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1. 发明授权

US12063914B2 DNA sequence that increases odorant receptor representation in the olfactory system 有权
公开(公告)号：US12063914B2
公开(公告)日：2024-08-20
申请号：US16704740
申请日：2019-12-05
申请人： Research Foundation of the City University of New York
发明人： Paul Feinstein , Charlotte D'Hulst
IPC分类号： C12N15/85 , A01K67/0275
CPC分类号： A01K67/0275 , C12N15/85 , C12N15/8509 , A01K2217/072 , A01K2217/20 , A01K2227/10 , A01K2267/02
摘要： A genetically modified vertebrate is provided that has an enhanced sense due to an over representation of a predetermined odorant receptor. The vertebrate is genetically modified by introduction of DNA that comprises at least four sequential repeats of a sequence whose primary structure is at least 90% homologous with ACATAACTTTTTAATGAGTCT (SEQ ID NO: 1). The DNA causes a nearby odorant receptor coding sequence to be over represented in a singular gene choice fashion relative to a corresponding vertebrate that lacks the DNA.

2. 发明授权

US11963521B2 Humanized IL-4 and IL-4Rα animals 有权
公开(公告)号：US11963521B2
公开(公告)日：2024-04-23
申请号：US17394492
申请日：2021-08-05
申请人： Regeneron Pharmaceuticals, Inc.
发明人： Li-Hsien Wang , Yingzi Xue , Andrew J. Murphy , Sean Stevens
IPC分类号： G01N33/00 , A01K67/0278 , C07K14/54 , C07K14/715
CPC分类号： A01K67/0278 , C07K14/5406 , C07K14/7155 , A01K2207/15 , A01K2217/072 , A01K2217/20 , A01K2227/105 , A01K2267/01 , A01K2267/0368 , A01K2267/0393
摘要： Non-human animals comprising a human or humanized IL-4 and/or IL-4Rα nucleic acid sequence are provided. Non-human animals that comprise a replacement of the endogenous IL-4 gene and/or IL-4Rα gene with a human IL-4 gene and/or IL-4Rα gene in whole or in part, and methods for making and using the non-human animals, are described. Non-human animals comprising a human or humanized IL-4 gene under control of non-human IL-4 regulatory elements is also provided, including non-human animals that have a replacement of non-human IL-4-encoding sequence with human IL-4-encoding sequence at an endogenous non-human IL-4 locus. Non-human animals comprising a human or humanized IL-4Rα gene under control of non-human IL-4Rα regulatory elements is also provided, including non-human animals that have a replacement of non-human IL-4Rα-encoding sequence with human or humanized IL-4Rα-encoding sequence at an endogenous non-human C IL-4Rα locus. Non-human animals comprising human or humanized IL-4 gene and/or IL-4Rα sequences, wherein the non-human animals are rodents, e.g., mice or rats, are provided.

3. 发明申请

US20180140720A1 COMPOSITIONS AND METHODS FOR TISSUE REGENERATION 审中-公开
公开(公告)号：US20180140720A1
公开(公告)日：2018-05-24
申请号：US15461551
申请日：2017-03-17
申请人： Duke University
发明人： Kenneth D. Poss , Junsu Kang , Ravi Karra
IPC分类号： A61K48/00 , C12N5/10 , C12N5/074 , C07K14/46 , C12N15/861 , A61P9/00
CPC分类号： A61K48/005 , A01K2217/20 , A61P9/00 , C07K14/461 , C12N5/0696 , C12N5/10 , C12N15/86 , C12N15/861 , C12N2015/8572 , C12N2320/10 , C12N2510/00 , C12N2750/14143 , C12N2800/106
摘要： The present disclosure relates to compositions and methods for tissue regeneration.

4. 发明申请

US20160060651A1 EXPRESSION SYSTEMS 审中-公开
标题翻译：表达系统
公开(公告)号：US20160060651A1
公开(公告)日：2016-03-03
申请号：US14839683
申请日：2015-08-28
申请人： Oxitec Limited
发明人： Luke ALPHEY
IPC分类号： C12N15/85
CPC分类号： C12N15/85 , A01K67/0333 , A01K2217/05 , A01K2217/20 , A01K2227/70 , A01K2227/706 , A01K2267/02 , C12N15/8509 , C12N2830/007 , C12N2830/008
摘要： A gene expression system is provided. The system comprises at least one coding sequence to be expressed in an organism, and at least one promoter operably linked thereto. It further comprises at least one splice control sequence which, in cooperation with a spliceosome, mediates alternative splicing of RNA transcripts of the coding sequence. The mediation of alternative splicing is in a sex-specific, stage-specific, germline-specific and tissue-specific manner.
摘要翻译：提供了基因表达系统。该系统包含至少一个要在生物体中表达的编码序列，以及至少一个与其可操作地连接的启动子。它还包括至少一个剪接控制序列，其与剪接体协同介导编码序列的RNA转录物的可变剪接。选择性剪接的调解是以性别特异性，阶段特异性，种系特异性和组织特异性方式。

5. 发明申请

US20150320021A1 HUMANIZED IL-4 AND IL-4Ra ANIMALS 有权
公开(公告)号：US20150320021A1
公开(公告)日：2015-11-12
申请号：US14706319
申请日：2015-05-07
申请人： REGENERON PHARMACEUTICALS, INC.
发明人： Li-Hsien Wang , Yingzi Xue , Andrew Murphy , Sean Stevens
IPC分类号： A01K67/027
CPC分类号： A01K67/0278 , A01K2207/15 , A01K2217/072 , A01K2217/20 , A01K2227/105 , A01K2267/01 , A01K2267/0368 , A01K2267/0393 , C07K14/5406 , C07K14/7155
摘要： Non-human animals comprising a human or humanized IL-4 and/or IL-4Rα nucleic acid sequence are provided. Non-human animals that comprise a replacement of the endogenous IL-4 gene and/or IL-4Rα gene with a human IL-4 gene and/or IL-4Rα gene in whole or in part, and methods for making and using the non-human animals, are described. Non-human animals comprising a human or humanized IL-4 gene under control of non-human IL-4 regulatory elements is also provided, including non-human animals that have a replacement of non-human IL-4-encoding sequence with human IL-4-encoding sequence at an endogenous non-human IL-4 locus. Non-human animals comprising a human or humanized IL-4Rα gene under control of non-human IL-4Rα regulatory elements is also provided, including non-human animals that have a replacement of non-human IL-4Rα-encoding sequence with human or humanized IL-4Rα-encoding sequence at an endogenous non-human C IL-4Rα locus. Non-human animals comprising human or humanized IL-4 gene and/or IL-4Rα sequences, wherein the non-human animals are rodents, e.g., mice or rats, are provided.

6. 发明授权

US09133477B2 Expression systems 有权
标题翻译：表达系统
公开(公告)号：US09133477B2
公开(公告)日：2015-09-15
申请号：US11352177
申请日：2006-02-10
申请人： Luke Alphey
发明人： Luke Alphey
IPC分类号： C12N15/00 , A01K67/00 , C12N15/85 , A01K67/033
CPC分类号： C12N15/85 , A01K67/0333 , A01K2217/05 , A01K2217/20 , A01K2227/70 , A01K2227/706 , A01K2267/02 , C12N15/8509 , C12N2830/007 , C12N2830/008
摘要： A gene expression system is provided. The system comprises at least one coding sequence to be expressed in an organism, and at least one promoter operably linked thereto. It further comprises at least one splice control sequence which, in cooperation with a spliceosome, mediates alternative splicing of RNA transcripts of the coding sequence. The mediation of alternative splicing is in a sex-specific, stage-specific, germline-specific and tissue-specific manner.
摘要翻译：提供了基因表达系统。该系统包含至少一个要在生物体中表达的编码序列，以及至少一个与其可操作地连接的启动子。它还包括至少一个剪接控制序列，其与剪接体协同介导编码序列的RNA转录物的可变剪接。选择性剪接的调解是以性别特异性，阶段特异性，种系特异性和组织特异性方式。

7. 发明授权

US09121036B2 Expression system for insect pest control 有权
标题翻译：用于虫害防治的表达系统
公开(公告)号：US09121036B2
公开(公告)日：2015-09-01
申请号：US10566448
申请日：2004-07-28
申请人： Luke Alphey
发明人： Luke Alphey
IPC分类号： C12N15/00 , A01K67/00 , C12N15/85 , A01K67/033
CPC分类号： C12N15/85 , A01K67/0333 , A01K2217/05 , A01K2217/20 , A01K2227/70 , A01K2227/706 , A01K2267/02 , C12N15/8509 , C12N2830/007 , C12N2830/008
摘要： Promoters active in insects can be enhanced by positive feedback mechanisms and associated with repressible lethal effects.
摘要翻译：通过正反馈机制可以增强活跃于昆虫中的启动子，并与抑制性致死作用相关联。

8. 发明申请

US20150240260A1 BACULOVIRAL DNA ELEMENTS FOR THE EXPRESSION OF RECOMBINANT PROTEINS IN A HOST INSECT 有权
标题翻译：用于在宿主体内表达重组蛋白的细菌DNA元件
公开(公告)号：US20150240260A1
公开(公告)日：2015-08-27
申请号：US14407709
申请日：2012-06-12
申请人： Silvia Gomez Sebastain , Javier López Vidal , José Angel Martinez Escribano
发明人： Silvia Gomez Sebastain , Javier López Vidal , José Angel Martinez Escribano
IPC分类号： C12N15/86 , A01K67/033
CPC分类号： C12N15/86 , A01K67/0339 , A01K2207/05 , A01K2217/20 , A01K2227/706 , A01K2267/01 , C12N2710/14043 , C12N2710/14122 , C12N2830/002 , C12N2830/205 , C12N2830/60
摘要： Reagents and methods are provided that allow for an improved expression of a recombinant protein in an insect, More specifically, the introduction of recombinant DNA elements into an insect larva allows for the increased expression of a recombinant protein, an improvement of the correct folding of said protein and an increase in the survival rate after infection of the insect These recombinant DNA elements can be introduced, for example, into insect larvae via a recombinant baculovirus, which has incorporated said elements. The recombinant DNA elements include nucleic acids encoding transcriptional regulators, such as IE-0 and IE-1, transcriptional, enhancer elements, such as the homologous region (hr) and promoters.
摘要翻译：提供了允许在昆虫中重组蛋白质的改进表达的试剂和方法。更具体地，将重组DNA元件引入昆虫幼虫允许增加表达重组蛋白质，改善所述重组蛋白质的正确折叠蛋白质和昆虫感染后的存活率的增加这些重组DNA元件可以通过重组杆状病毒引入到昆虫幼虫中，该重组杆状病毒已经结合了所述元件。重组DNA元件包括编码转录调节物的核酸，例如IE-0和IE-1，转录，增强子元件，例如同源区（hr）和启动子。

9. 发明申请

US20150208621A1 Transgenic Animal 审中-公开
标题翻译：转基因动物
公开(公告)号：US20150208621A1
公开(公告)日：2015-07-30
申请号：US14420638
申请日：2013-08-03
申请人： Foundation for Research & Technology Hellas-FORTH
发明人： George Mavrothalassitis
IPC分类号： A01K67/027 , C12N15/85
CPC分类号： A01K67/0276 , A01K2217/054 , A01K2217/075 , A01K2217/20 , A01K2227/105 , A01K2267/03 , A01K2267/0306 , C07K14/4703 , C12N15/8509
摘要： The present invention concerns a non-human transgenic animal comprising a modification in its genome which results in the animal exhibiting a level of Erf expression and/or ERF activity which is reduced compared to a wildtype animal, wherein said animal has a defect in ossification. Further provided is a non-human transgenic animal comprising an insertion of a promoter-marker gene cassette in one or both Erf alleles wherein the cassette is present in an intron of Erf and wherein said animal exhibits an expression level of Erf and/or ERF activity which is reduced compared to a wildtype animal. Uses of these animals and of a non-human transgenic animal comprising a modification in its genome which results in the animal exhibiting a level of expression of Erf and/or ERF activity which is reduced compared to a wildtype animal for producing animals with ossification defects, for identifying treatments and as disease models are encompassed.
摘要翻译：本发明涉及一种非人转基因动物，其包含其基因组中的修饰，其导致动物表现出与野生型动物相比降低的Erf表达和/或ERF活性水平，其中所述动物具有骨化缺陷。还提供了非人转基因动物，其包括在一个或两个Erf等位基因中插入启动子 - 标记基因盒，其中所述盒存在于Erf的内含子中，并且其中所述动物表现出Erf和/或ERF活性的表达水平其与野生型动物相比减少。这些动物和非人转基因动物的使用在其基因组中包含修饰，导致动物表现出与用于产生具有骨化缺陷的动物有关的野生型动物的Erf和/或ERF活性的表达水平，用于识别治疗并且包括疾病模型。

10. 发明授权

US08809618B2 Transgenic mouse for screening and for studies of the pharmacodynamics and pharmacokinetics of ligands acting on the oestrogen receptor and its intracellular receptors, and method for the preparation thereof 有权
标题翻译：用于筛选和用于研究作用于雌激素受体及其细胞内受体的配体的药效学和药代动力学的转基因小鼠及其制备方法
公开(公告)号：US08809618B2
公开(公告)日：2014-08-19
申请号：US13076807
申请日：2011-03-31
申请人： Adriana Caterina Maggi , Paolo Ciana
发明人： Adriana Caterina Maggi , Paolo Ciana
IPC分类号： G01N33/00 , A01K67/027 , A01N63/00 , C12N15/00 , C12N15/63 , C12N15/79 , C12N15/85
CPC分类号： A01K67/0275 , A01K2217/05 , A01K2217/20 , A01K2227/105 , A01K2267/03 , C12N15/79 , C12N15/8509 , G01N33/5088 , G01N2333/72 , G01N2333/723
摘要： The object of the invention is a method for the production of a non-human transgenic mammal by means of which it is possible to monitor in vivo and in all the tissues the state of activation of any intracellular receptor, utilizing a reporter gene inducible by natural or synthetic molecules which modulate the activity of such receptor. The mammal is question is preferably a mouse.
摘要翻译：本发明的目的是一种用于生产非人转基因哺乳动物的方法，通过该方法可以利用可诱导天然的报道基因在体内和所有组织中监测任何细胞内受体的活化状态或调节这种受体的活性的合成分子。哺乳动物的问题最好是老鼠。

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