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1. 发明申请

US20190084966A1 SYNTHETIC ROUTE TO ANTI-VIRAL AGENTS 审中-公开
公开(公告)号：US20190084966A1
公开(公告)日：2019-03-21
申请号：US16132997
申请日：2018-09-17
申请人： AbbVie Inc.
发明人： Russell D. Cink , Kirill A. Lukin , Marvin R. Leanna , Matthew J. Pelc , Timothy B. Towne , Dennie S. Welch , Kenneth M. Engstrom , Matthew M. Ravn , Richard D. Bishop , Gang Zhao , Jianzhang Mei , Jeff M. Kallemeyn , David R. Hill , Michael J. Abrahamson , Westin H. Morrill
IPC分类号： C07D403/12 , C07C269/06 , C07C68/02 , C07C67/08 , C07C211/35 , C07C271/34 , C12P1/00 , C07C69/74 , C07C43/196 , C07C41/26 , C07D405/14 , C07D241/44 , C07D405/06 , C07D487/04 , C07C269/04
CPC分类号： C07D403/12 , C07C41/26 , C07C43/196 , C07C67/08 , C07C68/02 , C07C69/74 , C07C211/35 , C07C269/04 , C07C269/06 , C07C271/34 , C07C2601/08 , C07D241/44 , C07D405/06 , C07D405/14 , C07D487/04 , C12P1/00 , C12P41/005 , C07C69/96 , C07C69/14
摘要： The invention provides methods of synthesizing a viral protease inhibitor in high yield, without using expensive catalysts or challenging reaction conditions.

2. 发明授权

US09918473B2 Use of aryl carbamates in agriculture and other plant-related areas 有权
公开(公告)号：US09918473B2
公开(公告)日：2018-03-20
申请号：US15238847
申请日：2016-08-17
申请人： North Carolina State University
发明人： Christian Melander , Steven A. Rogers
IPC分类号： A01N47/18 , A01N59/20 , A01N63/00 , C07C271/34 , C07D213/40 , C07D209/14 , A01N47/12 , A01N47/16
CPC分类号： A01N47/18 , A01N47/12 , A01N47/16 , A01N59/20 , A01N63/00 , C07C271/34 , C07C2601/14 , C07D209/14 , C07D213/40
摘要： Disclosure is provided for methods of preventing, removing or inhibiting microbial biofilm formation or microbial infection in a plant or plant part thereof, including applying thereto a treatment effective amount of an aryl carbamate as described herein, or an agriculturally acceptable salt thereof. Methods of enhancing a microbicide (e.g., including a copper, antibiotic, bacteriophage, etc.) and/or plant defense activator are also provided, including applying an active compound as described herein. Compositions comprising an aryl carbamate compound as described herein in an agriculturally acceptable carrier are also provided, and in some embodiments the compositions further include a microbicide (e.g., including copper, antibiotic, bacteriophage, etc.) and/or a plant defense activator.

3. 发明申请

US20170066714A1 DISUBSTITUTED AMINO ACIDS AND METHODS OF PREPARATION AND USE THEREOF 有权
标题翻译：分离的氨基酸及其制备和使用方法
公开(公告)号：US20170066714A1
公开(公告)日：2017-03-09
申请号：US15278824
申请日：2016-09-28
申请人： Aileron Therapeutics, Inc.
发明人： Krzysztof Darlak , Noriyuki Kawahata , Sameer Ahmed Athamneh
IPC分类号： C07C271/22 , C07K1/00
CPC分类号： C07C271/34 , C07B2200/07 , C07C269/08 , C07C271/22 , C07C2603/18 , C07K1/006
摘要： Provided are crystalline α, α-disubstituted amino acids and their crystalline salts containing a terminal alkene on one of their side chains, as well as optionally crystalline halogenated and deuterated analogs of the α, α-disubstituted amino acids and their salts; methods of making these, and methods of using these.
摘要翻译：提供的结晶α，α-二取代氨基酸及其在其一个侧链上含有末端烯烃的结晶盐，以及α，α-二取代氨基酸及其盐的任选结晶卤代和氘代类似物; 制作这些的方法，以及使用这些的方法。

4. 发明授权

US09440991B2 Synthesis of an antiviral compound 有权
标题翻译：抗病毒化合物的合成
公开(公告)号：US09440991B2
公开(公告)日：2016-09-13
申请号：US14576143
申请日：2014-12-18
申请人： GILEAD SCIENCES, INC.
发明人： Amy Cagulada , Johann Chan , Lina Chan , Denise A. Colby , Kapil Kumar Karki , Darryl Kato , Katie Ann Keaton , Sudha Kondapally , Chris Levins , Adam Littke , Ruben Martinez , Dominika Pcion , Troy Reynolds , Bruce Ross , Michael Sangi , Adam J. Schrier , Pamela Seng , Dustin Siegel , Nathan Shapiro , Donald Tang , James G. Taylor , Jonathan Tripp , Andrew W. Waltman , Lawrence Yu
IPC分类号： C07D403/12 , C07D413/14 , C07D498/16 , C07C227/02 , C07D453/02 , C07C209/00 , C07C51/09 , C07K5/083
CPC分类号： C07D498/18 , C07C51/09 , C07C205/57 , C07C209/00 , C07C227/02 , C07C233/09 , C07C251/12 , C07C255/61 , C07C271/34 , C07C2601/02 , C07D241/44 , C07D403/12 , C07D453/02 , C07D498/16 , C07K5/0808
摘要： The present disclosure provides processes for the preparation of a compound of formula I: which is useful as an antiviral agent. The disclosure also provides compounds and processes for the preparation of the compounds that are synthetic intermediates to the compound of formula I.

5. 发明申请

US20160209746A1 ACTIVE LIGHT SENSITIVE OR RADIATION SENSITIVE RESIN COMPOSITION, ACTIVE LIGHT SENSITIVE OR RADIATION SENSITIVE FILM, MASK BLANK PROVIDED WITH ACTIVE LIGHT SENSITIVE OR RADIATION SENSITIVE FILM, PATTERN FORMING METHOD, METHOD FOR MANUFACTURING ELECTRONIC DEVICE, ELECTRONIC DEVICE AND NOVEL COMPOUND 审中-公开
标题翻译：活性光敏或辐射敏感性树脂组合物，主动感光或辐射敏感膜，主动光敏或辐射敏感膜，图案形成方法，制造电子器件的方法，电子器件和新化合物的掩蔽层
公开(公告)号：US20160209746A1
公开(公告)日：2016-07-21
申请号：US15080714
申请日：2016-03-25
申请人： FUJIFILM Corporation
发明人： Shuhei YAMAGUCHI , Tomotaka TSUCHIMURA , Natsumi YOKOKAWA , Koutarou TAKAHASHI
IPC分类号： G03F7/038 , G03F7/20 , C07D487/04 , C07C275/24 , C07C233/36 , G03F7/32 , C07D239/10
CPC分类号： G03F7/038 , C07C233/36 , C07C271/16 , C07C271/24 , C07C271/34 , C07C275/10 , C07C275/24 , C07C275/26 , C07C323/60 , C07C2601/14 , C07D211/26 , C07D233/32 , C07D233/36 , C07D235/26 , C07D239/10 , C07D251/30 , C07D403/12 , C07D487/04 , G03F1/08 , G03F7/0382 , G03F7/0387 , G03F7/20 , G03F7/32
摘要： There is provided an active light sensitive or radiation sensitive resin composition which contains (A) an alkali soluble resin and (C) a cross-linking agent represented by the following General Formula (1-0).
摘要翻译：提供了含有（A）碱溶性树脂和（C）由以下通式（1-0）表示的交联剂的活性光敏或辐射敏感性树脂组合物。

6. 发明授权

US09238604B2 Process and intermediates for preparing macrolactams 有权
标题翻译：制备马来酰胺的方法和中间体
公开(公告)号：US09238604B2
公开(公告)日：2016-01-19
申请号：US14239393
申请日：2012-08-16
申请人： Feng Xu , Guy Humphrey , Tao Pei , Zhiguo Jake Song , Tao Wang , Laura Artino
发明人： Feng Xu , Guy Humphrey , Tao Pei , Zhiguo Jake Song , Tao Wang , Laura Artino
IPC分类号： C07K5/08 , C07K5/10 , C07K5/12 , C07D401/12 , C07C35/04 , C07K5/083 , C07D403/12 , C07D498/16 , C07C67/14 , C07C69/013 , C07C69/12 , C07C269/04 , C07C271/34 , A61K38/00
CPC分类号： C07C35/04 , A61K38/00 , C07C67/14 , C07C69/013 , C07C69/12 , C07C269/04 , C07C271/34 , C07D403/12 , C07D498/16 , C07K5/0808 , C07K5/126
摘要： The present invention includes compounds useful as intermediates in the preparation of macrolactams, methods for preparing the intermediates, and methods for preparing macrolactams from the intermediates. One use of the methods and intermediates described herein is in the production of macrolactam compounds able to inhibit HCV NS3 protease activity. HCV NS3 inhibitory compounds have therapeutic and research applications.
摘要翻译：本发明包括可用作制备中性物质的中间体的化合物，制备中间体的方法，以及从中间体制备大环内酯的方法。本文描述的方法和中间体的一个用途是制备能够抑制HCV NS3蛋白酶活性的大环内酰胺化合物。 HCV NS3抑制化合物具有治疗和研究应用。

7. 发明授权

US09125408B2 Use of aryl carbamates in agriculture and other plant-related areas 有权
标题翻译：在农业和其他植物相关领域使用芳基氨基甲酸酯
公开(公告)号：US09125408B2
公开(公告)日：2015-09-08
申请号：US13778425
申请日：2013-02-27
申请人： North Carolina State University
发明人： Christian Melander , Steven A. Rogers
IPC分类号： A01N45/02 , A01N47/12 , A01N47/16 , A01N47/18
CPC分类号： A01N47/18 , A01N47/12 , A01N47/16 , A01N59/20 , A01N63/00 , C07C271/34 , C07C2601/14 , C07D209/14 , C07D213/40
摘要： Disclosure is provided for methods of preventing, removing or inhibiting microbial biofilm formation or microbial infection in a plant or plant part thereof, including applying thereto a treatment effective amount of an aryl carbamate as described herein, or an agriculturally acceptable salt thereof. Methods of enhancing a microbicide (e.g., including a copper, antibiotic, bacteriophage, etc.) and/or plant defense activator are also provided, including applying an active compound as described herein. Compositions comprising an aryl carbamate compound as described herein in an agriculturally acceptable carrier are also provided, and in some embodiments the compositions further include a microbicide (e.g., including copper, antibiotic, bacteriophage, etc.) and/or a plant defense activator.
摘要翻译：提供了用于预防，去除或抑制植物或植物部分中的微生物生物膜形成或微生物感染的方法的公开，包括向其施用有效量的本文所述的氨基甲酸芳基酯或其农业上可接受的盐。还提供了增强杀微生物剂（例如包括铜，抗生素，噬菌体等）和/或植物防御活化剂的方法，包括施用如本文所述的活性化合物。还提供了包含在农业上可接受的载体中的如本文所述的芳基氨基甲酸酯化合物的组合物，并且在一些实施方案中，组合物还包括杀微生物剂（例如包括铜，抗生素，噬菌体等）和/或植物防御活化剂。

8. 发明授权

US09073825B2 Methods and intermediates for preparing macrolactams 有权
标题翻译：制备大环内酯的方法和中间体
公开(公告)号：US09073825B2
公开(公告)日：2015-07-07
申请号：US14239391
申请日：2012-08-16
申请人： Nobuyoshi Yasuda , Jeffrey T. Kuethe , Guy Humphrey , Gregory L. Beutner , Yong-Li Zhong , Edward Cleator , Carl Baxter
发明人： Nobuyoshi Yasuda , Jeffrey T. Kuethe , Guy Humphrey , Gregory L. Beutner , Yong-Li Zhong , Edward Cleator , Carl Baxter
IPC分类号： A01N43/04 , A01N43/42 , C07C35/04 , C07K5/083 , C07D403/12 , C07D498/16 , C07K5/12 , C07C67/14 , C07C69/013 , C07C69/12 , C07C269/04 , C07C271/34 , A61K38/00
CPC分类号： C07C35/04 , A61K38/00 , C07C67/14 , C07C69/013 , C07C69/12 , C07C269/04 , C07C271/34 , C07D403/12 , C07D498/16 , C07K5/0808 , C07K5/126
摘要： A first aspect of the present invention describes a compound selected from group consisting of: wherein R is either H, C(O)RA, or C(O)NHCH(X)COOH; provided that X is a C2-C6 alkyl, or a C3-C8 cycloalkyl and RA is a C1-6 alkyl or aryl; These compounds are used to make Compound A
摘要翻译：本发明的第一方面描述了选自下组的化合物：其中R是H，C（O）RA或C（O）NHCH（X）COOH; 条件是X是C 2 -C 6烷基或C 3 -C 8环烷基，RA是C 1-6烷基或芳基; 这些化合物用于制备化合物A.

9. 发明申请

US20140303344A1 METHOD FOR THE STEREOSELECTIVE PREPARATION OF AMINO ACID DERIVATIVES 审中-公开
标题翻译：氨基酸衍生物的立体选择性制备方法
公开(公告)号：US20140303344A1
公开(公告)日：2014-10-09
申请号：US14205793
申请日：2014-03-12
申请人： BCN PÉPTIDES, S.A.
发明人： Llorenç RAFECAS JANE , Antoni RIERA ESCALE , Rosario RAMON ALBALATE , Monica ALONSO XALMA
IPC分类号： C07C271/22 , C07K5/087
CPC分类号： C07C271/22 , C07B53/00 , C07B2200/07 , C07C67/31 , C07C227/32 , C07C229/36 , C07C247/12 , C07C271/34 , C07C2603/18 , C07D203/02 , C07D203/06 , C07K1/04 , C07K5/0812 , C07C69/732
摘要： The invention relates to a process for the stereoselective preparation of amino acid derivatives, comprising a hydrogenation reaction of the compound of formula (III), alternatively its enantiomer, wherein R is (C1-C8)-alkyl; followed by a hydrolysis reaction to obtain L-mesityl alanine, alternatively its enantiomer D-mesityl alanine and, optionally, subjecting said compound to an amino group protection reaction, particularly as Fmoc. It also comprises Fmoc-L- or Fmoc-D- mesityl alanine as products per se, useful as intermediates in preparing peptides or peptide analogs with therapeutic or biological activity.
摘要翻译：本发明涉及一种用于立体选择性制备氨基酸衍生物的方法，包括式（III）化合物或其对映异构体的氢化反应，其中R是（C 1 -C 8） - 烷基; 然后进行水解反应以获得L-均三甲基丙氨酸，或者其对映体D-均三甲基丙氨酸，以及任选地使所述化合物进行氨基保护反应，特别是作为Fmoc。它还包含Fmoc-L-或Fmoc-D-三甲基丙氨酸作为产品本身，可用作制备具有治疗或生物活性的肽或肽类似物的中间体。

10. 发明申请

US20140206605A1 CRYSTAL FORMS OF A HCV PROTEASE INHIBITOR 有权
标题翻译： HCV蛋白酶抑制剂的晶体形态
公开(公告)号：US20140206605A1
公开(公告)日：2014-07-24
申请号：US14239389
申请日：2012-08-16
申请人： Gregory L. Beutner , Robert M. Wenslow, JR. , Eric J. Choi , Clinton Scott Shultz , Jeremy Scott , Juan D. Arredondo , Laura Artino
发明人： Gregory L. Beutner , Robert M. Wenslow, JR. , Eric J. Choi , Clinton Scott Shultz , Jeremy Scott , Juan D. Arredondo , Laura Artino
IPC分类号： C07K5/12
CPC分类号： C07C35/04 , A61K38/00 , C07C67/14 , C07C69/013 , C07C69/12 , C07C269/04 , C07C271/34 , C07D403/12 , C07D498/16 , C07K5/0808 , C07K5/126
摘要： The present invention relates to different forms of a HCV inhibitory compound.
摘要翻译：本发明涉及不同形式的HCV抑制化合物。

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