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1. 发明授权

US08193188B2 Methods of using pyridodihydropyrazinones 有权
标题翻译：吡啶二氢吡嗪酮的使用方法
公开(公告)号：US08193188B2
公开(公告)日：2012-06-05
申请号：US12578737
申请日：2009-10-14
申请人： Matthias Hoffmann , Matthias Grauert , Trixi Brandl , Martin Steegmaier , Rudolf Hauptmann
发明人： Matthias Hoffmann , Matthias Grauert , Trixi Brandl , Martin Steegmaier , Rudolf Hauptmann
IPC分类号： A01N43/58 , A01N43/60 , A61K31/50 , A61K31/495
CPC分类号： C07D471/04
摘要： Disclosed are pyridodihydropyrazinone compounds, processes for preparing them and their use as pharmaceutical compositions. The compounds according to the invention correspond to general formula (I), while the groups L, R1, R2, R3, R4 and R5 may have the meanings given in the claims and specification.
摘要翻译：公开了吡啶二氢吡嗪酮化合物，其制备方法及其作为药物组合物的用途。根据本发明的化合物对应于通式（I），而基团L，R 1，R 2，R 3，R 4和R 5可以具有权利要求和说明书中给出的含义。

2. 发明授权

US07521457B2 Pyrimidines as PLK inhibitors 有权
标题翻译：嘧啶类作为PLK抑制剂
公开(公告)号：US07521457B2
公开(公告)日：2009-04-21
申请号：US11206703
申请日：2005-08-17
申请人： Heinz Stadtmueller , Harald Engelhardt , Martin Steegmaier , Anke Baum , Ulrich Guertler , Andreas Schoop , Jens Juergen Quant , Flavio Solca , Rudolf Hauptmann , Ulrich Reiser , Stephan Karl Zahn , Lars Herfurth
发明人： Heinz Stadtmueller , Harald Engelhardt , Martin Steegmaier , Anke Baum , Ulrich Guertler , Andreas Schoop , Jens Juergen Quant , Flavio Solca , Rudolf Hauptmann , Ulrich Reiser , Stephan Karl Zahn , Lars Herfurth
IPC分类号： C07D239/42 , C07D239/46 , A61K31/505 , A61K31/506 , A61P35/00
CPC分类号： C07D239/42 , C07D239/48 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/12 , C07D405/14 , C07D413/12 , C07D413/14 , C07D453/02 , C07D471/04 , C07D487/04 , C07D487/08 , C07D491/08 , C07D491/10
摘要： The present invention encompasses compounds of general formula (1), wherein A, W, X, Y, Z, Ra, Rb, Rc, R1 and R3 are defined as in claim 1, which are suitable for the treatment of diseases characterised by excessive or abnormal cell proliferation, and the use thereof for preparing a pharmaceutical composition having the above-mentioned properties.
摘要翻译：本发明包括通式（1）的化合物，其中A，W，X，Y，Z，Ra，Rb，Rc，R 1和R 3如权利要求1中所定义，其适用于治疗以过量或异常细胞增殖，以及其用于制备具有上述性质的药物组合物的用途。

3. 发明授权

US07241769B2 Pyrimidines as PLK inhibitors 有权
标题翻译：嘧啶类作为PLK抑制剂
公开(公告)号：US07241769B2
公开(公告)日：2007-07-10
申请号：US11132091
申请日：2005-05-18
申请人： Heinz Stadtmueller , Harald Engelhardt , Ulrich Reiser , Stephan Karl Zahn , Rudolf Hauptmann , Martin Steegmaier , Ulrich Guertler , Matthias Hoffmann , Matthias Grauert
发明人： Heinz Stadtmueller , Harald Engelhardt , Ulrich Reiser , Stephan Karl Zahn , Rudolf Hauptmann , Martin Steegmaier , Ulrich Guertler , Matthias Hoffmann , Matthias Grauert
IPC分类号： C07D239/42 , C07D239/46 , A61K31/505 , A61P35/00
CPC分类号： C07D239/48 , C07D401/12 , C07D403/12
摘要： The present invention comprises compounds of general formula (1) wherein A, X, Y, Z, Ra, Rb, Rc, R1, R2 and R3 are defined as in claim 1, which are suitable for the treatment of diseases characterised by excessive or anomalous cell proliferation, and the use thereof for preparing a pharmaceutical composition with the above-mentioned properties.
摘要翻译：本发明包括通式（1）的化合物，其中A，X，Y，Z，R a，O，R b，R c， R 1，R 2和R 3定义如权利要求1所述，其适用于治疗以过度或异常细胞为特征的疾病增殖及其用于制备具有上述性质的药物组合物的用途。

4. 发明申请

US20060009457A1 New pyridodihydropyrazinones, process for their manufacture and use thereof as medicaments 有权
标题翻译：新的吡啶二氢吡嗪酮，其制备方法和用途作为药物
公开(公告)号：US20060009457A1
公开(公告)日：2006-01-12
申请号：US11176737
申请日：2005-07-07
申请人： Matthias Hoffmann , Matthias Grauert , Trixi Brandl , Martin Steegmaier , Rudolf Hauptmann
发明人： Matthias Hoffmann , Matthias Grauert , Trixi Brandl , Martin Steegmaier , Rudolf Hauptmann
IPC分类号： A61K31/498 , C07D487/02
CPC分类号： C07D471/04
摘要： Disclosed are pyridodihydropyrazinone compounds, processes for preparing them and their use as pharmaceutical compositions. The compounds according to the invention correspond to general formula (I), while the groups L, R1, R2, R3, R4 and R5 may have the meanings given in the claims and specification.
摘要翻译：公开了吡啶二氢吡嗪酮化合物，其制备方法及其作为药物组合物的用途。根据本发明的化合物对应于通式（I），而基团L，R 1，R 2，R 3，R “4”和“5”可以具有权利要求书和说明书中给出的含义。

5. 发明授权

US5602010A DNA encoding equine-gamma interferon and recombinant production of equine IFN-.gamma. polypeptides 失效
标题翻译：编码马γ干扰素的DNA和马IFN-γ多肽的重组产生
公开(公告)号：US5602010A
公开(公告)日：1997-02-11
申请号：US263214
申请日：1994-06-17
申请人： Rudolf Hauptmann , Adolf Himmler , Peter Swetly
发明人： Rudolf Hauptmann , Adolf Himmler , Peter Swetly
IPC分类号： G01N33/53 , A61K38/00 , A61K38/21 , A61P43/00 , C07K14/005 , C07K14/195 , C07K14/52 , C07K14/555 , C07K14/57 , C07K16/00 , C07K16/24 , C12N5/10 , C12N15/02 , C12N15/09 , C12N15/23 , C12P21/02 , C12P21/08 , C12R1/19 , C12R1/865 , C12R1/91 , G01N33/577 , C12N1/21 , C12N15/71
CPC分类号： C07K16/249 , C07K14/57 , A61K38/00
摘要： The present invention relates to a process for preparing horse interferon-gamma (equine interferon gamma, EqIFN-.gamma., DNA sequences which encode this polypeptide, suitable vectors and host organisms containing these DNA sequences and the EqIFN-.gamma. itself. The invention further relates to partial DNA sequences which encode polypeptides which differ structurally from the natural EqIFN-.gamma. polypeptide. The use of the proteins is also described.
摘要翻译：本发明涉及制备马干扰素-γ（马干扰素γ，EqIFN-γ，编码该多肽的DNA序列，合适的载体和含有这些DNA序列的宿主生物体和EqIFN-γ本身）的方法，本发明还涉及编码与天然EqIFN-γ多肽结构不同的多肽的部分DNA序列也描述了蛋白质的用途。

6. 发明授权

US4528565A Pulse doppler radar receiver with a circuit for reducing spurious signals 失效
标题翻译：脉冲多普勒雷达接收机具有减少杂散信号的电路
公开(公告)号：US4528565A
公开(公告)日：1985-07-09
申请号：US363769
申请日：1982-03-31
申请人： Rudolf Hauptmann
发明人： Rudolf Hauptmann
IPC分类号： G01S13/522 , G01S7/28
CPC分类号： G01S13/522
摘要： A pulse Doppler radar receiver which continuously monitors successively obtained amplitude values Ao through An with the disrupted amplitude values which deviate by a prescribed value from an interpolation value obtained from adjacent undisturbed amplitude values are determined and are limited to a value obtained from the interpolation value or from the largest or smallest adjacent undisrupted amplitude values and are substituted for the disrupted values. The apparatus includes an interpolation circuit which includes the shift register and limiter with the memory for adjusting the output signal level of the limiter.
摘要翻译：确定连续监视连续获得的振幅值Ao至An的脉冲多普勒雷达接收机，其中从相邻未受干扰振幅值获得的内插值偏离规定值的扰动幅度值被限定为从插值值或从最大或最小相邻的未破坏的幅度值，并代替中断的值。该装置包括内插电路，其包括移位寄存器和限幅器以及用于调节限幅器的输出信号电平的存储器。

7. 发明授权

US4367472A Circuit arrangement for side lobe suppression in radar apparatuses 失效
标题翻译：用于雷达装置旁瓣抑制的电路装置
公开(公告)号：US4367472A
公开(公告)日：1983-01-04
申请号：US181760
申请日：1980-08-27
申请人： Rudolf Hauptmann , Gerhard Foeller
发明人： Rudolf Hauptmann , Gerhard Foeller
IPC分类号： G01S7/28 , H04B1/10 , G01S7/02
CPC分类号： G01S7/2813
摘要： A circuit arrangement for side lobe suppression in radar wherein the undesired signals which arrive at the radar receiver by way of the side lobes of the antenna are cancelled by using a compensation circuit formed as a loop. Additional circuit means for the formation of a weighting factor for the weighting multiplier are provided in the feedback of the loop between a correlator and a weighting amplifier.When the noise power at the output of the compensating circuit is greater than the noise power that the radar receiver supplies without the compensation circuit, the output will be switched from the compensation circuit to a direct output of the radar receiver. The comparison of the noise power in a comparator then supplies the control signal for the change-over. The change-over can also occur as a function of thermal noises when the amount of the weighting factor exceeds a predetermined value. The weighting factor is monitored by a control circuit. So as to make the response behaviour of the compensated loop independent of the noise signal power, a controlled amplifier is incorporated in the control circuit with the gain of the amplifier being inversely proportional to the square of the noise amplitude in the auxiliary channel. The controlled amplifier can be mounted in the feedback branch between the correlator and the weighting multiplier or can be inserted in front of one of the two inputs of the correlator.
摘要翻译：用于雷达旁瓣抑制的电路装置，其中通过使用形成为环路的补偿电路来消除通过天线的旁瓣到达雷达接收机的不需要的信号。在相关器和加权放大器之间的回路的反馈中提供了用于形成加权乘数的加权因子的附加电路装置。当补偿电路输出的噪声功率大于雷达接收机不用补偿电路的噪声功率时，输出将从补偿电路切换到雷达接收机的直接输出。比较器中的噪声功率的比较提供用于转换的控制信号。当加权因子的量超过预定值时，转换也可以作为热噪声的函数发生。加权因子由控制电路监控。为了使补偿回路的响应行为独立于噪声信号功率，控制放大器并入控制电路中，放大器的增益与辅助通道中的噪声幅度的平方成反比。控制放大器可以安装在相关器和加权乘数之间的反馈支路中，或者可以插入到相关器的两个输入之一的前面。

8. 发明申请

US20110086842A1 Pyrimidines as PLK inhibitors 审中-公开
标题翻译：嘧啶类作为PLK抑制剂
公开(公告)号：US20110086842A1
公开(公告)日：2011-04-14
申请号：US12972976
申请日：2010-12-20
申请人： Heinz STADTMUELLER , Harald ENGELHARDT , Martin STEEGMAIER , Anke BAUM , Ulrich GUERTLER , Andreas SCHOOP , Jens Juergen QUANT , Flavio SOLCA , Rudolf HAUPTMANN , Ulrich REISER , Stephan Karl ZAHN , Lars HERFURTH
发明人： Heinz STADTMUELLER , Harald ENGELHARDT , Martin STEEGMAIER , Anke BAUM , Ulrich GUERTLER , Andreas SCHOOP , Jens Juergen QUANT , Flavio SOLCA , Rudolf HAUPTMANN , Ulrich REISER , Stephan Karl ZAHN , Lars HERFURTH
IPC分类号： A61K31/553 , A61K31/506 , A61K31/5355 , A61P35/00 , A61P31/00 , A61P37/00
CPC分类号： C07D239/42 , C07D239/48 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/12 , C07D405/14 , C07D413/12 , C07D413/14 , C07D453/02 , C07D471/04 , C07D487/04 , C07D487/08 , C07D491/08 , C07D491/10
摘要： The present invention encompasses compounds of general formula (1), wherein A, W, X, Y, Z, Ra, Rb, Rc, R1 and R3 are defined as in claim 1, which are suitable for the treatment of diseases characterised by excessive or abnormal cell proliferation, and the use thereof for preparing a pharmaceutical composition having the above-mentioned properties.
摘要翻译：本发明包括通式（1）的化合物，其中A，W，X，Y，Z，Ra，Rb，Rc，R 1和R 3如权利要求1中所定义，其适用于治疗以过量或异常细胞增殖，以及其用于制备具有上述性质的药物组合物的用途。

9. 发明授权

US07625899B2 Pyridodihydropyraziones, process for their manufacture and use thereof as medicaments 有权
标题翻译：吡啶二氢吡喃硫酮，其制备方法和用途作为药物
公开(公告)号：US07625899B2
公开(公告)日：2009-12-01
申请号：US11176737
申请日：2005-07-07
申请人： Matthias Hoffmann , Matthias Grauert , Trixi Brandl , Martin Steegmaier , Rudolf Hauptmann
发明人： Matthias Hoffmann , Matthias Grauert , Trixi Brandl , Martin Steegmaier , Rudolf Hauptmann
IPC分类号： A01N43/58 , A01N43/60 , A61K31/50 , A61K31/495 , C07D237/00 , C07D239/00 , C07D241/00 , C07D471/00 , C07D487/00 , C07D491/00 , C07D495/00 , C07D497/00
CPC分类号： C07D471/04
摘要： Disclosed are pyridodihydropyrazinone compounds, processes for preparing them and their use as pharmaceutical compositions. The compounds according to the invention correspond to general formula (I), while the groups L, R1, R2, R3, R4 and R5 may have the meanings given in the claims and specification.
摘要翻译：公开了吡啶二氢吡嗪酮化合物，其制备方法及其作为药物组合物的用途。根据本发明的化合物对应于通式（I），而基团L，R 1，R 2，R 3，R 4和R 5可以具有权利要求书和说明书中给出的含义。

10. 发明授权

US06440693B1 TNF receptors, TNF binding proteins and DNAS coding for them 失效
标题翻译： TNF受体，TNF结合蛋白和编码它们的DNAS
公开(公告)号：US06440693B1
公开(公告)日：2002-08-27
申请号：US08484307
申请日：1995-06-07
申请人： Rudolf Hauptmann , Adolf Himmler , Ingrid Maurer-Fogy , Christian Stratowa
发明人： Rudolf Hauptmann , Adolf Himmler , Ingrid Maurer-Fogy , Christian Stratowa
IPC分类号： C12N1509
CPC分类号： G01N33/57484 , A61K38/00 , C07K14/7151 , C12Q1/6886 , C12Q2600/136 , G01N33/6863 , Y02A50/473 , Y10S930/12 , Y10S930/144
摘要： DNA sequences coding for a TNF-binding protein and for the TNF receptor of which this protein constitutes the soluble domain. The DNA sequences can be used for preparing recombinant DNA molecules in order to produce TNF-binding protein and TNF receptor. Recombinant TNF-binding protein is used in pharmaceutical preparations for treating indications in which TNF has a harmful effect. With the aid of the TNF receptor or fragments thereof or with the aid of suitable host organisms transformed with recombinant DNA molecules containing the DNA which codes for the TNF receptor or fragments or modifications thereof, it is possible to investigate substances for their interaction with the TNF receptor and/or for their effect on the biological activity of TNF.
摘要翻译：编码TNF结合蛋白的DNA序列和该蛋白质构成可溶性结构域的TNF受体。 DNA序列可用于制备重组DNA分子，以产生TNF结合蛋白和TNF受体。重组TNF结合蛋白用于药物制剂中，用于治疗TNF具有有害作用的适应症。借助于TNF受体或其片段或借助含有编码TNF受体的DNA的重组DNA分子或其片段或修饰物转化的合适的宿主生物，可以研究它们与TNF相互作用的物质受体和/或其对TNF的生物活性的影响。

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