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1. 发明授权

US09770554B2 Cardioplegia apparatus and method 有权
公开(公告)号：US09770554B2
公开(公告)日：2017-09-26
申请号：US13613705
申请日：2012-09-13
申请人： Michael L. Dollar , Cristo Suresh Corera , Kenneth A. Jones
发明人： Michael L. Dollar , Cristo Suresh Corera , Kenneth A. Jones
IPC分类号： A61M5/172 , G09B23/28 , A61M1/36 , G06F19/00
CPC分类号： A61M5/172 , A61M1/3664 , A61M1/369 , A61M2205/505 , G09B23/285 , G16H40/63
摘要： A microplegia console for controlling the delivery of cardioplegia to a patient, comprising an integrated display/touch screen for displaying cardioplegia information and patient information and allowing inputting of parameters via the display/touch screen into the console for computer-controlled perfusion of cardioplegia into the patient. The invention further comprises a method for delivery of cardioplegia to a patient, including defining and selecting a protocol from a displayed list and sequencing a series of the protocols. The invention also comprises a method for cardioplegia delivery to achieve aortic valve closure. Additionally, the invention comprises a method for activating an icon whereby, upon a first selection of the icon, displaying an indicia indicating that the icon has been first selected; and upon a second selection of the icon, activating the icon.

2. 发明授权

US07842003B2 Pulsatile fluid delivery system 有权
标题翻译：脉动流体输送系统
公开(公告)号：US07842003B2
公开(公告)日：2010-11-30
申请号：US11297989
申请日：2005-12-09
申请人： Kenneth A. Jones , Cristo Suresh Corera , Richard S. Hayes
发明人： Kenneth A. Jones , Cristo Suresh Corera , Richard S. Hayes
IPC分类号： A61M37/00 , F04B43/12 , A61N1/362
CPC分类号： F04B49/065
摘要： A system for delivering blood, cardioplegia solution, and other medications or fluids in a pulsatile flow pattern to a patient during cardiopulmonary bypass is disclosed. In a preferred embodiment, a pumping apparatus having at least one chamber is utilized in which a pumping action is achieved by compressing one of the chambers with a piston mechanism, while allowing the other chamber to fill with fluid via retracting its respective piston. The instantaneous flow rate of either of the chambers is determined by the speed of the piston. In a preferred embodiment, a pulsatile flow of fluid is achieved by cyclically alternating the velocity of the piston between two different speeds. A desired average flow rate and/or delivery pressure and/or constant pulse pressure is maintained by adjusting the alternating velocities at the desired frequency and duty cycle. The calculations necessary to obtain a desired average flow rate are performed by a microprocessor, which also controls the movement of the pistons.
摘要翻译：公开了一种用于在体外循环期间向患者输送血液，心麻痹液和脉动流动模式的其它药物或流体的系统。在优选实施例中，使用具有至少一个室的泵送装置，其中通过用活塞机构压缩其中一个室来实现泵送作用，同时允许另一个室通过缩回其相应的活塞来填充流体。任何一个室的瞬时流量由活塞的速度决定。在优选实施例中，通过在两个不同速度之间循环地交替活塞的速度来实现流体的脉动流。通过在所需的频率和占空比下调节交变速度来维持期望的平均流速和/或输送压力和/或恒定脉冲压力。获得所需平均流量所需的计算由微处理器执行，微处理器也控制活塞的运动。

3. 发明授权

US07371535B2 Processes for determining compounds that interact with snorf33 receptor 失效
标题翻译：确定与snorf33受体相互作用的化合物的方法
公开(公告)号：US07371535B2
公开(公告)日：2008-05-13
申请号：US11217710
申请日：2005-09-01
申请人： Beth E. Borowsky , Kristine L. Ogozalek , Kenneth A. Jones
发明人： Beth E. Borowsky , Kristine L. Ogozalek , Kenneth A. Jones
IPC分类号： G01N33/566 , G01N33/53
CPC分类号： C07K14/705 , A61K38/00 , A61K48/00
摘要： This invention provides isolated nucleic acids encoding mammalian SNORF33 receptors, purified mammalian SNORF33 receptors, vectors comprising nucleic acid encoding mammalian SNORF33 receptors, cells comprising such vectors, antibodies directed to mammalian SNORF33 receptors, nucleic acid probes useful for detecting nucleic acid encoding mammalian SNORF33 receptors, antisense oligonucleotides complementary to unique sequences of nucleic acid encoding mammalian SNORF33 receptors, transgenic, nonhuman animals which express DNA encoding normal or mutant mammalian SNORF33 receptors, methods of isolating mammalian SNORF33 receptors, methods of treating an abnormality that is linked to the activity of the mammalian SNORF33 receptors, as well as methods of determining binding of compounds to mammalian SNORF33 receptors, methods of identifying agonists and antagonists of SNORF33 receptors, and agonists and antagonists so identified.
摘要翻译：本发明提供编码哺乳动物SNORF33受体的分离的核酸，纯化的哺乳动物SNORF33受体，包含编码哺乳动物SNORF33受体的核酸的载体，包含此类载体的细胞，针对哺乳动物SNORF33受体的抗体，用于检测编码哺乳动物SNORF33受体的核酸的核酸探针，与编码哺乳动物SNORF33受体的核酸的独特序列互补的反义寡核苷酸，表达编码正常或突变的哺乳动物SNORF33受体的DNA的转基因非人动物，分离哺乳动物SNORF33受体的方法，治疗与哺乳动物的活性相关的异常的方法 SNORF33受体以及确定化合物与哺乳动物SNORF33受体的结合的方法，识别SNORF33受体的激动剂和拮抗剂的方法，以及所鉴定的激动剂和拮抗剂。

4. 发明授权

US07276339B2 DNA encoding mammalian neuropeptide FF (NPFF) receptors and uses thereof 失效
标题翻译：编码哺乳动物神经肽FF（NPFF）受体的DNA及其用途
公开(公告)号：US07276339B2
公开(公告)日：2007-10-02
申请号：US10992577
申请日：2004-11-18
申请人： Christophe P. G. Gerald , Kenneth A. Jones , James A. Bonini , Beth E. Borowsky , Douglas A. Craig
发明人： Christophe P. G. Gerald , Kenneth A. Jones , James A. Bonini , Beth E. Borowsky , Douglas A. Craig
IPC分类号： C12Q1/68 , G01N33/53 , C12N15/00
CPC分类号： C07K14/70571 , A01K2217/075
摘要： This invention provides isolated nucleic acids encoding mammalian NPFF receptors, purified mammalian NPFF receptors, vectors comprising nucleic acid encoding mammalian NPFF receptors, cells comprising such vectors, antibodies directed to mammalian NPFF receptors, nucleic acid probes useful for detecting nucleic acid encoding mammalian NPFF receptors, antisense oligonucleotides complementary to unique sequences of nucleic acid encoding mammalian NPFF receptors, transgenic, nonhuman animals which express DNA encoding normal or mutant mammalian NPFF receptors, methods of isolating mammalian NPFF receptors, methods of treating an abnormality that is linked to the activity of the mammalian NPFF receptors, as well as methods of determining binding of compounds to mammalian NPFF receptors, methods of identifying agonists and antagonists of NPFF receptors, and agonists and antagonists so identified.
摘要翻译：本发明提供编码哺乳动物NPFF受体的分离的核酸，纯化的哺乳动物NPFF受体，包含编码哺乳动物NPFF受体的核酸的载体，包含该载体的细胞，针对哺乳动物NPFF受体的抗体，用于检测编码哺乳动物NPFF受体的核酸的核酸探针，与编码哺乳动物NPFF受体的核酸的独特序列互补的反义寡核苷酸，其表达编码正常或突变型哺乳动物NPFF受体的DNA的转基因非人动物，分离哺乳动物NPFF受体的方法，治疗与哺乳动物活性相关的异常的方法 NPFF受体，以及确定化合物与哺乳动物NPFF受体的结合的方法，识别NPFF受体的激动剂和拮抗剂的方法，以及如此鉴定的激动剂和拮抗剂。

5. 发明授权

US07067277B1 Chimeric G proteins and uses thereof 失效
标题翻译：嵌合G蛋白及其用途
公开(公告)号：US07067277B1
公开(公告)日：2006-06-27
申请号：US09471572
申请日：1999-12-23
申请人： Kenneth A. Jones , Mary W. Walker , Joseph Tamm , Theresa A. Branchek , Christophe P. G. Gerald
发明人： Kenneth A. Jones , Mary W. Walker , Joseph Tamm , Theresa A. Branchek , Christophe P. G. Gerald
IPC分类号： C12N15/12 , C12N15/63 , C12N15/00 , C07H21/04 , C07K14/00
CPC分类号： C07K14/43581 , C07K14/43545
摘要： This invention provides isolated nucleic acids encoding chimeric G proteins, vectors comprising nucleic acids encoding chimeric G proteins, cells comprising such vectors, processes of determining agonists and antagonists of mammalian G protein-coupled receptors utilizing chimeric G proteins, processes of determining compounds which bind to mammalian G protein-coupled receptors utilizing chimeric G proteins, processes for making a composition of matter which specifically binds to a mammalian G protein-coupled receptor utilizing chimeric G proteins, processes for preparing a composition which comprises admixing a carrier and a pharmaceutically effective amount of a chemical compound identified by a process of the invention utilizing chimeric G proteins, processes of identifying a ligand for a mammalian G protein-coupled receptor utilizing chimeric G proteins, and processes of screening a plurality of independent clones to identify and isolate a clone encoding a mammalian G protein-coupled receptor utilizing chimeric G proteins.
摘要翻译：本发明提供编码嵌合G蛋白的分离的核酸，包含编码嵌合G蛋白的核酸的载体，包含此类载体的细胞，利用嵌合G蛋白确定哺乳动物G蛋白偶联受体的激动剂和拮抗剂的方法，确定与使用嵌合G蛋白的哺乳动物G蛋白偶联受体，使用嵌合G蛋白特异性结合哺乳动物G蛋白偶联受体的物质组合物的方法，制备组合物的方法，该组合物包含将载体和药学上有效量的通过利用嵌合G蛋白的本发明方法鉴定的化合物，利用嵌合G蛋白鉴定哺乳动物G蛋白偶联受体的配体的方法，以及筛选多个独立克隆以识别和分离编码哺乳动物G蛋白偶联 d受体。

6. 发明授权

US06287788B1 DNA encoding galanin GALR3 receptors and uses thereof 失效
标题翻译：编码甘丙肽GALR3受体的DNA及其用途
公开(公告)号：US06287788B1
公开(公告)日：2001-09-11
申请号：US09199737
申请日：1998-11-25
申请人： Jonathan A. Bard , Beth Borowsky , Kelli E. Smith , Theresa A. Branchek , Christophe P. G. Gerald , Kenneth A. Jones
发明人： Jonathan A. Bard , Beth Borowsky , Kelli E. Smith , Theresa A. Branchek , Christophe P. G. Gerald , Kenneth A. Jones
IPC分类号： G01N3353
CPC分类号： C07K16/2869 , A01K2217/05 , A61K38/00 , C07K14/72 , G01N33/5088 , G01N33/74 , G01N2333/72 , G01N2500/10
摘要： This invention provides an isolated nucleic acid encoding a mammalian galanin receptor, an isolated galanin receptor protein, vectors comprising isolated nucleic acid encoding a mammalian galanin receptor, cells comprising such vectors, antibodies directed to a mammalian galanin receptor, nucleic acid probes useful for detecting nucleic acid encoding a mammalian galanin receptor, antisense oligonucleotides complementary to unique sequences of nucleic acid encoding a mammalian galanin receptor, nonhuman transgenic animals which express DNA encoding a normal or a mutant mammalian galanin receptor, as well as methods of determining binding of compounds to mammalian galanin receptors.
摘要翻译：本发明提供编码哺乳动物甘丙肽受体的分离的核酸，分离的甘丙肽受体蛋白，包含编码哺乳动物甘丙肽受体的分离的核酸的载体，包含该载体的细胞，针对哺乳动物甘丙肽受体的抗体，用于检测核酸的核酸探针编码哺乳动物甘丙肽受体的酸，与编码哺乳动物甘丙肽受体的核酸的唯一序列互补的反义寡核苷酸，表达编码正常或突变型哺乳动物甘丙肽受体的DNA的非人转基因动物，以及确定化合物与哺乳动物甘丙肽的结合的方法受体。

7. 发明授权

US5917967A Techniques for forming optical electronic integrated circuits having interconnects in the form of semiconductor waveguides 失效
标题翻译：用于形成具有半导体波导形式的互连的光学电子集成电路的技术
公开(公告)号：US5917967A
公开(公告)日：1999-06-29
申请号：US861387
申请日：1997-05-21
申请人： Madan Dubey , Kenneth A. Jones , Weiyu Han , Lawrence C. West
发明人： Madan Dubey , Kenneth A. Jones , Weiyu Han , Lawrence C. West
IPC分类号： G02B6/10 , G02B6/12 , G02B6/122 , G02B6/132 , G02B6/136 , G02B6/43
CPC分类号： G02B6/10 , G02B6/12004 , G02B6/122 , G02B6/132 , G02B6/136 , G02B2006/12176 , G02B6/43
摘要： An optical electronic integrated circuit (OEIC) having optical waveguides as device interconnects. An optical waveguide is formed by depositing, in an oxygen-free atmosphere, a film of semiconductor material on a semiconductor substrate at a temperature that substantially diminishes the porosity of the film and the diffusion of material from the substrate into the film. The semiconductor film, which has an index of refraction greater than that of the substrate, is etched to form the optical waveguide on the substrate. The substrate also supports a to plurality of active optical devices between which the optical waveguide extends. The substrate is preferably formed from gallium-arsenide and the waveguide from germanium. The active devices may also include these materials as well as aluminum-gallium-arsenide. When using these materials, the germanium film is deposited in an oxygen-free environment at about 100 degrees centigrade.
摘要翻译：一种具有光波导作为器件互连的光电子集成电路（OEIC）。通过在基本上降低膜的孔隙率和材料从衬底扩散到膜中的温度下，在半导体衬底上在无氧气氛中沉积半导体材料的膜而形成光波导。蚀刻具有大于基板的折射率的半导体膜，以在基板上形成光波导。基板还支撑一个至多个有源光学器件，光波导延伸在其间。衬底优选由砷化镓和来自锗的波导形成。有源器件还可以包括这些材料以及砷化镓铝。当使用这些材料时，锗膜在大约100摄氏度的无氧环境中沉积。

8. 发明授权

US5645531A Constant pressure blood mixture delivery system and method 失效
标题翻译：恒压血液输送系统及方法
公开(公告)号：US5645531A
公开(公告)日：1997-07-08
申请号：US204530
申请日：1994-03-01
申请人： Thomas C. Thompson , Martyn Abbott , Kenneth A. Jones
发明人： Thomas C. Thompson , Martyn Abbott , Kenneth A. Jones
IPC分类号： F04B43/00 , A61M1/10 , A61M1/36 , A61M5/168 , A61M5/44 , A61M19/00 , A61M31/00
CPC分类号： A61M1/3664 , A61M1/3621 , A61M5/16827 , A61M5/44 , A61M2205/12 , A61M2205/3344 , A61M2205/3355 , A61M2205/3606 , A61M2205/366 , Y10S128/03
摘要： A system and method for blood mixture fluid delivery to a patient includes fluid delivery conduits connected to the patient for delivering blood mixture fluid, a pump for controlled pumping of blood mixture fluid through the conduits to the patient, and an automatic control mechanism operatively connected to the pump for controlling the pump so that the blood mixture fluid is continuously delivered to the patient at a defined constant pressure.
摘要翻译：用于向患者输送血液混合物的系统和方法包括连接到患者以输送血液混合物流体的流体输送管道，用于通过导管将血液混合物流体受控地泵送到患者的泵，以及可操作地连接到用于控制泵的泵，使得血液混合物流体以规定的恒定压力连续递送到患者体内。

9. 发明授权

US5385540A Cardioplegia delivery system 失效
标题翻译：心脏停搏分娩系统
公开(公告)号：US5385540A
公开(公告)日：1995-01-31
申请号：US67683
申请日：1993-05-26
申请人： Martyn S. Abbott , Thomas C. Thompson , Kenneth A. Jones , Albert M. Davis , Andrew P. Mattson
发明人： Martyn S. Abbott , Thomas C. Thompson , Kenneth A. Jones , Albert M. Davis , Andrew P. Mattson
IPC分类号： F04B43/00 , A61M1/36 , A61M5/168 , A61M5/44 , A61M19/00 , A61M37/00 , A61M1/00 , A61M31/00
CPC分类号： A61M5/16827 , A61M1/3664 , A61M5/44 , A61M2205/12 , A61M2205/3344 , A61M2205/3355 , A61M2205/3606 , A61M2205/366 , Y10S128/03
摘要： A cardioplegia system for delivering cardioplegic solution to the heart during open heart surgery in cooperation with an extracorporeal blood circuit employing a heart/lung machine, includes a conduit diverting a portion of the blood flow from the heart/lung machine to a cardioplegia delivery line. A heat exchanger for controlling fluid temperature is provided in the cardioplegia delivery line. A first pump combines the blood from the conduit with a second fluid and delivers the combined flow into the delivery line leading to the heat exchanger. A control panel is operatively connected for adjusting the ratio of blood and second fluid delivered by the first pump and for adjusting the total volumetric rate of flow from the first pump.
摘要翻译：一种心脏停搏系统，用于在开心心脏手术期间与使用心脏/肺机的体外血液回路相结合，将心脏停搏液提供给心脏，包括导管将一部分血流从心脏/肺机转移到心麻痹输送管线。用于控制流体温度的热交换器设置在心麻痹输送管线中。第一泵将来自导管的血液与第二流体结合，并将组合的流输送到通向热交换器的输送管线。控制面板可操作地连接，用于调节由第一泵输送的血液和第二流体的比例，并用于调节来自第一泵的总体积流速。

10. 发明授权

US5358689A Hollow fiber blood oxygenator 失效
标题翻译：中空纤维血液充氧器
公开(公告)号：US5358689A
公开(公告)日：1994-10-25
申请号：US31172
申请日：1993-04-15
申请人： Kenneth A. Jones , Francis M. Servas , Timothy C. Ryan , Gregory G. Ulrich
发明人： Kenneth A. Jones , Francis M. Servas , Timothy C. Ryan , Gregory G. Ulrich
IPC分类号： A61M1/14 , A61M1/16 , A61M1/36 , B01D63/02 , F28D7/02 , F28F13/00 , F28F21/06
CPC分类号： A61M1/1698 , A61M1/1625 , A61M1/1629 , B01D63/02 , F28D7/024 , F28F13/003 , F28F21/062 , A61M1/3627 , B01D2313/146 , B01D2313/38 , F28F2265/16 , Y10S128/03 , Y10S261/28
摘要： A hollow fiber blood oxygenator is provided having an plurality of enclosed, coaxial heat exchanger coils, having a common header to insure uniform temperature in the coils. An enclosed fiber bundle is concentrically positioned inside the heat exchanger coils to define a flow path around the coils and through the fiber bundle. The heat exchanger coils and the outside of the fiber bundle are tapered to provide a close fit. Gas manifolds direct gas flow to and from the hollow fibers.
摘要翻译：提供一种中空纤维血液充氧器，其具有多个封闭的同轴热交换器线圈，其具有共同的头部以确保线圈中的均匀温度。封闭的纤维束同心地位于热交换器盘管的内部，以限定围绕线圈和通过纤维束的流动路径。热交换器线圈和纤维束的外侧是锥形的以提供紧密配合。气体歧管直接将气体流入和流出中空纤维。

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