放。

9. 发明申请

WO2006080010A3 DEVICE AND METHOD FOR CORONARY ARTERY BYPASS PROCEDURE 审中-公开
标题翻译：冠状动脉旁路手术的装置及方法
公开(公告)号：WO2006080010A3
公开(公告)日：2008-01-24
申请号：PCT/IL2006000104
申请日：2006-01-25
申请人： NICAST LTD , SHALEV ALON
发明人： SHALEV ALON
IPC分类号： A61B17/04 , A61F2/06
CPC分类号： A61F2/06 , A61F2/07 , A61F2/24 , A61F2002/072 , A61F2250/0039 , A61F2250/006 , A61F2250/0067
摘要： A method of bypassing a coronary artery being at least partially occluded. The method comprises: using a branching graft for establishing direct fluid communication between three or more vascular locations. Specifically direct fluid communication is established between an upstream vascular location, a downstream vascular location and a distal vascular location. The distal vascular location is preferably selected on a distal artery or a distal portion of an artery to ensure that arterial blood flow in the distal artery generates sufficient pressure gradient in the branching graft to maintain the direct fluid communication.
摘要翻译：绕过冠状动脉至少部分闭塞的方法。该方法包括：使用分枝移植物来建立三个或更多个血管位置之间的直接流体连通。在上游血管位置，下游血管位置和远端血管位置之间建立直接的流体连通。优选在远端动脉或动脉的远端部分选择远端血管位置，以确保远端动脉中的动脉血流在分支移植物中产生足够的压力梯度以保持直接的流体连通。

10. 发明申请

WO2006080009A3 IMPLANTABLE BIOREACTORS AND USES THEREOF 审中-公开
标题翻译：可植入的生物反应器及其用途
公开(公告)号：WO2006080009A3
公开(公告)日：2007-01-25
申请号：PCT/IL2006000103
申请日：2006-01-25
申请人： NICAST LTD , SHALEV ALON
发明人： SHALEV ALON
IPC分类号： A61K9/22
CPC分类号： A61F2/022
摘要： An implantable bioreactor device and methods of use are provided. The device comprises a first compartment being configured capable of fluidic communication with a vasculature of a subject; and a second compartment configured for containing cells, said second compartment being separated from said first compartment by a membrane.
摘要翻译：提供可植入生物反应器装置和使用方法。该装置包括配置成能够与受试者的脉管系统流体连通的第一隔室; 以及构造成容纳细胞的第二隔室，所述第二隔室通过膜与所述第一隔室分离。

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