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1. 发明授权

US09738907B2 Viral vector 有权
公开(公告)号：US09738907B2
公开(公告)日：2017-08-22
申请号：US10841603
申请日：2004-05-07
申请人： Philippa Radcliffe , James E. Miskin , Fraser J. Wilkes , Kyriacos A. Mitrophanous , Susan M. Kingsman
发明人： Philippa Radcliffe , James E. Miskin , Fraser J. Wilkes , Kyriacos A. Mitrophanous , Susan M. Kingsman
IPC分类号： C12N15/867 , C12N15/11 , C12N7/00 , A61K48/00 , C12N15/86
CPC分类号： C12N15/86 , A61K48/00 , C12N2740/15043 , C12N2830/003 , C12N2830/008 , C12N2830/50 , C12N2830/85 , C12N2840/20 , C12N2840/203 , C12N2840/44
摘要： Provided is a multicistronic retroviral vector genome having a first nucleic acid sequence upstream of at least one internal regulatory element, such that the level of genomic RNA available for packaging in the absence of rev, or a functional equivalent thereof, is increased.

2. 发明授权

US09714414B2 Reprogramming of somatic cells 有权
公开(公告)号：US09714414B2
公开(公告)日：2017-07-25
申请号：US14473250
申请日：2014-08-29
申请人： Whitehead Institute for Biomedical Research
发明人： Rudolf Jaenisch , Yaqub Hanna , Marius Wernig , Christopher J. Lengner , Alexander Meissner , Oliver Tobias Brambrink , G. Grant Welstead , Ruth Foreman
IPC分类号： C12N5/074 , C07K14/47 , A01K67/027 , C12N15/85 , C12N15/877 , G01N33/50
CPC分类号： C12N5/0696 , A01K67/0273 , A01K67/0275 , A01K2217/05 , A01K2227/105 , C07K14/4702 , C12N15/8509 , C12N15/8775 , C12N2501/602 , C12N2501/603 , C12N2501/604 , C12N2501/605 , C12N2501/606 , C12N2506/11 , C12N2506/13 , C12N2800/30 , C12N2830/003 , C12N2830/006 , G01N33/5023 , G01N2333/91011
摘要： The disclosure relates to a method of reprogramming one or more somatic cells, e.g., partially differentiated or fully/terminally differentiated somatic cells, to a less differentiated state, e.g., a pluripotent or multipotent state. In further embodiments the invention also relates to reprogrammed somatic cells produced by methods of the invention, to uses of said cells, and to methods for identifying agents useful for reprogramming somatic cells.

3. 发明申请

US20170159072A9 Endothelial-targeted Adenoviral Vectors, Methods and Uses Therefor 审中-公开
公开(公告)号：US20170159072A9
公开(公告)日：2017-06-08
申请号：US14966078
申请日：2015-12-11
申请人： Washington University
发明人： Jefferey Arbeit , David Curiel
IPC分类号： C12N15/86 , C12N7/00 , C07K14/715 , A61K48/00 , C12N9/78 , C07K14/71
CPC分类号： C12N15/86 , A61K38/00 , A61K48/00 , A61K48/0058 , C07K14/71 , C07K14/715 , C07K14/7158 , C07K2319/32 , C07K2319/735 , C12N7/00 , C12N9/78 , C12N2710/10321 , C12N2710/10332 , C12N2710/10343 , C12N2710/10345 , C12N2830/002 , C12N2830/003 , C12N2830/008 , C12Y305/04001 , Y02A50/475
摘要： Disclosed are adenovirus vectors comprising a ROBO4 enhancer/promoter operatively linked to a transgene. Also disclosed are adenovirus vectors comprising a chimeric AD5-T4 phage fibritin shaft, a trimerization domain displaying a myeloid cell-binding peptide (MBP), and a ROBO4 enhancer promoter operatively linked to a transgene. Also disclosed are methods of expressing a transgene in an endothelial cell in vivo, comprising administering to a mammal an adenovirus comprising a ROBO4 enhancer/promoter operatively linked to a transgene. Also disclosed are uses of the adenoviral vectors, including mobilization of granulocytes, monocytes and lymphocytes from bone marrow, mobilization of cancer cells in vivo, selective targeting of endothelial cells, and cancer treatment methods.

4. 发明申请

US20170028058A1 HERPES SIMPLEX VIRUS VACCINES 审中-公开
公开(公告)号：US20170028058A1
公开(公告)日：2017-02-02
申请号：US15201783
申请日：2016-07-05
申请人： THE BRIGHAM AND WOMEN'S HOSPITAL, INC.
发明人： Feng Yao
IPC分类号： A61K39/245 , C12N7/00
CPC分类号： A61K39/245 , A61K35/763 , A61K39/12 , A61K2039/5254 , A61K2039/5256 , A61K2039/545 , A61K2039/57 , C12N7/00 , C12N15/869 , C12N15/8695 , C12N2710/16011 , C12N2710/16021 , C12N2710/16034 , C12N2710/16062 , C12N2710/16071 , C12N2710/16611 , C12N2710/16621 , C12N2710/16622 , C12N2710/16634 , C12N2710/16661 , C12N2710/16662 , C12N2830/003 , C12N2830/006 , G01N33/56994
摘要： The present invention is directed to Herpes simplex-2 viruses that may be used in vaccines to immunize patients against genital herpes.
摘要翻译：本发明涉及可用于免疫患者的生殖器疱疹疫苗的单纯疱疹病毒2型病毒。

5. 发明申请

US20160303174A1 STEM CELL DELIVERED ONCOLYTIC HERPES SIMPLEX VIRUS AND METHODS FOR TREATING BRAIN TUMORS 审中-公开
标题翻译： STEM CELL传播肿瘤性肝炎简单病毒和治疗脑肿瘤的方法
公开(公告)号：US20160303174A1
公开(公告)日：2016-10-20
申请号：US15102962
申请日：2014-12-11
申请人： THE GENERAL HOSPITAL CORPORATION
发明人： Khalid SHAH
IPC分类号： A61K35/763 , A61K38/17 , C07K14/705 , A61K9/00 , C12N7/00 , A61K35/28
CPC分类号： A61K35/763 , A61K9/0019 , A61K35/28 , A61K35/30 , A61K35/35 , A61K35/51 , A61K35/545 , A61K38/177 , C07K14/705 , C07K14/70575 , C12N7/00 , C12N2710/16132 , C12N2710/16632 , C12N2710/16671 , C12N2830/003
摘要： Disclosed herein is an isolated stem cell or population thereof that comprises oncolytic herpes simplex virus (oHSV). Examples of possible stem cells include mesenchymal stem cells (MSC), neuronal stem cells and induced pluripotent stem cells. Various forms of the oHSV are disclosed. Also disclosed are methods of treating brain cancer in a subject by administering the stem cells containing oHSV to the subject to deliver the oHSV to brain cancer cells in the subject. The method is for the treatment of primary brain cancer and secondary metastatic brain cancer.
摘要翻译：本文公开了包含溶瘤性单纯疱疹病毒（oHSV）的分离的干细胞或其群体。可能的干细胞的实例包括间充质干细胞（MSC），神经元干细胞和诱导多能干细胞。公开了各种形式的oHSV。还公开了通过向受试者施用含有oHSV的干细胞以将oHSV输送到受试者的脑癌细胞中来治疗受试者的脑癌的方法。该方法用于治疗原发性脑癌和继发性转移性脑癌。

6. 发明申请

US20160145643A1 Endothelial-targeted Adenoviral Vectors, Methods and Uses Therefor 审中-公开
标题翻译：内皮靶向腺瘤病毒载体，其方法和用途
公开(公告)号：US20160145643A1
公开(公告)日：2016-05-26
申请号：US14966078
申请日：2015-12-11
申请人： Washington University
发明人： Jefferey Arbeit , David Curiel
IPC分类号： C12N15/86 , C12N7/00 , C07K14/715 , A61K48/00 , C12N9/78 , C07K14/71
CPC分类号： C12N15/86 , A61K38/00 , A61K48/00 , A61K48/0058 , C07K14/71 , C07K14/715 , C07K14/7158 , C07K2319/32 , C07K2319/735 , C12N7/00 , C12N9/78 , C12N2710/10321 , C12N2710/10332 , C12N2710/10343 , C12N2710/10345 , C12N2830/002 , C12N2830/003 , C12N2830/008 , C12Y305/04001 , Y02A50/475
摘要： Disclosed are adenovirus vectors comprising a ROBO4 enhancer/promoter operatively linked to a transgene. Also disclosed are adenovirus vectors comprising a chimeric AD5-T4 phage fibritin shaft, a trimerization domain displaying a myeloid cell-binding peptide (MBP), and a ROBO4 enhancer promoter operatively linked to a transgene. Also disclosed are methods of expressing a transgene in an endothelial cell in vivo, comprising administering to a mammal an adenovirus comprising a ROBO4 enhancer/promoter operatively linked to a transgene. Also disclosed are uses of the adenoviral vectors, including mobilization of granulocytes, monocytes and lymphocytes from bone marrow, mobilization of cancer cells in vivo, selective targeting of endothelial cells, and cancer treatment methods.
摘要翻译：公开了包含可操作地连接到转基因的ROBO4增强子/启动子的腺病毒载体。还公开了包含嵌合AD5-T4噬菌体纤维蛋白轴，显示骨髓细胞结合肽（MBP）的三聚体结构域和可操作地连接到转基因的ROBO4增强子启动子的腺病毒载体。还公开了在体内在内皮细胞中表达转基因的方法，包括向哺乳动物施用包含可操作地连接到转基因的ROBO4增强子/启动子的腺病毒。还公开了腺病毒载体的使用，包括从骨髓中移动粒细胞，单核细胞和淋巴细胞，体内移动癌细胞，选择性靶向内皮细胞和癌症治疗方法。

7. 发明申请

US20160143951A1 DOSAGE COMPENSATING TRANSGENES AND CELLS 有权
标题翻译：剂量补充转基因和细胞
公开(公告)号：US20160143951A1
公开(公告)日：2016-05-26
申请号：US14776672
申请日：2014-03-14
申请人： UNIVERSITY OF MASSACHUSETTS
发明人： Jeanne B. Lawrence , Jun Jiang , Lisa L. Hall
IPC分类号： A61K35/28 , C12N15/85
CPC分类号： A61K35/28 , A01K67/0271 , A01K67/0275 , A01K2207/12 , A01K2217/072 , A01K2217/15 , A01K2217/203 , A01K2227/105 , A01K2267/0318 , A01K2267/0356 , A61K48/005 , A61K48/0075 , A61K2035/124 , C12N9/12 , C12N15/111 , C12N15/1137 , C12N15/85 , C12N15/8509 , C12N15/907 , C12N2310/111 , C12N2310/113 , C12N2310/14 , C12N2330/51 , C12N2800/40 , C12N2810/10 , C12N2830/003 , C12N2830/32 , C12N2999/005 , C12Y207/12001
摘要： Methods and compositions for reducing expression of genes on Chromosome 21 (“Chr 21”) by targeting an XIST transgene to the Dual specificity tyrosine-phosphorylation-regulated kinase 1A (DYRK1A) gene or a Regulator of calcineurin 1 (RCAN1) gene, and cells and transgenic animals comprising an XIST transgene inserted into a DYRK1A or RCAN1 allele, e.g., cells and animals trisomic for human Chr 21 and mouse Chr 16.
摘要翻译：通过将XIST转基因靶向双重特异性酪氨酸磷酸化调节激酶1A（DYRK1A）基因或钙调神经磷酸酶1（RCAN1）基因的调节剂）和细胞，减少染色体21（“Chr 21”）上基因表达的方法和组合物以及包含插入到DYRK1A或RCAN1等位基因中的XIST转基因的转基因动物，例如用于人Chr 21和小鼠Chr 16的三体细胞和动物。

8. 发明申请

US20160115456A1 METHODS FOR REPROGRAMMING SOMATIC CELLS 有权
公开(公告)号：US20160115456A1
公开(公告)日：2016-04-28
申请号：US14923321
申请日：2015-10-26
申请人： Whitehead Institute for Biomedical Research
发明人： Rudolf Jaenisch , Konrad Hochedlinger
IPC分类号： C12N5/074
CPC分类号： C12N5/0696 , A01K67/0273 , A01K67/0275 , A01K2217/05 , A01K2227/105 , C07K14/4702 , C12N15/85 , C12N15/8509 , C12N15/8775 , C12N2501/602 , C12N2501/603 , C12N2501/605 , C12N2506/1307 , C12N2510/00 , C12N2830/003 , C12N2830/006
摘要： The invention provides methods for reprogramming somatic cells to generate multipotent or pluripotent cells. Such methods are useful for a variety of purposes, including treating or preventing a medical condition in an individual. The invention further provides methods for identifying an agent that reprograms somatic cells to a less differentiated state.

9. 发明申请

US20160040186A1 DNA CONSTRUCT AND METHOD FOR TRANSGENE EXPRESSION 审中-公开
标题翻译： DNA结构和转移表达方法
公开(公告)号：US20160040186A1
公开(公告)日：2016-02-11
申请号：US14454697
申请日：2014-08-07
申请人： Xiaoyun Liu
发明人： Xiaoyun Liu
IPC分类号： C12N15/86 , C12N15/80 , C12N15/81
CPC分类号： C12N15/80 , C12N15/815 , C12N15/85 , C12N2740/16043 , C12N2830/003 , C12N2830/36 , C12N2830/42 , C12N2840/20
摘要： This invention relates to a DNA construct that is capable of expressing a desired transgene in a trackable manner. The construct comprises in 5′ to 3′ downstream direction: a promoter; a fluorescent reporter gene positioned within an intron defined by a 5′-donor splice site comprising a splice donor sequence and a 3′-acceptor splice site comprising a splice acceptor sequence; a desired gene and a transcription terminator. A method of producing a transgenic host cell having a desired product is also disclosed.
摘要翻译：本发明涉及能以可追踪方式表达所需转基因的DNA构建体。该构建体包含5'至3'下游方向：启动子; 位于由包含剪接供体序列和包含剪接受体序列的3'-受体剪接位点的5'供体剪接位点限定的内含子内的荧光报告基因; 所需基因和转录终止子。还公开了产生具有所需产物的转基因宿主细胞的方法。

10. 发明授权

US09181556B2 Tetracycline inducible transcription control sequence 有权
标题翻译：四环素诱导型转录调控序列
公开(公告)号：US09181556B2
公开(公告)日：2015-11-10
申请号：US13121673
申请日：2009-08-19
申请人： Hermann Bujard , Rainer Loew
发明人： Hermann Bujard , Rainer Loew
IPC分类号： C07H21/04 , C12N15/63 , A61K31/70
CPC分类号： C12N15/635 , C12N2770/40043 , C12N2830/003
摘要： The present invention relates to inducible transcription control sequences for the regulation of gene expression. Specifically, it relates to an transcription control sequence comprising at least two tet operator sequence motifs allowing the binding of tetracycline-dependent transcriptional regulators, wherein each of the tetracycline-dependent transcriptional regulators binds with respect to its neighbor to an opposite face of the DNA helix, and a minimal promoter comprising a TATA box which is linked at its 5′ end to a general transcription factor binding site. Further, the present invention relates to a vector, a host cell, a plant or a non-human transgenic animal comprising the transcription control sequence. Also contemplated is a method for regulating the expression of a nucleic acid sequence being operatively linked to the transcription control sequence of the present invention in a host cell, a plant or a non-human transgenic animal.
摘要翻译：本发明涉及用于调节基因表达的诱导型转录调控序列。具体地说，本发明涉及包含至少两个允许四环素依赖性转录调节因子结合的tet操纵子序列基序的转录控制序列，其中四环素依赖性转录调节因子中的每一个相对于其邻近的DNA螺旋结构，以及包含在其5'末端与一般转录因子结合位点连接的TATA盒的最小启动子。此外，本发明涉及包含转录调控序列的载体，宿主细胞，植物或非人转基因动物。还考虑了在宿主细胞，植物或非人转基因动物中调节与本发明的转录调控序列有效连接的核酸序列的表达的方法。

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