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151. 发明申请

WO1996029410A1 IN VIVO GENERATION OF ANTIBODIES AGAINST ANTIGENS SECRETED IN A HOST BY TRANSFECTED MEL CELLS 审中-公开
标题翻译：在转基因细胞中分泌抗原的抗体生物体内
公开(公告)号：WO1996029410A1
公开(公告)日：1996-09-26
申请号：PCT/GB1996000616
申请日：1996-03-18
申请人： ZENECA LIMITED , NEEDHAM, Maurice, Ronald, Charles , HOLLIS, Melvyn
发明人： ZENECA LIMITED
IPC分类号： C12N15/13
CPC分类号： C07K16/00 , A61K39/00 , A61K48/00 , C07K14/52 , C07K14/70542
摘要： A method for the generation in a mammalian host of antibodies to a biological of interest which method comprises incorporating murine erythroleukemia (MEL) cell comprising DNA encoding the biological of interest into the mammalian host, allowing the MEL cells to express and secrete the biological of interest, allowing the host to raise antibodies thereto, and isolating said antibodies from the host.
摘要翻译：在哺乳动物宿主中产生感兴趣的生物学抗体的方法包括将包含编码目的生物学信息的DNA的鼠红白血病（MEL）细胞掺入到哺乳动物宿主中，允许MEL细胞表达和分泌感兴趣的生物学，允许宿主产生抗体，并从宿主中分离所述抗体。

152. 发明申请

WO1996028762A1 LIQUID PHOTOCURABLE COMPOSITIONS 审中-公开
标题翻译：液体光电组合物
公开(公告)号：WO1996028762A1
公开(公告)日：1996-09-19
申请号：PCT/GB1996000517
申请日：1996-03-06
申请人： ZENECA LIMITED , POPAT, Ajay, Haridas , LAWSON, John, Robert , MCLEAN, Colin, Henry
发明人： ZENECA LIMITED
IPC分类号： G03F07/027
CPC分类号： G03F7/0037 , G03F7/027
摘要： A liquid composition comprising: a) 5 to 25 parts of a monomeric aliphatic or cycloaliphatic di(meth)acrylate having a MW of not more than 800; b) 2 to 20 parts of a monomeric poly(meth)acrylate having a functionality of at least 3 and a MW of at least 610; c) 12 to 40 parts of a urethane(meth)acrylate having a functionality of 2 to 4 and a MW of 400 to 10,000; d) 35 to 70 parts of a monomeric or oligomeric di(meth)acrylate based on bisphenol A or bisphenol F; and e) 0.1 to 10 parts of a photoinitiator; wherein all parts are by weight, the total number of parts of a) + b) does not exceed 30 and the total number of parts of a) + b) + c) + d) + e) add up to 100. The compositions are suitable for the stereolighographic production of three-dimensional solid articles such as mechanical parts and models of body parts.
摘要翻译：一种液体组合物，其包含：a）5〜25份MW不大于800的单体脂族或脂环族二（甲基）丙烯酸酯; b）2至20份官能度至少为3且MW至少为610的单体聚（甲基）丙烯酸酯; c）12〜40份官能度为2〜4，MW为400〜10,000的氨基甲酸酯（甲基）丙烯酸酯; d）35〜70份基于双酚A或双酚F的单体或低聚二（甲基）丙烯酸酯; 和e）0.1至10份光引发剂; 其中所有部分都是重量比，a）+ b）的部分总数不超过30，a）+ b）+ c）+ d）+ e）的总数量加到100上。组合物适用于三维固体制品如机械零件和车身部件型号的立体定向生产。

153. 发明申请

WO1996028151A2 USE OF A PYRUVATE DEHYDROGENASE ACTIVATOR FOR THE TREATMENT OF ISCHAEMIA IN LIMBS 审中-公开
标题翻译：用于治疗肢体血浆的吡啶类脱氢酶活化剂
公开(公告)号：WO1996028151A2
公开(公告)日：1996-09-19
申请号：PCT/GB1996000555
申请日：1996-03-11
申请人： ZENECA LIMITED , CONSTANTIN-TEODOSIU, Dumitru , TIMMONS, James, Archibald , GREENHAFF, Paul, Leonard , POUCHER, Simon, Martin
发明人： ZENECA LIMITED
IPC分类号： A61K31/22
CPC分类号： A61K31/222 , A61K31/00 , A61K31/19 , A61K31/22
摘要： Agents which inhibit PDH kinase such as dichloroacetic acid, its salts and derivatives are described as being useful in the treatment of ischaemia in limbs. In particular, dichloroacetic acid and its salts are useful in treating intermittent claudification. Pharmaceutical compositions are also described.
摘要翻译：抑制PDH激酶如二氯乙酸，其盐和衍生物的药物被描述为可用于治疗肢体中的局部缺血。特别地，二氯乙酸及其盐可用于治疗间歇性跛行。还描述了药物组合物。

154. 发明申请

WO1996024842A1 APPLICATION OF COUNTERCURRENT CHROMATOGRAPHY TO THE DECONVOLUTION OF CHEMICAL LIBRARIES 审中-公开
标题翻译：反相色谱应用于化学文库的解体
公开(公告)号：WO1996024842A1
公开(公告)日：1996-08-15
申请号：PCT/GB1996000242
申请日：1996-02-07
申请人： ZENECA LIMITED , SHUTE, Richard, Eden , MAIN, Brian, Geoffrey
发明人： ZENECA LIMITED
IPC分类号： G01N30/42
CPC分类号： G01N30/42 , B01J2219/00707 , C07K1/047
摘要： A method for separating a chemical library into sub-library fractions which method comprises applying countercurrent chromatography (CCC) to the library and collecting sub-library fraction(s).
摘要翻译：一种将化学文库分离成亚文库级分的方法，该方法包括向文库中应用逆流色谱法（CCC）并收集子文库级分。

155. 发明申请

WO1996022957A1 PROCESS FOR THE PRODUCTION OF 2-(SUBSTITUTED BENZOYL)-1,3 CYCLOHEXANEDIONES 审中-公开
标题翻译： 2-（取代苯甲酰基）-1,3环己酮的制备方法
公开(公告)号：WO1996022957A1
公开(公告)日：1996-08-01
申请号：PCT/GB1996000081
申请日：1996-01-16
申请人： ZENECA LIMITED , BROWN, Stephen, Martin , RAWLINSON, Howard , WIFFEN, Jonathan, William
发明人： ZENECA LIMITED
IPC分类号： C07C45/54
CPC分类号： C07C315/04 , C07C45/54 , C07C317/24 , C07C49/792
摘要： A process for preparing a compound of formula (I), where R , R , R , R , R and R are independently hydrogen or C1-6 alkyl; R is halogen, cyano, NO2, C1-4 alkyl, C1-4 haloalkyl, C1-4 alkoxy or RaS in which Ra is C1-4 alkyl; R , R and R independently are hydrogen, halogen, C1-4 alkyl, C1-4 alkoxy, C1-4 haloalkyl, C1-4 haloalkoxy, CN, NO2, phenoxy or substituted phenoxy; RbS(O)n Om in which m is 0 or 1, n is 0, 1 or 2 and Rb is C1-4 alkyl, C1-4 haloalkyl, phenyl or benzyl, NHCORc in which Rc is C1-4 alkyl, NRdRe in which Rd and Re independently are hydrogen or C1-4 alkyl; RfC(O)- in which Rf is hydrogen, C1-4 alkyl, C1-4 haloalkyl or C1-4 alkoxy; SO2NRgRh in which Rg and Rh independently are hydrogen or C1-4 alkyl; or any two of R , R and R together with the carbon atoms to which they are attached form a 5 or 6 membered heterocyclic ring containing up to three heteroatoms selected from O, N or S and which may be optionally substituted by C1-4 alkyl, C1-4 haloalkyl, C1-4 alkoxy, =NOC1-4 alkyl, or halogen; which process comprises the rearrangement of a compound of formula (II), where R , R , R , R , R , R , R , R , R and R are as defined in relation to formula (I), in the presence of a base and a polar aprotic solvent characterised in that the process is carried out in a reaction medium substantially free of hydrogen cyanide or cyanide anion.
摘要翻译：制备式（I）化合物的方法，其中R 1，R 2，R 3，R 4，R 5和R 6独立地是氢或C 1-6烷基 ; R 7是卤素，氰基，NO 2，C 1-4烷基，C 1-4卤代烷基，C 1-4烷氧基或R a，其中R a是C 1-4烷基; R 8，R 9和R 10独立地是氢，卤素，C 1-4烷基，C 1-4烷氧基，C 1-4卤代烷基，C 1-4卤代烷氧基，CN，NO 2，苯氧基或取代的苯氧基; RbS（O）n Om，其中m为0或1，n为0,1或2，Rb为C1-4烷基，C1-4卤代烷基，苯基或苄基，NHCORc，其中Rc为C1-4烷基，NRdRe为哪个Rd和Re独立地是氢或C 1-4烷基; RfC（O） - ，其中R f为氢，C 1-4烷基，C 1-4卤代烷基或C 1-4烷氧基; 其中Rg和Rh独立地为氢或C1-4烷基的SO2NRgRh; 或R 8，R 9和R 10中的任何两个与它们所连接的碳原子一起形成含有至多三个选自O，N或S的杂原子的5或6元杂环，并且其中可以任选地被C 1-4烷基，C 1-4卤代烷基，C 1-4烷氧基，= NOC 1-4烷基或卤素取代; 该方法包括式（II）化合物的重排，其中R 1，R 2，R 3，R 4，R 5，R 6，R 7，在碱和极性非质子溶剂的存在下，R 8，R 9和R 10如关于式（I）所定义，其特征在于该方法在基本上无反应的反应介质中进行的氰化氢或氰化物阴离子。

156. 发明申请

WO1996020436A1 COMPOSITION, COMPOUND AND USE 审中-公开
标题翻译：组合物，化合物和用途
公开(公告)号：WO1996020436A1
公开(公告)日：1996-07-04
申请号：PCT/GB1995002852
申请日：1995-12-07
申请人： ZENECA LIMITED , CAMPBELL, James, Stanley , GREGORY, Peter , FAWKES, David, Melville
发明人： ZENECA LIMITED
IPC分类号： G03G09/097
CPC分类号： G03G9/09775 , C07C65/11 , C07C229/38 , G03G9/09733 , G03G9/09783
摘要： A toner resin composition comprising a toner resin and the metal salt or complex of a carbocyclic hydroxy carboxylic acid containing at least one methylene group optionally substituted by hydroxy or amino such as 4-(N-methyl-N-2-hydroxyethyl)aminomethyl-3-hydroxy-2-naphthoic acid. Iron and zinc salts are preferred.
摘要翻译：一种调色剂树脂组合物，其包含调色剂树脂和含有至少一个任选被羟基或氨基取代的亚甲基的碳环羟基羧酸的金属盐或络合物，例如4-（N-甲基-N-2-羟乙基）氨基甲基-3 - 羟基-2-萘甲酸。优选铁和锌盐。

157. 发明申请

WO1996020216A1 FIBRONECTIN ADHESION INHIBITORS 审中-公开
标题翻译：纤维素粘合抑制剂
公开(公告)号：WO1996020216A1
公开(公告)日：1996-07-04
申请号：PCT/GB1995002992
申请日：1995-12-21
申请人： ZENECA LIMITED , DUTTA, Anand, Swaroop
发明人： ZENECA LIMITED
IPC分类号： C07K14/78
CPC分类号： C07K14/78 , A61K38/00
摘要： Cyclic peptides of formula (1) wherein: AA1 is an L or D amino acid selected form Ile and Leu or amino acid analogue thereof; AA2 is an L amino acid selected from Leu or amino acid analogue thereof; AA3 is an L amino acid selected from Asp or amino acid analogue thereof containing a carboxyl group in its side chain; AA4 is an L amino acid selected from Val or amino acid analogue thereof and; LINKER represents a linking moiety for linking N terminus of AA1 to C terminus of AA4 to form a cyclic peptide containing a heterocyclic ring having 17 to 30 members. The cyclic peptides inhibit the interaction of vascular cell adhesion molecule-1 and fibronectin with integrin very late antigen 4 and have therapeutic applications such as in rheumatoid arthritis or multiple sclerosis.
摘要翻译：式（1）的环肽，其中：AA1是选自Ile和Leu或其氨基酸类似物的L或D / D氨基酸; AA2是选自Leu或其氨基酸类似物的一种L 氨基酸; AA3是选自Asp或其侧链中具有羧基的氨基酸类似物的L-氨基酸; AA4是选自Val或其氨基酸类似物的L9A氨基酸; LINKER表示将AA1的N末端与AA4的C末端连接的连接部分，形成含有17〜30个成员的杂环的环状肽。环肽抑制血管细胞粘附分子-1和纤连蛋白与整联蛋白非常晚的抗原4的相互作用，并具有治疗应用，例如类风湿性关节炎或多发性硬化。

158. 发明申请

WO1996019512A1 METHOD OF GRAFTING 审中-公开
标题翻译：招募方式
公开(公告)号：WO1996019512A1
公开(公告)日：1996-06-27
申请号：PCT/EP1995005021
申请日：1995-12-19
申请人： ZENECA LIMITED , ZENECA RESINS B.V. , PADGET, John, Christopher , BEDELLS, Alison, Dawn , OVERBEEK, Gerardus, Cornelis
发明人： ZENECA LIMITED , ZENECA RESINS B.V.
IPC分类号： C08F291/00
CPC分类号： C08F290/141 , C08F291/00 , C08F2/16
摘要： Method of grafting a water-soluble organic oligomer(s) to an organic polymer(s) in aqueous latex form, which method comprises forming a water-based mixture of a water-soluble oligomer(s), an aqueous latex of a polymer(s), and at least one free radical polymerisable monomer, both of said oligomer(s) and polymer(s) being preformed, and carrying out free radical polymerisation of said at least one monomer to effect grafting between said oligomer(s) and said polymer(s).
摘要翻译：将水溶性有机低聚物以水性胶乳形式接枝到有机聚合物的方法，该方法包括形成水溶性低聚物，聚合物的水性胶乳的水基混合物（ s）和至少一种可自由基可聚合单体，所述低聚物和聚合物都被预先形成，并且进行所述至少一种单体的自由基聚合以实现所述低聚物和所述聚合物之间的接枝聚合物（S）。

159. 发明申请

WO1996017829A3 3-BENZOYLPYRIDINE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS HERBICIDES 审中-公开
公开(公告)号：WO1996017829A3
公开(公告)日：1996-06-13
申请号：PCT/US1995015840
申请日：1995-12-06
申请人： ZENECA LIMITED , KANNE, David, B.
发明人： ZENECA LIMITED
IPC分类号： C07D213/69

160. 发明申请

WO1996015672A1 FUNGICIDAL COMPOSITION 审中-公开
标题翻译：杀真菌剂
公开(公告)号：WO1996015672A1
公开(公告)日：1996-05-30
申请号：PCT/GB1995002576
申请日：1995-11-02
申请人： ZENECA LIMITED , TURNBULL, Michael, Drysdale , CROWLEY, Patrick, Jelf , CHRYSTAL, Ewan, James, Turner , CLOUGH, John, Martin , YOULE, David , BEAUTEMENT, Kevin , BARNETT, Susan, Patricia , PONSFORD, Roger, John , OUTRED, Dennis, James , MAMALIS, Patrick , HATTER, Glenn , SMITH, Peter, Duncan , BELLINI, Peter
发明人： ZENECA LIMITED
IPC分类号： A01N43/64
CPC分类号： C07D403/12 , A01N43/64 , C07D251/10 , C07D251/72 , C07F9/6521
摘要： A fungicidal composition comprising, as an active ingredient, a compound of formula (Ia) or (Ib) or a tautomer thereof, wherein R and R are, independently, hydrogen; C1-C6 alkyl, optionally substituted with OH or halo; C2-C6 alkenyl, optionally substituted with OH or halo; or R and R together form a 3 to 8 membered cycloalkyl or cycloalkenyl ring either of which is optionally substituted with C1-C6 alkyl, C2-C6 alkenyl, OH or halo; R is hydrogen, C1-C20 alkyl, C2-C20 alkenyl or C2-C20 alkynyl group, any of which is optionally substituted; R and R are, independently, hydrogen, CO2R , COR , CONR R , OCOR , CO2X, COX, SO2X or CONHX, wherein X is benzyl, phenyl, a 3 to 8 membered cycloalkyl, cycloalkenyl or saturated or unsaturated heterocyclic ring, or a fused ring system; R and R are, independently, hydrogen, C1-C8 alkyl, C2-C8 alkenyl, C1-C8 haloalkyl or C2-C8 haloalkenyl; or a salt or metal complex thereof; and a fungicidally acceptable carrier or diluent.
摘要翻译：一种杀真菌组合物，其包含作为活性成分的式（Ia）或（Ib）化合物或其互变异构体，其中R 1和R 2独立地是氢; 任选被OH或卤素取代的C 1 -C 6烷基; 任选被OH或卤素取代的C 2 -C 6烯基; 或R 1和R 2一起形成任选被C 1 -C 6烷基，C 2 -C 6烯基，OH或卤素取代的3至8元环烷基或环烯基环; R 3是氢，C 1 -C 20烷基，C 2 -C 20烯基或C 2 -C 20炔基，其中任何一个任选被取代; R 4和R 5独立地是氢，CO 2 R 9，COR 9，CONR 9 R 9，OCOR 9，CO 2 X，COX，SO 2 X或CONHX，其中X 是苄基，苯基，3至8元环烷基，环烯基或饱和或不饱和杂环，或稠环体系; R 9和R 9独立地是氢，C 1 -C 8烷基，C 2 -C 8烯基，C 1 -C 8卤代烷基或C 2 -C 8卤代烯基; 或其盐或金属络合物; 和杀真菌剂可接受的载体或稀释剂。

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