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1. 发明申请

US20020151723A1 Benzimidazole derivatives, their production and use 失效
标题翻译：苯并咪唑衍生物，其生产和使用
公开(公告)号：US20020151723A1
公开(公告)日：2002-10-17
申请号：US10046189
申请日：2002-01-16
申请人： TAKEDA CHEMICAL INDUSTRIES, LTD.
发明人： Takehiko Naka , Kohei Nishikawa , Takeshi Kato
IPC分类号： C07D43/02
CPC分类号： C07D235/02 , C07D235/26 , C07D235/28 , C07D235/30 , C07D403/04 , C07D403/10 , C07D405/14
摘要： A method for producing a compound represented by the formula: 1 wherein the ring A is a benzene ring which may be substituted in addition to the Rnull group; R1 is hydrogen or an optionally substituted hydrocarbon residue; X is a direct bond or a spacer having an atomic length or two or less between the phenylene group and the phenyl group; Y is nullOnull, nullS(O)mnull or nullN(R4)null wherein m is an integer of 0, 1 or 2 and R4 is hydrogen or an optionally substituted alkyl group; Rnull is carboxyl, an ester thereof, an amide thereof or a group capable of forming an anion or a group convertible thereinto; n is an integer of 1 or 2; or a salt thereof, which comprises deprotecting a compound represented by the formula: 2 wherein R is triphenylmethyl, 2-tetrahydropyranyl, methoxymethyl or ethoxy methyl, the other symbols as defined above; or a salt thereof.
摘要翻译：一种制备由下式表示的化合物的方法：其中环A是除R'基之外可被取代的苯环; R1是氢或任选取代的烃残基; X是在亚苯基和苯基之间具有原子长度或者两个或更少的直接键或间隔子; Y是-O - ， - S（O）m - 或-N（R4） - ，其中m是0,1或2的整数，R4是氢或任选取代的烷基; R'是羧基，其酯，其酰胺或能够形成阴离子的基团或可转化的基团; n为1或2的整数; 其包括使由下式表示的化合物脱保护：其中R是三苯甲基，2-四氢吡喃基，甲氧基甲基或乙氧基甲基，其它符号如上定义; 或其盐

2. 发明授权

US4986984A HIGHLY SOLUBILIZED PROTEIN AND PRODUCTION THEREOF 失效
标题翻译：高度溶解的蛋白质及其生产
公开(公告)号：US4986984A
公开(公告)日：1991-01-22
申请号：US25097388
申请日：1988-09-23
申请人： TAKEDA CHEMICAL INDUSTRIES LTD
发明人： KIYOSHI NARA , SUSUMU HONDA
IPC分类号： A61K20060101 , A61K38/00 , C07K1/113 , C07K14/57 , A61K45/02 , C07K13/00 , C12P21/00
CPC分类号： C07K1/1133 , A61K38/00 , C07K14/57
摘要： A highly concentrated aqueous solution of human gamma -interferon is produced by removing a protein-denaturing agent from a diluted aqueous solution of human gamma -interferon containing the protein-denaturing agent, aging the resulting solution in situ and concentrating the same.
摘要翻译：通过从含有蛋白质变性剂的人γ-干扰素的稀释水溶液中除去蛋白质变性剂，将所得溶液原位老化并浓缩，从而产生高度浓缩的人γ-干扰素水溶液。

3. 发明授权

US3926729A Method for producing deacetylcephalosporin c 失效
标题翻译：生产脱乙酰壳多糖的方法C
公开(公告)号：US3926729A
公开(公告)日：1975-12-16
申请号：US34984973
申请日：1973-04-10
申请人： TAKEDA CHEMICAL INDUSTRIES LTD
发明人： KANZAKI TOSHIHIKO , FUJISAWA YUKIO , SHIRAFUJI HIDEO , NARA KIYOSHI , YONEDA MASAHIKO
IPC分类号： C12P1/02 , C12P35/06 , C12D9/04
CPC分类号： C12P35/06 , Y10S435/926
摘要： Deacetylcephalosporin C is produced by cultivating a microorganism which belongs to genus Cephalosporium and is capable of producing deacetylcephalosporin C and accumulating it in the culture broth. The accumulated deacetylcephalosporin C can easily be recovered from the culture broth.

4. 发明授权

US3925465A Crystallization of alpha monosodium citrate monohydrate 失效
标题翻译： α单柠檬酸钠一水合物的结晶
公开(公告)号：US3925465A
公开(公告)日：1975-12-09
申请号：US46461474
申请日：1974-04-25
申请人： TAKEDA CHEMICAL INDUSTRIES LTD
发明人： NARA KIYOSHI , KATAMOTO KAZUYOSHI , OHTA KAZUHIKO , FUKUDA HIDEO
IPC分类号： C07C59/265 , C07C59/16
CPC分类号： C07C59/265
摘要： Monosodium citrate monohydrate crystals are prepared by evaporating an aqueous solution containing monosodium citrate whilst maintaining said solution between 20*C and 60*C and at a concentration of monosodium citrate of not less than 155 % (W/V) of saturation solubility of gamma -crystals of monosodium citrate. Thus obtained crystals have a good filtrability and separability from a solution and are widely applicable as foods, pharmaceuticals and chemical products.
摘要翻译：通过蒸发含有柠檬酸单钠的水溶液制备柠檬酸一钠水合物晶体，同时保持所述溶液在20℃至60℃之间，柠檬酸单钠的浓度不低于γ - 饱和溶解度的155％（W / V）柠檬酸钠的晶体。这样获得的晶体具有良好的过滤性和与溶液的分离性，并且广泛用作食品，药品和化学产品。

5. 发明授权

US3925362A {60 -Alkylsulfobenzyl penicillins and production thereof 失效
标题翻译： {60-烷基亚磺酰基青霉素及其制备
公开(公告)号：US3925362A
公开(公告)日：1975-12-09
申请号：US35414073
申请日：1973-04-24
申请人： TAKEDA CHEMICAL INDUSTRIES LTD
发明人： SUGIMOTO KEIICHI , NISHIJIMA KOUJI , KAKEYA NOBUHARU
IPC分类号： C07D499/00 , C07D499/62 , C07D499/44
CPC分类号： C07D499/00
摘要： Novel penicillins shown by the general formula:

(WHEREIN R is a straight alkyl group of not less than 7 carbon atoms) and their pharmaceutically acceptable salts are easily absorbed in blood and tissues through oral administration and show excellent antimicrobial activity against Gram-positive and Gram-negative bacteria, particularly against microorganisms of the genus Pseudomonas aeruginosa.
摘要翻译：新型青霉素由通式表示：

6. 发明授权

US3923807A 6-Aminouracil derivatives 失效
标题翻译： 6-氨基尿嘧啶衍生物
公开(公告)号：US3923807A
公开(公告)日：1975-12-02
申请号：US39544873
申请日：1973-09-10
申请人： TAKEDA CHEMICAL INDUSTRIES LTD
发明人： FURUKAWA YOSHIYASU , SUNO MASAHIRO , NOSE SAWAMI
IPC分类号： C07D239/54 , C07D239/06
CPC分类号： C07D239/54 , Y10S514/822 , Y10S514/869
摘要： Novel 6-aminouracil derivatives of the formula

WHEREIN R1 is lower alkyl which may be substituted with hydroxy or lower alkoxy, R2 is halogen, nitro or lower alkyl and n is 0, 1 or 2, show a strong inhibitory action against adenosine -3'', 5'' cyclic phosphate phosphodiesterase in vitro, and exhibit excellent pharmacological actions such as diuretic, platelet aggregation inhibitory and broncho-dilating actions.

D R A W I N G
摘要翻译：新颖的式6-氨基尿嘧啶衍生物，其中，R 1为可被羟基或低级烷氧基取代的低级烷基，R 2为卤素，硝基或低级烷基，n为0,1或2，对腺苷-3' 5'环磷酸二酯酶，体外表现出优异的药理作用，如利尿，血小板聚集抑制和支气管扩张作用。

7. 发明授权

US3919207A Intermediates for producing cephalosporins 失效
标题翻译：用于生产头孢菌素的中间体
公开(公告)号：US3919207A
公开(公告)日：1975-11-11
申请号：US28834372
申请日：1972-09-12
申请人： TAKEDA CHEMICAL INDUSTRIES LTD
发明人： TERAO SHINJI , MATSUO TAISUKE , TSUSHIMA SUSUMU , MIYAWAKI TOSHIO , MATSUMOTO NORICHIKA
IPC分类号： A61K31/545 , C07D501/02 , C07D501/04 , C07D501/18
摘要： The present invention relates to novel intermediates and a process for producing a compound of formula:
摘要翻译：本发明涉及新的中间体及其制备方法，其中R4是被一个或两个苯基，环己烯基，噻吩基，吡啶硫基，氨基或磺基取代的乙酰基，其中氨基被未被保护或用盐酸保护酸，异冰片氧基羰基，β-甲基磺酰基乙氧基羰基，苯甲酰基或硝基苯甲酰基，A表示式WHEREIN X为氢或乙酰氧基，R5为β-甲基磺酰基，三甲基甲硅烷基，甲氧基甲基或对硝基苄基的头孢菌素部分，式：R1-C = NA | SR2其中R1是苄基或苯氧基甲基，R2是烷基，A具有与上述相同的含义，与下式的化合物R6-W其中R6是如上定义的乙酰基，W是氯化物，溴化物，SO 3，NO 3或对甲苯磺酰基，在pH低于8.0的溶剂中。

8. 发明授权

US3919046A Method of producing d-ribose 失效
标题翻译：生产D-核糖的方法
公开(公告)号：US3919046A
公开(公告)日：1975-11-11
申请号：US41556173
申请日：1973-11-14
申请人： TAKEDA CHEMICAL INDUSTRIES LTD
发明人： SASAJIMA KEN-ICHI , YONEDA MASAHIKO
IPC分类号： C12P19/02 , C12D13/02
CPC分类号： C12P19/02 , Y10S435/832 , Y10S435/839
摘要： D-ribose is produced by cultivating a strain belonging to the genus Bacillus whose transketolase activity is nil to cause said strain to elaborate and accumulate a large amount of D-ribose. The thus accumulated D-ribose can be recovered in a good yield.
摘要翻译：通过培养属于芽孢杆菌属的杆菌属的菌株产生D-核糖，其转酮酶活性为零，以使所述菌株精制并积累大量的D-核糖。可以以良好的收率回收这样积累的D-核糖。

9. 发明授权

US3907766A L-aspartyl-aminomalonic acid diester 失效
标题翻译： L-天冬氨酰氨基马来酸二酯
公开(公告)号：US3907766A
公开(公告)日：1975-09-23
申请号：US37713873
申请日：1973-07-06
申请人： TAKEDA CHEMICAL INDUSTRIES LTD
发明人： FUJINO MASAHIKO , WAKIMASU MITSUHIRO , NAKAJIMA NOBUO , AOKI HISASHI
IPC分类号： A23L27/30 , C07K5/072 , C07K5/075 , C07C103/52 , A23L1/22
CPC分类号： C07K5/06113 , A23L27/32 , Y10S530/801
摘要： A novel dipeptide, L-aspartyl-aminomalonic acid alkyl fenchyl diester, and its physiologically acceptable salts which are useful as a sweetener, and production thereof and sweetening compositions containing the dipeptide ester or its salt.
摘要翻译：可用作甜味剂的新型二肽，L-天冬氨酰基 - 氨基马来酸烷基酯基二酯及其生理学上可接受的盐及其生产物和含有二肽酯或其盐的甜味组合物。

10. 发明授权

US3886207A Process for producing indan-1-carboxylic acid derivatives 失效
标题翻译：茚满-1-羧酸衍生物的制备方法
公开(公告)号：US3886207A
公开(公告)日：1975-05-27
申请号：US37152773
申请日：1973-06-19
申请人： TAKEDA CHEMICAL INDUSTRIES LTD
发明人： KISHIMOTO SHOJI , AONO TETSUYA , NOGUCHI SHUNSAKU
IPC分类号： C07C61/39 , C07C51/00 , C07C61/12 , C07C61/40 , C07C67/00 , C07C69/753 , C07C233/58 , C07C63/44
CPC分类号： C07C61/12 , Y10S514/916
摘要： 5-Cycloalkyl-6-halogenoindan-1-carboxylic acid (cycloalkyl group herein is six- or five-membered one) is produced through halogenation of indan-1-carboxylic acid to introduce halogen at its 6-position selectively, and following alkylation to introduce cycloalkyl group at the 5-position. The latter reaction is effectively conducted by acting on 6-halogenoindan-1-carboxylic acid a cycloalkyhalide, a cycloalkanol, its sulfonates or a cycloalkene. The product may be converted into the form of its pharmaceutically acceptable salts. The products are useful as antipyretic, analgesic or anti-inflammatory agent for human or animal use.
摘要翻译： 5-环烷基-6-卤代茚满-1-羧酸（本文环烷基是六或五元一个）是通过茚满-1-羧酸的卤化反应制备的，以在其6-位选择性地引入卤素，并在烷基化至在5位引入环烷基。后一反应通过作用于6-卤代茚满-1-羧酸环烷基卤化物，环烷醇，其磺酸盐或环烯烃而有效地进行。产物可以转化为其药学上可接受的盐的形式。该产品可用作人或动物使用的解热止痛剂或抗炎剂。

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