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91. 发明申请

WO2006093822A1 IMPLANTABLE CARDIAC DEVICE WITH DYSPNEA MEASUREMENT 审中-公开
标题翻译：具有DYSPNEA测量的可植入心脏装置
公开(公告)号：WO2006093822A1
公开(公告)日：2006-09-08
申请号：PCT/US2006/006558
申请日：2006-02-24
申请人： CARDIAC PACEMAKERS, INC.
发明人： HOPPER, Donald , VOEGELE, John, M. , HARTLEY, Jesse, W. , SCHEINER, Avram
IPC分类号： A61N1/362 , A61N1/37
CPC分类号： A61B5/686 , A61B5/0022 , A61B5/0024 , A61B5/02028 , A61B5/0205 , A61B5/04012 , A61B5/0402 , A61B5/076 , A61B5/0809 , A61B5/0816 , A61B5/0826 , A61B5/085 , A61B5/091 , A61B5/1118 , A61B5/4836 , A61B5/7275 , A61B5/7282 , A61B5/746 , A61B5/747 , A61N1/3627 , A61N1/36585 , A61N1/3702 , A61N1/3987 , G06F19/00 , G16H50/20 , G16H50/30
摘要： Cardiac monitoring and/or stimulation methods and systems employing dyspnea measurement. An implantable cardiac device may sense transthoracic impedance and determine a patient activity level. An index indicative of pulmonary function is implantably computed to detect an episode of dyspnea based on a change, trend, and/or value exceeding a threshold at a determined patient activity level. Trending one or more pulmonary function index values may be done to determine a patient's pulmonary function index profile, which may be used to adapt a cardiac therapy. A physician may be automatically alerted in response to a pulmonary function index value and/or a trend of the patient's pulmonary index being beyond a threshold. Computed pulmonary function index values and their associated patient's activity levels may be stored periodically in a memory and/or transmitted to a patient-external device.
摘要翻译：使用呼吸困难测量的心脏监测和/或刺激方法和系统。可植入的心脏装置可以感测经胸阻抗并确定患者活动水平。基于在确定的患者活动水平的超过阈值的变化，趋势和/或值来植入式地计算指示肺功能的指标以检测呼吸困难发作。可以进行一个或多个肺功能指数值的变化以确定患者的肺功能指数分布，其可用于适应心脏疗法。响应于肺功能指数值和/或患者肺部指数的趋势超过阈值，医生可以自动地被警报。计算的肺功能指数值及其相关的患者的活动水平可以周期性地存储在存储器中和/或被发送到患者外部设备。

92. 发明申请

WO2006090362A2 VASCULAR GRAFT FOR IN VIVO HEMODYALISIS AND/OR TARGETED DELIVERY OF A DRUG 审中-公开
标题翻译：用于血液透析和/或有针对性地输送药物的血管瘤
公开(公告)号：WO2006090362A2
公开(公告)日：2006-08-31
申请号：PCT/IL2006/000188
申请日：2006-02-14
申请人： NICAST LTD. , SHALEV, Alon
发明人： SHALEV, Alon
IPC分类号： A61F7/02
CPC分类号： A61F2/064 , A61B5/14528 , A61B5/14532 , A61B5/412 , A61B5/686 , A61F2/06
摘要： A vascular graft having two lumens which are in fluid communication therebetween via a membrane disposed along at least a portion of a wall separating the two lumens is provided. Also provided are methods of performing in vivo hemodialysis and/or targeted drug delivery by implanting the vascular graft and administering a dialysate and/or drug fluid, respectively, therein. In addition, the vascular graft can be used for low invasiveness sampling of components of a biological fluid (e.g., plasma) for diagnostic purposes.
摘要翻译：提供了具有两个腔的血管移植物，其通过沿着分隔两个腔的壁的至少一部分设置的膜流体连通。还提供了通过植入血管移植物并分别在其中施用透析液和/或药物流体进行体内血液透析和/或靶向药物递送的方法。此外，为了诊断目的，血管移植物可用于生物流体（例如血浆）的组分的低侵入性取样。

93. 发明申请

WO2006085908A2 DEVICES AND METHODS FOR MEASURING AND ENHANCING DRUG OR ANALYTE TRANSPORT TO/FROM MEDICAL IMPLANT 审中-公开
标题翻译：用于测量和增强药物或分析至/从医疗植入物运输的装置和方法
公开(公告)号：WO2006085908A2
公开(公告)日：2006-08-17
申请号：PCT/US2005/019021
申请日：2005-06-01
申请人： MICROCHIPS, INC. , HERMAN, Stephen, J. , KRIEGER, Timothy , SANTINI, John, T., Jr. , PRESCOTT, James, H. , STAPLES, Mark, Andrew , LIPKA, Sara, A.
发明人： HERMAN, Stephen, J. , KRIEGER, Timothy , SANTINI, John, T., Jr. , PRESCOTT, James, H. , STAPLES, Mark, Andrew , LIPKA, Sara, A.
IPC分类号： A61M37/00 , A61K9/00 , A61N1/30 , A61N1/05 , A61K49/00 , A61B5/00
CPC分类号： A61K9/0009 , A61B5/03 , A61B5/04001 , A61B5/042 , A61B5/076 , A61B5/14528 , A61B5/14532 , A61B5/14546 , A61B5/1486 , A61B5/686 , A61K9/0024 , A61K9/0097 , A61M37/00 , A61N1/05 , A61N1/30 , A61N1/306
摘要： Methods and devices are provided for enhancing mass transport through any fibrous tissue capsule that may form around an implanted medical device following implantation. Methods and devices are also provided to enhance vascularization around the implanted device, which also will aid in mass transport to/from the device. The device preferably comprises multiple reservoirs containing (i) a drug formulation for short- or long-term, controlled drug delivery, (ii) sensors for sensing an analyte in the patient, or (iii) a combination thereof.
摘要翻译：提供的方法和装置用于增强通过植入后可能在植入的医疗装置周围形成的任何纤维组织胶囊的质量传递。还提供了方法和装置以增强植入装置周围的血管化，这也有助于大量运输到装置。装置优选地包括多个储存器，其包含（i）用于短期或长期，受控药物递送的药物制剂，（ii）用于感测患者中的分析物的传感器，或（iii）其组合。

94. 发明申请

WO2005028029A3 PATIENT MONITORING, DIAGNOSIS, AND/OR THERAPY SYSTEMS AND METHODS 审中-公开
标题翻译：患者监测，诊断和/或治疗系统和方法
公开(公告)号：WO2005028029A3
公开(公告)日：2005-09-29
申请号：PCT/US2004030787
申请日：2004-09-17
申请人： CARDIAC PACEMAKERS INC
发明人： STAHMANN JEFFREY E , LEE KENT , HARTLEY JESSE W , NI QUAN , HATLESTAD JOHN D , ZHU QINGSHENG , SIEJKO KRZYSZTOF J
IPC分类号： A61B5/00 , A61B5/0205 , A61B5/0215 , A61B5/042 , A61B5/0464 , A61B5/0476 , A61B5/0488 , A61B5/0496 , A61B5/053 , A61B5/08 , A61B5/083 , A61B5/085 , A61B5/087 , A61B5/103 , A61B5/113 , A61M15/00 , A61M16/00 , A61M16/10 , A61N1/18 , A61N1/20 , A61N1/362 , A61N1/365 , A61N1/37
CPC分类号： A61B5/4818 , A61B5/0031 , A61B5/02055 , A61B5/0215 , A61B5/02405 , A61B5/0421 , A61B5/0422 , A61B5/0464 , A61B5/0476 , A61B5/0488 , A61B5/0496 , A61B5/053 , A61B5/0809 , A61B5/0836 , A61B5/087 , A61B5/103 , A61B5/1116 , A61B5/113 , A61B5/145 , A61B5/14539 , A61B5/14542 , A61B5/4035 , A61B5/4519 , A61B5/6814 , A61B5/6823 , A61B5/6828 , A61B5/686 , A61B5/6891 , A61B5/7275 , A61B2562/0219 , A61M16/0051 , A61M16/026 , A61M16/0666 , A61M16/10 , A61M2016/0021 , A61M2016/0036 , A61M2016/0039 , A61M2016/0042 , A61M2202/0208 , A61M2205/3303 , A61M2205/3306 , A61M2205/3375 , A61M2205/3561 , A61M2205/3592 , A61M2205/52 , A61M2230/04 , A61M2230/10 , A61M2230/202 , A61M2230/205 , A61M2230/30 , A61M2230/432 , A61M2230/435 , A61M2230/50 , A61M2230/60 , A61M2230/63 , A61M2230/65 , A61N1/3601 , A61N1/362 , A61N1/3627 , A61N1/365 , A61N1/36514 , A61N1/36535 , A61N1/36557 , A61N1/36578 , A61N1/36585 , A61N1/36592 , A61N1/37
摘要： Systems and methods for monitoring, diagnosing, and/or treating a patient are provided. One or more individual medical procedures may be utilized to monitor, diagnose and/or treat the patient. Two or more of the individual medical procedures or may be used in combination to provide more comprehensive patient monitoring, diagnosis and/or therapy. One or more functions of two or more individual medical procedures may be used in combination to enhance patient monitoring, diagnosis and/or therapy. The medical procedures may be coordinated. Coordinated medical procedures may involve cooperative operation of two or more of the individual processes. Coordinated medical procedures may also involve cooperative operation of one or more functions of two or more of the individual processes.
摘要翻译：提供了用于监测，诊断和/或治疗患者的系统和方法。可以使用一个或多个单独的医疗程序来监测，诊断和/或治疗患者。两种或多种单独的医疗程序或可以组合使用以提供更全面的患者监测，诊断和/或治疗。可以组合使用两个或更多个单独医疗程序的一个或多个功能，以增强患者监测，诊断和/或治疗。医疗程序可以协调一致。协调的医疗程序可能涉及两个或多个个别过程的合作运作。协调的医疗程序还可以涉及两个或更多个独立过程的一个或多个功能的合作操作。

95. 发明申请

WO2004105871A1 METHOD FOR DISCRIMINATING BETWEEN VENTRICULAR AND SUPRAVENTRICULAR ARRHYTHMIAS 审中-公开
标题翻译：用于分离心室和子宫颈间质瘤的方法
公开(公告)号：WO2004105871A1
公开(公告)日：2004-12-09
申请号：PCT/US2004/017229
申请日：2004-05-28
申请人： CAMERON HEALTH, INC. , OSTROFF, Alan, H. , WARREN, Jay, A. , BARDY, Gust, H.
发明人： OSTROFF, Alan, H. , WARREN, Jay, A. , BARDY, Gust, H.
IPC分类号： A61N1/39
CPC分类号： A61N1/3956 , A61B5/0422 , A61B5/04525 , A61B5/0464 , A61B5/686 , A61N1/3925 , A61N1/3987
摘要： The present invention is directed toward a detection architecture for use in implantable cardiac rhythm devices. The detection architecture of the present invention provides methods and devices for discriminating between arrhythmias. Moreover, by exploiting the enhanced specificity in the origin of the identified arrhythmia, the detection architecture can better discriminate between rhythms appropriate for device therapy and those that are not.
摘要翻译：本发明涉及用于可植入心律装置的检测架构。本发明的检测架构提供了用于区分心律失常的方法和装置。此外，通过利用识别的心律失常起源的增强的特异性，检测架构可以更好地区分适合于设备治疗的节律和不适合的治疗节律。

96. 发明申请

WO2004049931A1 SLEEP DETECTION USING AN ADJUSTABLE THRESHOLD 审中-公开
标题翻译：使用可调节阈值进行睡眠检测
公开(公告)号：WO2004049931A1
公开(公告)日：2004-06-17
申请号：PCT/US2003/038477
申请日：2003-12-04
申请人： CARDIAC PACEMAKERS, INC.
发明人： NI, Quan , HAJENGA, Zoe , DAUM, Douglas, R. , STAHMANN, Jeffrey, E. , HATLESTAD, John, D. , LEE, Kent
IPC分类号： A61B5/0205
CPC分类号： A61B5/4815 , A61B5/0031 , A61B5/0205 , A61B5/021 , A61B5/085 , A61B5/1116 , A61B5/4809 , A61B5/686 , A61B5/7271 , A61B5/7282 , A61N1/362 , A61N1/365 , A61N1/36542 , G16H40/63 , G16H50/20
摘要： Devices and methods for sleep detection involve the use of an adjustable threshold for detecting sleep onset and termination. A method for detecting sleep includes adjusting a sleep threshold associated with a first sleep-related signal using a second sleep-related signal. The first sleep-related signal is compared to the adjusted threshold and sleep is detected based on the comparison. The sleeprelated signals may be derived from implantable or external sensors. Additional sleep-related signals may be used to confirm the sleep condition. A sleep detector . device implementing a sleep detection method may be a component of an implantable pulse generator such as a pacemaker or defibrillator.
摘要翻译：用于睡眠检测的装置和方法涉及使用可调阈值来检测睡眠开始和终止。一种用于检测睡眠的方法包括使用第二睡眠相关信号来调整与第一睡眠相关信号相关联的睡眠阈值。将第一睡眠相关信号与调整后的阈值进行比较，并根据比较检测睡眠。睡眠相关信号可以从可植入或外部传感器获得。可以使用附加的睡眠相关信号来确认睡眠状况。睡眠探测器实现睡眠检测方法的装置可以是诸如起搏器或除颤器的可植入脉冲发生器的部件。

97. 发明申请

WO00030529A1 WORLD WIDE PATIENT LOCATION AND DATA TELEMETRY SYSTEM FOR IMPLANTABLE MEDICAL DEVICES 审中-公开
标题翻译：世界广泛的患者位置和数据远程系统用于可植入医疗设备
公开(公告)号：WO00030529A1
公开(公告)日：2000-06-02
申请号：PCT/US1999/026390
申请日：1999-11-09
IPC分类号： A61B5/00 , A61N1/372
CPC分类号： A61B5/0031 , A61B5/1112 , A61B5/686 , A61B2505/07 , A61B2560/0295 , A61N1/37282 , G06F19/00 , G06F19/3418
摘要： A system for communicating with a medical device implanted (12, 14) in an ambulatory patient (10) and locating the patient in order to selectively monitor device function, alter device operating parameters and modes and provide emergency assistance to and communications with a patient. The implanted device (12, 14) includes a telemetry transceiver for communicating data and operating instructions between the implanted device and an external patient communications control device (20) that is either worn by or located in proximity to the patient (10) within the implanted device transceiving range. The control device (20) preferably includes a communication link with a remote medical support network (50), a global positioning satellite receiver (60) for receiving positioning data identifying the global position of the control device, and a patient activated link (26) for permitting patient initiated personal communication with the medical support network.
摘要翻译：一种用于与移动患者（10）中植入（12,14）的医疗设备进行通信并定位患者以便选择性地监视设备功能，改变设备操作参数和模式并且向患者提供紧急援助并与患者通信的系统。植入装置（12,14）包括遥测收发器，用于在所述植入装置和外部患者通信控制装置（20）之间传送数据和操作指令，所述外部患者通信控制装置（20）在所述植入装置内被佩戴或位于患者（10）附近设备收发范围。控制装置（20）优选地包括与远程医疗支持网络（50）的通信链路，用于接收识别控制装置的全局位置的定位数据的全球定位卫星接收机（60）和患者激活的链路（26）用于允许患者发起与医疗支持网络的个人通信。

98. 发明申请

WO99039629A1 CHEMICAL SENSORS HAVING MICROFLOW SYSTEMS 审中-公开
标题翻译：具有微流量系统的化学传感器
公开(公告)号：WO99039629A1
公开(公告)日：1999-08-12
申请号：PCT/US1999/002493
申请日：1999-02-04
IPC分类号： A61B5/00
CPC分类号： A61B5/1459 , A61B5/14528 , A61B5/14532 , A61B5/686
摘要： The present invention provides an implantable sensing arrangement having long-term stability. The sensing arrangement utilizes microdialysis sampling techniques and includes a micro-flow reservoir (10a) having a reagent which reacts with a target chemical and a sensor (80a) connected to the micro-flow reservoir (10a) for detecting the reaction of the reagent and the target chemical. The sensor may include a thermopile (80) or optical cell.
摘要翻译：本发明提供了具有长期稳定性的可植入感测装置。感测装置利用微透析取样技术，并且包括具有与目标化学物质反应的试剂的微流量储存器（10a）和连接到微流量储存器（10a）的传感器（80a），用于检测试剂的反应和目标化学品。传感器可以包括热电堆（80）或光电池。

99. 发明申请

WO1989002720A1 A PROCESS AND SYSTEM AND MEASURING CELL ASSEMBLY FOR GLUCOSE DETERMINATION 审中-公开
标题翻译：一种用于葡萄糖测定的方法和系统和测量细胞组件
公开(公告)号：WO1989002720A1
公开(公告)日：1989-04-06
申请号：PCT/NL1988000039
申请日：1988-10-05
申请人： STICHTING SCIENCE PARK GRONINGEN , SCHOONEN, Adelbert, Jozef, Martinus , SCHMIDT, Fransiscus, Josephus
发明人： STICHTING SCIENCE PARK GRONINGEN
IPC分类号： A61B05/00
CPC分类号： A61B5/14865 , A61B5/14528 , A61B5/686 , C12Q1/006
摘要： A wearable-type glucose sensor for continuously or intermittently determining the glucose content comprises a short hollow fiber (2) to be positioned in the subcutaneous tissue. This hollow fiber is connected via tubes (3, 4) with component parts (5 ... 12) located outside the body, such as a measuring unit (11). When a perfusion fluid containing the enzyme glucose oxidase is passed through the hollow fiber, a subcutaneous dialysis will take place in which some glucose dissolves in the perfusion fluid through the wall of the hollow fiber. This glucose is completely oxidized by the oxygen dissolved in the perfusion fluid in the presence of the glucose oxidase. By means of the measuring unit the resultant amount of H2O2 or, preferably, the employed amount of O2 is determined, both of which are a measure of the subcutaneous glucose concentration.

100. 发明申请

WO1988009684A1 SYSTEM AND METHOD FOR SENSING MINUTE VENTILATION 审中-公开
标题翻译：用于感测分钟通风的系统和方法
公开(公告)号：WO1988009684A1
公开(公告)日：1988-12-15
申请号：PCT/US1988001912
申请日：1988-06-03
申请人： ELLIOTT, Clyde, D.
IPC分类号： A61N01/00
CPC分类号： A61N1/36514 , A61B5/11 , A61B5/686 , A61B5/6869
摘要： A sensing system for detecting the frequency and amplitude of motion of a patient's diaphragm (1) comprising a transducer (7) for detecting movement, transvenously formed as a J-electrode with a bend at (9) and two opposing portions (10) and (11), coupled to transducer (7), transvenously implantable in a patient's heart (2); and a sensing instrument coupled to lead (6) for correlating transducer (7) movement with the frequency and amplitude of diaphragm (1) motion. The present invention also provides a method for using the system.

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