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1. 发明授权

US06420529B1 Genetic selection method for identifying ligands for transmembrane proteins 失效
标题翻译：用于鉴定跨膜蛋白配体的遗传选择方法
公开(公告)号：US06420529B1
公开(公告)日：2002-07-16
申请号：US09035233
申请日：1998-03-05
申请人： Pamela Silver , Tom Roberts , Charles Stiles
发明人： Pamela Silver , Tom Roberts , Charles Stiles
IPC分类号： C07K1900
CPC分类号： C12N9/1205 , C07K14/39 , C07K2319/00
摘要： A chimeric protein having an (a) IRE1 or analog cytoplasmic kinase domain, (b) a transmembrane domain, and (c) a ligand binding domain of a transmembrane protein other than IRE1 is described. This protein can be used to identify and/or screen for ligands and other molecules that interact with the ligand binding domain.
摘要翻译：描述了具有（a）IRE1或类似细胞质激酶结构域的嵌合蛋白，（b）跨膜结构域，和（c）除了IRE1之外的跨膜蛋白的配体结合结构域。该蛋白质可用于鉴定和/或筛选与配体结合结构域相互作用的配体和其他分子。

2. 发明授权

US06248867B1 Trabecular meshwork induced glucocorticoid response (TIGR) fusion protein 失效
标题翻译：小梁网诱导糖皮质激素反应（TIGR）融合蛋白
公开(公告)号：US06248867B1
公开(公告)日：2001-06-19
申请号：US08546568
申请日：1995-10-20
申请人： Thai D. Nguyen , Jon R. Polansky , Weidong Huang
发明人： Thai D. Nguyen , Jon R. Polansky , Weidong Huang
IPC分类号： C07K1900
CPC分类号： C12Q1/6883 , A01K2217/05 , C07K14/47 , C07K2319/00 , C12Q2600/106 , C12Q2600/158 , G01N33/6893 , G01N33/743 , G01N2800/168
摘要： A glucocorticoid-induced protein, TIGR, that is produced by cells of the trabecular meshwork can be used to diagnose glaucoma. The TIGR protein, anti-TIGR antibodies, and TIGR encoding sequences also provide a diagnostic for glaucoma and its related diseases.
摘要翻译：可以使用由小梁网细胞产生的糖皮质激素诱导的蛋白质TIGR来诊断青光眼。 TIGR蛋白，抗TIGR抗体和TIGR编码序列也为青光眼及其相关疾病提供诊断。

3. 发明授权

US06730303B1 Fused G-CSF and IL-3 proteins and uses thereof 失效
标题翻译：融合的G-CSF和IL-3蛋白及其用途
公开(公告)号：US06730303B1
公开(公告)日：2004-05-04
申请号：US09510238
申请日：2000-02-22
申请人： Yiqing Feng , Nicholas R. Staten , Charles M. Baum , Neena L. Summers , Maire Helena Caparon , S. Christopher Bauer , Linda L. Zurfluh , John P. McKearn , Barbara K. Klein , Stephen C. Lee , Charles A. McWherter , Judith G. Giri
发明人： Yiqing Feng , Nicholas R. Staten , Charles M. Baum , Neena L. Summers , Maire Helena Caparon , S. Christopher Bauer , Linda L. Zurfluh , John P. McKearn , Barbara K. Klein , Stephen C. Lee , Charles A. McWherter , Judith G. Giri
IPC分类号： C07K1900
CPC分类号： C07K14/5403 , A61K38/00 , A61K48/00 , A61K2035/124 , A61K2039/51 , C07K14/524 , C07K14/53 , C07K2319/00 , C07K2319/75 , C12N15/62
摘要： Disclosed are novel multi-functional hematopoietic receptor agonist proteins, DNAs which encode the multi-functional hematopoietic receptor agonists proteins, methods of making the multi-functional hematopoietic receptor agonists proteins and methods of using the multi-functional hematopoietic receptor agonists proteins.
摘要翻译：公开了新型多功能造血受体激动剂蛋白质，编码多功能造血受体激动剂蛋白质的DNA，制备多功能造血受体激动剂蛋白质的方法和使用多功能造血受体激动剂蛋白质的方法。

4. 发明授权

US06500646B1 Cell membrane-directed drugs 失效
标题翻译：细胞膜导向药物
公开(公告)号：US06500646B1
公开(公告)日：2002-12-31
申请号：US09331793
申请日：1999-06-25
申请人： Shinichi Kuriyama , Takashi Hasegawa
发明人： Shinichi Kuriyama , Takashi Hasegawa
IPC分类号： C07K1900
CPC分类号： C12N9/6464 , A61K38/00 , A61K47/6425 , C07K14/70596 , C07K14/7455 , C07K14/755 , C07K14/8114 , C07K2319/00 , C12N9/647 , C12P21/02 , C12Y304/21069
摘要： Drugs in which peptides having affinity specific for phospholipids, preferably those which are contained in the constituents of lipid bilayers forming the surface layers of cells and of which the proportion in the outer part of each lipid bilayer increases when the cell is not normal, for example, in the case where it is damaged, denatured or activated, and biologically active substances bind to each other, deoxyribonucleic acid (DNA) which codes for the amino acid sequence of the drug in the case where the biologically active substance is a peptide, and processes for producing such drugs. The drugs and novel peptides are useful as preventives and therapeutics of diseases involving coagulopathy, inflammations and immune response.
摘要翻译：药物，其中对磷脂具有亲和性的肽，优选包含在形成细胞表面层的脂质双层组分中的肽，并且当细胞不正常时，其在每种脂质双层的外部部分中的比例增加在损伤，变性或活化的情况下，生物活性物质彼此结合时，在生物活性物质为肽的情况下编码药物的氨基酸序列的脱氧核糖核酸（DNA），以及生产此类药物的方法。药物和新型肽可用作涉及凝血病，炎症和免疫应答的疾病的预防药物和治疗剂。

5. 发明授权

US06498233B1 Nucleic acid transfer system 失效
标题翻译：核酸转运系统
公开(公告)号：US06498233B1
公开(公告)日：2002-12-24
申请号：US08840713
申请日：1997-04-25
申请人： Winfried Wels , Jesus Fominaya
发明人： Winfried Wels , Jesus Fominaya
IPC分类号： C07K1900
CPC分类号： C07K5/1024 , A61K38/00 , C07K5/1019 , C07K14/21 , C07K14/39 , C07K2319/00 , C07K2319/02 , C07K2319/43 , C07K2319/55 , C07K2319/75 , C07K2319/81 , C12N15/62 , C12N15/87
摘要： The invention pertains to a nucleic acid transfer system including a translocation domain of toxins, especially of diphtheria toxin suitable for targeting a nucleic acid, e.g. a gene, to a specific cell, and obtaining expression of said nucleic acid. The nucleic acid transfer system of the invention comprises a multidomain protein component and a nucleic acid component. Furthermore, the present invention relates to the multidomain protein, a nucleic acid encoding said protein, suitable amplification and expression systems for said nucleic acid, and processes for the preparation and uses of the above subject matters.
摘要翻译：本发明涉及包含毒素易位结构域的核酸转运系统，特别是适于靶向核酸的白喉毒素的易位结构域。基因，特定细胞，获得所述核酸的表达。本发明的核酸转移系统包含多结构域蛋白质组分和核酸组分。此外，本发明涉及多结构域蛋白，编码所述蛋白的核酸，所述核酸的合适的扩增和表达系统，以及上述主题的制备和用途的方法。

6. 发明授权

US06613882B1 Chimeric polypeptide comprising the fragment B of shiga toxin and peptides of therapeutic interest 有权
标题翻译：包含志贺毒素片段B的嵌合多肽和具有治疗兴趣的肽
公开(公告)号：US06613882B1
公开(公告)日：2003-09-02
申请号：US09484471
申请日：2000-01-18
申请人： Bruno Goud , Ludger Johannes
发明人： Bruno Goud , Ludger Johannes
IPC分类号： C07K1900
CPC分类号： C07K14/4748 , A61K38/00 , A61K39/0011 , A61K2039/53 , A61K2039/572 , C07K14/245 , C07K14/25 , C07K14/4712 , C07K14/705 , C07K2319/00 , C07K2319/40 , C07K2319/55
摘要： The invention pertains to chimeric polypeptides of the formula: B—X wherein B represents the B fragment of Shiga toxin or a functional equivalent thereof, and X represents one or more polypeptides of therapeutic significance. Compositions for therapeutic use comprising the polypeptide B—X are also included.
摘要翻译：本发明涉及下式的嵌合多肽：其中B表示志贺毒素的B片段或其功能等同物，X表示一种或多种具有治疗意义的多肽。也包括含多肽B-X的用于治疗用途的组合物。

7. 发明授权

US06500436B2 Clostridial toxin derivatives and methods for treating pain 有权
公开(公告)号：US06500436B2
公开(公告)日：2002-12-31
申请号：US09922093
申请日：2001-08-03
申请人： Stephen Donovan
发明人： Stephen Donovan
IPC分类号： C07K1900
CPC分类号： A61K38/4893 , A61K47/6415 , A61K47/642 , A61K48/00 , C07K7/22 , C07K14/33 , C07K2319/00
摘要： Agents for treating pain, methods for producing the agents and methods for treating pain by administration to a patient of a therapeutically effective amount of the agent. The agent can include a clostridial neurotoxin, or a component or fragment or derivative thereof, attached to a targeting moiety, wherein the targeting moiety is selected from a group consisting of transmission compounds which can be released from neurons upon the transmission of pain signals by the neurons, and compounds substantially similar to the transmission compounds.

8. 发明授权

US06271348B1 Tetracycline-inducible transcriptional inhibitor fusion proteins 有权
标题翻译：四环素诱导型转录抑制剂融合蛋白
公开(公告)号：US06271348B1
公开(公告)日：2001-08-07
申请号：US09489777
申请日：2000-01-24
申请人： Hermann Bujard , Manfred Gossen
发明人： Hermann Bujard , Manfred Gossen
IPC分类号： C07K1900
CPC分类号： C07K14/005 , A01K67/0275 , A01K2217/05 , A01K2217/075 , A01K2217/20 , A01K2227/105 , A01K2267/0393 , A61K48/00 , C07K14/245 , C07K2319/00 , C07K2319/09 , C07K2319/61 , C07K2319/71 , C07K2319/80 , C12N15/62 , C12N15/63 , C12N15/635 , C12N15/67 , C12N15/85 , C12N15/8509 , C12N2710/16622 , C12N2830/003 , C12N2830/006 , C12N2830/32
摘要： Methods of regulating gene expression in subjects using tetracycline-responsive fusion proteins are disclosed. In one embodiment, the method involves introducing into a cell the subject a nucleic acid molecule encoding a fusion protein which inhibits transcription, the fusion protein comprising a first polypeptide which binds to a tet operator sequence, operatively linked to a heterologous second polypeptide which inhibits transcription in eukaryotic cells; and modulating the concentration of a tetracycline, or analogue thereof, in the subject. The first polypeptide can binds to a tet operator sequence in the absence, but not the presence, of tetracycline. Alternatively, the first polypeptide can binds to a tet operator sequence in the presence, but not the absence, of tetracycline. In another embodiment, the method of the invention involves obtaining a cell from a subject, introducing into the cell a first nucleic acid molecule which operatively links a gene to at least one tet operator sequence, introducing into the cell a second nucleic acid molecule encoding an inhibitory fusion protein of the invention to form a modified cell, administering the modified cell to the subject and modulating the concentration of a tetracycline, or analogue thereof, in the subject. The first and second nucleic acid molecules can be linked or can be separate molecules.
摘要翻译：公开了使用四环素响应融合蛋白调节受试者基因表达的方法。在一个实施方案中，该方法包括向受试者引入编码抑制转录的融合蛋白的核酸分子，该融合蛋白包含与tet操纵子序列结合的第一多肽，该第一多肽与抑制转录的异源第二多肽有效连接在真核细胞中并调节受试者中四环素或其类似物的浓度。在不存在但不存在四环素的情况下，第一种多肽可以结合tet操纵子序列。或者，第一多肽可以在四环素存在下但不存在时与tet操纵子序列结合。在另一个实施方案中，本发明的方法涉及从受试者获得细胞，将在第一核酸分子中引入至少一个tet操纵子序列的第一核酸分子，将编码本发明的抑制性融合蛋白以形成修饰的细胞，向受试者施用修饰的细胞并调节受试者中四环素或其类似物的浓度。第一和第二核酸分子可以连接或可以是分开的分子。

9. 发明授权

US06818747B2 G&agr;q protein variants and their use in the analysis and discovery of agonists and antagonists of chemosensory receptors 有权
标题翻译： Galphaq蛋白质变体及其在分析和发现化学感应受体激动剂和拮抗剂中的用途
公开(公告)号：US06818747B2
公开(公告)日：2004-11-16
申请号：US09984292
申请日：2001-10-29
申请人： Yong Yao , Hong Xu
发明人： Yong Yao , Hong Xu
IPC分类号： C07K1900
CPC分类号： C07K14/4722 , C07K2319/00
摘要： The invention provides a series of G&agr;q protein variants that functionally couple to sensory cell receptors such as taste GPCRs (TRs) and olfactory GPCRs (ORs) in an overly promiscuous manner. According to the invention, the functional coupling can be determined, for example, by measuring changes in intracellular IP3, or calcium. In a particular embodiment, the G&agr;q protein variants can be expressed in mammalian cell lines or Xenopus oocytes, and then evaluated using calcium fluorescence imaging and electrophysiological recording.
摘要翻译：本发明提供了一系列Galphaq蛋白质变体，其以过度混杂的方式功能性地耦合到感觉细胞受体，例如味道GPCR（TR）和嗅觉GPCR（OR））。根据本发明，功能性偶联可以通过例如测量细胞内IP3或钙的变化来确定。在一个具体实施方案中，Galphaq蛋白质变体可以在哺乳动物细胞系或非洲爪蟾卵母细胞中表达，然后使用钙荧光成像和电生理记录进行评估。

10. 发明授权

US06663867B2 Hybrid heterodimeric protein hormone comprising a TNF binding protein and a glycoprotein hormone subunit and method of using same 失效
标题翻译：包含TNF结合蛋白和糖蛋白激素亚基的杂合异二聚体蛋白激素及其使用方法
公开(公告)号：US06663867B2
公开(公告)日：2003-12-16
申请号：US09756186
申请日：2001-01-09
申请人： Robert K. Campbell , Bradford A. Jameson , Scott C. Chappel
发明人： Robert K. Campbell , Bradford A. Jameson , Scott C. Chappel
IPC分类号： C07K1900
CPC分类号： C07C209/22 , A61K38/00 , C07K14/59 , C07K14/715 , C07K2319/00
摘要： A hybrid protein includes two coexpressed amino acid sequences forming a dimer. Each sequence contains the binding portion of a receptor, such as TBP1 or TBP2, or a ligand, such as IL-6, IFN-&bgr; and TPO, linked to a subunit of a heterodimeric proteinaceous hormone, such as hCG. Each coexpressed sequence contains a corresponding hormone subunit so as to form a heterodimer upon expression. Corresponding DNA molecules, expression vectors and host cells are also disclosed as are pharmaceutical compositions and a method of producing such proteins.
摘要翻译：杂交蛋白包括形成二聚体的两个共表达的氨基酸序列。每个序列包含与异源二聚体蛋白质激素例如hCG的亚基连接的受体的结合部分，例如TBP1或TBP2，或配体，例如IL-6，IFN-β和TPO。每个共表达序列含有相应的激素亚基，以便在表达时形成异二聚体。还公开了相应的DNA分子，表达载体和宿主细胞，药物组合物和生产这种蛋白质的方法。

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