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    • 121. 发明申请
    • AN IMPLANTABLE HEART STIMULATING DEVICE, A SYSTEM INCLUDING SUCH A DEVICE AND A MANNER OF USING THE SYSTEM
    • 可植入心脏刺激装置,包括这样一个装置的系统和使用该系统的手段
    • WO2003051457A1
    • 2003-06-26
    • PCT/SE2002/001817
    • 2002-10-04
    • ST. JUDE MEDICAL ABNORÉN, KjellLJUNGSTRÖM, KarinKALLING, SvenMANDAL, LarsBJÖRLING, Anders
    • NORÉN, KjellLJUNGSTRÖM, KarinKALLING, SvenMANDAL, LarsBJÖRLING, Anders
    • A61N1/368
    • A61N1/3627A61N1/36521A61N1/3682A61N1/3684
    • The invention concerns an implantable heart stimulating device (10) comprising, inter alia, a control circuit (14) adapted to enable at least the following: a) delivering electrical stimulating pulses to the two ventricles (RV, LV) of a heart with a variable time interval (ΔT) between the pulses; b) sensing signals receivable from electrodes (31, 32; 41, 42; 51 , 52; 61, 62) positionable at two different positions in the heart, c) deriving an impedance value (Z) based on said sensed signals, d) determining a minimum value (Z min ) and a maximum value (Z max ) of said impedance value (Z) during a heart cycle, e) determining a relationship between said minimum (Z min ) and maximum (Z max )values, f) varying said time interval (ΔT) and monitoring said relationship over a plurality of heart cycles, g) setting said time interval (ΔT) such that said relationship fulfi1s a predetermined requirement. The invention also concerns a system including such a heart stimulating device (10) as well as a manner of using such a system.
    • 本发明涉及一种植入式心脏刺激装置(10),其特别地包括控制电路(14),该控制电路适于至少能够实现以下功能:a)将电刺激脉冲输送到心脏的两个心室(RV,LV) 脉冲之间的可变时间间隔(DeltaT); b)感测可定位在心脏中两个不同位置的电极(31,32; 41,42; 51,52; 61,62)的信号,c)基于所述感测信号导出阻抗值(Z),d) 在心脏周期中确定所述阻抗值(Z)的最小值(Z> min <)和最大值(Z> max <),e)确定所述最小值(Z> min <)和最大值(Z > max <)值,​​f)改变所述时间间隔(DeltaT)并监视多个心脏周期的所述关系,g)设置所述时间间隔(DeltaT)使得所述关系满足预定要求。 本发明还涉及包括这种心脏刺激装置(10)的系统以及使用这种系统的方式。
    • 125. 发明申请
    • IMPLANTABLE SENSOR DEVICE AND SYSTEM
    • 可植入传感器装置和系统
    • WO2011157299A1
    • 2011-12-22
    • PCT/EP2010/058624
    • 2010-06-18
    • St. Jude Medical ABHILL, RolfPERSSON, TorbjörnSTEGFELDT, Olof
    • HILL, RolfPERSSON, TorbjörnSTEGFELDT, Olof
    • A61N1/05
    • A61B5/02055A61B5/01A61B5/0205A61B5/0215A61B5/1118A61B5/14532A61B5/14542A61B5/6848A61N1/0573A61N1/362A61N1/36564
    • The present invention relates generally to implantable medical devices and more particularly to implantable sensors, such as pressure sensors. The implantable medical device (10; 100) for measuring pressure is connectable to a medical lead (11; 111) and comprises an outer sheath (13; 113) and a helically shaped needle (14; 114) arranged at the outer sheath (13; 113). A pressure sensing body (15; 30; 40; 50; 60; 115) having a distal part (16; 36; 46; 56; 66; 116) is movably arranged in the outer sheath (13; 113). The pressure sensing body (15; 30; 40; 50; 60; 115) is arranged such that the distal part (16; 36; 46; 56; 66; 116) is located within the outer sheath (13; 113) in an initial state of the pressure sensing body (15; 30; 40; 50; 60; 115), wherein the pressure sensing body (15; 30; 40; 50; 60; 115) is arranged to be advanced from the initial state to protrude from the outer sheath (13; 113) and such that it is at least partially surrounded by the helically shaped needle (14; 114); and a pressure sensor (12, 34; 48; 58; 68) arranged at or adjacent to the distal part (16; 36; 46; 56; 66; 116) of the pressure sensing body (15; 30; 40; 50; 60; 115) for sensing pressure.
    • 本发明一般涉及可植入医疗装置,更具体地涉及可植入传感器,例如压力传感器。 用于测量压力的可植入医疗装置(10; 100)可连接到医用引线(11; 111)并且包括外护套(13; 113)和布置在外鞘(13; 113)处的螺旋形针(14; 114) ; 113)。 具有远端部分(16; 36; 46; 56; 66; 116)的压力感测体(15; 30; 40; 50; 60; 115)可移动地布置在外护套(13; 113)中。 压力感测体(15; 30; 40; 50; 60; 115)被布置成使得远端部分(16; 36; 46; 56; 66; 116)位于外护套(13; 113)内, 压力感测体(15; 30; 40; 50; 60; 115)的初始状态,其中所述压力感测体(15; 30; 40; 50; 60; 115)布置成从所述初始状态前进到突出 并且使得其至少部分被螺旋形针(14; 114)包围; 以及压力传感器(12,34; 48; 58; 68),布置在所述压力感测体(15; 30; 40; 50; 50; 60; 115)用于感测压力。
    • 127. 发明申请
    • CARDIAC STIMULATING DEVICE WITH BACKUP PULSE
    • 具有备用脉冲的CARDIAC刺激装置
    • WO2011069535A1
    • 2011-06-16
    • PCT/EP2009/066594
    • 2009-12-08
    • ST. JUDE MEDICAL ABECKERDAL, Johan
    • ECKERDAL, Johan
    • A61N1/37
    • A61N1/37276A61N1/3622A61N1/3688A61N1/371
    • An implantable medical device, IMD, (100) comprises atrial and ventricular sensing units (125, 135) for sensing atrial or ventricular electric events. The IMD (100) also comprises atrial and ventricular pulse generators (120, 130) for generating atrial or ventricular pacing pulses. A controller (140) controls the operation of the IMD (100) according to a first mode, in which the ventricular pulse generator (130) is prevented from generating a back-up pulse if an evoked response detector (133) fails to detect evoked response to a delivered ventricular pacing pulse, and a second mode, in which the ventricular pulse generator (130) is controlled to generate a back-up pulse if no evoked response is detected following delivery of a ventricular stimulating pulse. The controller (140) switches operation from the first mode to the second mode based on the evoked response detector (133) failing to detect an evoked response to a delivered ventricular pacing pulse.
    • 植入式医疗装置IMD(100)包括用于感测心房或心室电气事件的心房和心室感测单元(125,135)。 IMD(100)还包括用于产生心房或心室起搏脉冲的心房和心室脉冲发生器(120,130)。 控制器(140)根据第一模式控制IMD(100)的操作,其中如果诱发响应检测器(133)未能检测到诱发的响应检测器(133),则防止心室脉冲发生器(130)产生备用脉冲 响应于递送的心室起搏脉冲,以及第二模式,其中如果在递送心室刺激脉冲之后没有检测到诱发反应,则控制心室脉冲发生器(130)以产生备用脉冲。 控制器(140)基于诱发响应检测器(133)未能检测对所传送的心室起搏脉冲的诱发响应,将操作从第一模式切换到第二模式。
    • 129. 发明申请
    • LATE POTENTIAL DETECTION
    • 最终的潜在检测
    • WO2010151181A1
    • 2010-12-29
    • PCT/SE2009/000330
    • 2009-06-26
    • ST. JUDE MEDICAL ABBLOMQVIST, Andreas
    • BLOMQVIST, Andreas
    • A61N1/365A61B5/0452
    • A61B5/0452A61B5/0006A61B5/002A61B5/0031A61B5/0422A61B5/686A61B5/7242A61B5/7275A61B2505/07A61N1/362G06F19/00
    • A late potential detecting system (1) comprises an implantable medical device (100) connected to at least one cardiac lead (200) having implantable electrodes (211-218) positioned at different sites of a ventricle myocardium. A sampling unit (120) of the implantable medical device (100) records electrogram samples for the different implantable electrodes (211-218) to get different sample sets. The electrogram samples of the sample sets are time synchronized and magnitude potential representations of the potential data of the electrogram samples are determined. The magnitude potential representations of the time synchronized electrogram samples are then co-processed and used for determining a parameter that is indicative of any late potentials of the monitored ventricle (25).
    • 晚期电位检测系统(1)包括连接到至少一个具有位于心室心肌不同部位的可植入电极(211-218)的心脏引线(200)的可植入医疗装置(100)。 可植入医疗装置(100)的采样单元(120)记录用于不同可植入电极(211-218)的电描记图样本以获得不同的样本集。 样本集的电描记图样本是时间同步的,并且确定电描记图样本的潜在数据的幅度电位表示。 然后对时间同步电描记图样本的幅度电位表示进行协处理,并用于确定指示所监测的心室的任何后期电位的参数(25)。
    • 130. 发明申请
    • IMPLANTABLE CORONARY PERFUSION MONITORING DEVICE
    • 可植入冠脉灌注监测装置
    • WO2010126404A1
    • 2010-11-04
    • PCT/SE2009/000223
    • 2009-04-29
    • ST. JUDE MEDICAL ABBLOMQVIST, AndreasJARVERUD, KarinBROOME, Michael
    • BLOMQVIST, AndreasJARVERUD, KarinBROOME, Michael
    • A61B5/0215A61B5/053
    • A61B5/02158A61B5/02007A61B5/02028A61B5/02125A61B5/0295A61B5/053
    • An implantable coronary perfusion monitoring device for in- vivo determination of a coronary perfusion index ( CPI ) indicative of the coronary perfusion of a heart. The device comprises a time measurement unit to determine a blood pressure reflection wave measure t indicating the timely position in the heart cycle of the maximum of a reflected blood pressure wave and being a time period starting at a preset point of time in systole and ending at a local maximum of blood pressure following aortic valve closure; a diastolic peak pressure measurement unit adapted to determine a diastolic peak blood pressure measure DPP related to diastolic aortic peak pressure; a systolic arterial pressure measurement unit adapted to determine a systolic arterial blood pressure measure SAP related to systolic arterial pressure, and a coronary perfusion index calculating unit adapted to determine said coronary perfusion index CPI as ( t . DPP ) / SAP .
    • 一种用于体内确定冠状动脉灌注指数(CPI)的植入式冠状动脉灌注监测装置,其指示心脏的冠状动脉灌注。 该装置包括时间测量单元,用于确定表示心脏周期中及时反映血压波的最大值的血压反射波测量t,并且是从收缩期的预设时间点开始的时间段,并且以 主动脉瓣关闭后局部最大血压; 舒适峰值压力测量单元,其适于确定与舒张主动脉峰值压力相关的舒张峰值血压测量DPP; 用于确定与收缩期动脉压相关的收缩期动脉血压测量SAP的收缩期动脉压测量单元和适于将所述冠状动脉灌注指数CPI确定为(t.DPP)/ SAP的冠状动脉灌注指数计算单元。