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1. 发明公开

US20240292819A1 ANTI-CRISPR CONSTRUCT AND ITS USE TO COUNTERACT A CRISPR-BASED GENE-DRIVE IN AN ARTHROPOD POPULATION 审中-公开
公开(公告)号：US20240292819A1
公开(公告)日：2024-09-05
申请号：US18573114
申请日：2022-06-23
申请人： Imperial College Innovations Limited , Polo D’Innovazione di Genomica Genetica e Biologia SRL
发明人： Chrysanthi Taxiarchi , Roberto Galizi , Andrea Crisanti , Alekos Simoni , Rocco D'Amato
IPC分类号： A01K67/033 , C12N15/85
CPC分类号： A01K67/0339 , C12N15/8509 , A01K2217/052 , A01K2227/706 , A01K2267/01 , C12N2800/105
摘要： The present invention relates to an anti-CRISPR construct useful to counteract the spread of a gene-drive in an arthropod population. The invention is also concerned with a system comprising the anti-CRISPR construct and a crispr-based gene-drive construct, a method of producing a genetically modified arthropod, a genetically modified arthropod, and a method for counteracting a CRISPR-based gene-drive in an arthropod population.

2. 发明授权

US12031139B2 Stable transformation of a population and a method of biocontainment using haploinsufficiency and underdominance principles 有权
公开(公告)号：US12031139B2
公开(公告)日：2024-07-09
申请号：US16538602
申请日：2019-08-12
申请人： MAX-PLANCK-GESELLSCHAFT ZUR FÖRDERUNG DER WISSENSCHAFTEN E.V.
发明人： Guy Reeves , Floyd Reed
IPC分类号： C12N15/113 , A01K67/033 , C12N15/82
CPC分类号： C12N15/8218 , A01K67/033 , A01K67/0333 , A01K67/0339 , C12N15/113 , A01K2207/05 , A01K2217/15 , A01K2227/706 , A01K2267/02 , C12N2310/14
摘要： The present invention relates to a method for reducing the competitive fitness of an organism hemizygous for a transgenic locus compared to the organism homozygous for the transgenic locus comprising the steps of: (a) reducing the expression of a haploinsufficient gene in the organism, wherein said reduction is conveyed by a transgenic locus in the organism; and (b) rescuing the reduced expression in the organism, wherein said rescue is conveyed by the same transgenic locus in the organism, yielding an organism which is less competitively fit if hemizygous for the transgenic locus than if homozygous for the transgenic locus. The present invention also relates to a method for decreasing the introgression of a transgenic locus in an organism into a population of otherwise interfertile sexually reproducing organisms comprising the steps of: (a) reducing the expression of a haploinsufficient gene in the organism, wherein said reduction is conveyed by a transgenic locus in the organism; (b) rescuing the reduced expression in the organism, wherein said rescue is conveyed by the same transgenic locus in the organism, and (c) using a transgenic organism obtained in step (b) in an environment comprising otherwise interfertile sexually reproducing wildtype individuals of the organism, wherein the competitive fitness of hemizygous progeny is reduced, thereby decreasing the rate of sexually reproduction and/or viability and/or the competitive fitness of hemizygous progeny. Further envisaged are corresponding genetic systems and genetically modified organisms.

3. 发明公开

US20240074417A1 BREEDING APPARATUS 审中-公开
公开(公告)号：US20240074417A1
公开(公告)日：2024-03-07
申请号：US18261759
申请日：2021-03-04
申请人： JTEKT CORPORATION , Tokushima University
发明人： Nozomu MIURA , Yasuhiro MURATA , Shigekazu KAWAI , Takahito WATANABE , Taro MITO
IPC分类号： A01K67/033
CPC分类号： A01K67/0339
摘要： Provided is a breeding apparatus that can facilitate disposition and collection of a spawning bed. A breeding apparatus includes a breeding area forming member that forms breeding areas for organisms and is open at least at the bottoms of the breeding areas, and a spawning bed sheet that forms the bottom surfaces of the breeding areas, has a belt shape, and is provided so as to be movable in a longitudinal direction of the belt shape relative to the breeding area forming member.

4. 发明公开

US20240010704A1 CHIMERIC SENSOR PROTEIN AND METHODS OF USE THEREOF 审中-公开
公开(公告)号：US20240010704A1
公开(公告)日：2024-01-11
申请号：US18044948
申请日：2021-09-23
申请人： Universitaet Leipzig
发明人： Tobias LANGENHAN , Nicole SCHOLZ
IPC分类号： C07K14/705 , C12N15/85 , G01N33/50 , A01K67/033 , C07K14/47
CPC分类号： C07K14/70596 , C12N15/8509 , G01N33/5085 , A01K67/0339 , C07K14/705 , C07K14/4702 , C12N2015/859 , G01N2333/43573 , A01K2267/01 , A01K2227/706 , A01K2267/0393 , A01K2217/05 , C07K2319/03 , C07K2319/50
摘要： The present invention provides polypeptides and nucleic acid molecules that are useful in identifying.

5. 发明公开

US20230371483A1 METHODS AND COMPOSITIONS FOR SEXING AND STERILIZATION IN DROSOPHILA SUZUKII AND AEDES AEGYPTI 审中-公开
公开(公告)号：US20230371483A1
公开(公告)日：2023-11-23
申请号：US17629348
申请日：2020-07-24
申请人： The Regents of the University of California
发明人： Omar Akbari , Ming Li , Ting Yang , Nikolay Kandul
IPC分类号： A01K67/033 , C12N15/11 , C12N9/22 , C12N15/90
CPC分类号： A01K67/0339 , C12N15/11 , C12N9/22 , C12N15/902 , A01K2227/706 , A01K2217/077 , C12N2310/20
摘要： Provided herein is a next-generation highly-efficient technology that can be used for biocontrol of D. suzukii and/or Aedes aegypti. The composition and technique termed precision guided SIT (pgSIT) functions by exploiting the precision and accuracy of CRISPR to simultaneously disrupt genes essential for either female viability or male fertility. It utilizes a simple breeding scheme requiring two homozygous strains—one expressing Cas9 and the other expressing double guide RNAs (dgRNAs). A single mating between these strains mechanistically results in synchronous RNA-guided dominant biallelic knockouts of both target genes throughout development, resulting in the complete penetrance of desired phenotypes in all progeny. This document provides methods and compositions relating to producing such insect eggs, insects, insect populations and uses thereof in reducing a wild-type insect population, along with methods and materials for producing genetically modified progeny of D. suzukii and/or Aedes aegypti.

6. 发明公开

US20230363364A1 BOX FOR GROWING LARVAE 审中-公开
公开(公告)号：US20230363364A1
公开(公告)日：2023-11-16
申请号：US18029889
申请日：2021-10-01
申请人： Entosystème Inc.
发明人： Tony RENOUX , Raphaël SMIA
IPC分类号： A01K67/033
CPC分类号： A01K67/0339
摘要： The invention relates to a box (10) for growing larvae, comprising: a rectangular base (12); lateral walls (14) extending from the base (12), forming a flat closed contour parallel to the base (12), and defining a growth container together with the base (12); a rim (16) extending from the upper edges towards the exterior of the container parallel to the base (12), the rim (16) comprising two first reliefs (26) on its surface opposite the base (12), and having four edges (18, 20) which are connected to one another by four corners (22); at least four feet (24, 25) with the same height extending at least partly from the rim (16) towards the base (12), the feet (24, 25) extending from different edges (18, 20) or from different corners (22), at least two of the feet (24) facing the first reliefs (26), and comprising a second relief (29) which is complementary to the said first relief (26); the first reliefs (26) fitting together with the second reliefs (29) of a superimposed box (10); the feet (24, 25) being supported against the rim (16) of a box (10) below; the height being at least 8 cm greater than the depth of the container.

7. 发明授权

US11737436B2 Gene expression system 有权
公开(公告)号：US11737436B2
公开(公告)日：2023-08-29
申请号：US16997416
申请日：2020-08-19
申请人： Oxitec Limited
发明人： Martha Koukidou , Luke Alphey , Simon Warner
IPC分类号： C12N15/85 , A01K67/033 , C12Q1/6888
CPC分类号： A01K67/0339 , C12N15/8509 , C12Q1/6888 , A01K2217/072 , A01K2217/15 , A01K2217/203 , A01K2217/206 , A01K2217/30 , A01K2227/706 , A01K2267/02 , C12N2800/90 , C12N2830/006 , C12N2830/008 , C12N2830/15 , C12N2840/007 , C12N2840/44 , C12N2840/75 , C12N2999/007 , C12Q2600/158
摘要： Two or more conditional, dominant, lethal gene expression systems provide high levels of penetrance in insects. Lethality is induced at an earlier stage of development and the risk of biochemical resistance is reduced, as compared to a single insect conditional, dominant, lethal gene expression system. The invention is useful for the control of insect populations.

8. 发明申请

US20180265892A1 GENETICALLY ENGINEERED LARVAE FOR WOUND HEALING 审中-公开
公开(公告)号：US20180265892A1
公开(公告)日：2018-09-20
申请号：US15923595
申请日：2018-03-16
申请人： North Carolina State University
发明人： Maxwell J. Scott , Rebecca J. Davis , Esther J. Belikoff
IPC分类号： C12N15/85 , C07K14/435 , C07K14/49 , A61K35/64 , A61K38/18
CPC分类号： C12N15/8509 , A01K67/0339 , A01K2217/072 , A01K2227/706 , A01K2267/02 , A61K35/64 , A61K38/1858 , C07K14/43577 , C07K14/49 , C12N2015/8518 , C12N2830/00
摘要： The present invention relates to methods and compositions for maggot debridement therapy. More specifically, the invention relates to recombinant nucleic acid constructs, transgenic maggots comprising the recombinant nucleic acids, methods for making the maggots, and methods for the use of the maggots, including debridement and promoting of wound healing.

9. 发明授权

US09926558B2 Culicinae mosquito Tra-2 RNA interference technique to genetically produce maleness population 有权
公开(公告)号：US09926558B2
公开(公告)日：2018-03-27
申请号：US14356978
申请日：2011-12-29
申请人： Duong Thanh Hoang , Kim Phuc Hoang
发明人： Duong Thanh Hoang , Kim Phuc Hoang
IPC分类号： C12N15/113 , C12N15/85 , A01K67/033
CPC分类号： C12N15/113 , A01K67/0333 , A01K67/0339 , A01K2217/058 , A01K2227/706 , A01K2267/02 , C12N2310/14 , C12N2330/51
摘要： The present invention develops a novel method for controlling mosquito populations. Culicinae mosquitoes carrying one or more loci of transformant Tra-2 RNAi constructs which target to mosquito Transformer-2 locus in respective or none respective Culicinae mosquitoes. Tra-2 sequences used to assemble Tra-2 RNAi recombinant constructs are Tra-2 gene sequences of Culicinae mosquitoes and can be derived from endogenous or exogenous sequences. The Tra-2 RNAi expression is conditional, wherein the expression causing a knockdown effect into the endogenous Tra-2 gene results in mortality of X (m) chromosome bearing sperms and produces maleness mosquito population in the nature environmental of the species.

10. 发明申请

US20170360015A1 INSECT MUSCLE ACTIN PROMOTER 审中-公开
公开(公告)号：US20170360015A1
公开(公告)日：2017-12-21
申请号：US15632213
申请日：2017-06-23
申请人： Oxitec Limited
发明人： Martha KOUKIDOU , Sarah SCAIFE , Luke ALPHEY
IPC分类号： A01K67/033 , C12N15/85 , C07K14/435
CPC分类号： A01K67/0339 , A01K2217/05 , A01K2227/706 , A01K2267/0393 , C07K14/43577 , C07K14/43586 , C12N15/8509 , C12N2800/105 , C12N2830/008
摘要： Provided is a gene expression system, suitable for expression in an insect, comprising an insect muscle actin promoter operably linked to a marker gene, which overcomes or ameliorates one or more of: cost of rearing; amount of handling; errors in identification due to human error or loss of marker by the insect; and health concerns related to the effects of marker powders on workers in mass rearing facilities.

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