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1. 发明申请

WO2019140407A1 METHODS AND SYSTEMS FOR THE RAPID DETECTION OF CRONOBACTER USING INFECTIOUS AGENTS 审中-公开
公开(公告)号：WO2019140407A1
公开(公告)日：2019-07-18
申请号：PCT/US2019/013541
申请日：2019-01-14
申请人： LABORATORY CORPORATION OF AMERICA HOLDINGS
发明人： NGUYEN, Minh Mindy Bao , GIL, Jose S. , ERICKSON, Stephen , ANDERSON, Dwight Lyman , STACH, Jessica
IPC分类号： C12N7/00 , C12N15/74 , C12Q1/66 , C12Q1/70 , G01N33/50 , C12R1/01
CPC分类号： C12Q1/10 , A61K35/76 , C12N7/00 , C12N15/65 , C12N15/74 , C12N15/86 , C12N2795/00021 , C12N2795/00031 , C12N2795/00051 , C12N2795/10131 , C12N2795/10143 , C12Q1/025 , C12Q1/66 , C12Q1/6897 , C12Q1/70 , C12Q2304/60 , G01N33/50 , G01N2800/52
摘要： Disclosed herein are methods and systems for rapid detection of microorganisms such as Cronobacter spp . in a sample. A genetically modified bacteriophage is also disclosed which comprises an indicator gene in the late gene region. The specificity of the bacteriophage, such as Cronobacter -speciiic bacteriophage, allows detection of a specific microorganism, such as Cronobacter spp . and an indicator signal may be amplified to optimize assay sensitivity.

2. 发明申请

WO2018045369A1 HIGH-THROUGHPUT SCREENING ASSAY 审中-公开
标题翻译：高通量筛选分析
公开(公告)号：WO2018045369A1
公开(公告)日：2018-03-08
申请号：PCT/US2017/050060
申请日：2017-09-05
申请人： BELLBROOK LABS
发明人： KUMAR, Meera , ZIELINSKI, Tom , LOWERY, Robert, G.
IPC分类号： A61K39/00 , A61K39/39 , C12Q1/25 , G01N33/566 , G01N33/573
CPC分类号： G01N33/573 , C07K16/40 , C07K2317/622 , C07K2317/92 , C12Q1/025 , C12Q1/25 , C12Y207/07 , G01N33/5308 , G01N33/541 , G01N33/566 , G01N33/582
摘要： Methods and materials for development of high-throughput screening assays for detection of cyclic GMP (cGAMP) are provided by this invention.
摘要翻译：本发明提供了开发用于检测环GMP（cGAMP）的高通量筛选测定的方法和材料。

3. 发明申请

WO2018037242A1 METHODS AND SYSTEM FOR MONITORING BALLAST WATER 审中-公开
标题翻译：用于监测压载水的方法和系统
公开(公告)号：WO2018037242A1
公开(公告)日：2018-03-01
申请号：PCT/GB2017/052506
申请日：2017-08-25
申请人： BACTEST LIMITED
发明人： PRICE, Derek , RICKETT, Toby William
IPC分类号： C12Q1/02 , C12Q1/04 , C12M1/34
CPC分类号： C12Q1/025 , B63J4/002 , C12Q1/04 , G01N33/1826
摘要： We describe a ballast water test system, the system comprising: at least one microbe detector to test a sample of ballast water for the presence of microbes and to produce microbe detector data representing a detected level of microbes in said sample; a plankton detector to test said sample of ballast water for the presence of plankton and to produce plankton data representing a detected level of plankton in said sample; a biocide detector to test said sample of ballast water for the presence of biocide and to produce biocide data representing a detected level of biocide in said sample; and a compliance determination system comprising: at least one input to receive said microbe detector data, said plankton data, and said biocide data, at least one output to provide sample compliance data, and a processor coupled to said at least one input, to said output and to working memory and to program memory, and wherein said program memory stores processor control code to: input said microbe detector data, said plankton data, and said biocide data; process said microbe detector data, said plankton data, and said biocide data to compare said microbe detector data, said plankton data, and said biocide data with a set of rules defining permitted levels of microbes, plankton and biocide in said sample of ballast water for compliance with a standard; and output standard compliance data defining whether said sample of ballast water is in compliance with said standard; wherein said compliance determination system further comprises an anti-fraud system to control user fraud to inhibit a user from fraudulently producing a result indicating that said sample of ballast water is falsely in compliance with said standard.
摘要翻译：我们描述了一种压载水测试系统，该系统包括：至少一个微生物检测器，用于测试压载水的样本中是否存在微生物并产生代表微生物检测水平的微生物检测器数据所述样品; 浮游生物检测器，用于测试所述压舱水样品中浮游生物的存在并产生表示所述样品中检测到的浮游生物水平的浮游生物数据; 生物杀灭剂检测器，用于测试所述压舱水样品中是否存在杀生物剂并产生表示所述样品中检测到的杀生物剂水平的杀生物剂数据; 以及顺从性确定系统，其包括：接收所述微生物检测器数据，所述浮游生物数据和所述生物杀灭剂数据的至少一个输入，用于提供样品依从性数据的至少一个输出，以及耦合到所述至少一个输入的处理器，输出和工作存储器并编程存储器，并且其中所述程序存储器存储处理器控制代码以：输入所述微生物检测器数据，所述浮游生物数据和所述杀生物剂数据; 处理所述微生物检测器数据，所述浮游生物数据和所述杀生物剂数据以将所述微生物检测器数据，所述浮游生物数据和所述杀生物剂数据与一组规则相比较，所述规则定义所述压舱水样品中微生物，浮游生物和杀生物剂的允许水平，符合标准; 并输出标准符合性数据，所述标准符合性数据定义所述压载水样品是否符合所述标准; 其中所述顺从性确定系统进一步包括反欺诈系统以控制用户欺诈，以禁止用户欺骗性地产生指示所述压舱水样品错误地符合所述标准的结果。

4. 发明申请

WO2018028449A1 METHOD FOR PREDICTING EFFICACY OF IMMUNE CHECKPOINT INHIBITORS IN CANCER PATIENTS 审中-公开
标题翻译：预测癌症患者免疫检查点抑制剂有效性的方法
公开(公告)号：WO2018028449A1
公开(公告)日：2018-02-15
申请号：PCT/CN2017/095144
申请日：2017-07-31
申请人： BEIGENE, LTD. , LUO, Lusong , DAI, Chengliang , SUN, Zhijian
发明人： LUO, Lusong , DAI, Chengliang , SUN, Zhijian
IPC分类号： A61K39/395 , C07K16/00 , C07K16/30 , A61P35/00
CPC分类号： G01N33/574 , A61P35/00 , C07K16/2818 , C07K2317/76 , C12Q1/025 , G01N2500/02 , G01N2500/10
摘要： Disclosed is a method for predicting clinical response of a cancer patient to treatment with an immune checkpoint inhibitor, or a combination of two or more thereof, or with a combination of an immune checkpoint inhibitor and other antitumor drugs, by introducing bispecific T cell engager (BiTE) into the platform of lymphocytes containing T cells in vitro.
摘要翻译：公开了用于预测癌症患者用免疫检查点抑制剂或其两种或更多种的组合或用免疫检查点抑制剂与其它抗肿瘤药物的组合治疗的临床应答的方法，通过在体外将双特异性T细胞衔接子（BiTE）引入含有T细胞的淋巴细胞的平台中。

5. 发明申请

WO2018023120A1 PRECISION THERAPEUTIC BIOMARKER SCREENING FOR CANCER 审中-公开
标题翻译：精准的治疗性生物标志物筛查为癌症
公开(公告)号：WO2018023120A1
公开(公告)日：2018-02-01
申请号：PCT/US2017/044712
申请日：2017-07-31
申请人： UNIVERSITY OF MIAMI
发明人： RAO, Jonnagadda, Sunil , LIU, Hongmei
IPC分类号： A61K31/277 , A61K31/337 , A61K31/437 , A61K31/44 , A61K31/473 , A61K31/475
CPC分类号： C12Q1/025 , G01N33/5044 , G16B5/20 , G16B15/30 , G16B40/20 , G16H10/20 , G16H10/40 , G16H50/50 , G16H50/70
摘要： Computer-implemented processes for precision therapeutic biomarker screening for cancer include using a model-based overlapping clustering framework to assess large numbers of possible drugs and drug combinations against patient data, including cell line responsiveness. A multivariate regression model has been developed, along with a latent overlapping cluster indicator variable. The techniques employ a new finite mixture of multivariate regression (FMMR) model and expectation-maximization (EM) algorithm for modeling. The techniques can analyze large amounts of drug data and identify complex overlapping drug clusters, as well as cluster-wise drivers that facilitate identification of new drugs for treating pathologies, such as cancer, in patients.
摘要翻译：用于癌症的精确治疗性生物标志物筛选的计算机实现的过程包括使用基于模型的重叠聚类框架来评估针对患者数据的大量可能的药物和药物组合，包括细胞系反应性。已经开发了一个多变量回归模型，以及一个潜在的重叠群指标变量。这些技术采用多变量回归（FMMR）模型和期望最大化（EM）算法的新的有限混合来进行建模。这些技术可以分析大量的药物数据，并识别复杂的重叠药物簇，以及促进识别用于治疗患者病状的新药的集群驱动剂。

6. 发明申请

WO2017210494A1 MICROFLUIDIC-BASED MULTIPLEX CELL ASSAY FOR DRUG COMPOUND TESTING 审中-公开
标题翻译：用于药物复合测试的基于MICROFLUIDIC的多重细胞测定法
公开(公告)号：WO2017210494A1
公开(公告)日：2017-12-07
申请号：PCT/US2017/035560
申请日：2017-06-01
申请人： CARNEGIE MELLON UNIVERSITY , MASSACHUSETTS INSTITUTE OF TECHNOLOGY
发明人： ABIDI, Sabia , PAPAGEORGIOU, Dimitrios, P. , DAO, Ming , SURESH, Subra
IPC分类号： B01L1/02 , B01L5/00 , C12M1/34 , C12Q1/00 , F15C5/00 , G01N15/10
CPC分类号： G01N15/10 , B01L3/50 , B01L3/502761 , C12Q1/00 , C12Q1/025 , G01N15/147 , G01N15/1484 , G01N19/04 , G01N2015/0073 , G01N2015/1497 , G01N2203/0089
摘要： The invention in some aspects relates to high throughput methods and devices for evaluating mechanical and morphological properties of cells, such as blood cells under conditions of cell attachment and regulated gas conditions. In some aspects, the invention relates to methods for assessing cell adhesion under regulated conditions, for example gas concentration, temperature, shear force, and attachment to proteins. In some aspects, the invention relates to methods and devices for identifying therapeutic agents. In some aspects, the invention relates to methods and devices for diagnosing and/or characterizing a condition or disease in a subject, for example, by measuring a property of a cell from the subject under controlled conditions.
摘要翻译：本发明在一些方面涉及用于在细胞附着和调节气体条件下评估细胞（例如血细胞）的机械和形态特性的高通量方法和装置。在一些方面，本发明涉及用于在调节条件下评估细胞粘附的方法，例如气体浓度，温度，剪切力和与蛋白质的附着。在一些方面，本发明涉及用于鉴定治疗剂的方法和装置。在一些方面，本发明涉及用于诊断和/或表征受试者中的病症或疾病的方法和装置，例如通过在受控条件下测量来自受试者的细胞的特性。

7. 发明申请

WO2017127612A1 NOVEL RECOMBINASES AND TARGET SEQUENCES 审中-公开
标题翻译：新的重组和目标序列
公开(公告)号：WO2017127612A1
公开(公告)日：2017-07-27
申请号：PCT/US2017/014234
申请日：2017-01-20
申请人： MASSACHUSETTS INSTITUTE OF TECHNOLOGY , INRIA (FRENCH INSTITUTE FOR RESEARCH IN COMPUTER SCIENCE AND AUTOMATION)
发明人： WEISS, Ron , DUPORTET, Xavier, Cesar , BATT, Gregory , LI, Yinqing
IPC分类号： C12N15/10 , C12N15/90 , C12N5/10
CPC分类号： C12N15/1086 , C12N9/22 , C12N15/10 , C12N15/1034 , C12N15/1093 , C12N15/52 , C12N15/85 , C12N2800/30 , C12Q1/025 , C12Q1/6897
摘要： The disclosure provides novel large serine recombinases and their respective recognition sites, as well as libraries of orthogonal recombinase recognition sites. Uses of the large serine recombinases, recognition sites, and libraries of orthogonal recombinase recognition sites also are provided.
摘要翻译：本公开提供了新的大的丝氨酸重组酶及其各自的识别位点，以及正交重组酶识别位点的文库。还提供了大的丝氨酸重组酶，识别位点和正交重组酶识别位点的文库的使用。

8. 发明申请

WO2017004577A1 HIGH-THROUGHPUT FLUORESCENT SCREENING ASSAY FOR INHIBITORS OF GRAM-NEGATIVE BACTERIAL IRON UPTAKE 审中-公开
标题翻译：高渗透荧光屏幕检测用于抑制细菌铁吸收的抑制剂
公开(公告)号：WO2017004577A1
公开(公告)日：2017-01-05
申请号：PCT/US2016/040815
申请日：2016-07-01
申请人： KANSAS STATE UNIVERSITY RESEARCH FOUNDATION
发明人： KLEBBA, Phillip E. , NEWTON, Salete M. , NAIRN, Brittany L. , HANSON, Mathew
IPC分类号： A61K9/00 , A61K49/00 , A61K49/20 , C12N1/20 , C12Q1/02
CPC分类号： C12Q1/025 , C07K14/212 , C12N1/20 , G01N2333/212 , G01N2458/00
摘要： A cell-based assay for identifying a compound that inhibits iron transport in Gram-negative bacteria, engineered bacterial cells, and kits for conducting the same. The assay involves contacting a candidate compound with an engineered Gram-negative bacteria in the presence of iron for a sufficient period of time, exposing the reaction solution to an energy source to generate the detectable signal, and detecting changes in the detectable signal in the reaction solution over time. The engineered Gram-negative bacteria comprises an iron transport protein on its outer membrane that comprises an amino acid residue that has been engineered with a detectable label that generates a detectable signal. The changes in the detectable signal in the assay system over time correspond to the effect of the candidate compound on iron transport in the Gram-negative bacteria.
摘要翻译：用于鉴定在革兰氏阴性细菌中抑制铁转运的化合物的基于细胞的测定法，工程细菌细胞和用于进行其的试剂盒。该测定包括在铁存在下将候选化合物与工程革兰氏阴性细菌接触足够长的时间，将反应溶液暴露于能量源以产生可检测信号，并检测反应中可检测信号的变化解决方案随着时间的流逝。工程革兰氏阴性细菌在其外膜上包含铁转运蛋白，其包含已经用产生可检测信号的可检测标记进行工程化的氨基酸残基。随着时间的推移，测定系统中可检测信号的变化对应于候选化合物对革兰氏阴性细菌中铁转运的影响。

9. 发明申请

WO2016142696A1 AMBIENT IONIZATION MASS SPECTROMETRY IMAGING PLATFORM FOR DIRECT MAPPING FROM BULK TISSUE 审中-公开
标题翻译：用于从大块组织直接映射的环境离子质谱法成像平台
公开(公告)号：WO2016142696A1
公开(公告)日：2016-09-15
申请号：PCT/GB2016/050626
申请日：2016-03-07
申请人： MICROMASS UK LIMITED
发明人： JONES, Emrys , PRINGLE, Steven Derek , TAKÁTS, Zoltán
IPC分类号： G01N33/68
CPC分类号： H01J49/049 , A61B1/00013 , A61B1/041 , A61B1/31 , A61B5/0066 , A61B5/0075 , A61B5/015 , A61B5/0507 , A61B5/055 , A61B5/14542 , A61B6/032 , A61B6/037 , A61B8/13 , A61B10/00 , A61B10/0041 , A61B10/0233 , A61B10/0283 , A61B17/00 , A61B17/320068 , A61B18/00 , A61B18/042 , A61B18/14 , A61B18/1445 , A61B18/1815 , A61B18/20 , A61B90/13 , A61B2010/0083 , A61B2017/320069 , A61B2018/00577 , A61B2218/008 , A61F13/38 , C12Q1/025 , C12Q1/04 , C12Q1/18 , C12Q1/24 , G01N1/2202 , G01N3/00 , G01N9/00 , G01N27/622 , G01N27/624 , G01N30/724 , G01N33/487 , G01N33/48735 , G01N33/6848 , G01N33/6851 , G01N33/92 , G01N2001/2223 , G01N2333/195 , G01N2405/00 , G01N2405/04 , G01N2405/08 , G01N2570/00 , G01N2800/26 , G06F19/18 , G06F19/324 , G06F19/3481 , G16H50/20 , H01J49/0004 , H01J49/0031 , H01J49/0036 , H01J49/025 , H01J49/0404 , H01J49/0422 , H01J49/0445 , H01J49/0459 , H01J49/0463 , H01J49/0468 , H01J49/061 , H01J49/068 , H01J49/10 , H01J49/14 , H01J49/16 , H01J49/164 , H01J49/24 , H01J49/26
摘要： A method of ion imaging is disclosed that includes automatically sampling a plurality of different locations on a sample (20) using a first device (21) which is arranged and adapted to generate aerosol, smoke or vapour from the sample (20). Mass spectral data and/or ion mobility data corresponding to each location is obtained and the obtained mass spectral data and/or ion mobility data is used to construct, train or improve a sample classification model.
摘要翻译：公开了一种离子成像方法，其包括使用布置并适于从样品（20）产生气溶胶，烟雾或蒸气的第一装置（21）自动对样品（20）上的多个不同位置进行采样。获得对应于每个位置的质谱数据和/或离子迁移率数据，并且使用所获得的质谱数据和/或离子迁移率数据来构建，训练或改进样品分类模型。

10. 发明申请

WO2016142681A1 SPECTROMETRIC ANALYSIS OF MICROBES 审中-公开
标题翻译：微生物的光谱分析
公开(公告)号：WO2016142681A1
公开(公告)日：2016-09-15
申请号：PCT/GB2016/050610
申请日：2016-03-07
申请人： MICROMASS UK LIMITED
发明人： TAKÁTS, Zoltán , BOLT, Frances , KARANCSI, Tamás , JONES, Emrys , RICHARDSON, Keith , GÖDÖRHÁZY, Lajos , SZALAY, Dániel , BALOG, Júlia , PRINGLE, Steven Derek , SIMON, Dániel
IPC分类号： G01N33/68 , G01N33/02 , G01N33/48 , G01N27/62 , A61B17/00 , A61B18/00 , G01N3/00 , G01N9/00 , H01J49/00
CPC分类号： H01J49/049 , A61B1/00013 , A61B1/041 , A61B1/31 , A61B5/0066 , A61B5/0075 , A61B5/015 , A61B5/0507 , A61B5/055 , A61B5/14542 , A61B6/032 , A61B6/037 , A61B8/13 , A61B10/00 , A61B10/0041 , A61B10/0233 , A61B10/0283 , A61B17/00 , A61B17/320068 , A61B18/00 , A61B18/042 , A61B18/14 , A61B18/1445 , A61B18/1815 , A61B18/20 , A61B90/13 , A61B2010/0083 , A61B2017/320069 , A61B2018/00577 , A61B2218/008 , A61F13/38 , C12Q1/025 , C12Q1/04 , C12Q1/18 , C12Q1/24 , G01N1/2202 , G01N3/00 , G01N9/00 , G01N27/622 , G01N27/624 , G01N30/724 , G01N33/487 , G01N33/48735 , G01N33/6848 , G01N33/6851 , G01N33/92 , G01N2001/2223 , G01N2333/195 , G01N2405/00 , G01N2405/04 , G01N2405/08 , G01N2570/00 , G01N2800/26 , G06F19/18 , G06F19/324 , G06F19/3481 , G16H50/20 , H01J49/0004 , H01J49/0031 , H01J49/0036 , H01J49/025 , H01J49/0404 , H01J49/0422 , H01J49/0445 , H01J49/0459 , H01J49/0463 , H01J49/0468 , H01J49/061 , H01J49/068 , H01J49/10 , H01J49/14 , H01J49/16 , H01J49/164 , H01J49/24 , H01J49/26
摘要： A method of analysis using mass spectrometry and/or ion mobility spectrometry is disclosed. The method comprises: using a first device to generate smoke, aerosol or vapour from a target comprising or consisting of a microbial population; mass analysing and/or ion mobility analysing said smoke, aerosol or vapour, or ions derived therefrom, in order to obtain spectrometric data; and analysing said spectrometric data in order to analyse said microbial population.
摘要翻译：公开了使用质谱法和/或离子迁移光谱法进行分析的方法。该方法包括：使用第一装置从包含微生物群体或由微生物群体组成的靶产生烟雾，气溶胶或蒸汽; 质量分析和/或离子迁移率分析所述烟雾，气溶胶或蒸气或从其衍生的离子，以获得光谱数据; 并分析所述光谱数据以分析所述微生物群体。

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