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1. 发明授权

US5861497A Trabecular meshwork induced glucocorticoid response (TIGR) nucleic acid molecules 失效
标题翻译：小梁网诱导糖皮质激素反应（TIGR）核酸分子
公开(公告)号：US5861497A
公开(公告)日：1999-01-19
申请号：US667790
申请日：1996-06-21
申请人： Thai D. Nguyen , Jon R. Polansky , Weidong Huang
发明人： Thai D. Nguyen , Jon R. Polansky , Weidong Huang
IPC分类号： G01N33/53 , A61K38/00 , A61K45/00 , A61K48/00 , A61P27/02 , A61P27/06 , C07K14/47 , C07K16/18 , C07K19/00 , C12N5/10 , C12N15/09 , C12N15/12 , C12P21/02 , C12Q1/68 , C12R1/91 , G01N33/566 , G01N33/68 , G01N33/74 , C12N15/11
CPC分类号： C12Q1/6883 , C07K14/47 , G01N33/6893 , G01N33/743 , A01K2217/05 , C07K2319/00 , C12Q2600/106 , C12Q2600/158 , G01N2800/168
摘要： A glucocorticoid-induced protein, TIGR, that is produced by cells of the trabecular meshwork can be used to diagnose glaucoma. The TIGR protein, anti-TIGR antibodies, and TIGR encoding sequences also provide a diagnostic for glaucoma and its related diseases.
摘要翻译：可以使用由小梁网细胞产生的糖皮质激素诱导的蛋白质TIGR来诊断青光眼。 TIGR蛋白，抗TIGR抗体和TIGR编码序列也为青光眼及其相关疾病提供诊断。

2. 发明授权

US5606043A Methods for the diagnosis of glaucoma 失效
标题翻译：青光眼诊断方法
公开(公告)号：US5606043A
公开(公告)日：1997-02-25
申请号：US336235
申请日：1994-11-03
申请人： Thai D. Nguyen , Jon R. Polansky , Weidong Huang
发明人： Thai D. Nguyen , Jon R. Polansky , Weidong Huang
IPC分类号： G01N33/53 , A61K38/00 , A61K45/00 , A61K48/00 , A61P27/02 , A61P27/06 , C07K14/47 , C07K16/18 , C07K19/00 , C12N5/10 , C12N15/09 , C12N15/12 , C12P21/02 , C12Q1/68 , C12R1/91 , G01N33/566 , G01N33/68 , G01N33/74 , C07H21/04 , C12N15/00
CPC分类号： C12Q1/6883 , C07K14/47 , G01N33/6893 , G01N33/743 , A01K2217/05 , C07K2319/00 , C12Q2600/106 , C12Q2600/158 , G01N2800/168
摘要： A glucocorticoid-induced protein, TIGR, that is produced by cells of the trabecular meshwork can be used to diagnose glaucoma. The TIGR protein, anti-TIGR antibodies, and TIGR encoding sequences also provide a diagnostic for glaucoma and its related diseases.
摘要翻译：可以使用由小梁网细胞产生的糖皮质激素诱导的蛋白质TIGR来诊断青光眼。 TIGR蛋白，抗TIGR抗体和TIGR编码序列也为青光眼及其相关疾病提供诊断。

3. 发明授权

US06248867B1 Trabecular meshwork induced glucocorticoid response (TIGR) fusion protein 失效
标题翻译：小梁网诱导糖皮质激素反应（TIGR）融合蛋白
公开(公告)号：US06248867B1
公开(公告)日：2001-06-19
申请号：US08546568
申请日：1995-10-20
申请人： Thai D. Nguyen , Jon R. Polansky , Weidong Huang
发明人： Thai D. Nguyen , Jon R. Polansky , Weidong Huang
IPC分类号： C07K1900
CPC分类号： C12Q1/6883 , A01K2217/05 , C07K14/47 , C07K2319/00 , C12Q2600/106 , C12Q2600/158 , G01N33/6893 , G01N33/743 , G01N2800/168
摘要： A glucocorticoid-induced protein, TIGR, that is produced by cells of the trabecular meshwork can be used to diagnose glaucoma. The TIGR protein, anti-TIGR antibodies, and TIGR encoding sequences also provide a diagnostic for glaucoma and its related diseases.
摘要翻译：可以使用由小梁网细胞产生的糖皮质激素诱导的蛋白质TIGR来诊断青光眼。 TIGR蛋白，抗TIGR抗体和TIGR编码序列也为青光眼及其相关疾病提供诊断。

4. 发明授权

US5849879A Methods for the diagnosis of glaucoma 失效
公开(公告)号：US5849879A
公开(公告)日：1998-12-15
申请号：US645900
申请日：1996-05-14
申请人： Thai D. Nguyen , Jon R. Polansky , Weidong Huang
发明人： Thai D. Nguyen , Jon R. Polansky , Weidong Huang
IPC分类号： C07K14/47 , C07K16/18 , A61K39/44
CPC分类号： C07K14/47 , C07K2319/00 , G01N2800/168
摘要： A glucocorticoid-induced protein, TIGR, that is produced by cells of the trabecular meshwork can be used to diagnose glaucoma. The TIGR protein, anti-TIGR antibodies, and TIGR encoding sequences also provide a diagnostic for glaucoma and its related diseases.

5. 发明授权

US6150161A Methods for the diagnosis of glaucoma 失效
标题翻译：青光眼诊断方法
公开(公告)号：US6150161A
公开(公告)日：2000-11-21
申请号：US220459
申请日：1998-12-24
申请人： Thai D. Nguyen , Jon R. Polansky , Weidong Huang
发明人： Thai D. Nguyen , Jon R. Polansky , Weidong Huang
IPC分类号： C07K14/47 , C07K16/18 , C12Q1/68 , G01N33/68 , G01N33/74 , C07H21/04 , C12N5/10
CPC分类号： C07K16/18 , C07K14/47 , C12Q1/6883 , G01N33/6893 , G01N33/743 , C07K2319/00 , C12Q2600/156 , C12Q2600/158 , G01N2800/168
摘要： A glucocorticoid-induced protein, TIGR, that is produced by cells of the trabecular meshwork can be used to diagnose glaucoma. The TIGR protein, anti-TIGR antibodies, and TIGR encoding sequences also provide a diagnostic for glaucoma and its related diseases.
摘要翻译：可以使用由小梁网细胞产生的糖皮质激素诱导的蛋白质TIGR来诊断青光眼。 TIGR蛋白，抗TIGR抗体和TIGR编码序列也为青光眼及其相关疾病提供诊断。

6. 发明授权

US5854415A Methods for the diagnosis of glaucoma 失效
标题翻译：青光眼诊断方法
公开(公告)号：US5854415A
公开(公告)日：1998-12-29
申请号：US882238
申请日：1997-06-25
申请人： Thai D. Nguyen , Jon R. Polansky , Weidong Huang
发明人： Thai D. Nguyen , Jon R. Polansky , Weidong Huang
IPC分类号： C07K14/47 , C07K16/18 , C12Q1/68 , G01N33/68 , G01N33/74 , C07H21/04
CPC分类号： C07K16/18 , C07K14/47 , C12Q1/6883 , G01N33/6893 , G01N33/743 , C07K2319/00 , C12Q2600/156 , C12Q2600/158 , G01N2800/168
摘要： A glucocorticoid-induced protein, TIGR, that is produced by cells of the trabeclar meshwork can be used to diagnose glaucoma. The TIGR protein, anti-TIGR antibodies, and TIGR encoding sequences also provide a diagnostic for glaucoma and its related diseases.
摘要翻译：可以使用由小梁细胞细胞产生的糖皮质激素诱导蛋白TIGR来诊断青光眼。 TIGR蛋白，抗TIGR抗体和TIGR编码序列也为青光眼及其相关疾病提供诊断。

7. 发明授权

US5789169A Methods for the diagnosis of glaucoma 失效
标题翻译：青光眼诊断方法
公开(公告)号：US5789169A
公开(公告)日：1998-08-04
申请号：US649432
申请日：1996-05-17
申请人： Thai D. Nguyen , Jon R. Polansky , Weidong Huang
发明人： Thai D. Nguyen , Jon R. Polansky , Weidong Huang
IPC分类号： C07K14/47 , C07K16/18 , C12Q1/68 , G01N33/68 , G01N33/74 , C12P19/34
CPC分类号： C07K16/18 , C07K14/47 , C12Q1/6883 , G01N33/6893 , G01N33/743 , C07K2319/00 , C12Q2600/156 , C12Q2600/158 , G01N2800/168
摘要： A glucocorticoid-induced protein, TIGR, that is produced by cells of the trabecular meshwork can be used to diagnose glaucoma. The TIGR protein, anti-TIGR antibodies, and TIGR encoding sequences also provide a diagnostic for glaucoma and its related disease.
摘要翻译：可以使用由小梁网细胞产生的糖皮质激素诱导的蛋白质TIGR来诊断青光眼。 TIGR蛋白，抗TIGR抗体和TIGR编码序列也为青光眼及其相关疾病提供诊断。

8. 发明授权

US07138511B1 Nucleic acids, kits and methods for the diagnosis, prognosis and treatment of glaucoma and related disorders 失效
标题翻译：用于诊断，预后和治疗青光眼及相关疾病的核酸，试剂盒和方法
公开(公告)号：US07138511B1
公开(公告)日：2006-11-21
申请号：US09227881
申请日：1999-01-11
申请人： Thai D. Nguyen , Jon R. Polansky , Pu Chen , Hua Chen
发明人： Thai D. Nguyen , Jon R. Polansky , Pu Chen , Hua Chen
IPC分类号： C07H21/04 , A61K48/00 , C12Q1/68
CPC分类号： C07K14/47 , C12Q1/6883 , C12Q2600/156
摘要： In a preferred aspect of the invention, the upstream sequences of the TIGR protein encoding sequence can be used to diagnose a sensivity to steroids and a risk for glaucoma or ocular hypertensive disorders. Methods, kits, and nucleic acids containing polymorphisms, base substitutions, or base additions located within the upstream region and within protein-encoding regions of the TIGR gene are also provided. The upstream sequences disclosed, including the TIGR promoter regions and those regions possessing functional characterisitics associated with or possesssed by the TIGR gene 5′regulatory region, can also be used to generate cells, vectors, and nucleic acids useful in a variety of diagnostic and prognostic methods and kits as well as therapeutic compounds, compositions, and methods.
摘要翻译：在本发明的优选方面，TIGR蛋白编码序列的上游序列可用于诊断类固醇的敏感性和青光眼或眼高血压疾病的风险。还提供了位于TIGR基因的上游区域和蛋白质编码区域内的多态性，碱基取代或碱基添加的方法，试剂盒和核酸。所公开的上游序列，包括TIGR启动子区域和具有与TIGR基因5'调控区相关或拥有的功能特征的那些区域也可用于产生可用于多种诊断和预后的细胞，载体和核酸方法和试剂盒以及治疗化合物，组合物和方法。

9. 发明授权

US06171788B2 Methods for the diagnosis, prognosis and treatment of glaucoma and related disorders 失效
标题翻译：青光眼及相关疾病的诊断，预后和治疗方法
公开(公告)号：US06171788B2
公开(公告)日：2001-01-09
申请号：US08938669
申请日：1997-09-26
申请人： Thai D. Nguyen , Jon R. Polansky , Pu Chen , Hua Chen
发明人： Thai D. Nguyen , Jon R. Polansky , Pu Chen , Hua Chen
IPC分类号： C12Q170
CPC分类号： C07K14/47 , C12Q1/6883 , C12Q2600/156
摘要： The nucleic acid upstream of the TIGR protein encoding sequence can be used to diagnose glaucoma. Polymorphisms, base substitutions, base additions located with the upstream and within TIGR exons can also be used to diagnose glaucoma. In addition, polymorphisms, base substitutions, base additions located with the upstream and within TIGR exons can also be used to prognose glaucoma.
摘要翻译： TIGR蛋白编码序列上游的核酸可用于诊断青光眼。位于TIGR上游和TIGR外显子内的多态性，碱基取代，碱基添加也可用于诊断青光眼。此外，位于TIGR上游和TIGR外显子内的多态性，碱基取代，碱基添加也可用于预后青光眼。

10. 发明授权

US06475724B1 Nucleic acids, kits, and methods for the diagnosis, prognosis and treatment of glaucoma and related disorders 失效
标题翻译：用于诊断，预后和治疗青光眼及相关疾病的核酸，试剂盒和方法
公开(公告)号：US06475724B1
公开(公告)日：2002-11-05
申请号：US09306828
申请日：1999-05-07
申请人： Thai D. Nguyen , Jon R. Polansky , Pu Chen , Hua Chen
发明人： Thai D. Nguyen , Jon R. Polansky , Pu Chen , Hua Chen
IPC分类号： C12Q168
CPC分类号： C07K14/47 , C12Q1/6883 , C12Q2600/156
摘要： In a preferred aspect of the invention, the upstream sequences of the TIGR protein encoding sequence can be used to diagnose a sensivity to steroids and a risk for glaucoma or ocular hypertensive disorders. Methods, kits, and nucleic acids containing polymorphisms, base substitutions, or base additions located within the upstream region and within protein-encoding regions of the TIGR gene are also provided. The upstream sequences disclosed, including the TIGR promoter regions and those regions possessing functional characteristics associated with or possessed by the TIGR gene 5′regulatory region, can also be used to generate cells, vectors, transgenic animals, and nucleic acid constructs useful in a variety of diagnostic and prognostic methods and kits as well as therapeutic compounds, compositions, and methods.
摘要翻译：在本发明的优选方面，TIGR蛋白编码序列的上游序列可用于诊断类固醇的敏感性和青光眼或眼高血压疾病的风险。还提供了位于TIGR基因的上游区域和蛋白质编码区域内的多态性，碱基取代或碱基添加的方法，试剂盒和核酸。公开的包括TIGR启动子区域和具有与TIGR基因5'调控区域相关或拥有的功能特征的那些区域的上游序列也可用于产生可用于多种的细胞，载体，转基因动物和核酸构建体诊断和预后方法和试剂盒以及治疗化合物，组合物和方法。

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