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1. 发明授权

US10494332B2 Protein tyrosine phosphatases or SHP2 inhibitors and uses thereof 有权
公开(公告)号：US10494332B2
公开(公告)日：2019-12-03
申请号：US15577417
申请日：2016-06-01
申请人： Indiana University Research and Technology Corporation
发明人： Zhong-Yin Zhang , Rongjun He
IPC分类号： C07C317/02 , C07C317/08 , C07C317/18 , C07D211/14 , C07D215/00 , C07D209/04 , C07D307/52 , C07C309/24 , A61K45/06 , C07C309/17 , A61P25/28 , A61P3/10 , A61P31/06 , A61P35/00 , C07D211/16 , C07D211/18 , C07D215/08 , C07D231/40 , C07D233/64 , C07D235/10 , C07D235/14 , C07D277/46 , C07D277/82 , C07D285/135 , C07D307/68 , C07D333/20 , A61P35/02 , C07C309/18 , C07D215/38 , C07D233/61 , C07D295/135
CPC分类号： C07C309/24 , A61K45/06 , A61P3/10 , A61P25/28 , A61P31/06 , A61P35/00 , A61P35/02 , C07C309/17 , C07C309/18 , C07D211/16 , C07D211/18 , C07D215/08 , C07D215/38 , C07D231/40 , C07D233/61 , C07D233/64 , C07D235/10 , C07D235/14 , C07D277/46 , C07D277/82 , C07D285/135 , C07D295/135 , C07D307/68 , C07D333/20
摘要： Small molecule compounds derived from α-sulfophenylacetic amide (SPAA) are provided as novel sulfonic acid based pTyr mimetics. These compounds effectively inhibit a variety of protein tyrosine phosphatases (PTPs), such as mPTPA, mPTPB, LMWPTP, and Laforin. Use of these compounds as pharmaceutical agents for treating diseases associated with abnormal protein tyrosine phosphatase activity is also provided.

2. 发明授权

US10238611B2 Methods, compounds, compositions and vehicles for delivering 3-amino-1-propanesulfonic acid 有权
公开(公告)号：US10238611B2
公开(公告)日：2019-03-26
申请号：US15293965
申请日：2016-10-14
申请人： BHI Limited Partnership
发明人： Xianqi Kong , Mohamed Atfani , Benoit Bachand , Abderrahim Bouzide , Stephane Ciblat , Sophie Levesque , David Migneault , Isabelle Valade , Xinfu Wu , Daniel Delorme
IPC分类号： A61K31/145 , A61K47/54 , C07C309/18 , C07C309/19 , C07C309/24 , C07D333/24 , C07D317/40 , A61K47/64 , C07J9/00 , C07D285/38 , C07H7/02 , C07D323/02 , C07H15/12 , C12P13/00 , C07D285/36 , C07D291/02 , C07K5/062 , C12P11/00 , C07D233/64 , C07D217/24 , C07D209/20 , C07D207/16 , C07C309/15 , C07K5/083 , C07K5/068
摘要： The invention relates to methods, compounds, compositions and vehicles for delivering 3-amino-1-propanesulfonic acid (3APS) in a subject, preferably a human subject. The invention encompasses compound that will yield or generate 3APS, either in vitro or in vivo. Preferred compounds include amino acid prodrugs of 3APS for use, including but not limited to the prevention and treatment of Alzheimer's disease.

3. 发明申请

US20160370700A1 PHOTORESIST COMPOSITION, COMPOUND, AND PRODUCTION METHOD THEREOF 有权
公开(公告)号：US20160370700A1
公开(公告)日：2016-12-22
申请号：US15252553
申请日：2016-08-31
申请人： JSR CORPORATION
发明人： Hayato NAMAI , Norihiko IKEDA , Takanori KAWAKAMI
IPC分类号： G03F7/004 , G03F7/038 , C07D207/416 , C07C381/12 , C07D295/185 , C07D493/10 , C07D307/94 , C07D311/20 , C07C309/17 , C07D317/24 , C07D307/93 , C07D327/04 , C07D307/33 , C07D307/60 , C07D211/46 , C07D237/04 , C07C309/18 , C07D319/06 , C07C309/27 , C07D321/12 , G03F7/039
CPC分类号： G03F7/0045 , C07C309/17 , C07C309/18 , C07C309/27 , C07C381/12 , C07C2601/08 , C07C2601/10 , C07C2601/14 , C07C2601/18 , C07C2603/74 , C07D207/416 , C07D211/46 , C07D237/04 , C07D237/16 , C07D295/18 , C07D295/185 , C07D307/33 , C07D307/60 , C07D307/64 , C07D307/93 , C07D307/94 , C07D311/20 , C07D311/74 , C07D313/06 , C07D317/24 , C07D319/06 , C07D321/12 , C07D327/04 , C07D493/10 , G03F7/0046 , G03F7/027 , G03F7/038 , G03F7/0388 , G03F7/039 , G03F7/0392 , G03F7/0397 , G03F7/11 , G03F7/2041
摘要： A photoresist composition containing (A) a polymer having a structural unit (I) that includes an acid-labile group, and (I) a compound represented by the following formula (1). In the following formula (1), R1, R2, R3 and R represent a hydrogen atom or a monovalent organic group having 1 to 20 carbon atoms. X represents a single bond, an oxygen atom or —NRa—. Ra represents a hydrogen atom, a hydroxy group or a monovalent organic group having 1 to 20 carbon atoms, and optionally taken together represents a ring structure by binding with R each other. A− represents —SO3− or —CO2−. M+ represents a monovalent onium cation.

4. 发明授权

US08835498B2 Anti-wrinkle agents 有权
标题翻译：抗皱剂
公开(公告)号：US08835498B2
公开(公告)日：2014-09-16
申请号：US13126714
申请日：2009-11-12
申请人： Noriko Suenobu , Chihiro Kondo , Takashi Yamasaki
发明人： Noriko Suenobu , Chihiro Kondo , Takashi Yamasaki
IPC分类号： A61K8/46 , A61K8/44 , C07C321/14 , C07C309/04 , C07C309/07 , C07C309/18 , A61Q19/08 , A61K8/42 , A61K31/198
CPC分类号： A61K31/198 , A61K8/42 , A61K8/46 , A61K8/466 , A61Q19/08
摘要： Provided are anti-wrinkle agents having a novel scaffold that is suitable as components for external skin preparations such as cosmetics. The anti-wrinkle agents comprise compounds represented by general formula (1), stereoisomers thereof, or pharmacologically acceptable salts thereof. Said anti-wrinkle agents have excellent efficacy in improving wrinkles and sagging that are caused by skin aging with increased age or occur as a result of photoaging due to ultraviolet rays exposure. [In the formula, R1 represents a hydrogen atom or a 1 to 8 carbon straight or branched alkyl group. R2 represents —SH, —SO3H, —S—S—X1, —S—X2, —SO—X3, —SO2—X4, —SO2—NY1—X5 or —SO2—NY2—Y3. X1-X5 independently are hydrogen atoms or 1 to 8 carbon aliphatic hydrocarbon groups or 5 to 12 carbon aromatic moiety wherein carbon atoms may be substituted with heteroatoms. Y1 to Y3 independently represent hydrogen atoms or 1 to 8 carbon linear or branched alkyl groups. R3 represents a hydrogen atom or acyl group having a 1 to 8 carbon straight or branched alkyl chain. R4 represents a 5 to 12 carbon aromatic group or polycyclic condensed aromatic group that may have unsubstituted or substituted groups. m represents an integer 0-3 and n represents an integer 1 or 2].
摘要翻译：提供了具有适合作为外用皮肤制剂如化妆品的组分的新型支架的抗皱剂。抗皱剂包括由通式（1）表示的化合物，其立体异构体或其药理学上可接受的盐。所述抗皱剂在改善由老化引起的皱纹和下垂的作用方面具有优异的效果，或者由于紫外线暴露引起的光老化而发生。 [式中，R 1表示氢原子或1〜8碳直链或支链烷基。 R2表示-SH，-SO3H，-S-S-X1，-S-X2，-SO-X3，-SO2-X4，-SO2-NY1-X5或-SO2-NY2-Y3。 X 1 -X 5独立地是氢原子或1至8个碳脂族烃基或5至12个碳芳族部分，其中碳原子可以被杂原子取代。 Y 1〜Y 3独立地表示氢原子或1〜8个碳直链或支链烷基。 R3表示氢原子或具有1-8个碳直链或支链烷基链的酰基。 R 4表示可以具有未取代或取代基的5〜12个碳芳香族基团或多环稠合芳香族基团。 m表示0-3的整数，n表示1或2的整数]。

5. 发明申请

US20130058990A1 COMPOSITION CONTAINING A DIBENZOYLMETHANE SCREENING AGENT AND A HYDROPHILIC OR WATER-SOLUBLE MEROCYANIN UV-SCREENING AGENT; PROCESS FOR PHOTOSTABILIZING THE DIBENZOYLMETHANE SCREENING AGENT 有权
标题翻译：含有二苯甲基氯乙烯筛选剂的组合物和水解或水溶性紫外线屏蔽剂; 二苯甲基氯化物筛选剂的光化学方法
公开(公告)号：US20130058990A1
公开(公告)日：2013-03-07
申请号：US13634194
申请日：2011-03-07
申请人： Herve Richard , Benoit Muller
发明人： Herve Richard , Benoit Muller
IPC分类号： A61K8/49 , A61K8/42 , A61K8/44 , A61K8/46 , A61K8/11 , C07D295/145 , C07C229/46 , C07C317/48 , C07D277/04 , C07D263/06 , C07D211/46 , A61Q17/04 , C07C309/18
CPC分类号： A61K8/35 , A61K8/40 , A61K8/41 , A61K8/44 , A61K8/46 , A61K8/466 , A61K8/49 , A61K8/4926 , A61Q17/04 , C07C229/30 , C07C229/46 , C07C255/30 , C07C255/31 , C07C309/12 , C07C309/14 , C07C309/15 , C07C309/22 , C07C309/23 , C07C317/48 , C07C2601/16 , C07D211/46 , C07D263/14 , C07D277/10
摘要： The present invention relates to a cosmetic composition containing a combination i) of at least one screening agent of the dibenzoylmethane derivative type and ii) of at least one particular hydrophilic or water-soluble merocyanin UV-screening agent, especially corresponding to one of the formulae (I) or (II) below: in which at least one or two of the radicals contain: either an alkylsulfonate radical in its acid or salified form, or one or two hydroxyl radicals. The invention also relates to a process for the radiation-photostabilization of at least one screening agent of the dibenzoylmethane derivative type with an effective amount of at least one particular hydrophilic or water-soluble merocyanin UV-screening agent, especially corresponding to one of the formulae (I) or (II).
摘要翻译：本发明涉及包含至少一种二苯甲酰甲烷衍生物类型的筛选剂的组合i）和ii）至少一种特别亲水或水溶性的花青素UV-筛选剂的化妆品组合物，特别是对应于式（I）或（II）：其中至少一个或两个基团含有：其酸或盐化形式的烷基磺酸根基团或一个或两个羟基基团。本发明还涉及至少一种二苯甲酰甲烷衍生物类型的筛选剂与有效量的至少一种特别的亲水或水溶性的花青素UV-筛选剂的辐射光稳定化方法，特别是对应于式（I）或（II）。

7. 发明授权

US4812555A Peptides possessing renin inhibitory activity 失效
标题翻译：具有肾素抑制活性的肽
公开(公告)号：US4812555A
公开(公告)日：1989-03-14
申请号：US171973
申请日：1988-03-22
申请人： Peter Raddatz , Gunter Holzemann , Alfred Jonczyk , Claus J. Schmitges , Klaus O. Minck
发明人： Peter Raddatz , Gunter Holzemann , Alfred Jonczyk , Claus J. Schmitges , Klaus O. Minck
IPC分类号： C07K7/06 , A61K38/00 , A61K38/55 , A61P9/12 , A61P43/00 , C07C67/00 , C07C231/00 , C07C237/12 , C07C237/22 , C07C239/00 , C07C269/00 , C07C301/00 , C07C303/40 , C07C309/18 , C07C313/00 , C07D233/54 , C07K1/113 , C07K5/00 , C07K5/02 , C07K5/06 , C07K5/08 , C07K5/10 , C07K14/81 , A61K37/02
CPC分类号： C07D233/64 , C07K5/00 , C07K5/0227 , Y10S530/86
摘要： New peptides of the formula IX--Z--NR.sup.2 --CHR.sup.3 --CHOH--(CHR.sup.4).sub.n --CO--Ewherein X, Z, R.sup.2, R.sup.3, R.sup.4, E and n are as defined herein and their salts inhibit the activity of human plasma renin.
摘要翻译：式XZ-NR2-CHR3-CHOH-（CHR4）n-CO-E的新肽，其中X，Z，R2，R3，R4，E和n如本文所定义，并且它们的盐抑制人血浆肾素的活性。

8. 发明授权

US3968110A Sulfosuccinate derivatives as detergent builders 失效
标题翻译：磺基琥珀酸盐衍生物作为洗涤剂助洗剂
公开(公告)号：US3968110A
公开(公告)日：1976-07-06
申请号：US578703
申请日：1975-05-19
申请人： Vincent Lamberti
发明人： Vincent Lamberti
IPC分类号： C07C291/04 , C07C309/17 , C07C309/18 , C07C323/65 , C07C323/66 , C11D1/00 , C11D1/12 , C11D1/755 , C11D3/00 , C11D3/16 , C11D3/34 , C07D295/00 , C07C143/54
CPC分类号： C11D3/349 , C07C291/04 , C07C309/17 , C07C309/18 , C07C323/65 , C07C323/66 , C11D1/123 , C11D1/755 , C11D3/3427 , C11D3/3445 , C11D3/3454 , C11D3/3472
摘要： Novel salts of .alpha.-substituted-.beta.-sulfosuccinic acids having the general formula: ##EQU1## wherein R is hydrogen or an organic moiety, Z is selected from the group consisting of O, S, SO, SO.sub.2, N and NO and M is an alkali metal, ammonium or substituted ammonium cations, useful as detergents and/or detergent builders and detergent compositions containing same.
摘要翻译：具有以下通式的α-取代-β-磺基琥珀酸的新盐：RZ-CH --- CH-SO3M || COOMCOOM其中R是氢或有机部分，Z选自O，S，SO ，SO 2，N和NO，M是可用作洗涤剂和/或洗涤剂助洗剂的碱金属，铵或取代的铵阳离子和含有它们的洗涤剂组合物。

9. 发明授权

US3957775A Sulfosuccinate derivatives as detergent builders 失效
标题翻译：作为洗涤剂建筑物的硫酸盐衍生物
公开(公告)号：US3957775A
公开(公告)日：1976-05-18
申请号：US484920
申请日：1974-07-01
申请人： Vincent Lamberti
发明人： Vincent Lamberti
IPC分类号： C07C291/04 , C07C309/17 , C07C309/18 , C07C323/65 , C07C323/66 , C11D1/00 , C11D1/12 , C11D1/755 , C11D3/00 , C11D3/16 , C11D3/34 , C07C143/00 , C07D295/00
CPC分类号： C11D3/349 , C07C291/04 , C07C309/17 , C07C309/18 , C07C323/65 , C07C323/66 , C11D1/123 , C11D1/755 , C11D3/3427 , C11D3/3445 , C11D3/3454 , C11D3/3472
摘要： Novel salts of .alpha.-substituted-.beta.-sulfosuccinic acids having the general formula: ##EQU1## wherein R is hydrogen or an organic moiety, Z is selected from the group consisting of O, S, SO, SO.sub.2, N and NO and M is an alkali metal, ammonium or substituted ammonium cations, useful as detergents and/or detergent builders and detergent compositions containing same.

10. 发明授权

US3936448A .alpha.-Amino-.beta.-sulfosuccinates 失效
标题翻译： {60-氨基 - （62-磺基琥珀酸盐）
公开(公告)号：US3936448A
公开(公告)日：1976-02-03
申请号：US484916
申请日：1974-07-01
申请人： Vincent Lamberti
发明人： Vincent Lamberti
IPC分类号： C07C291/04 , C07C309/17 , C07C309/18 , C07C323/65 , C07C323/66 , C11D1/00 , C11D1/12 , C11D1/755 , C11D3/00 , C11D3/16 , C11D3/34 , C07C143/15
CPC分类号： C11D3/349 , C07C291/04 , C07C309/17 , C07C309/18 , C07C323/65 , C07C323/66 , C11D1/123 , C11D1/755 , C11D3/3427 , C11D3/3445 , C11D3/3454 , C11D3/3472
摘要： Novel salts of .alpha.-substituted-.beta.-sulfosuccinic acids having the general formula: ##EQU1## wherein R is hydrogen or an organic moiety, Z is selected from the group consisting of O, S, SO, SO.sub.2, N and NO and M is an alkali metal, ammonium or substituted ammonium cations, useful as detergents and/or detergent builders and detergent compositions containing same.
摘要翻译：具有以下通式的α-取代-β-磺基琥珀酸的新盐：RZ-CH-CH-SO3M || COOMCOOM其中R是氢或有机部分，Z选自O，S，SO，SO 2 ，N和NO和M是可用作洗涤剂和/或洗涤剂助洗剂的碱金属，铵或取代的铵阳离子和含有它们的洗涤剂组合物。

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