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11. 发明申请

WO2010044506A2 TMPRSS4-SPECIFIC HUMAN ANTIBODY 审中-公开
标题翻译： TMPRSS4特异性人抗体
公开(公告)号：WO2010044506A2
公开(公告)日：2010-04-22
申请号：PCT/KR2008/006614
申请日：2008-11-10
申请人： KOREA RESEARCH INSTITUTE OF BIOSCIENCE AND BIOTECHNOLOGY , PARK, Young Woo , CHOI, So-Young , JANG, Young-Soon , PARK, Ji Hyun , SONG, Eun-Jung , YU, Jung , SOHN, Myung-Ho , JEON, Jae Won , JUNG, Joon-Goo , KIM, Sungsub , JANG, Myeoung Hee
发明人： PARK, Young Woo , CHOI, So-Young , JANG, Young-Soon , PARK, Ji Hyun , SONG, Eun-Jung , YU, Jung , SOHN, Myung-Ho , JEON, Jae Won , JUNG, Joon-Goo , KIM, Sungsub , JANG, Myeoung Hee
IPC分类号： C07K16/18
CPC分类号： C07K16/40 , A61K2039/505 , C07K2317/21 , C07K2317/52 , C07K2317/622 , C07K2317/73 , C07K2319/00 , C12N9/6424
摘要： The present invention relates to a transmembrane protease, serine (TMPRSS4) -specific human antibody, and more particularly to a human antibody including a complementarity determining region (CDR) and a framework region (FR) derived from a human antibody specifically bound to TMPRSS4. The TMPRSS4- specific human antibody expressed in the various kinds of cancer cells of the present invention may be used in diagnosis of the cancer, classification of the disease, visualization, treatment, and prognostic evaluation.
摘要翻译：本发明涉及跨膜蛋白酶丝氨酸（TMPRSS4）特异性人抗体，并且更具体地涉及包含互补决定区（CDR）和框架区（FR）的人抗体，所述互补决定区（CDR）和框架区（FR）来源于与TMPRSS4特异性结合的人抗体。在本发明的各种癌细胞中表达的TMPRSS4特异性人抗体可用于癌症的诊断，疾病的分类，可视化，治疗和预后评估。

12. 发明申请

WO2010021454A2 METHOD OF PREPARING CARBON-DOPED TITANIUM DIOXIDE NANOPARTICLES BY DECOMPOSITING CARBON DIOXIDE USING THERMAL PLASMA 审中-公开
标题翻译：通过使用热等离子体分解二氧化碳来制备二氧化碳纳米二氧化钛的方法
公开(公告)号：WO2010021454A2
公开(公告)日：2010-02-25
申请号：PCT/KR2009/003105
申请日：2009-06-10
申请人： INHA-INDUSTRY PARTNERSHIP INSTITUTE , PARK, Dong-Wha , PARK, Jung Wan
发明人： PARK, Dong-Wha , PARK, Jung Wan
IPC分类号： B82B3/00
CPC分类号： C01G23/07 , B01J21/18 , B01J35/0013 , B01J35/002 , B01J35/004 , B01J37/342 , B01J37/349 , B82Y30/00 , B82Y40/00 , C01P2002/54 , C01P2002/72 , C01P2002/85 , C01P2004/03 , C01P2004/32 , C01P2004/64
摘要： Disclosed is a method of preparing carbon-doped titanium dioxide nanoparticles by de¬ composing carbon dioxide using thermal plasma, including injecting carbon dioxide and titanium tetrachloride into a reaction tube of a thermal plasma jet system, decomposing the injected carbon dioxide by a thermal plasma jet generated using argon, so that it reacts with titanium tetrachloride transferred by a carrier gas, thus producing carbon-doped titanium dioxide, and cooling the carbon-doped titanium dioxide, thus preparing carbon-doped titanium dioxide nanoparticles. This method decomposes carbon dioxide within a short time thus reducing global warming and showing high decomposition efficiency, and does not need post-treatment thanks to the use of thermal plasma having high temperature and high activity, without concern about the production of secondary pollutants. The carbon-doped anatase titanium dioxide having a size of 20-50 nm exhibits superior photocatalytic activity in the UV/visible range, with a high specific surface area, and thus is efficiently employed as a photocatalyst.
摘要翻译：公开了一种通过使用热等离子体制备二氧化碳来制备掺碳二氧化钛纳米颗粒的方法，包括将二氧化碳和四氯化钛注入到等离子体喷射系统的反应管中，通过热等离子体射流分解注入的二氧化碳使用氩气使其与载气转移的四氯化钛反应，从而产生碳掺杂的二氧化钛，并冷却碳掺杂的二氧化钛，从而制备碳掺杂的二氧化钛纳米颗粒。该方法在短时间内分解二氧化碳，从而减少全球变暖并显示高分解效率，并且由于使用具有高温和高活性的热等离子体而不需要后处理，而不考虑二次污染物的产生。尺寸为20-50nm的碳掺杂锐钛矿型二氧化钛在UV /可见光范围内表现出优异的光催化活性，具有高比表面积，因此有效地用作光催化剂。

13. 发明申请

WO2010013987A2 EXTRACTION METHOD FOR INCREASING LIQUIRITIGENIN CONTENT IN GLYCYRRHIZAE RADIX ET RHIZOMA OR GLYCYRRHIZAE RADIX EXTRACT 审中-公开
标题翻译：提取甘草提取物中甘草素含量的提取方法
公开(公告)号：WO2010013987A2
公开(公告)日：2010-02-04
申请号：PCT/KR2009/004331
申请日：2009-08-03
申请人： DAEWON PHARM., CO., LTD , JEONG, Chankyu , SOHN, Seil , KIM, HongKi , KIM, Hyungson
发明人： JEONG, Chankyu , SOHN, Seil , KIM, HongKi , KIM, Hyungson
IPC分类号： A61K36/484 , A61K31/352 , A61P39/02
CPC分类号： A61K36/484
摘要： Disclosed herein is an extraction method for increasing liquiritigenin content in Glycyrrhizae Radix et Rhizoma or Glycyrrhizae radix extract, the method comprising: using water, an organic solvent, or a mixed solvent of water and the organic solvent to Glycyrrhizae Radix et Rhizoma to extract a product containing liquiritin (Step 1); and introducing water, an organic solvent, or a mixed solvent of water and the organic solvent into the product containing liquiritin extracted in Step 1, adding acid or base into the solution, and hydrolyzing the mixture to prepare a product containing liquiritigenin (Step 2).
摘要翻译：本文公开了用于增加甘草根或甘草提取物中甘草素含量的提取方法，所述方法包括：使用水，有机溶剂或水和所述有机溶剂的混合溶剂，甘草提取含甘草苷的产品（步骤1）; 将水，有机溶剂或水和有机溶剂的混合溶剂引入到步骤1中提取的含有甘草苷的产物中，向溶液中加入酸或碱，并水解混合物以制备含有甘草素的产物（步骤2）

14. 发明申请

WO2009154425A9 MULTIMODAL IMAGING METHOD USING NANO-EMULSION COMPRISING OPTICAL NANO-PARTICLES AND PERFLUOROCARBONS 审中-公开
公开(公告)号：WO2009154425A9
公开(公告)日：2009-12-23
申请号：PCT/KR2009/003308
申请日：2009-06-19
申请人： KOREA RESEARCH INSTITUTE OF BIOSCIENCE AND BIOTECHNOLOGY , CHUNG, Bong Hyun , LIM, Yong Taik
发明人： CHUNG, Bong Hyun , LIM, Yong Taik
IPC分类号： A61K49/06
摘要： The present invention relates to a multimodal imaging method using a nano-emulsion comprising optical nano-particles and perfluorocarbons, and more particularly, to a method of obtaining multimodal images using a nano-emulsion consisted of perfluorocarbons for multispectral magnetic resonance imaging (MRI) and nano-particles for multicolor fluorescent detection. In the multimodal imaging method, various multispectral MRI images and multicolor fluorescent rays can be obtained by varing the kind and combination of perfluorocarbons and the kind and combination of optical nano-particles, so that multiplexed analysis is possible. Accordingly, the multimodal imaging method can be applied to various fields, including biological and medical fields in which studies on cell molecular imaging has been conducted.

15. 发明申请

WO2009151236A2 THE COMPOSITION COMPRISING EXTRACTS OR FRACTIONS OF MAGNOLIA OBOVATA THUNB FOR TREATING AND PREVENTING INFLAMMATION DISEASE 审中-公开
标题翻译：包含MAGNOLIA OBOVATA THUNB用于治疗和预防炎症疾病的提取物或成分的组合物
公开(公告)号：WO2009151236A2
公开(公告)日：2009-12-17
申请号：PCT/KR2009/003031
申请日：2009-06-05
申请人： KOREA RESEARCH INSTITUTE OF BIOSCIENCE AND BIOTECHNOLOGY , KWON, Byoung-Mog , HAN, Dong Cho , KIM, Hye-Nan , HAN, Young-Min , LEE, So Young , SHIN, Dae-Seop
发明人： KWON, Byoung-Mog , HAN, Dong Cho , KIM, Hye-Nan , HAN, Young-Min , LEE, So Young , SHIN, Dae-Seop
IPC分类号： A61K36/57
CPC分类号： A61K36/575 , A23L2/52 , A23L33/105 , A23L33/15 , A23L33/16 , A61K9/0095 , A61K9/145 , A61K9/2018 , A61K9/2059 , A61K9/4858 , A61K9/4866 , A61K31/05 , A61K31/09
摘要： The present invention relates to a composition for the prevention and treatment of inflammatory disease containing the extracts of Magnolia obovata or fractions thereof as an active ingredient, more precisely, a composition for the prevention and treatment of inflammatory disease containing the extracts of Magnolia obovata fruits and floral buds extracted with alcohol or alcohol aqueous solution as a solvent and active fractions isolated from the same. The extracts and fractions of the present invention inhibit lipopolysaccharide (LPS) induced nitric oxide (NO) generation significantly, have anti-inflammation activity and low cytotoxicity, and contain all of major effective components isolated from Magnolia obovata such as obovatol, honokiol and magnolol, so that they can be effectively used for the prevention and treatment of inflammatory disease.
摘要翻译：本发明涉及用于预防和治疗炎症疾病的组合物，所述组合物含有木兰或其部分的提取物作为活性成分，更准确地说，涉及用于预防和治疗含有木兰果实提取物的炎性疾病的组合物，用醇或醇水溶液作为溶剂提取花芽，并从其中分离出活性级分。本发明的提取物和级分显着抑制脂多糖（LPS）诱导的一氧化氮（NO）产生，具有抗炎活性和低细胞毒性，并且含有从木兰如云母，厚朴酚和厚朴酚分离的所有主要有效成分，使其可以有效地用于预防和治疗炎症性疾病。

16. 发明申请

WO2009151160A1 METHOD FOR MANUFACTURING THE COLOR CONTROLLED SAPPIRE 审中-公开
标题翻译：制造颜色控制SAPPIRE的方法
公开(公告)号：WO2009151160A1
公开(公告)日：2009-12-17
申请号：PCT/KR2008/003268
申请日：2008-06-12
申请人： KOREA ATOMIC ENERGY RESEARCH INSTITUTE , PARK, Jae-Won , AHN, Ju-Hyung , KIM, Young-chool , HAN, Jang-Min , KIM, Junyeon
发明人： PARK, Jae-Won , AHN, Ju-Hyung , KIM, Young-chool , HAN, Jang-Min , KIM, Junyeon
IPC分类号： C30B29/20 , C30B33/02
CPC分类号： C30B31/22 , C30B29/20 , C30B33/02
摘要： Disclosed herein is a method of manufacturing a color-controlled sapphire, comprising: vaporizing a metal material, irradiating the vaporized metal material with electron beams or high-frequency waves to form the vaporized metal material into a plasma state, and then implanting the metal ions into a sapphire by extracting the metal ions from the plasma and accelerating the metal ions (step 1); and heat-treating the sapphire implanted with the metal plasma ions in an oxygen atmosphere or in air (step 2). According to the method of manufacturing a sapphire of the present invention, a sapphire, which can exhibit various colors, can be manufactured by implanting the ions, which can cause optical band gap changes into the sapphire, and a sapphire, which cannot be damaged by radiation and can exhibit colors uniformly, can be manufactured by conducting heat treatment under an oxygen atmosphere. Further, according to the present invention, a sapphire, which cannot be damaged by radiation and can be made to exhibit uniform colors, can be manufactured by performing the above processes repeatedly.
摘要翻译：本发明公开了一种制造颜色控制蓝宝石的方法，包括：蒸发金属材料，用电子束或高频波照射蒸发的金属材料，以将蒸发的金属材料形成等离子体状态，然后注入金属离子通过从等离子体中提取金属离子并加速金属离子而成为蓝宝石（步骤1）; 并在氧气氛或空气中热处理注入金属等离子体离子的蓝宝石（步骤2）。根据本发明的制造蓝宝石的方法，可以通过将能够引起光学带隙变化的离子注入到蓝宝石中来制造能够呈现各种颜色的蓝宝石，并且不会被损坏的蓝宝石可以均匀地显示颜色，可以通过在氧气氛下进行热处理来制造。此外，根据本发明，可以通过重复执行上述处理来制造不能被辐射损坏并且可以制成呈现均匀颜色的蓝宝石。

17. 发明申请

WO2009145399A1 A COMPOSITION CONTAINING OSTEOPONTIN FOR DIFFERENTIATING NATURAL KILLER CELL AS AN ACTIVE INGREDIENT AND A METHOD OF DIFFERENTIATION USING THEREOF 审中-公开
标题翻译：含有OSTEOPONTIN的组合物，用于将自然杀伤细胞分解为活性成分，以及使用其分化的方法
公开(公告)号：WO2009145399A1
公开(公告)日：2009-12-03
申请号：PCT/KR2008/006612
申请日：2008-11-10
申请人： KOREA RESEARCH INSTITUTE OF BIOSCIENCE AND BIOTECHNOLOGY , CHOI, Inpyo , CHUNG, Jin Woong , KIM, Misun , YOON, Suk Ran
发明人： CHOI, Inpyo , CHUNG, Jin Woong , KIM, Misun , YOON, Suk Ran
IPC分类号： A61K38/21
CPC分类号： A61K38/19 , A61K35/17 , C12N5/0646 , C12N2501/998
摘要： The present invention relates to a composition for differentiating natural killer cells comprising osteopontin (OPN) as an active ingredient and a method for differentiation using the same. More precisely, osteopontin of the present invention accelerates differentiation of natural killer cells from hematopoietic stem cells and increases cytotoxic activity of natural killer cells, so that it can be effectively used as a composition for differentiating natural killer cells. OPN of the present invention regulates differentiation of natural killer cells capable of killing cancer cells, so that it can be effectively used for the treatment of cancer.
摘要翻译：本发明涉及用于分化包含骨桥蛋白（OPN）作为活性成分的天然杀伤细胞的组合物和使用其的分化方法。更准确地说，本发明的骨桥蛋白加速了造血干细胞中天然杀伤细胞的分化，并增加了天然杀伤细胞的细胞毒活性，因此可有效地用作分化天然杀伤细胞的组合物。本发明的OPN调节能够杀死癌细胞的天然杀伤细胞的分化，从而可以有效地用于治疗癌症。

18. 发明申请

WO2009104851A1 DEVICE FOR XOR MAGNETO-LOGIC CIRCUIT USING STT-MTJ 审中-公开
标题翻译：使用STT-MTJ进行异或逻辑电路的器件
公开(公告)号：WO2009104851A1
公开(公告)日：2009-08-27
申请号：PCT/KR2008/005568
申请日：2008-09-19
申请人： EWHA UNIVERSITY-INDUSTRY COLLABORATION FOUNDATION , SHIN, Hyungsoon , LEE, Seungyeon , LEE, Hyunjoo , LEE, Gamyoung
发明人： SHIN, Hyungsoon , LEE, Seungyeon , LEE, Hyunjoo , LEE, Gamyoung
IPC分类号： H01L29/768
CPC分类号： G11C11/1675 , G11C11/1673
摘要： The present invention relates to an XOR logic operation apparatus using a spin torque transfer-based MTJ device. The XOR logic operation apparatus includes two parallel-connected magnetic memory cells (100, 200), and a sense amplifier (300) connected to first ends of the two magnetic memory cells. Each of the magnetic memory cells includes an MTJ device (10) and a current control circuit (50). Each magnetic memory cell includes a top electrode (11) and a bottom electrode (13) configured to allow current to flow therethrough, an insulating layer (19) configured to electrically insulate the top electrode from the bottom electrode, and a free magnetic layer (17) and a pinned magnetic layer (15) respectively formed on a top and a bottom of the insulating layer. The current control circuit controls flow of current passing between the top electrode and the bottom electrode, and changes a magnetization direction of the free magnetic layer.
摘要翻译：本发明涉及使用基于自旋转矩传输的MTJ装置的异或逻辑运算装置。 XOR逻辑运算装置包括两个并联的磁存储单元（100,200）和连接到两个磁存储单元的第一端的读出放大器（300）。每个磁存储单元包括MTJ装置（10）和电流控制电路（50）。每个磁存储单元包括被配置为允许电流流过其中的顶部电极（11）和底部电极（13），被配置为使顶部电极与底部电极电绝缘的绝缘层（19）和自由磁性层 17）和分别形成在绝缘层的顶部和底部上的钉扎磁性层（15）。电流控制电路控制在顶部电极和底部电极之间流动的电流，并且改变自由磁性层的磁化方向。

19. 发明申请

WO2009102083A1 NOVEL CLITOCYBIN DERIVATIVES, PREPARATION METHOD THEREOF AND COMPOSITION CONTAINING THE EXTRACT OF CLITOCYBE AURANTIACA KCTC 11143BP OR THE NOVEL CLITOCYBIN DERIVATIVES FOR PREVENTION OF AGING AS AN ACTIVE INGREDIENT 审中-公开
标题翻译：新戊酰胆碱衍生物及其制备方法及其组合物，其含有CLITOCYBE AURANTIACA KCTC 11143BP或用于预防老化作为活性成分的新型CLITOCYBIN衍生物
公开(公告)号：WO2009102083A1
公开(公告)日：2009-08-20
申请号：PCT/KR2008/000804
申请日：2008-02-12
申请人： KOREA RESEARCH INSTITUTE OF BIOSCIENCE AND BIOTECHNOLOGY , YOO, Ick-Dong , RYOO, In-Ja , KIM, Young-Hee , CHOO, Soo-Jin , LEE, Sangku
发明人： YOO, Ick-Dong , RYOO, In-Ja , KIM, Young-Hee , CHOO, Soo-Jin , LEE, Sangku
IPC分类号： C07D209/46 , A61K31/4035 , A61K8/49
CPC分类号： A61Q19/08 , A61K8/492 , A61K8/97 , C07D209/46
摘要： Disclosed are novel clitocybin derivatives and methods for the preparation thereof. Also, anti-aging, pharmaceutical or cosmetic composition comprising the clitocybin derivatives as active ingredient are also provided. The extract from Clitocybe aurantiaca (KCTC 11143BP) or the novel clitocybin derivatives have excel lent ability to scavenge oxygen radicals, to inhibit oxidative DNA damage and to reduce UV-induced erythema, so that they can be useful in the prophylaxis and treatment of diseases attributable to the accumulation of excess active oxygen and can be applied to the preparation of pharmaceutical or cosmetic compositions for the prevention of aging.
摘要翻译：公开了新型胞质胞苷衍生物及其制备方法。此外，还提供了包含作为活性成分的胞质胞苷衍生物的抗衰老，药物或化妆品组合物。来自Clitocybe aurantiaca（KCTC 11143BP）或新型胞质蛋白衍生物的提取物具有清除氧自由基，抑制氧化性DNA损伤和减少紫外线诱发的红斑的能力，从而可用于预防和治疗可归因于对于过量的活性氧的积累，并且可以应用于药物或化妆品组合物的制备以防止老化。

20. 发明申请

WO2009093769A3 SYSTEM FOR CONTROLLING THE FORCE REBALANCE USING AUTOMATIC GAIN CONTROLLING LOOP AND METHOD FOR THE SAME 审中-公开
公开(公告)号：WO2009093769A3
公开(公告)日：2009-07-30
申请号：PCT/KR2008/000471
申请日：2008-01-25
申请人： KONKUK UNIVERSITY INDUSTRIAL COOPERATION CORP. , SUNG, Sang-Kyung , SUNG, Woon-Tahk
发明人： SUNG, Sang-Kyung , SUNG, Woon-Tahk
IPC分类号： G01C19/5726
摘要： The present invention relates to a force rebalance control system and method using an automatic gain control loop, which are configured to perform the force rebalance feedback control of a vibratory gyroscope using the automatic gain control loop for controlling the velocity signal of a mass body. Accordingly, the present invention is advantageous in that a conventional digital circuit, which is complicated and sensitive to noise, can be implemented using a simple analog circuit, and the present invention can be extended and applied to general-purpose vibratory gyroscopes or various sensor fields, such as those of an inertial sensor, a pressure sensor, and a temperature sensor, as well as micro-gyroscopes. Further, a force rebalance control system using an automatic gain control loop according to the present invention is applied to various sensors, thus improving performance, such as the dynamic range, bandwidth, and linearity of the sensors.

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