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1. 发明授权

US06709831B1 DNA encoding mammalian neuropeptide FF (NPFF) receptors and uses thereof 失效
标题翻译：编码哺乳动物神经肽FF（NPFF）受体的DNA及其用途
公开(公告)号：US06709831B1
公开(公告)日：2004-03-23
申请号：US09405558
申请日：1999-09-24
申请人： Christophe P. G. Gerald , Kenneth A. Jones , James A. Bonini , Beth E. Borowsky , Douglas A. Craig
发明人： Christophe P. G. Gerald , Kenneth A. Jones , James A. Bonini , Beth E. Borowsky , Douglas A. Craig
IPC分类号： G01N33566
CPC分类号： C07K14/70571 , A01K2217/075
摘要： This invention provides isolated nucleic acids encoding mammalian NPFF receptors, purified mammalian NPFF receptors, vectors comprising nucleic acid encoding mammalian NPFF receptors, cells comprising such vectors, antibodies directed to mammalian NPFF receptors, nucleic acid probes useful for detecting nucleic acid encoding mammalian NPFF receptors, antisense oligonucleotides complementary to unique sequences of nucleic acid encoding mammalian NPFF receptors, transgenic, nonhuman animals which express DNA encoding normal or mutant mammalian NPFF receptors, methods of isolating mammalian NPFF receptors, methods of treating an abnormality that is linked to the activity of the mammalian NPFF receptors, as well as methods of determining binding of compounds to mammalian NPFF receptors, methods of identifying agonists and antagonists of NPFF receptors, and agonists and antagonists so identified.
摘要翻译：本发明提供编码哺乳动物NPFF受体的分离的核酸，纯化的哺乳动物NPFF受体，包含编码哺乳动物NPFF受体的核酸的载体，包含该载体的细胞，针对哺乳动物NPFF受体的抗体，用于检测编码哺乳动物NPFF受体的核酸的核酸探针，与编码哺乳动物NPFF受体的核酸的独特序列互补的反义寡核苷酸，其表达编码正常或突变型哺乳动物NPFF受体的DNA的转基因非人动物，分离哺乳动物NPFF受体的方法，治疗与哺乳动物活性相关的异常的方法 NPFF受体，以及确定化合物与哺乳动物NPFF受体的结合的方法，识别NPFF受体的激动剂和拮抗剂的方法，以及如此鉴定的激动剂和拮抗剂。

2. 发明授权

US06387638B1 Heregulin variants 失效
标题翻译：特殊蛋白变体
公开(公告)号：US06387638B1
公开(公告)日：2002-05-14
申请号：US09101544
申请日：1998-07-17
申请人： Marcus D. Ballinger , Jennifer T. Jones , Wayne J. Fairbrother , Mark X. Sliwkowski , James A. Wells
发明人： Marcus D. Ballinger , Jennifer T. Jones , Wayne J. Fairbrother , Mark X. Sliwkowski , James A. Wells
IPC分类号： G01N33566
CPC分类号： G01N33/74 , A61K38/00 , C07K14/4756 , G01N2333/485
摘要： The present invention provides heregulin variants that are capable of binding an ErbB receptor. Included in the invention are variants of human heregulins, and, in particular, variants of human heregulin-&bgr;1 having enhanced affinity for the ErbB-3 and ErbB-4 receptors. These variants include at least one amino acid substitution and can include further modifications. The invention also provides nucleic acid molecules encoding heregulin variants and related vectors, host cells, pharmaceutical compositions, and methods.
摘要翻译：本发明提供能够结合ErbB受体的调节蛋白变体。本发明中包括本发明的变体，尤其是具有对ErbB-3和ErbB-4受体具有增强亲和性的人类调节蛋白-β1的变体。这些变体包括至少一个氨基酸取代并且可以包括进一步的修饰。本发明还提供了编码本领域变体和相关载体的核酸分子，宿主细胞，药物组合物和方法。

3. 发明授权

US06331440B1 Peptide binding the KLVFF-sequence of amyloid-&bgr; 失效
标题翻译：肽结合淀粉样蛋白-β的KLVFF序列
公开(公告)号：US06331440B1
公开(公告)日：2001-12-18
申请号：US09095106
申请日：1998-06-10
申请人： Christer Nordstedt , Jan Näslund , Johan Thyberg , Lars O. Tjernberg , Lars Terenius
发明人： Christer Nordstedt , Jan Näslund , Johan Thyberg , Lars O. Tjernberg , Lars Terenius
IPC分类号： G01N33566
CPC分类号： C07K5/0821 , A61K38/00 , C07K5/0808 , C07K5/0815 , C07K5/0819 , C07K5/101 , C07K5/1019 , C07K5/1021 , C07K5/1024 , C07K14/4711 , G01N33/6896 , G01N2800/2821
摘要： The invention relates to compounds of formula (I) or (II), which are of interest especially for inhibition of polymerization of amyloid &bgr; peptide, as model substances for synthesis of amyloid &bgr; peptide-ligands, as tools for the identification of other organic compounds with similar functional properties and/or as ligands for detection of amyloid deposits using e.g., positron emission tomography (PET). Formula (II) is: R1—A′—Y′—Leu—X′—Z′—B′—R2 in which X′ means any group or amino acid imparting to the compound according to formula (I) the ability to bind to the KLVFF-sequence in amyloid &bgr; peptide, or two amino acids imparting the same ability, but with the proviso that one is not proline; Y′ means any amino acid; Z′ means any non-acidic amino acid; A′ means a direct bond or an &agr;-amino acid bonded at the carboxyl terminal of the &agr;-carboxy group or a di-, tri-, tetra- or pentapeptide bonded at the carboxyl terminal of the &agr;-carboxy group; B′ means a direct bond or an &agr;-amino acid bonded at the &agr;-nitrogen or a di-, tri-, tetra- or pentapeptide bonded at the &agr;-nitrogen of the N-terminal &agr;-amino acid; R1 is H or —CO—R3 bonded at the &agr;-amino group of A′; R2 is H, —OR4 or NR5R6, all bonded to the &agr;-carboxyl group of the &agr;-carboxyterminal of B′; R3 and R4 are straight or branched carbon chain of 1-4 carbon atoms; R5 and R6 are independently H, alkyl, cycloalkyl, aryl or substituted aryl or together are —(CH2)n— where n is 4-5; and R1 and R2 together can form a hydrocarbon ring of heterocyclic ring; all &agr;-amino acids being either D- or L-isomers.
摘要翻译：本发明涉及式（I）或（II）的化合物，其特别用于抑制淀粉样蛋白β肽的聚合作为淀粉样蛋白β肽配体的合成的模型物质，作为鉴定其它有机化合物的工具具有类似的功能性质和/或用于使用例如正电子发射断层摄影（PET）检测淀粉样蛋白沉积物的配体。式（II）是：R1-A'-Y'-Leu-X'-Z'-B'-R2，其中X'表示赋予根据式（I）的化合物的任何基团或氨基酸，到淀粉样蛋白β肽中的KLVFF序列或赋予相同能力的两个氨基酸，但条件是一个不是脯氨酸; Y'表示任何氨基酸; Z'表示任何非酸性氨基酸; A'是指在α-羧基的羧基末端键合的直接键或α-氨基酸，或在α-羧基的羧基末端键合的二，三，四或五肽; B'是指在α-氮键合键或在N-末端α-氨基酸的α-氮键合的二 - ，三 - ，四 - 或五肽的直接键或α-氨基酸; R1是在A'的α-氨基键合的H或-CO-R3; R2是H，-OR4或NR5R6，均与B'的α-羧基末端的α-羧基键合; R3和R4是1-4个碳原子的直链或支链碳链; R 5和R 6独立地为H，烷基，环烷基，芳基或取代的芳基，或一起为 - （CH 2）n - ，其中n为4-5; R1和R2一起可以形成杂环的烃环; 所有α-氨基酸都是D-或L-异构体。

4. 发明授权

US06306663B1 Controlling protein levels in eucaryotic organisms 失效
标题翻译：控制真核生物中的蛋白质水平
公开(公告)号：US06306663B1
公开(公告)日：2001-10-23
申请号：US09406781
申请日：1999-09-28
申请人： John H. Kenten , Steven F. Roberts
发明人： John H. Kenten , Steven F. Roberts
IPC分类号： G01N33566
CPC分类号： C07K14/005 , A61K38/00 , C07K14/00 , C12N2740/16222 , Y02A50/463
摘要： The invention relates to novel compounds comprising a ubiquitination recognition element and a protein binding element. The invention also relates to the use of said compounds for modulating the level and/or activity of a target protein. The compounds are useful for the treatment of disease such as infections, inflammatory conditions, cancer and genetic diseases. The compounds are also useful as insecticides and herbicides.
摘要翻译：本发明涉及包含泛素识别元件和蛋白质结合元件的新型化合物。本发明还涉及所述化合物用于调节靶蛋白的水平和/或活性的用途。该化合物可用于治疗感染，炎性病症，癌症和遗传疾病等疾病。这些化合物也可用作杀虫剂和除草剂。

5. 发明授权

US06284475B1 Assays for diagnosis of thrombophilic disease 失效
公开(公告)号：US06284475B1
公开(公告)日：2001-09-04
申请号：US09113715
申请日：1998-07-10
申请人： Jacob H. Rand
发明人： Jacob H. Rand
IPC分类号： G01N33566
CPC分类号： G01N33/92 , G01N33/86 , G01N2333/4718 , G01N2405/04 , Y10S435/81 , Y10S435/968 , Y10S436/801 , Y10S436/804 , Y10S436/806 , Y10S436/811 , Y10S436/812 , Y10T436/105831 , Y10T436/107497
摘要： The present invention provides methods for diagnosing and/or monitoring thrombophilic disease in a patient that can result from the antiphospholipid antibody syndrome (aPL syndrome). The methods of the invention are premised on the inhibition of binding of an anticoagulant protein, annexin, preferably annexin-V, to phospholipids by antiphospholipid (aPL) antibodies in a patient blood sample.

6. 发明授权

US06261786B1 Screening assays for hedgehog agonists and antagonists 失效
标题翻译：刺猬激动剂和拮抗剂的筛选试验
公开(公告)号：US06261786B1
公开(公告)日：2001-07-17
申请号：US08674509
申请日：1996-07-02
申请人： Valeria Marigo , Clifford J. Tabin , Philip W. Ingham , Andrew P. McMahon
发明人： Valeria Marigo , Clifford J. Tabin , Philip W. Ingham , Andrew P. McMahon
IPC分类号： G01N33566
CPC分类号： A01K67/0339 , A01K67/0271 , A01K67/0275 , A01K2217/05 , A01K2227/105 , A01K2267/03 , A61K38/00 , C07K14/46 , C07K14/475 , C07K2319/00 , C12N15/8509
摘要： The present invention concerns the discovery that proteins encoded by a family of vertebrate genes, termed here hedgehog-related genes, comprise morphogenic signals produced by embryonic patterning centers, and are involved in the formation of ordered spatial arrangements of differentiated tissues in vertebrates. The present invention makes available compositions and methods that can be utilized, for example to generate and/or maintain an array of different vertebrate tissue both in vitro and in vivo.
摘要翻译：本发明涉及这样的发现：由脊椎动物家族（称为这些刺猬蛋白相关基因）编码的蛋白质包含由胚胎图案化中心产生的形态发生信号，并且涉及脊椎动物中分化组织的有序空间排列的形成。本发明提供可用于例如在体外和体内产生和/或维持不同脊椎动物组织阵列的组合物和方法。

7. 发明授权

US06242199B1 Assays for growth hormone secretagogue receptors 失效
标题翻译：生长激素促分泌受体的测定
公开(公告)号：US06242199B1
公开(公告)日：2001-06-05
申请号：US09077675
申请日：1998-06-03
申请人： Lee-Yuh Pai , Scott D. Feighner , Andrew D. Howard , Sheng-Shung Pong , Leonardus H. T. Van Der Ploeg
发明人： Lee-Yuh Pai , Scott D. Feighner , Andrew D. Howard , Sheng-Shung Pong , Leonardus H. T. Van Der Ploeg
IPC分类号： G01N33566
CPC分类号： G01N33/74 , C07K14/723 , C12Q1/6897 , G01N2333/726 , G01N2500/10
摘要： An assay for the detection of growth hormone secretagogue receptors and growth hormone secretagogue related receptors is described. As these receptors are a member of the G protein coupled receptors, a subunit of the G protein must be present in order for expression to be detected. A similar assay is described where the presence of growth hormone secretagogues are detected.
摘要翻译：描述了用于检测生长激素促分泌素受体和生长激素促分泌素相关受体的测定法。由于这些受体是G蛋白偶联受体的成员，所以必须存在G蛋白的亚基以便表达被检测。描述了检测到生长激素促分泌素的存在的类似的测定。

8. 发明授权

US06221675B1 TNF receptors, TNF binding proteins and DNAs coding for them 失效
标题翻译： TNF受体，TNF结合蛋白和编码它们的DNA
公开(公告)号：US06221675B1
公开(公告)日：2001-04-24
申请号：US08477639
申请日：1995-06-07
申请人： Rudolf Hauptmann , Adolf Himmler , Ingrid Maurer-Fogy , Christian Stratowa
发明人： Rudolf Hauptmann , Adolf Himmler , Ingrid Maurer-Fogy , Christian Stratowa
IPC分类号： G01N33566
CPC分类号： G01N33/6863 , A61K38/00 , C07K14/7151 , C12Q1/6886 , C12Q2600/136 , G01N33/57484
摘要： DNA sequences coding for a TNF-binding protein and for the TNF receptor of which this protein constitutes the soluble domain. The DNA sequences can be used for preparing recombinant DNA molecules in order to produce TNF-binding protein and TNF receptor. With the aid of the TNF receptor or fragments thereof or with the aid of suitable host organisms transformed with recombinant DNA molecules containing the DNA which codes for the TNF receptor or fragments or modifications thereof, it is possible to investigate substances for their interaction with the TNF is receptor and/or for their effect on the biological activity of TNF.
摘要翻译：编码TNF结合蛋白的DNA序列和该蛋白质构成可溶性结构域的TNF受体。 DNA序列可用于制备重组DNA分子，以产生TNF结合蛋白和TNF受体。借助于TNF受体或其片段或借助含有编码TNF受体的DNA的重组DNA分子或其片段或修饰物转化的合适的宿主生物，可以研究它们与TNF相互作用的物质是受体和/或其对TNF的生物活性的影响。

9. 发明授权

US06210974B1 Compositions and methods for promoting nerve regeneration 失效
标题翻译：促进神经再生的组合物和方法
公开(公告)号：US06210974B1
公开(公告)日：2001-04-03
申请号：US09288061
申请日：1999-04-07
申请人： Bruce G. Gold
发明人： Bruce G. Gold
IPC分类号： G01N33566
CPC分类号： A61K31/4745 , A61K31/395 , A61K38/1883 , A61K45/06 , G01N33/5058 , G01N33/743 , G01N2500/02 , Y10T436/14 , A61K2300/00
摘要： FK506 and geldanamycin promote nerve regeneration by a common mechanism that involves the binding of these compounds to polypeptide components of steroid receptor complexes other than the steroid hormone binding portion of the complex (FKBP52 and hsp90, respectively). These and other agents cause hsp90 dissociation from steroid receptor complexes or block association of hsp90 with steroid receptor complexes.
摘要翻译： FK506和格尔德霉素通过一种共同的机制促进神经再生，这种机制涉及这些化合物与复合物类固醇激素结合部分以外的类固醇受体复合物的多肽组分的结合（分别为FKBP52和hsp90）。这些和其他药物导致hsp90从类固醇受体复合物解离或阻断hsp90与类固醇受体复合物的结合。

10. 发明授权

US06197525B1 Assay kits for detection and methods of inhibiting IL-17 binding 失效
标题翻译：用于检测的测定试剂盒和抑制IL-17结合的方法
公开(公告)号：US06197525B1
公开(公告)日：2001-03-06
申请号：US09022257
申请日：1998-02-11
申请人： Zhengbin Yao , Melanie K. Spriggs , William C. Fanslow
发明人： Zhengbin Yao , Melanie K. Spriggs , William C. Fanslow
IPC分类号： G01N33566
CPC分类号： C07K14/54 , A61K38/00 , A61K48/00 , C07K14/7155 , C07K2319/00 , Y10S514/885 , Y10S514/886
摘要： Isolated receptors for IL-17, DNA's encoding such receptors, pharmaceutical compositions made therefrom, detection assays and methods of inhibiting binding of the receports are disclosed. The isolated receptors can be used to regulate an immune response.
摘要翻译：公开了用于IL-17的分离的受体，编码这种受体的DNA，由其制备的药物组合物，检测测定法和抑制受体结合的方法。分离的受体可用于调节免疫应答。

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