专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US09926466B2 Amic acids as surface treatments 有权
公开(公告)号：US09926466B2
公开(公告)日：2018-03-27
申请号：US14974187
申请日：2015-12-18
申请人： Alice Hudson
发明人： Alice Hudson
IPC分类号： C09D5/08 , C04B24/08 , C07C231/02 , C07C233/35 , C09D179/08 , C09D4/00 , C09D5/16
CPC分类号： C09D179/08 , C08F8/32 , C09D4/00 , C09D5/08 , C09D5/1662
摘要： Surfaces are modified with polymeric or monomeric amic acids that also comprise one or more tertiary amine functional groups. The amic acids may provide benefits including hydrophilicity, soil resistance, and corrosion inhibition to the treated surfaces. Compositions and methods for treating surfaces are provided.

2. 发明申请

US20180078517A1 BETA-SUBSTITUTED BETA-AMINO ACIDS AND ANALOGS AS CHEMOTHERAPEUTIC AGENTS 审中-公开
公开(公告)号：US20180078517A1
公开(公告)日：2018-03-22
申请号：US15826042
申请日：2017-11-29
申请人： QUADRIGA BIOSCIENCES, INC.
发明人： BERND JANDELEIT , WOLF-NICOLAS FISCHER , KERRY J. KOLLER
IPC分类号： A61K31/197 , C07F9/30 , C07C233/35 , C07C237/20 , C07C229/42 , A61K31/27 , A61K31/255 , C07C229/08 , C07F9/32 , C07C239/20 , C07C237/30 , C07C229/34 , C07C229/22 , C07F9/48 , A61K31/662 , C07C309/69 , C07C271/46 , C07C237/04 , C07C309/66
CPC分类号： A61K31/197 , A61K31/255 , A61K31/27 , A61K31/662 , C07C229/08 , C07C229/22 , C07C229/34 , C07C229/42 , C07C233/35 , C07C237/04 , C07C237/20 , C07C237/30 , C07C239/20 , C07C271/46 , C07C309/66 , C07C309/69 , C07F9/306 , C07F9/3264 , C07F9/48 , C07F9/4816
摘要： β-Substituted β-amino acids, β-substituted β-amino acid derivatives, and β-substituted β-amino acid analogs and (bio)isosteres and their use as chemotherapeutic agents are disclosed. The β-substituted β-amino acid derivatives and β-substituted β-amino acid analogs and (bio)isosteres are selective LAT1/4F2hc substrates and exhibit rapid uptake and retention in tumors expressing the LAT1/4F2hc transporter. Methods of synthesizing the β-substituted β-amino acid derivatives and β-substituted β-amino acid analogs and methods of using the compounds for treating cancer are also disclosed. The β-substituted β-amino acid derivatives and β-substituted β-amino acid analogs exhibit selective uptake in tumor cells expressing the LAT1/4F2hc transporter and accumulate in cancerous cells when administered to a subject in vivo. The β-substituted β-amino acid derivatives and β-substituted β-amino acid analogs and (bio)isosteres exhibit cytotoxicity toward several tumor types.

3. 发明授权

US5962709A Process for the aftertreatment of betaines and amphoteric surfactants 失效
标题翻译：甜菜碱和两性表面活性剂后处理工艺
公开(公告)号：US5962709A
公开(公告)日：1999-10-05
申请号：US525693
申请日：1995-09-12
申请人： Gunter Uphues , Uwe Ploog , Rainer Jeschke , Renate Schick
发明人： Gunter Uphues , Uwe Ploog , Rainer Jeschke , Renate Schick
IPC分类号： B01F17/28 , C07C227/40 , C07C227/44 , C07C229/12 , C07C231/00 , C07C231/22 , C07C231/24 , C07C233/35 , C07C233/36 , C07C233/38 , C11D1/88 , C11D1/90
CPC分类号： A61K8/442 , A61K8/44 , C07C227/40 , C07C227/44 , C07C229/12 , C07C231/22 , C07C231/24 , C07C233/36 , C07C233/38 , C11D1/90 , A61Q19/10 , A61Q5/02
摘要： Process for the aftertreatment of betaine and amphoteric surfactants comprising adjusting the pH to the range of from 11 to 14 by addition of an alkali metal hydroxide, followed by a thermal aftertreatment if the surfactant contains dichloroacetic acid residues.
摘要翻译： PCT No.PCT / EP94 / 00621 Sec。 371 1995年9月12日第 102（e）日期1995年9月12日PCT 1994年3月3日PCT公布。第WO94 / 20452号公报日期1994年9月15日用于甜菜碱和两性表面活性剂后处理的方法，包括通过加入碱金属氢氧化物将pH调节至11至14的范围，然后如果表面活性剂含有二氯乙酸残基，则进行热后处理。

4. 发明授权

US5837533A Complexes comprising a nucleic acid bound to a cationic polyamine having an endosome disruption agent 失效
标题翻译：包含与具有内体破坏剂的阳离子多胺结合的核酸的复合物
公开(公告)号：US5837533A
公开(公告)日：1998-11-17
申请号：US314060
申请日：1994-09-28
申请人： Raymond H. Boutin
发明人： Raymond H. Boutin
IPC分类号： C12N15/09 , A61K47/48 , A61K48/00 , C07C211/14 , C07C233/35 , C07C271/22 , C07K7/08 , C07K14/005 , C07K14/11 , C12N15/64 , C12N15/86 , C12N15/87 , C12N15/88 , C12N5/00 , C12N150/00
CPC分类号： C07K14/005 , A61K47/48046 , A61K47/48123 , C12N15/64 , C12N15/87 , A61K48/00 , C12N2760/16022
摘要： A multifunctional molecular complex for the transfer of a nucleic acid composition to a target cell is provided which comprises in any functional combination: A) said nucleic acid composition; and B) a transfer moiety comprising 1) one or more cationic polyamine components bound to said nucleic acid composition, each comprising from three to twelve nitrogen atoms; 2) one or more endosome membrane disruption promoting components attached to at least one nitrogen atom of at least one of said polyamine components, through an alkyl, carboxamide, carbamate, thiocarbamate, or carbamoyl bridging group, comprising a) at least one lipophilic long chain alkyl group, b) a fusogenic peptide comprising spike glycoproteins of enveloped animal viruses, or c) cholic acid or cholesteryl or derivatives; and optionally 3) one or more receptor specific binding components which are ligands for natural receptors of said target cell, attached through an alkyl, carboxamide, carbamate, thiocarbamate, or carbamoyl bridging group to either i) a further nitrogen atom of at least one of said polyamine components to which said one or more endosome membrane disruption promoting components is attached, or ii) a nitrogen atom of at least one further polyamine component which does not have attached thereto any endosome membrane disruption promoting component. Also provided are the transfer moiety alone, or in combination with the nucleic acid composition as a self-assembling combination, and the use of these compositions in methods for transfering nucleic acid compositions to cells or to cells of individuals, for immunizing individuals against a pathogen or disease, and for treating an individual with a disease.
摘要翻译：提供了用于将核酸组合物转移到靶细胞的多功能分子复合物，其包含任何功能组合：A）所述核酸组合物; 和B）转移部分，其包含1）与所述核酸组合物结合的一种或多种阳离子多胺组分，每个包含3至12个氮原子; 2）通过烷基，羧酰胺，氨基甲酸酯，硫代氨基甲酸酯或氨基甲酰基桥连连接到至少一个所述多胺组分的至少一个氮原子上的一种或多种内体膜破坏促进组分，其包含a）至少一种亲脂性长链烷基，b）包含包膜动物病毒的尖峰糖蛋白的融合肽，或c）胆酸或胆固醇或衍生物; 和任选地3）一种或多种受体特异性结合组分，其是所述靶细胞的天然受体的配体，通过烷基，羧酰胺，氨基甲酸酯，硫代氨基甲酸酯或氨基甲酰基桥连基团连接到i）至少一个的另外的氮原子所述一种或多种内体膜破坏促进组分所连接的所述多胺组分，或ii）至少一种不附着任何内体膜破坏促进组分的多胺组分的氮原子。还提供了转移部分单独或与作为自组装组合的核酸组合物组合，以及这些组合物在用于将核酸组合物转移至个体细胞或细胞的方法中的用途，用于免疫个体抵抗病原体或疾病，并用于治疗患有疾病的个体。

6. 发明授权

US4329489A Method of preparation of fluorocarbon compounds 失效
标题翻译：氟碳化合物的制备方法
公开(公告)号：US4329489A
公开(公告)日：1982-05-11
申请号：US151499
申请日：1980-05-19
申请人： Peter R. Saunders , Raymond J. Biron
发明人： Peter R. Saunders , Raymond J. Biron
IPC分类号： C07C67/00 , C07C69/76 , C07C231/00 , C07C233/16 , C07C233/17 , C07C233/18 , C07C233/35 , C07C233/36 , C07C235/08 , C07C235/10 , C07C253/00 , C07C255/16 , D06M13/02 , D06M13/08 , D06M13/144 , D06M13/224 , D06M13/248 , D06M13/256 , D06M13/322 , D06M13/402 , D06M13/408 , C07C67/08
CPC分类号： C07C233/16 , C07C67/08 , C07C67/62 , C07C69/76 , D06M13/08
摘要： Preparation of a fluorocarbon compound used to make a soil-resistant yarn is improved by removing most of the impurities from the fluoro-carbon compound mass with heat and vacuum after the final washing step and then adding an emulsifier to the fluorocarbon compound mass so that the mass can be handled as a liquid concentrate rather than a tacky solid.
摘要翻译：通过在最后的洗涤步骤之后，用热和真空除去氟碳化合物的大多数杂质，然后向氟碳化合物料中加入乳化剂，从而改善用于制造耐污染纱线的氟碳化合物的制备，质量可以作为液体浓缩物而不是粘性固体处理。

7. 发明授权

US4015011A Phenylalkylamines and salts thereof 失效
标题翻译：苯基烷基胺及其盐
公开(公告)号：US4015011A
公开(公告)日：1977-03-29
申请号：US571719
申请日：1975-04-25
申请人： Kurt Schromm , Anton Mentrup , Ernst Otto Renth , Ludwig Pichler , Werner Traunecker
发明人： Kurt Schromm , Anton Mentrup , Ernst Otto Renth , Ludwig Pichler , Werner Traunecker
IPC分类号： A61K31/165 , A61K31/137 , A61K31/27 , A61P9/02 , A61P25/02 , A61P25/26 , C07C67/00 , C07C209/00 , C07C209/08 , C07C209/10 , C07C209/40 , C07C209/52 , C07C209/62 , C07C211/27 , C07C211/49 , C07C231/00 , C07C231/02 , C07C231/12 , C07C233/35 , C07C233/43 , C07C239/00 , C07C255/24 , C07C271/26 , C07C271/28 , C07C275/40 , C07C307/10 , C07C325/00 , C07C333/08
CPC分类号： C07C275/40 , Y02P20/55
摘要： Compounds of the formula ##STR1## wherein R.sub.1 is hydrogen, --(CH.sub.2).sub.n --R.sub.4 or --CO--R.sub.5, wheren is 1 or 2,R.sub.4 is hydrogen, cyano or benzoyl, andR.sub.5 is hydrogen, lower alkoxy, benzyloxy, --CH.sub.2 --NH.sub.2, --CH(CH.sub.3)--NH.sub.2, --CH.sub.2 --NH--CH.sub.2 --C.sub.6 H.sub.5 or --CH(CH.sub.3)--NH--CH.sub.2 --C.sub.6 H.sub.5,R.sub.2 is hydrogen or methyl, andR.sub.3 is amino, nitro, --NH--CO--R.sub.6 or --NH--A--R.sub.7, whereR.sub.6 is hydrogen, methyl, methoxy, ethoxy, methylthio or ethylthio,R.sub.7 is amino, methylamino or dimethylamino, andA is --CO-- or --SO.sub.2 --,and non-toxic, pharmacologically acceptable acid addition salts thereof; the compounds as well as their salts are useful as hypertensives.
摘要翻译：其中R 1是氢， - （CH 2）n -R 4或-CO-R 5，其中N IS 1 OR 2，R 4是氢，氰基或苯甲酰基，R 5是氢，低级烷氧基，苄氧基， -CH 2 -NH 2，-CH（CH 3）-NH 2，-CH 2 -NH-CH 2 -C 6 H 5或-CH（CH 3）-NH-CH 2 -C 6 H 5，R 2是氢或甲基，R 3是氨基，硝基， CO-R6或-NH-A-R7，其中R6是氢，甲基，甲氧基，乙氧基，甲硫基或乙硫基，R7是氨基，甲氨基或二甲氨基，A是-CO-或-SO2-，无毒，其药理学上可接受的酸加成盐; 化合物及其盐可用作高血压药。

8. 发明授权

US09861599B2 Beta-substituted beta-amino acids and analogs as chemotherapeutic agents 有权
公开(公告)号：US09861599B2
公开(公告)日：2018-01-09
申请号：US15182851
申请日：2016-06-15
申请人： QUADRIGA BIOSCIENCES, INC.
发明人： Bernd Jandeleit , Wolf-Nicolas Fischer , Kerry J. Koller
IPC分类号： C07F9/30 , C07C309/66 , C07C237/20 , C07C229/42 , C07C237/04 , C07F9/32 , C07F9/48 , C07C233/35 , C07C229/34 , C07C229/22 , C07C229/08 , C07C309/69 , C07C271/46 , C07C237/30 , A61K31/197 , A61K31/662 , C07C239/20 , A61K31/255 , A61K31/27
CPC分类号： A61K31/197 , A61K31/255 , A61K31/27 , A61K31/662 , C07C229/08 , C07C229/22 , C07C229/34 , C07C229/42 , C07C233/35 , C07C237/04 , C07C237/20 , C07C237/30 , C07C239/20 , C07C271/46 , C07C309/66 , C07C309/69 , C07F9/306 , C07F9/3264 , C07F9/48 , C07F9/4816
摘要： β-Substituted β-amino acids, β-substituted β-amino acid derivatives, and β-substituted β-amino acid analogs and (bio)isosteres and their use as chemotherapeutic agents are disclosed. The β-substituted β-amino acid derivatives and β-substituted β-amino acid analogs and (bio)isosteres are selective LAT1/4F2hc substrates and exhibit rapid uptake and retention in tumors expressing the LAT1/4F2hc transporter. Methods of synthesizing the β-substituted β-amino acid derivatives and β-substituted β-amino acid analogs and methods of using the compounds for treating cancer are also disclosed. The β-substituted β-amino acid derivatives and β-substituted β-amino acid analogs exhibit selective uptake in tumor cells expressing the LAT1/4F2hc transporter and accumulate in cancerous cells when administered to a subject in vivo. The β-substituted β-amino acid derivatives and β-substituted β-amino acid analogs and (bio)isosteres exhibit cytotoxicity toward several tumor types.

9. 发明授权

US09394237B2 β-substituted β-amino acids and analogs as chemotherapeutic agents 有权
标题翻译：氨基酸和类似物作为化学治疗剂
公开(公告)号：US09394237B2
公开(公告)日：2016-07-19
申请号：US14613143
申请日：2015-02-03
申请人： QUADRIGA BIOSCIENCES, INC.
发明人： Bernd Jandeleit , Wolf-Nicolas Fischer , Kerry J. Koller
IPC分类号： C07C229/08 , C07C233/35 , C07C271/46 , C07C309/69 , C07F9/48 , A61K31/197 , A61K31/662 , C07C229/22 , C07C229/34 , C07C237/30 , C07C239/20 , C07C237/04 , C07F9/32
CPC分类号： A61K31/197 , A61K31/255 , A61K31/27 , A61K31/662 , C07C229/08 , C07C229/22 , C07C229/34 , C07C229/42 , C07C233/35 , C07C237/04 , C07C237/20 , C07C237/30 , C07C239/20 , C07C271/46 , C07C309/66 , C07C309/69 , C07F9/306 , C07F9/3264 , C07F9/48 , C07F9/4816
摘要： β-Substituted β-amino acids, β-substituted β-amino acid derivatives, and β-substituted β-amino acid analogs and (bio)isosteres and their use as chemotherapeutic agents are disclosed. The β-substituted β-amino acid derivatives and β-substituted β-amino acid analogs and (bio)isosteres are selective LAT1/4F2hc substrates and exhibit rapid uptake and retention in tumors expressing the LAT1/4F2hc transporter. Methods of synthesizing the β-substituted β-amino acid derivatives and β-substituted β-amino acid analogs and methods of using the compounds for treating cancer are also disclosed. The β-substituted β-amino acid derivatives and β-substituted β-amino acid analogs exhibit selective uptake in tumor cells expressing the LAT1/4F2hc transporter and accumulate in cancerous cells when administered to a subject in vivo. The β-substituted β-amino acid derivatives and β-substituted β-amino acid analogs and (bio)isosteres exhibit cytotoxicity toward several tumor types.
摘要翻译：＆amp; bgr; - 取代的和bgr-氨基酸，和取代的＆bgr - - 氨基酸衍生物和＆amp;取代的＆amp; bgr - 氨基酸类似物和（生物）等体积以及它们作为化学治疗剂的用途。取代和取代的 - 氨基酸衍生物和（取代） - 氨基酸类似物和（生物）等分子体是选择性LAT1 / 4F2hc底物，并且在表达LAT1 / 4F2hc转运蛋白的肿瘤中表现出快速吸收和保留。还公开了合成取代的和取代的 - 氨基酸衍生物和取代的和 - 取代的 - 氨基酸类似物的方法和使用该化合物治疗癌症的方法。取代和取代的 - 氨基酸衍生物和“取代的” - 氨基酸类似物在表达LAT1 / 4F2hc转运蛋白的肿瘤细胞中表现出选择性吸收，并且当在体内施用于受试者时，其累积在癌细胞中。取代的＆bgr - - 氨基酸衍生物和“取代的”和“氨基酸”类似物和（生物）等分子体对几种肿瘤类型表现出细胞毒性。

10. 发明申请

US20150218086A1 BETA-SUBSTITUTED BETA-AMINO ACIDS AND ANALOGS AS CHEMOTHERAPEUTIC AGENTS 有权
标题翻译：作为化学治疗剂的β-取代的氨基酸和类似物
公开(公告)号：US20150218086A1
公开(公告)日：2015-08-06
申请号：US14613143
申请日：2015-02-03
申请人： QUADRIGA BIOSCIENCES, INC.
发明人： BERND JANDELEIT , WOLF-NICOLAS FISCHER , KERRY J. KOLLER
IPC分类号： C07C229/08 , C07C271/46 , C07C233/35 , C07F9/48 , C07C309/69
CPC分类号： A61K31/197 , A61K31/255 , A61K31/27 , A61K31/662 , C07C229/08 , C07C229/22 , C07C229/34 , C07C229/42 , C07C233/35 , C07C237/04 , C07C237/20 , C07C237/30 , C07C239/20 , C07C271/46 , C07C309/66 , C07C309/69 , C07F9/306 , C07F9/3264 , C07F9/48 , C07F9/4816
摘要： β-Substituted β-amino acids, β-substituted β-amino acid derivatives, and β-substituted β-amino acid analogs and (bio)isosteres and their use as chemotherapeutic agents are disclosed. The β-substituted β-amino acid derivatives and β-substituted β-amino acid analogs and (bio)isosteres are selective LAT1/4F2hc substrates and exhibit rapid uptake and retention in tumors expressing the LAT1/4F2hc transporter. Methods of synthesizing the β-substituted β-amino acid derivatives and β-substituted β-amino acid analogs and methods of using the compounds for treating cancer are also disclosed. The β-substituted β-amino acid derivatives and β-substituted β-amino acid analogs exhibit selective uptake in tumor cells expressing the LAT1/4F2hc transporter and accumulate in cancerous cells when administered to a subject in vivo. The β-substituted β-amino acid derivatives and β-substituted β-amino acid analogs and (bio)isosteres exhibit cytotoxicity toward several tumor types.
摘要翻译：＆amp; bgr; - 取代的和bgr-氨基酸，和取代的＆bgr - - 氨基酸衍生物和＆amp;取代的＆amp; bgr - 氨基酸类似物和（生物）等体积以及它们作为化学治疗剂的用途。取代和取代的 - 氨基酸衍生物和（取代） - 氨基酸类似物和（生物）等分子体是选择性LAT1 / 4F2hc底物，并且在表达LAT1 / 4F2hc转运蛋白的肿瘤中表现出快速吸收和保留。还公开了合成取代的和取代的 - 氨基酸衍生物和取代的和 - 取代的 - 氨基酸类似物的方法和使用该化合物治疗癌症的方法。取代和取代的 - 氨基酸衍生物和“取代的” - 氨基酸类似物在表达LAT1 / 4F2hc转运蛋白的肿瘤细胞中表现出选择性吸收，并且当在体内施用于受试者时，其累积在癌细胞中。取代的＆bgr - - 氨基酸衍生物和“取代的”和“氨基酸”类似物和（生物）等分子体对几种肿瘤类型表现出细胞毒性。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式