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1. 发明申请

US20090240039A1 Polypeptide fusion 审中-公开
标题翻译：多肽融合
公开(公告)号：US20090240039A1
公开(公告)日：2009-09-24
申请号：US11929292
申请日：2007-10-30
申请人： Robert K. CAMPBELL , Bradford A. Jameson , Scott C. Chappel
发明人： Robert K. CAMPBELL , Bradford A. Jameson , Scott C. Chappel
IPC分类号： C07K14/00
CPC分类号： C07C209/22 , A61K38/00 , C07K14/59 , C07K14/715 , C07K2319/00
摘要： A hybrid protein includes two coexpressed amino acid sequences forming a dimer. Each sequence contains the binding portion of a receptor, such as TBP1 or TBP2, or a ligand, such as IL-6, IFN-β and TPO, linked to a subunit of a natural heterodimeric scaffold. Each coexpressed sequence contains a corresponding subunit so as to form a heterodimer upon expression. Corresponding DNA molecules, expression vectors and host cells are also disclosed as are pharmaceutical compositions and a method of producing such proteins.
摘要翻译：杂交蛋白包括形成二聚体的两个共表达的氨基酸序列。每个序列包含与天然异二聚体支架的亚基连接的受体的结合部分，例如TBP1或TBP2，或配体，例如IL-6，IFN-β和TPO。每个共表达序列含有相应的亚基，以便在表达时形成异二聚体。还公开了相应的DNA分子，表达载体和宿主细胞，药物组合物和生产这种蛋白质的方法。

2. 发明授权

US07291339B2 Homogeneity and secretion of a recombinant follicle stimulating hormone (FSH) in mammalian systems 失效
标题翻译：在哺乳动物系统中重组卵泡刺激素（FSH）的同质性和分泌
公开(公告)号：US07291339B2
公开(公告)日：2007-11-06
申请号：US10724226
申请日：2003-12-01
申请人： Robert K. Campbell , Bradford A. Jameson , Scott C. Chappel
发明人： Robert K. Campbell , Bradford A. Jameson , Scott C. Chappel
IPC分类号： A61K39/00 , C07K19/00 , C07K14/435 , C07K209/22 , C07K209/00 , C07K14/59 , C07K14/715
CPC分类号： C07C209/22 , A61K38/00 , C07K14/59 , C07K14/715 , C07K2319/00
摘要： A hybrid protein includes two coexpressed amino acid sequences forming a dimer. Each sequence contains the binding portion of a receptor, such as TBP1 or TBP2, or a ligand, such as IL-6, IFN-β and TPO, linked to α subunit of a natural heterodimeric scaffold. Each coexpressed sequence contains a corresponding subunit so as to form a heterodimer upon expression. Corresponding DNA molecules, expression vectors and host cells are also disclosed as are pharmaceutical compositions and a method of producing such proteins.
摘要翻译：杂交蛋白包括形成二聚体的两个共表达的氨基酸序列。每个序列含有与天然异二聚体支架的α亚基连接的受体的结合部分，例如TBP1或TBP2，或配体，例如IL-6，IFN-β和TPO。每个共表达序列含有相应的亚基，以便在表达时形成异二聚体。还公开了相应的DNA分子，表达载体和宿主细胞，药物组合物和生产这种蛋白质的方法。

3. 发明授权

US06194177B1 DNA encoding a hybrid heterodimeric protein 失效
标题翻译：编码杂交异二聚体蛋白的DNA
公开(公告)号：US06194177B1
公开(公告)日：2001-02-27
申请号：US08910991
申请日：1997-08-14
申请人： Robert K. Campbell , Bradford A. Jameson , Scott C. Chappel
发明人： Robert K. Campbell , Bradford A. Jameson , Scott C. Chappel
IPC分类号： C12P2104
CPC分类号： C07C209/22 , A61K38/00 , C07K14/59 , C07K14/715 , C07K2319/00
摘要： A hybrid protein includes two coexpressed amino acid sequences forming a dimer. Each sequence contains the binding portion of a receptor, such as TBP1 or TBP2, or a ligand, such as IL-6, IFN-&bgr;and TPO, linked to a subunit of a heterodimeric proteinaceous hormone, such as hCG. Each coexpressed sequence contains a corresponding hormone subunit so as to form a heterodimer upon expression. Corresponding DNA molecules, expression vectors and host cells are also disclosed as are pharmaceutical compositions and a method of producing such proteins.
摘要翻译：杂交蛋白包括形成二聚体的两个共表达的氨基酸序列。每个序列含有受体的结合部分，例如TBP1或TBP2，或与异源二聚体蛋白质激素例如hCG的亚基连接的配体，例如IL-6，IFN-β和TPO。每个共表达序列含有相应的激素亚基，以便在表达时形成异二聚体。还公开了相应的DNA分子，表达载体和宿主细胞，药物组合物和生产这种蛋白质的方法。

4. 发明申请

US20100075402A1 DNA coding for polypeptide fusion 审中-公开
标题翻译：编码多肽融合的DNA
公开(公告)号：US20100075402A1
公开(公告)日：2010-03-25
申请号：US11861835
申请日：2007-09-26
申请人： Robert K. Campbell , Bradford A. Jameson , Scott C. Chappel
发明人： Robert K. Campbell , Bradford A. Jameson , Scott C. Chappel
IPC分类号： C12N1/16 , C07H21/04 , C12N15/74
CPC分类号： C07C209/22 , A61K38/00 , C07K14/59 , C07K14/715 , C07K2319/00
摘要： A hybrid protein includes two coexpressed amino acid sequences forming a dimer. Each sequence contains the binding portion of a receptor, such as TBP1 or TBP2, or a ligand, such as IL-6, IFN-β and TPO, linked to a subunit of a natural heterodimeric scaffold. Each coexpressed sequence contains a corresponding subunit so as to form a heterodimer upon expression. Corresponding DNA molecules, expression vectors and host cells are also disclosed as are pharmaceutical compositions and a method of producing such proteins.
摘要翻译：杂交蛋白包括形成二聚体的两个共表达的氨基酸序列。每个序列包含受体的结合部分，例如TBP1或TBP2，或配体，例如IL-6，IFN-和bgr; 和TPO，其与天然异二聚体支架的亚基连接。每个共表达序列含有相应的亚基，以便在表达时形成异二聚体。还公开了相应的DNA分子，表达载体和宿主细胞，药物组合物和生产这种蛋白质的方法。

5. 发明授权

US06663867B2 Hybrid heterodimeric protein hormone comprising a TNF binding protein and a glycoprotein hormone subunit and method of using same 失效
标题翻译：包含TNF结合蛋白和糖蛋白激素亚基的杂合异二聚体蛋白激素及其使用方法
公开(公告)号：US06663867B2
公开(公告)日：2003-12-16
申请号：US09756186
申请日：2001-01-09
申请人： Robert K. Campbell , Bradford A. Jameson , Scott C. Chappel
发明人： Robert K. Campbell , Bradford A. Jameson , Scott C. Chappel
IPC分类号： C07K1900
CPC分类号： C07C209/22 , A61K38/00 , C07K14/59 , C07K14/715 , C07K2319/00
摘要： A hybrid protein includes two coexpressed amino acid sequences forming a dimer. Each sequence contains the binding portion of a receptor, such as TBP1 or TBP2, or a ligand, such as IL-6, IFN-&bgr; and TPO, linked to a subunit of a heterodimeric proteinaceous hormone, such as hCG. Each coexpressed sequence contains a corresponding hormone subunit so as to form a heterodimer upon expression. Corresponding DNA molecules, expression vectors and host cells are also disclosed as are pharmaceutical compositions and a method of producing such proteins.
摘要翻译：杂交蛋白包括形成二聚体的两个共表达的氨基酸序列。每个序列包含与异源二聚体蛋白质激素例如hCG的亚基连接的受体的结合部分，例如TBP1或TBP2，或配体，例如IL-6，IFN-β和TPO。每个共表达序列含有相应的激素亚基，以便在表达时形成异二聚体。还公开了相应的DNA分子，表达载体和宿主细胞，药物组合物和生产这种蛋白质的方法。

6. 发明授权

US06193972B1 Hybrid heterodimeric protein hormone 失效
标题翻译：杂种异二聚体蛋白激素
公开(公告)号：US06193972B1
公开(公告)日：2001-02-27
申请号：US08804166
申请日：1997-02-20
申请人： Robert K. Campbell , Bradford A. Jameson , Scott C. Chappel
发明人： Robert K. Campbell , Bradford A. Jameson , Scott C. Chappel
IPC分类号： C07K1900
CPC分类号： C07C209/22 , A61K38/00 , C07K14/59 , C07K14/715 , C07K2319/00
摘要： A hybrid protein includes two coexpressed amino acid sequences forming a dimer. Each sequence contains the binding portion of a receptor, such as TBP1 or TBP2, or a ligand, such as IL-6, IFN-&bgr; and TPO, linked to a subunit of a heterodimeric proteinaceous hormone, such as hCG. Each coexpressed sequence contains a corresponding hormone subunit so as to form a heterodimer upon expression. Corresponding DNA molecules, expression vectors and host cells are also disclosed as are pharmaceutical compositions and a method of producing such proteins.
摘要翻译：杂交蛋白包括形成二聚体的两个共表达的氨基酸序列。每个序列包含与异源二聚体蛋白质激素例如hCG的亚基连接的受体的结合部分，例如TBP1或TBP2，或配体，例如IL-6，IFN-β和TPO。每个共表达序列含有相应的激素亚基，以便在表达时形成异二聚体。还公开了相应的DNA分子，表达载体和宿主细胞，药物组合物和生产这种蛋白质的方法。

7. 发明授权

US5272071A Method for the modification of the expression characteristics of an endogenous gene of a given cell line 失效
标题翻译：修饰给定细胞系内源基因表达特征的方法
公开(公告)号：US5272071A
公开(公告)日：1993-12-21
申请号：US893447
申请日：1992-05-28
申请人： Scott C. Chappel
发明人： Scott C. Chappel
IPC分类号： C12N15/67 , C12N15/85 , C12N15/90 , C12N15/00 , C12N5/00 , C12P21/06
CPC分类号： C12N15/85 , C12N15/67 , C12N15/907
摘要： Normally transcriptionally silent genes in a cell line or microorganism may be activated for expression by inserting a DNA regulatory element which is capable of promoting the expression of a normally expressed gene product in that cell or which is promiscuous, the regulatory element being inserted so as to be operatively linked with the normally silent gene in question. The insertion is accomplished by means of homologous recombination by creating a DNA construct including a segment having a DNA segment of the normally silent gene (targeting DNA) and the DNA regulatory element to induce gene transcription. The technique is also used to modify the expression characteristics of any endogenous gene of a given cell line or microorganism.
摘要翻译： PCT No.PCT / US90 / 07642 Sec。 371日期：1992年5月28日 102（e）日期1992年5月28日PCT 1990年12月21日PCT。通过插入能够促进正常表达基因表达的DNA调节元件，细胞系或微生物中的正常转录沉默基因可以被激活以进行表达该细胞中的产物或者是混杂的，所述调节元件被插入以便与所讨论的通常沉默的基因有效连接。通过产生包含具有正常沉默基因的DNA区段（靶向DNA）的区段和DNA调节元件诱导基因转录的DNA构建体，通过同源重组来实现插入。该技术还用于修饰给定细胞系或微生物的任何内源基因的表达特征。

8. 发明授权

US5679340A Cells with multiple altered epitopes on a surface antigen for use in transplantation 失效
标题翻译：在表面抗原上具有多个改变的表位的细胞用于移植
公开(公告)号：US5679340A
公开(公告)日：1997-10-21
申请号：US240150
申请日：1994-05-10
申请人： Scott C. Chappel
发明人： Scott C. Chappel
IPC分类号： A61K35/12 , A61K35/28 , A61K35/30 , A61K35/34 , A61K35/39 , A61K35/407 , A61K39/00 , C07K16/28 , C12N5/071 , C12N5/00 , A01N63/00
CPC分类号： C07K16/2833 , A61K35/28 , A61K35/30 , A61K35/34 , A61K35/39 , A61K35/407 , C12N5/0676 , A61K2035/122 , A61K2039/505 , A61K35/12 , C07K2317/54
摘要： Cells suitable for transplantation which have at least two different epitopes on a surface antigen altered prior to transplantation to inhibit rejection of the cells following transplantation into an allogeneic or xenogeneic recipient are disclosed. These cells are more successfully transplanted than cells which have only a single epitope on the surface antigen altered. Preferably, the antigen on the cell surface which is altered is an MHC class I antigen. Two different epitopes on an MHC class I antigen can be altered by contacting the cell with two molecules, such as antibodies or fragments thereof (e.g., F(ab').sub.2 fragments), which bind to two different epitopes on the antigen. Preferred epitopes on human MHC class I antigens to be altered are epitopes recognized by the monoclonal antibodies W6/32 and PT85. Improved methods for transplantation utilizing cells which have at least two different epitopes on a surface antigen altered prior to transplantation are also disclosed.
摘要翻译：公开了适用于在移植前在表面抗原上具有至少两个不同表位的移植的细胞，以在移植到同种异体或异种受体中后抑制细胞排斥。这些细胞比表面抗原上仅具有单个表位的细胞更能成功移植。优选地，改变的细胞表面上的抗原是MHC I类抗原。通过使细胞与两个分子例如抗体或其片段（例如，F（ab'）2片段）接触来改变MHC I类抗原上的两个不同表位，其结合抗原上的两个不同表位。待改变的人MHC I类抗原上的优选表位是由单克隆抗体W6 / 32和PT85识别的表位。还公开了利用在移植前改变的表面抗原上具有至少两个不同表位的细胞的改进的移植方法。

9. 发明授权

US5602006A Heteropolymeric protein production methods 失效
标题翻译：异构蛋白质生产方法
公开(公告)号：US5602006A
公开(公告)日：1997-02-11
申请号：US455396
申请日：1995-05-31
申请人： Christie A. Kelton , Noreen P. Nugent , Scott C. Chappel
发明人： Christie A. Kelton , Noreen P. Nugent , Scott C. Chappel
IPC分类号： C07K14/575 , C07K14/59 , C12N15/00 , C12N15/16 , C12N15/67 , C12N15/79 , C12N15/85 , C12P21/04 , C12P21/02 , C12N5/10
CPC分类号： C07K14/59 , C07K14/575 , C12N15/00 , C12N15/67 , C12N15/79 , C12N15/85 , C12N2800/108 , C12N2830/002 , C12N2830/42 , C12N2830/85 , C12N2840/44 , Y10S930/11
摘要： Cultured mammalian cell transfected with new vectors comprising full-length or partial .alpha. and .beta. subunit genomic DNA sequences produce significantly higher levels of dimeric glycoprotein hormone than do cells transfected with .alpha. and .beta. subunit cDNA sequences. In cases where only the cDNA clones are available, the cDNA sequences can be used in new expression vectors comprising introns or other important genomic regions from a homologous or heterologous source.
摘要翻译：用包含全长或部分α和β亚基基因组DNA序列的新载体转染的培养的哺乳动物细胞产生比用α和β亚基cDNA序列转染的细胞显着更高水平的二聚糖蛋白激素。在只有cDNA克隆可用的情况下，cDNA序列可用于包含内含子或来自同源或异源的其他重要基因组区域的新表达载体。

10. 发明授权

US6096537A Cells with multiple altered epitopes on a surface antigen for use in transplantation 失效
标题翻译：在表面抗原上具有多个改变的表位的细胞用于移植
公开(公告)号：US6096537A
公开(公告)日：2000-08-01
申请号：US946637
申请日：1997-10-07
申请人： Scott C. Chappel
发明人： Scott C. Chappel
IPC分类号： A61K35/12 , A61K35/28 , A61K35/30 , A61K35/34 , A61K35/39 , A61K35/407 , A61K39/00 , C07K16/28 , C12N5/071 , C12N5/00 , A61F13/00 , G01N33/53 , C07K16/00
CPC分类号： C07K16/2833 , A61K35/28 , A61K35/30 , A61K35/34 , A61K35/39 , A61K35/407 , C12N5/0676 , A61K2035/122 , A61K2039/505 , A61K35/12 , C07K2317/54
摘要： Cells suitable for transplantation which have at least two different epitopes on a surface antigen altered prior to transplantation to inhibit rejection of the cells following transplantation into an allogeneic or xenogeneic recipient are disclosed. These cells are more successfully transplanted than cells which have only a single epitope on the surface antigen altered. Preferably, the antigen on the cell surface which is altered is an MHC class I antigen. Two different epitopes on an MHC class I antigen can be altered by contacting the cell with two molecules, such as antibodies or fragments thereof (e.g., F(ab').sub.2 fragments), which bind to two different epitopes on the antigen. Preferred epitopes on human MHC class I antigens to be altered are epitopes recognized by the monoclonal antibodies W6/32 and PT85. Improved methods for transplantation utilizing cells which have at least two different epitopes on a surface antigen altered prior to transplantation are also disclosed.
摘要翻译：公开了适用于在移植前在表面抗原上具有至少两个不同表位的移植的细胞，以在移植到同种异体或异种受体中后抑制细胞排斥。这些细胞比表面抗原上仅具有单个表位的细胞更能成功移植。优选地，改变的细胞表面上的抗原是MHC I类抗原。通过使细胞与两个分子例如抗体或其片段（例如，F（ab'）2片段）接触来改变MHC I类抗原上的两个不同表位，其结合抗原上的两个不同表位。待改变的人MHC I类抗原上的优选表位是由单克隆抗体W6 / 32和PT85识别的表位。还公开了利用在移植前改变的表面抗原上具有至少两个不同表位的细胞的改进的移植方法。

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