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1. 发明申请

WO2003051457A1 AN IMPLANTABLE HEART STIMULATING DEVICE, A SYSTEM INCLUDING SUCH A DEVICE AND A MANNER OF USING THE SYSTEM 审中-公开
标题翻译：可植入心脏刺激装置，包括这样一个装置的系统和使用该系统的手段
公开(公告)号：WO2003051457A1
公开(公告)日：2003-06-26
申请号：PCT/SE2002/001817
申请日：2002-10-04
申请人： ST. JUDE MEDICAL AB , NORÉN, Kjell , LJUNGSTRÖM, Karin , KALLING, Sven , MANDAL, Lars , BJÖRLING, Anders
发明人： NORÉN, Kjell , LJUNGSTRÖM, Karin , KALLING, Sven , MANDAL, Lars , BJÖRLING, Anders
IPC分类号： A61N1/368
CPC分类号： A61N1/3627 , A61N1/36521 , A61N1/3682 , A61N1/3684
摘要： The invention concerns an implantable heart stimulating device (10) comprising, inter alia, a control circuit (14) adapted to enable at least the following: a) delivering electrical stimulating pulses to the two ventricles (RV, LV) of a heart with a variable time interval (ΔT) between the pulses; b) sensing signals receivable from electrodes (31, 32; 41, 42; 51 , 52; 61, 62) positionable at two different positions in the heart, c) deriving an impedance value (Z) based on said sensed signals, d) determining a minimum value (Z min ) and a maximum value (Z max ) of said impedance value (Z) during a heart cycle, e) determining a relationship between said minimum (Z min ) and maximum (Z max )values, f) varying said time interval (ΔT) and monitoring said relationship over a plurality of heart cycles, g) setting said time interval (ΔT) such that said relationship fulfi1s a predetermined requirement. The invention also concerns a system including such a heart stimulating device (10) as well as a manner of using such a system.
摘要翻译：本发明涉及一种植入式心脏刺激装置（10），其特别地包括控制电路（14），该控制电路适于至少能够实现以下功能：a）将电刺激脉冲输送到心脏的两个心室（RV，LV）脉冲之间的可变时间间隔（DeltaT）; b）感测可定位在心脏中两个不同位置的电极（31,32; 41,42; 51,52; 61,62）的信号，c）基于所述感测信号导出阻抗值（Z），d）在心脏周期中确定所述阻抗值（Z）的最小值（Z> min <）和最大值（Z> max <），e）确定所述最小值（Z> min <）和最大值（Z > max <）值，f）改变所述时间间隔（DeltaT）并监视多个心脏周期的所述关系，g）设置所述时间间隔（DeltaT）使得所述关系满足预定要求。本发明还涉及包括这种心脏刺激装置（10）的系统以及使用这种系统的方式。

2. 发明申请

WO2004008959A1 A CONGESTIVE HEART FAILURE MONITOR 审中-公开
标题翻译：一个焦虑心脏故障监测器
公开(公告)号：WO2004008959A1
公开(公告)日：2004-01-29
申请号：PCT/SE2003/001081
申请日：2003-06-23
申请人： ST JUDE MEDICAL AB , HOLMSTRÖM, Nils , OBEL, Martin , NORLIN, Anna , DAHLBERG, Kenneth , BJÖRLING, Anders , KALLING, Sven , LJUNGSTRÖM, Karin , NORÉN, Kjell
发明人： HOLMSTRÖM, Nils , OBEL, Martin , NORLIN, Anna , DAHLBERG, Kenneth , BJÖRLING, Anders , KALLING, Sven , LJUNGSTRÖM, Karin , NORÉN, Kjell
IPC分类号： A61B5/053
CPC分类号： A61B5/0538 , A61B5/053 , A61N1/3627
摘要： A congestive heartvfailure monitor comprises an impedance measuring unit to measure the impedance between at least two electrodes intended to be implanted in a patient such that a change in the left atrium volume results in a change of the measured impedance. Analysing means are provided for analysing the measured impedance for detecting an incipient congestive heart failure.
摘要翻译：充血性心脏衰竭监测器包括阻抗测量单元，用于测量旨在植入患者中的至少两个电极之间的阻抗，使得左心房容积的变化导致测量的阻抗的变化。提供分析装置用于分析用于检测初始充血性心力衰竭的测量阻抗。

3. 发明申请

WO2011142702A1 AN IMPLANTABLE MEDICAL DEVICE AND METHOD COMPRISING MEANS FOR DETECTING AND CLASSIFYING AN ARRHYTHMIA 审中-公开
标题翻译：一种可植入医疗装置和方法，包括用于检测和分类ARRHYTHMIA的手段
公开(公告)号：WO2011142702A1
公开(公告)日：2011-11-17
申请号：PCT/SE2010/050527
申请日：2010-05-12
申请人： St. Jude Medical AB , BJÖRLING, Anders , HOLLMARK, Malin , SVENSSON, Tomas , HJELM, Stefan , NORÉN, Kjell , JÄRVERUD, Karin
发明人： BJÖRLING, Anders , HOLLMARK, Malin , SVENSSON, Tomas , HJELM, Stefan , NORÉN, Kjell , JÄRVERUD, Karin
IPC分类号： A61N1/362 , A61N1/365 , A61N1/37 , A61N1/39
CPC分类号： A61N1/3621 , A61N1/3622 , A61N1/36521 , A61N1/3704 , A61N1/3962
摘要： An implantable medical device (100) is configured for generating a cardiogenic impedance signal representative of the cardiogenic impedance of at least a portion of a heart (10) of a subject (20) during at least a portion of cardiac cycle. A moment processor (132) calculates a moment parameter value based on the cardiogenic impedance signal. The moment parameter is representative of a weighted sum of impedance amplitudes within a time window centered at defined time instance within the cardiac cycle. The weights of the impedance amplitudes are further dependent on the length in time between the defined time instance and the point of time of the associated impedance amplitude. The moment parameter is of high diagnostic value and is employed by an arrhythmia classifier (132) in order to classify a detected arrhythmia of the heart (10), such as discriminate between hemodynamically stable or unstable arrhythmias and/or supraventricular or ventricular tachycardia.
摘要翻译：可植入医疗装置（100）被配置为在心脏周期的至少一部分期间产生代表受试者（20）的心脏（10）的至少一部分的心源阻抗的心源阻抗信号。时刻处理器（132）基于心源阻抗信号计算力矩参数值。力矩参数代表以心动周期内规定时间范围为中心的时间窗内的阻抗振幅加权和。阻抗幅度的权重进一步取决于所定义的时间实例和相关联的阻抗幅度的时间点之间的时间长度。时刻参数具有很高的诊断价值，并被心律失常分类器（132）使用，以便将检测到的心脏（10）的心律失常进行分类，例如区分血流动力学稳定或不稳定的心律失常和/或室上或室性心动过速。

4. 发明申请

WO2011134499A1 ARRHYTHMIA CLASSIFICATION 审中-公开
标题翻译： ARRHYTHMIA分类
公开(公告)号：WO2011134499A1
公开(公告)日：2011-11-03
申请号：PCT/EP2010/055639
申请日：2010-04-27
申请人： ST. JUDE MEDICAL AB , BJÖRLING, Anders , HOLLMARK, Malin , SVENSSON, Tomas , HJELM, Stefan , NORÉN, Kjell , JÄRVERUD, Karin
发明人： BJÖRLING, Anders , HOLLMARK, Malin , SVENSSON, Tomas , HJELM, Stefan , NORÉN, Kjell , JÄRVERUD, Karin
IPC分类号： A61B5/0452 , A61B5/053 , A61N1/365
CPC分类号： A61B5/0452 , A61B5/053 , A61B5/0538 , A61B5/7257 , A61B5/7264 , A61N1/3622 , A61N1/36521 , A61N1/36564 , A61N1/36585 , A61N1/3962
摘要： An implantable medical device (100) is configured for generating a cardiogenic impedance signal representative of the cardiogenic impedance of at least a portion of a heart (10) of a subject (20) during multiple cardiac cycles. A transform processor (132) generates a spectrum signal by applying a time- to-frequency transform to the cardiogenic impedance signal. The spectrum signal is processed by a distribution processor (133) configured to calculate a distribution parameter indicative of a distribution in at least a portion of the spectrum signal. The calculated distribution parameter is of high diagnostic value and is employed by an arrhythmia classifier (134) in order to classify a detected arrhythmia of the heart (10), such as discriminate between hemodynamically stable or unstable arrhythmias and/or supraventricular or ventricular tachycardia.
摘要翻译：可植入医疗装置（100）被配置为在多个心动周期期间产生代表受试者（20）的心脏（10）的至少一部分的心源阻抗的心源阻抗信号。变换处理器（132）通过对心源性阻抗信号进行时间 - 频率变换来产生频谱信号。频谱信号由分配处理器（133）处理，分配处理器（133）被配置为计算指示频谱信号的至少一部分中的分布的分布参数。计算出的分布参数具有很高的诊断价值，并被心律失常分类器（134）采用，以便将检测到的心脏心律不齐（10）进行分类，例如区分血流动力学稳定或不稳定的心律失常和/或室上或室性心动过速。

5. 发明申请

WO2007149019A1 IMPLANTABLE HEART STIMULATING DEVICE WITH STIMULATION RATE OPTIMIZATION 审中-公开
标题翻译：具有刺激率优化的可植入心脏刺激装置
公开(公告)号：WO2007149019A1
公开(公告)日：2007-12-27
申请号：PCT/SE2006/000757
申请日：2006-06-21
申请人： ST. JUDE MEDICAL AB , NORÉN, Kjell , NILSSON, Kenth
发明人： NORÉN, Kjell , NILSSON, Kenth
IPC分类号： A61N1/365
CPC分类号： A61N1/36585 , A61N1/36521 , A61N1/36564 , A61N1/36578
摘要： Implantable heart stimulating device adapted to generate stimulation pulses at a stimulation rate to be applied to a patients heart, comprising an activity sensor (2), generating an activity signal (4) in response of detected activity of the patient, and a physiological parameter sensor (6), preferably a pressure sensor, generating a physiological sensor signal (8) in response of a detected physiological parameter. The activity and physiological sensor signals are applied to a control means (10, 12, 14) adapted to determine a stimulation rate based upon an stimulation rate algorithm in dependence of those signals, such that if the physiological signal indicates an emotional stress for the patient, the stimulation rate is increased to an adjustable emotional stress rate level and if no increase of the activity signal is indicated, during a predetermined time period from the stimulation rate increase, the stimulation rate is decreased.
摘要翻译：植入式心脏刺激装置，其适于以刺激速率产生刺激速率以施加到患者心脏，包括活动传感器（2），响应于检测到的患者的活动而产生活动信号（4）和生理参数传感器（6），优选地是压力传感器，响应检测到的生理参数产生生理传感器信号（8）。活动和生理传感器信号被施加到适于根据这些信号基于刺激速率算法确定刺激速率的控制装置（10,12,14），使得如果生理信号指示患者的情绪压力刺激率增加到可调情绪应激速率水平，并且如果没有指示活动信号的增加，则在从刺激速率增加的预定时间段期间，刺激速率降低。

6. 发明申请

WO2003071945A1 MEDICAL DEVICE 审中-公开
标题翻译：医疗装置
公开(公告)号：WO2003071945A1
公开(公告)日：2003-09-04
申请号：PCT/SE2003/000338
申请日：2003-02-27
申请人： ST. JUDE MEDICAL AB , NORÉN, Kjell
发明人： NORÉN, Kjell
IPC分类号： A61B5/0452
CPC分类号： A61N1/3622 , A61B5/0452 , A61B5/046 , A61B5/0464 , A61B5/7257
摘要： Implantable heart condition determining device comprising detecting means (2) arranged to detect a heart related signal (4) and to generate a corresponding input signal (6) in dependence of the heart related signal. The input signal is applied to an analytic signal block (8) that provides an analytic signal based upon the input signal, the analytic signal comprises a real part essentially being the input signal and an imaginary part being a predefined transformation of the input signal. The analytic signal is applied to a calculation unit (12) that calculates at least one heart related parameter from the analytic signal, said heart related parameter(s) is then applied to a processing unit (16) in order to identify heart conditions.
摘要翻译：可植入心脏病状确定装置，包括检测装置（2），用于检测心脏相关信号（4）并根据心脏相关信号产生对应的输入信号（6）。输入信号被施加到基于输入信号提供分析信号的分析信号块（8），分析信号包括基本上是输入信号的实部，以及作为输入信号的预定变换的虚部。分析信号被应用于从分析信号计算至少一个心脏相关参数的计算单元（12），然后将所述心脏相关参数应用于处理单元（16），以便识别心脏状况。

7. 发明申请

WO2003061760A1 A DUAL CHAMBER PACING SYSTEM WITH A MODE SWITCH 审中-公开
标题翻译：具有模式开关的双室开关系统
公开(公告)号：WO2003061760A1
公开(公告)日：2003-07-31
申请号：PCT/SE2002/001722
申请日：2002-09-23
申请人： ST. JUDE MEDICAL AB , NORÉN, Kjell
发明人： NORÉN, Kjell
IPC分类号： A61N1/368
CPC分类号： A61N1/3622 , A61N1/3688
摘要： A dual chamber pacing system normally operating in an atrial synchronized mode comprises a mode switch means (10) adapted to switch the pacing mode to a non-atrial synchronized ventricular stimulating mode in response to the detection of an atrial tachyarrhythmia and switch the pacing mode back to the atrial synchronized mode in response to or after a preset time of detection of ceased atrial tachyarrhythmia. A mode switch supervising means (2, 4) comprises 10 a counter means for accumulating the amount of modes switches from a starting point and supplying said accumulated amount to a comparison means (6) for comparing it with a predetermined mode switch amount threshold (8). The super-vising means is adapted to control the mode switch (10) to lock the pacing mode to the non-atrial synchronized ventricle stimulating mode for at least predeter mined time period in response to the mode switch amount exceeding the amount threshold.
摘要翻译：通常以心房同步模式操作的双室起搏系统包括适于将起搏模式切换到非心房同步心室刺激模式的模式切换装置（10），以响应于心房快速性心律失常的检测并且将起搏模式切换回响应于预先设定的停止的心房快速性心律失常的时间之后或之后的心房同步模式。模式开关监控装置（2,4）包括10个计数器装置，用于从开始点累积模式切换量并将所述累积量提供给比较装置（6），用于将其与预定模式切换量阈值（8 ）。响应于模式切换量超过量阈值，超维护装置适于控制模式切换（10）至少预定开启时间周期将起搏模式锁定到非心房同步心室刺激模式。

8. 发明申请

WO2007142563A1 SYSTEM AND METHOD FOR CONTROLLING A HEART STIMULATOR 审中-公开
标题翻译：用于控制心脏刺激器的系统和方法
公开(公告)号：WO2007142563A1
公开(公告)日：2007-12-13
申请号：PCT/SE2006/000699
申请日：2006-06-09
申请人： ST. JUDE MEDICAL AB , NORÉN, Kjell , FARAZI, Taraneh, G.
发明人： NORÉN, Kjell , FARAZI, Taraneh, G.
IPC分类号： A61N1/362
CPC分类号： A61N1/365 , A61B5/02405 , A61B5/4035 , A61N1/36114 , A61N1/3622
摘要： System and method for controlling an implantable stimulator capable of producing pacing pulses to be delivered to cardiac tissue, as well as vagal stimulation pulses to be delivered to vagus nerve sites. Upon detection of a premature cardiac event, such as a premature ventricular or atrial contraction, a simulated heart rate turbulence (HRT) procedure is applied if the intrinsic heart rate turbulence is weakened or absent. The simulated HRT includes a first phase in which the heart rate is increased, from the existing level, for a number of heart beats, a second phase in which the heart rate is decreased for a number of heart beats, and an optional third phase in which the heart rate is returned to said existing level.
摘要翻译：用于控制能够产生要输送到心脏组织的起搏脉冲的可植入刺激器的系统和方法，以及要输送到迷走神经位点的迷走神经刺激脉冲。在检测到过早的心脏事件（例如心室早搏或心房收缩）时，如果固有心率湍流减弱或不存在，则应用模拟心率湍流（HRT）程序。模拟HRT包括第一阶段，其中心率从现有水平增加，对于多个心跳，第二阶段，其中多个心脏搏动的心率降低;以及可选择的第三阶段心率恢复到现有水平。

9. 发明申请

WO2006041337A1 DETECTION OF ISCHEMIA 审中-公开
标题翻译：检测ISCHEMIA
公开(公告)号：WO2006041337A1
公开(公告)日：2006-04-20
申请号：PCT/SE2004/001444
申请日：2004-10-11
申请人： ST JUDE MEDICAL , BJÖRLING, Anders , NORÉN, Kjell
发明人： BJÖRLING, Anders , NORÉN, Kjell
IPC分类号： A61B5/0205
CPC分类号： A61B5/029 , A61B5/02028 , A61B5/053 , A61B5/0538 , A61N1/36521 , A61N1/36557 , A61N1/3684
摘要： An ischemia detector comprises a workload sensor for sensing the workload of a patient, an ejection fraction, EF, determining means (2,4,6,8,10,12), a storing means for storing a predetermined reference relation between EF and workload for the patient, and an analysing means for detecting a state of ischemia of the patient from deviations in determined EF for various workloads from said stored reference relation. A heart stimulator comprises such a detector and stimulation controlling means for controlling the delivery of stimulation pulses to a patient´s heart in response to the detection of an ischemia. In a method of detecting ischemia of a patient a parameter indicative of ejection fraction, EF, and a variable indicative of the workload of the patient are measured, and a state of ischemia of the patient is detected from deviations in EF for various workloads from a predetermined reference relation between EF and workload for the patient in question.
摘要翻译：缺血检测器包括用于感测患者的工作量的工作负载传感器，射血分数EF，确定装置（2,4,6,8,10,12），用于存储EF和工作负载之间的预定参考关系的存储装置以及分析装置，用于根据来自所存储的参考关系的各种工作负荷的确定的EF中的偏差来检测患者的局部缺血状态。心脏刺激器包括这样的检测器和刺激控制装置，用于响应于缺血的检测而控制向患者的心脏递送刺激脉冲。在检测患者局部缺血的方法中，测量指示射血分数EF和指示患者工作量的变量的参数，并且从各种工作负荷的EF偏差中检测患者局部缺血状态 EF与所讨论患者的工作负荷之间的预设参考关系。

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