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1. 发明授权

US07022489B2 Method of using cells expressing galanin receptor 3 (GALR3) 失效
标题翻译：使用表达甘丙肽受体3（GALR3）的细胞的方法
公开(公告)号：US07022489B2
公开(公告)日：2006-04-04
申请号：US10007132
申请日：2001-12-03
申请人： Jonathan A. Bard , Beth Borowsky , Kelli E. Smith , Theresa A. Branchek , Christophe P. G. Gerald , Kenneth A. Jones
发明人： Jonathan A. Bard , Beth Borowsky , Kelli E. Smith , Theresa A. Branchek , Christophe P. G. Gerald , Kenneth A. Jones
IPC分类号： G01N33/53
CPC分类号： C07K16/2869 , A01K2217/05 , A61K38/00 , C07K14/72 , G01N33/5088 , G01N33/74 , G01N2333/72 , G01N2500/10
摘要： This invention provides an isolated nucleic acid encoding a mammalian galanin receptor, an isolated galanin receptor protein, vectors comprising isolated nucleic acid encoding a mammalian galanin receptor, cells comprising such vectors, antibodies directed to a mammalian galanin receptor, nucleic acid probes useful for detecting nucleic acid encoding a mammalian galanin receptor, antisense oligonucleotides complementary to unique sequences of nucleic acid encoding a mammalian galanin receptor, nonhuman transgenic animals which express DNA encoding a normal or a mutant mammalian galanin receptor, as well as methods of determining binding of compounds to mammalian galanin receptors.
摘要翻译：本发明提供编码哺乳动物甘丙肽受体的分离的核酸，分离的甘丙肽受体蛋白，包含编码哺乳动物甘丙肽受体的分离的核酸的载体，包含该载体的细胞，针对哺乳动物甘丙肽受体的抗体，用于检测核酸的核酸探针编码哺乳动物甘丙肽受体的酸，与编码哺乳动物甘丙肽受体的核酸的唯一序列互补的反义寡核苷酸，表达编码正常或突变型哺乳动物甘丙肽受体的DNA的非人转基因动物，以及确定化合物与哺乳动物甘丙肽的结合的方法受体。

2. 发明授权

US06818445B2 Methods of modifying feeding behavior, compounds useful in such methods, and DNA encoding a hypothalamic atypical neuropeptide Y/peptide YY receptor (Y5) 失效
标题翻译：修饰进食行为的方法，可用于这些方法的化合物和编码下丘脑非典型神经肽Y /肽YY受体（Y5）的DNA
公开(公告)号：US06818445B2
公开(公告)日：2004-11-16
申请号：US09962646
申请日：2001-09-24
申请人： Christophe P. G. Gerald , Richard L. Weinshank , Mary W. Walker , Theresa Branchek
发明人： Christophe P. G. Gerald , Richard L. Weinshank , Mary W. Walker , Theresa Branchek
IPC分类号： C07H2100
CPC分类号： G01N33/9406 , A01K2217/05 , A61K31/137 , A61K38/00 , C07K14/70571 , C12Q1/6883 , G01N2500/02
摘要： This invention provides isolated nucleic acid molecules encoding a neuropeptide Y (NPY) Y5 receptor which hybridizes under high stringency conditions to a nucleic acid molecule of SEQ ID NO:3, vectors comprising such isolated nucleic acid molecules, and cells comprising such vectors.
摘要翻译：本发明提供编码神经肽Y（NPY）Y5受体的分离的核酸分子，其在高严格条件下与SEQ ID NO：3的核酸分子，包含这种分离的核酸分子的载体和包含该载体的细胞杂交。

3. 发明授权

US06645774B1 Methods of modifying feeding behavior using compounds with afinity for the human hypothalamic atypical neuropeptide Y/peptide YY receptor (Y5) 失效
标题翻译：用于人类下丘脑非典型神经肽Y /肽YY受体（Y5）的化合物改变进食行为的方法
公开(公告)号：US06645774B1
公开(公告)日：2003-11-11
申请号：US09447907
申请日：1999-11-23
申请人： Christophe P. G. Gerald , Richard L. Weinshank , Mary W. Walker , Theresa Branchek
发明人： Christophe P. G. Gerald , Richard L. Weinshank , Mary W. Walker , Theresa Branchek
IPC分类号： G01N33566
CPC分类号： A61K31/137 , A01K2217/05 , A61K38/00 , C07K14/70571 , C12Q1/6883
摘要： This invention provides methods of modifying feeding behavior, including increasing or decreasing food consumption, e.g., in connection with treating obesity, bulimia or anorexia. These methods involve administration of compounds that are selective agonists or antagonists for the Y5 receptor. One such compound has the structure: In addition, this invention provides an isolated nucleic acid molecule encoding a Y5 receptor, an isolated Y5 receptor protein, vectors comprising an isolated nucleic acid molecule encoding a Y5 receptor, cells comprising such vectors, antibodies directed to the Y5 receptor, nucleic acid probes useful for detecting nucleic acid encoding Y5 receptors, antisense oligonucleotides complementary to any unique sequences of a nucleic acid molecule which encodes a Y5 receptor, and nonhuman transgenic animals which express DNA encoding a normal or a mutant Y5 receptor.
摘要翻译：本发明提供了改变进食行为的方法，包括增加或减少食物消耗，例如与治疗肥胖，贪食症或厌食症有关的方法。这些方法包括施用作为Y5受体的选择性激动剂或拮抗剂的化合物。一种这样的化合物具有以下结构：另外，本发明提供编码Y5受体的分离的核酸分子，分离的Y5受体蛋白，包含编码Y5受体的分离的核酸分子的载体，包含这种载体的细胞，针对 Y5受体，用于检测编码Y5受体的核酸的核酸探针，与编码Y5受体的核酸分子的任何独特序列互补的反义寡核苷酸，以及表达编码正常或突变型Y5受体的DNA的非人类转基因动物。

4. 发明授权

US5602024A DNA encoding a hypothalamic atypical neuropeptide Y/peptide YY receptor (Y5) and uses thereof 失效
标题翻译：编码下丘脑非典型神经肽Y /肽YY受体（Y5）的DNA及其用途
公开(公告)号：US5602024A
公开(公告)日：1997-02-11
申请号：US349025
申请日：1994-12-02
申请人： Christophe P. G. Gerald , Mary W. Walker , Theresa Branchek , Richard L. Weinshank
发明人： Christophe P. G. Gerald , Mary W. Walker , Theresa Branchek , Richard L. Weinshank
IPC分类号： A01K67/027 , A61K31/00 , A61K31/135 , A61K31/137 , A61K31/70 , A61K35/76 , A61K38/00 , A61K38/17 , A61K39/395 , A61K45/00 , A61K48/00 , A61P1/04 , A61P1/12 , A61P1/14 , A61P3/00 , A61P3/04 , A61P3/10 , A61P5/24 , A61P5/50 , A61P9/00 , A61P9/12 , A61P13/02 , A61P15/00 , A61P15/10 , A61P25/00 , A61P25/04 , A61P25/08 , A61P25/20 , A61P25/22 , A61P25/24 , A61P25/26 , A61P29/00 , A61P43/00 , C07H21/00 , C07K14/705 , C12N5/00 , C12N5/10 , C12N15/09 , C12N15/12 , C12N15/63 , C12P21/00 , C12P21/02 , C12P21/08 , C12Q1/02 , C12Q1/68 , C12R1/91 , G01N33/15 , G01N33/53 , G01N33/566
CPC分类号： G01N33/9406 , A61K31/137 , C07K14/70571 , C12Q1/6883 , A01K2217/05 , A61K38/00 , G01N2500/02
摘要： This invention provides an isolated nucleic acid molecule encoding a human Y5 receptor, an isolated protein which is a human Y5 receptor, vectors comprising an isolated nucleic acid molecule encoding a human Y5 receptor, mammalian cells comprising such vectors, antibodies directed to the human Y5 receptor, nucleic acid probes useful for detecting nucleic acid encoding human Y5 receptors, antisense oligonucleotides complementary to any sequences of a nucleic acid molecule which encodes a human Y5 receptor, pharmaceutical compounds related to human Y5 receptors, and nonhuman transgenic animals which express DNA a normal or a mutant human Y5 receptor. This invention further provides methods for determining ligand binding, detecting expression, drug screening, and treatment involving the human Y5 receptor.
摘要翻译：本发明提供了编码人Y5受体的分离的核酸分子，分离的人Y5受体的蛋白质，包含编码人Y5受体的分离的核酸分子的载体，包含该载体的哺乳动物细胞，针对人Y5受体的抗体可用于检测编码人Y5受体的核酸的核酸探针，与编码人Y5受体的核酸分子的任何序列互补的反义寡核苷酸，与人Y5受体相关的药物化合物，以及表达DNA正常的非人类转基因动物突变体人Y5受体。本发明还提供了用于测定配体结合，检测表达，药物筛选和涉及人Y5受体的治疗的方法。

5. 发明授权

US07132248B2 Uses of galanin GALR2 receptors 失效
公开(公告)号：US07132248B2
公开(公告)日：2006-11-07
申请号：US10285019
申请日：2002-10-31
申请人： Kelli E. Smith , David Linemeyer , Christophe P. G. Gerald , Theresa Branchek , Richard L. Weinshank , Carlos Forray
发明人： Kelli E. Smith , David Linemeyer , Christophe P. G. Gerald , Theresa Branchek , Richard L. Weinshank , Carlos Forray
IPC分类号： G01N33/53
CPC分类号： C12P21/02 , A01K2217/05 , A61K38/00 , A61K39/00 , A61K48/00 , C07K14/72
摘要： This invention provides isolated nucleic acids encoding mammalian galanin receptors, isolated galanin receptor proteins, vectors comprising isolated nucleic acid encoding a mammalian galanin receptor, cells comprising such vectors, antibodies directed to a mammalian galanin receptor, nucleic acid probes useful for detecting nucleic acid encoding a mammalian galanin receptor, antisense oligonucleotides complementary to unique sequences of nucleic acid encoding a mammalian galanin receptor, nonhuman transgenic animals which express DNA encoding a normal or a mutant mammalian galanin receptor, as well as methods of determining binding of compounds to mammalian galanin receptors.

6. 发明授权

US06713265B1 Methods of modifying feeding behavior, compounds useful in such methods, and DNA encoding a hypothalamic atypical neuropeptide Y/peptide YY receptor (Y5) 有权
标题翻译：修饰进食行为的方法，可用于这些方法的化合物和编码下丘脑非典型神经肽Y /肽YY受体（Y5）的DNA
公开(公告)号：US06713265B1
公开(公告)日：2004-03-30
申请号：US09194895
申请日：1999-09-27
申请人： Christophe P. G. Gerald , Richard L. Weinshank , Mary W. Walker , Theresa Branchek
发明人： Christophe P. G. Gerald , Richard L. Weinshank , Mary W. Walker , Theresa Branchek
IPC分类号： G01N33566
CPC分类号： G01N33/9406 , C07K14/70571 , G01N33/566 , G01N2500/10
摘要： The invention provides methods of modifying feeding behavior, including increasing or decreasing food consumption, e.g., in connection with treating obesity, bulimia or anorexia. These methods involve administration of compounds that are selective agonists or antagonists for the Y5 receptor. One such compound has structure (I). In addition, this invention provides an isolated nucleic acid molecule encoding a Y5 receptor, an isolated Y5 receptor protein, vectors comprising an isolated nucleic acid molecule encoding a Y5 receptor, cells comprising such vectors, antibodies directed to the Y5 receptor, nucleic acid probes useful for detecting nucleic acid encoding Y5 receptors, antisense oligonucleotides complementary to any unique sequences of a nucleic acid molecule which encodes a Y5 receptor, and nonhuman transgenic animals which express DNA encoding a normal or a mutant Y5 receptor.
摘要翻译：本发明提供了改变进食行为的方法，包括增加或减少食物消耗，例如与治疗肥胖，贪食症或厌食症有关的方法。这些方法包括施用作为Y5受体的选择性激动剂或拮抗剂的化合物。一种这样的化合物具有结构（I）。此外，本发明提供编码Y5受体，分离的Y5受体蛋白质的分离的核酸分子，包含编码Y5受体的分离的核酸分子的载体，包含该载体的细胞，针对Y5受体的抗体，有用的核酸探针用于检测编码Y5受体的核酸，与编码Y5受体的核酸分子的任何独特序列互补的反义寡核苷酸，以及表达编码正常或突变Y5受体的DNA的非人转基因动物。

7. 发明授权

US06316203B1 Methods of screening and preparing a composition using DNA encoding a hypothalamic atypical neuropeptide Y/peptide YY receptor (Y5) 有权
标题翻译：使用编码下丘脑非典型神经肽Y /肽YY受体（Y5）的DNA筛选和制备组合物的方法
公开(公告)号：US06316203B1
公开(公告)日：2001-11-13
申请号：US09200673
申请日：1998-11-25
申请人： Christophe P. G. Gerald , Richard L. Weinshank , Mary W. Walker , Theresa Branchek
发明人： Christophe P. G. Gerald , Richard L. Weinshank , Mary W. Walker , Theresa Branchek
IPC分类号： G01N33566
CPC分类号： G01N33/9406 , A01K2217/05 , A61K31/137 , A61K38/00 , C07K14/70571 , C12Q1/6883 , G01N2500/02
摘要： This invention provides methods of modifying feeding behavior, including increasing or decreasing food consumption, e.g., in connection with treating obesity, bulimia or anorexia. These methods involve administration of compounds are selective agonists or antagonists or the Y5 receptor. One such compound has the structure: In addition, this invention provides an isolated nucleic acid molecule encoding a Y5 receptor, an isolated Y5 receptor protein, vectors comprising an isolated nucleic acid molecule encoding a Y5 receptor, cells comprising such acid probes useful for detecting nucleic acid encoding Y5 receptors, antisense oligonucleotides complementary to any unique sequences of a nucleic acid molecule which encodes a Y5 receptor, and nonhuman transgenic animals which express DNA a normal or a mutant Y5 receptor.
摘要翻译：本发明提供了改变进食行为的方法，包括增加或减少食物消耗，例如与治疗肥胖，贪食症或厌食症有关的方法。这些方法包括施用化合物是选择性激动剂或拮抗剂或Y5受体。一种这样的化合物具有以下结构：此外，本发明提供编码Y5受体的分离的核酸分子，分离的Y5受体蛋白，包含编码Y5受体的分离的核酸分子的载体，包含用于检测核酸的所述酸性探针的细胞酸编码Y5受体，与编码Y5受体的核酸分子的任何独特序列互补的反义寡核苷酸，以及表达正常或突变Y5受体的非人类转基因动物。

8. 发明授权

US07252945B2 DNA encoding mammalian neuropeptide FF (NPFF) receptors and uses thereof 失效
公开(公告)号：US07252945B2
公开(公告)日：2007-08-07
申请号：US10992407
申请日：2004-11-18
申请人： Christophe P. G. Gerald , Kenneth A. Jones , James A. Bonini , Beth E. Borowsky , Douglas A. Craig
发明人： Christophe P. G. Gerald , Kenneth A. Jones , James A. Bonini , Beth E. Borowsky , Douglas A. Craig
IPC分类号： C12Q1/68 , G01N33/53 , C12N15/00
CPC分类号： C07K14/70571 , A01K2217/075
摘要： This invention provides isolated nucleic acids encoding mammalian NPFF receptors, purified mammalian NPFF receptors, vectors comprising nucleic acid encoding mammalian NPFF receptors, cells comprising such vectors, antibodies directed to mammalian NPFF receptors, nucleic acid probes useful for detecting nucleic acid encoding mammalian NPFF receptors, antisense oligonucleotides complementary to unique sequences of nucleic acid encoding mammalian NPFF receptors, transgenic, nonhuman animals which express DNA encoding normal or mutant mammalian NPFF receptors, methods of isolating mammalian NPFF receptors, methods of treating an abnormality that is linked to the activity of the mammalian NPFF receptors, as well as methods of determining binding of compounds to mammalian NPFF receptors, methods of identifying agonists and antagonists of NPFF receptors, and agonists and antagonists so identified.

9. 发明授权

US07060449B2 Method of preparing GALR2 receptors composition 失效
标题翻译：制备GALR2受体组成的方法
公开(公告)号：US07060449B2
公开(公告)日：2006-06-13
申请号：US10298992
申请日：2002-11-18
申请人： Kelli E. Smith , Christophe P. G. Gerald , Richard L. Weinshank , David Linemeyer , Theresa Branchek , Carlos Forray
发明人： Kelli E. Smith , Christophe P. G. Gerald , Richard L. Weinshank , David Linemeyer , Theresa Branchek , Carlos Forray
IPC分类号： G01N33/53
CPC分类号： C12P21/02 , A01K2217/05 , A61K38/00 , A61K39/00 , A61K48/00 , C07K14/72
摘要： This invention provides isolated nucleic acids encoding mammalian galanin receptors, isolated galanin receptor proteins, vectors comprising isolated nucleic acid encoding a mammalian galanin receptor, cells comprising such vectors, antibodies directed to a mammalian galanin receptor, nucleic acid probes useful for detecting nucleic acid encoding a mammalian galanin receptor, antisense oligonucleotides complementary to unique sequences of nucleic acid encoding a mammalian galanin receptor, nonhuman transgenic animals which express DNA encoding a normal or a mutant mammalian galanin receptor, as well as methods of determining binding of compounds to mammalian galanin receptors.
摘要翻译：本发明提供了编码哺乳动物甘丙肽受体的分离的核酸，分离的甘丙肽受体蛋白，包含编码哺乳动物甘丙肽受体的分离的核酸的载体，包含这种载体的细胞，针对哺乳动物甘丙肽受体的抗体，用于检测编码哺乳动物甘丙肽受体，与编码哺乳动物甘丙肽受体的核酸的唯一序列互补的反义寡核苷酸，表达编码正常或突变型哺乳动物甘丙肽受体的DNA的非人转基因动物，以及确定化合物与哺乳动物甘丙肽受体结合的方法。

10. 发明授权

US07041461B2 Methods of identifying agonists and antagonists of mammalian NPFF receptor 失效
标题翻译：识别哺乳动物NPFF受体的激动剂和拮抗剂的方法
公开(公告)号：US07041461B2
公开(公告)日：2006-05-09
申请号：US09866248
申请日：2001-05-25
申请人： Christophe P. G. Gerald , Kenneth A. Jones , James A. Bonini , Beth Borowsky
发明人： Christophe P. G. Gerald , Kenneth A. Jones , James A. Bonini , Beth Borowsky
IPC分类号： G01N33/566 , C12N15/00 , C12N15/12 , C12N15/63 , C07K14/00
CPC分类号： C07K14/70571 , A01K2217/075
摘要： This invention provides isolated nucleic acids encoding mammalian NPFF receptors, purified mammalian NPFF receptors, vectors comprising nucleic acid encoding mammalian NPFF receptors, cells comprising such vectors, antibodies directed to mammalian NPFF receptors, nucleic acid probes useful for detecting nucleic acid encoding mammalian NPFF receptors, antisense oligonucleotides complementary to unique sequences of nucleic acid encoding mammalian NPFF receptors, transgenic, nonhuman animals which express DNA encoding normal or mutant mammalian NPFF receptors, methods of isolating mammalian NPFF receptors, methods of treating an abnormality that is linked to the activity of the mammalian NPFF receptors, as well as methods of determining binding of compounds to mammalian NPFF receptors, methods of identifying agonists and antagonists of NPFF receptors, and agonists and antagonists so identified.
摘要翻译：本发明提供编码哺乳动物NPFF受体的分离的核酸，纯化的哺乳动物NPFF受体，包含编码哺乳动物NPFF受体的核酸的载体，包含该载体的细胞，针对哺乳动物NPFF受体的抗体，用于检测编码哺乳动物NPFF受体的核酸的核酸探针，与编码哺乳动物NPFF受体的核酸的独特序列互补的反义寡核苷酸，其表达编码正常或突变型哺乳动物NPFF受体的DNA的转基因非人动物，分离哺乳动物NPFF受体的方法，治疗与哺乳动物活性相关的异常的方法 NPFF受体，以及确定化合物与哺乳动物NPFF受体的结合的方法，识别NPFF受体的激动剂和拮抗剂的方法，以及如此鉴定的激动剂和拮抗剂。

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