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    • 4. 发明授权
    • Ligands specific for cannabinoid receptor subtype 2
    • 特异性大麻素受体亚型2的配体
    • US08466131B2
    • 2013-06-18
    • US12740099
    • 2008-10-31
    • Xiangqun XieJianzhong ChenYuxun Zhang
    • Xiangqun XieJianzhong ChenYuxun Zhang
    • A61K31/655C09B29/33
    • C07C257/14C07C2602/42
    • A compound of Formula I: (I) has activity as a cannabinoid receptor antagonist. In Formula 1, R1 is unsubstituted or substituted aryl, unsubstituted or substituted cycloalkyl, unsubstituted or substituted heterocyclyl, unsubstituted or substituted aralkyl, or unsubstituted or substituted heteroaryl; R2 is unsubstituted or substituted alkyl, unsubstituted or substituted aryl, or unsubstituted or substituted heteroaryl; and R3 is unsubstituted or substituted alkyl, unsubstituted or substituted aralkyl, or unsubstituted or substituted heteroaralkyl; with the proviso that at least one of Ri and R3 is other than unsubstituted aralkyl or R2 is other than unsubstituted aryl.
    • 式I的化合物:(I)具有作为大麻素受体拮抗剂的活性。 在式1中,R 1是未取代或取代的芳基,未取代或取代的环烷基,未取代或取代的杂环基,未取代或取代的芳烷基或未取代或取代的杂芳基; R2是未取代或取代的烷基,未取代或取代的芳基,或未取代或取代的杂芳基; 并且R 3是未取代或取代的烷基,未取代或取代的芳烷基,或未取代或取代的杂芳烷基; 条件是R 1和R 3中的至少一个不是未取代的芳烷基,或者R 2不是未被取代的芳基。
    • 5. 发明申请
    • Salts of Laked Monoazo Compounds
    • 盐酸单腙化合物的盐
    • US20070226920A1
    • 2007-10-04
    • US11587689
    • 2005-04-18
    • Gregoire FollyUrsula LuterbacherThomas Ruch
    • Gregoire FollyUrsula LuterbacherThomas Ruch
    • C09B29/33C08K5/42C09B63/00C09B67/48
    • C09B29/332
    • The present invention relates to monoazo compounds of formula (I) which are present in the form of mono-, di-, tri- or tetra-valent mixed salts of different cations, such as, for example, Ca2+, Na+, NH4+, NR4+, H+, Li+, K+, Mg2+, Ba2+, Sr2+, AI2+, Pb2+, Mn2+, Zn2+, Cr2+, Co2+, Fe2+, Fe3+, Zr4+ and CU2+, R being C2-C6alkyl, in freely selected ratios, and to the calcium salt of the monoazo compound of formula (I) which has two crystal polymorph forms—a reddish yellow and a greenish yellow—having different properties, for example colour shade or high-temperature stability, to the preparation of such compounds and to their use in the mass-pigmenting of organic materials and in the production of wax transfer ribbons, toners or colour filters.
    • 本发明涉及以不同阳离子的单 - ,二 - ,三 - 或四价混合盐形式存在的式(I)单偶氮化合物,例如Ca 2+, Na +,SO 4 +,SO 4 +,SO 4 +,SO 4, H +,+,SO 2 +,SO 2 +,SO 2 +,SO 2 + ,Sr 2+,2+,Pb 2+,Mn 2+,Zn 2+, 2 + ,2+ + 2,+ 2 +,+ 3,+ 3 + ,Zr 4+和C 2 H 2,R 2为C 2 -C 6烷基,以自由选择的比例 以及具有两种晶体多晶型形式的式(I)单偶氮化合物的钙盐,其具有不同性质的红黄色和绿黄色,例如色调或高温稳定性,用于制备这种化合物 以及它们在有机材料的大量着色和在蜡转移带,调色剂或colo的生产中的用途 ur过滤器。
    • 7. 发明授权
    • Monoazo compounds containing long-chain alkyl radicals
    • 含有长链烷基的单偶氮化合物
    • US4997920A
    • 1991-03-05
    • US405612
    • 1989-09-11
    • Stefan HariOlof WallquistJost von der Crone
    • Stefan HariOlof WallquistJost von der Crone
    • C07D239/88C07C245/06C07C245/10C07C255/65C07D235/26C07D263/58C07D265/36C07D277/82C08K5/00C08K5/23C08K5/34C08K5/35C08K5/46C09B29/01C09B29/20C09B29/33C09B67/20
    • C08K5/23C08K5/0041C09B29/0003C09B29/20C09B29/337C09B29/338
    • Compounds of the formulae I and II ##STR1## in which A is a radical of the formulae III, IV or V ##STR2## R.sub.1 and R.sub.4 are --H or --Cl, R.sub.2 and R.sub.5 are --H, halogen, --NO.sub.2, --CN, C.sub.1 -C.sub.4 -alkyl, C.sub.1 -C.sub.4 alkoxy, --CF.sub.3 or phenyloxy which is unsubstituted or substituted by one or two chlorine atoms and/or one or two methyl or methoxy groups, and R.sub.3 is alkyl having at least 10 C atoms, X is a radical of the formulae --NH--, --O--, ##STR3## n is the number 1 or 2, Y is the radical of the formulae --COO--, --OOC--, --CONH-- or --NHCO-- or a radical of the formulae ##STR4## in which R.sub.1 and R.sub.2 are as defined above, D is an aromatic heterocyclic 5- or 6-membered ring, in which the ring contains 1 or 2 N atoms and may additionally contain an O atom or S atom, Z is --H, --Br, --OCH.sub.3, --CN or --NO.sub.2 and X.sub.1 and X.sub.2, independently of one another, are --H, halogen, --CH.sub.3, --OCH.sub.3, --OC.sub.2 H.sub.5 or --NO.sub.2 and X.sub.3 is --H, --NHCO--C.sub.1 -C.sub.4 alkyl, benzoylamino or phenylcarboxamide which are each unsubstituted or substituted on the phenyl ring by one or two chlorine atoms and/or one or two methyl or methoxy groups or an --NHCO--C.sub.1 -C.sub.4 alkyl group, or X.sub.2 and X.sub.3 together with the carbon atom to which they are bound are an aromatic carbocyclic 6-membered ring or an aromatic heterocyclic 5- or 6-membered ring, in which the heterocyclic ring contains 1 or 2 N atoms and can additionally have an O atom or S atom, and Y.sub.1 is --H, --OCH.sub.3, --OC.sub.2 H.sub.5 or --NHCOCH.sub.3, with the proviso that X.sub.3 must not be H, if X is --O-- or --NH--, are highly suitable for the mass coloration of plastics, in particular of polyolefins.
    • 其中A是式III,IV或V的基团,其中A是式(I)的化合物,其中A是式III,IV或V的基团(III) (V)R 1和R 4是-H或-Cl,R 2和R 5是-H,卤素,-NO 2,-CN,C 1 -C 4 - 烷基,C 1 -C 4烷氧基,-CF 3或苯氧基,其未被取代或被 一个或两个氯原子和/或一个或两个甲基或甲氧基,并且R 3是具有至少10个C原子的烷基,X是式-NH-,-O-, 的基团 > + TR n是数字1或2,Y是式-COO-,-OOC-,-CONH-或-NHCO-的基团或式(IMAGE)+ TR 其中R1和R2如上定义,D是芳族杂环的5或6元环,其中环含有1或2个N原子,并且可以另外含有O原子或S原子,Z是-H, - Br,-OCH 3,-CN或-NO 2,X 1和X 2彼此独立地是-H,卤素,-CH 3,-OCH 3,-OC 2 H 5或-NO 2,X 3是-H,-NHCO-C 1 -C 4烷基, 苯甲酰氨基或苯基 甲酰胺,其各自未被取代或在苯环上被一个或两个氯原子和/或一个或两个甲基或甲氧基或-NHCO-C 1 -C 4烷基取代,或X 2和X 3与它们所在的碳原子一起 结合的是芳族碳环6元环或芳族杂环5或6元环,其中杂环含有1或2个N原子,并且可以另外具有O原子或S原子,Y 1是-H, - OCH 3,-OC 2 H 5或-NHCOCH 3,条件是如果X为-O-或-NH-,则X3不能为H,高度适用于塑料,特别是聚烯烃的大量着色。
    • 9. 发明授权
    • Cationic triazine azo dyes
    • 阳离子三嗪偶氮染料
    • US4486348A
    • 1984-12-04
    • US582997
    • 1984-02-24
    • Klaus Kunde
    • Klaus Kunde
    • C09B29/33C09B43/16C09B44/02C09B44/08D21H19/10D21H21/28C09B44/18D21D3/00D21H3/80D21H3/82
    • C09B44/02D21H21/28
    • Cationic triazinyl dyestuffs of the formula ##STR1## wherein R.sub.11 and R.sub.12 independently of one another are H, Cl, Br, OCH.sub.3, OC.sub.2 H.sub.5, CH.sub.3 or C.sub.2 H.sub.5,X is a radical of the formula COCH.sub.3, CN, COOCH.sub.3, COOC.sub.2 H.sub.5, CONH.sub.2 or COC.sub.6 H.sub.5,Y and Z independently of one another are C.sub.2 -C.sub.5 -alkylene,R.sub.1 and R.sub.2 independently of one another are H, Cl, Br, OCH.sub.3, OC.sub.2 H.sub.5, CH.sub.3 or C.sub.2 H.sub.5,R.sub.3 and R.sub.4 independently of one another are hydrogen or C.sub.1 -C.sub.4 -alkyl,R.sub.5 -R.sub.10 independently of one another are hydrogen, C.sub.1 -C.sub.4 -alkyl, .beta.- or .gamma.-hydroxy-C.sub.2 -C.sub.4 -alkyl, phenyl or benzyl, orR.sub.5 and R.sub.6, and/or R.sub.8 and R.sub.9 in each case together with the nitrogen, form a pyrrolidine, morpholine or piperidine ring, orR.sub.5, R.sub.6 and R.sub.7 and/or R.sub.8, R.sub.9 and R.sub.10, in each case together with the nitrogen, form a pyridinium or picolinium radical, andAn.sup.(-) is an anionare especially useful for dyeing paper.
    • 其中R 11和R 12彼此独立地是H,Cl,Br,OCH 3,OC 2 H 5,CH 3或C 2 H 5,X是式COCH 3,CN,COOCH 3的基团,其中R 11和R 12彼此独立地是下式的阳离子三嗪基染料: COOC2H5,CONH2或COC6H5,Y和Z彼此独立地是C2-C5-亚烷基,R1和R2彼此独立地是H,Cl,Br,OCH3,OC2H5,CH3或C2H5,R3和R4彼此独立地是 氢或C 1 -C 4烷基,R 5 -R 10彼此独立地是氢,C 1 -C 4 - 烷基,β-或γ-羟基-C 2 - C 4 - 烷基,苯基或苄基,或者R 5和R 6,和/或R 8 和R9各自与氮一起形成吡咯烷,吗啉或哌啶环,或者R 5,R 6和R 7和/或R 8,R 9和R 10在各种情况下与氮一起形成吡啶鎓或吡啶鎓基团,以及 An( - )是阴离子特别适用于染色纸。