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1. 发明授权

US11903386B2 Strigolactone analogs and their usage in plant control 有权
公开(公告)号：US11903386B2
公开(公告)日：2024-02-20
申请号：US16337198
申请日：2017-09-27
申请人： King Abdullah University of Science and Technology
发明人： Salim Al-Babili , Tadao Asami , Tsuyoshi Ohta
IPC分类号： A01N43/08 , C07D307/60
CPC分类号： A01N43/08 , C07D307/60
摘要： A strigolactone analog-based composition comprising at least one compound represented by: (I) wherein Ra, Rb, Rc, Rf, Re, and Rz are selected. The compositions can be used in, for example, plant growth regulation and weed control, including controlling the germination of parasitic root plants, inhibiting rice tillering, and triggering leaf senescence.

2. 发明授权

US11648545B2 Transition metal-based heterogeneous carbonylation reaction catalyst and method for preparing lactone or succinic anhydride using catalyst 有权
公开(公告)号：US11648545B2
公开(公告)日：2023-05-16
申请号：US17236665
申请日：2021-04-21
申请人： KOOKMIN UNIVERSITY INDUSTRY ACADEMY COOPERATION FOUNDATION
发明人： Sungho Yoon , Senkuttuvan Rajendiran , Jianwei Jiang , Kwang Ho Park
IPC分类号： B01J31/16 , B01J37/00 , C07D305/12 , C07D307/60
CPC分类号： B01J31/16 , B01J37/00 , C07D305/12 , C07D307/60
摘要： A transition metal-based heterogeneous carbonylation reaction catalyst has an excellent catalytic activity and selectivity in the carbonylation reaction and is easily separated from a product, by crosslinking polymerizing a transition metal-based homogeneous catalyst unit through a Friedel-Craft reaction. The catalyst may be used in a method for preparing lactone. The transition metal-based heterogeneous carbonylation reaction catalyst allows to produce lactone or succinic anhydride with an epoxide compound while showing a high selectivity, and can be applied in industrial very usefully due to easy separation from the product and thus reusing thereof.

3. 发明授权

US10493072B2 Lanthionine synthetase C-like 2-based therapeutics 有权
公开(公告)号：US10493072B2
公开(公告)日：2019-12-03
申请号：US16227940
申请日：2018-12-20
申请人： Landos Biopharma, Inc.
发明人： Josep Bassaganya-Riera , Adria Carbo Barrios , Richard Gandour , Julian D. Cooper , Raquel Hontecillas
IPC分类号： C07D307/68 , A61K31/341 , A61K31/496 , C07D403/12 , C07D401/14 , C07D413/14 , C07D413/12 , C07D213/69 , C07D307/60 , C07C65/40 , C07D213/79 , C07D403/14 , A61K31/4184 , A61K31/423 , A61K31/4439
CPC分类号： A61K31/496 , A61K31/4184 , A61K31/423 , A61K31/4439 , C07C65/40 , C07D213/69 , C07D213/79 , C07D307/60 , C07D307/68 , C07D401/14 , C07D403/12 , C07D403/14 , C07D413/12 , C07D413/14
摘要： Provided are compounds that target the lanthionine synthetase C-like protein 2 pathway. The compounds can be used to treat a number of conditions, including infectious disease, autoimmune disease, diabetes, and a chronic inflammatory disease.

4. 发明申请

US20180179449A1 METHOD AND APPARATUS FOR PRODUCING A CHEMICAL COMPOUND AND THE PRODUCED CHEMICAL COMPOUND 审中-公开
公开(公告)号：US20180179449A1
公开(公告)日：2018-06-28
申请号：US15735059
申请日：2016-06-09
申请人： TEKNOLOGIAN TUTKIMUSKESKUS VTT OY
发明人： Matti REINIKAINEN , Ilkka HILTUNEN
IPC分类号： C10G2/00 , C07C51/54 , C07C51/567 , C07C5/41 , C10J3/82
CPC分类号： C10G2/332 , B01J23/745 , B01J23/78 , B01J29/40 , C07C1/044 , C07C1/0485 , C07C2/76 , C07C5/41 , C07C7/04 , C07C51/54 , C07C51/567 , C07C2523/745 , C07C2529/40 , C07D307/60 , C10G2/00 , C10G2300/1011 , C10G2400/20 , C10G2400/22 , C10J3/82 , C10J2300/0916 , C10J2300/092 , C10J2300/1659 , D21H21/16 , Y02E50/32 , Y02P20/52 , C07C9/10 , C07C11/08 , C07C11/02 , C07C15/04 , C07C15/06
摘要： A method and an apparatus for producing a chemical compound from biomass based raw material. The bio-mass based raw material is gasified in a gasification device for forming a gasification gas, the gasification gas is treated in the reactor which includes at least one catalyst layer including Fe-based catalyst for forming a hydrocarbon composition, at least one hydrocarbon fraction including olefins is recovered from the hydrocarbon composition, and a chemical compound is formed from the hydrocarbon fraction. Further, the invention relates to the produced chemical compound.

5. 发明授权

US09751849B1 Method of producing a furanone compound 有权
公开(公告)号：US09751849B1
公开(公告)日：2017-09-05
申请号：US15370015
申请日：2016-12-06
申请人： KING FAHD UNIVERSITY OF PETROLEUM AND MINERALS
发明人： Chanbasha Basheer , Ahmed Abdi Hassan
IPC分类号： C07D307/00 , C07D307/60 , B01J19/12
CPC分类号： C07D307/60 , B01J19/127 , B01J2219/0877 , B01J2219/0892 , B01J2219/1203
摘要： A method of photooxygenating furfural in a photooxygenating system, whereby a liquid mixture comprising furfural, a photosensitizer, and a reaction solvent is passed through a reaction section of the photooxygenating system, wherein the liquid mixture is exposed to solar radiation, while a portion of the furfural is oxidized in presence of the photosensitizer and a furanone compound is produced. Various embodiments of the photocatalytic water splitting reactor, and the water splitting system are also provided.

6. 发明授权

US09493391B2 Process for beta-lactone production 有权
公开(公告)号：US09493391B2
公开(公告)日：2016-11-15
申请号：US14857313
申请日：2015-09-17
申请人： Novomer, Inc.
发明人： Scott D. Allen , Ronald R. Valente , Han Lee , Anna E. Cherian , Donald L. Bunning , Nye A. Clinton , Olan Stanley Fruchey , Bernard Duane Dombek
IPC分类号： C07C51/377 , C08G63/08 , C07C67/317 , C07C231/14 , C07D305/12 , C07D307/60 , C07C51/09 , C07C67/30
CPC分类号： C07C51/377 , C07C51/09 , C07C67/30 , C07C67/317 , C07C231/14 , C07D305/12 , C07D307/60 , C08G63/08 , Y02P20/584
摘要： The present application provides a method for producing an beta-lactone product. The method includes the steps of: reacting an epoxide, a solvent with a carbonylation catalyst and carbon monoxide to produce a reaction stream comprising a beta-lactone then separating a portion of the beta-lactone in the reaction stream from the solvent and carbonylation catalyst to produce: i) a beta-lactone stream with the beta-lactone, and ii) a catalyst recycling stream including the carbonylation catalyst and the high boiling solvent; and adding the catalyst recycling stream to the feed stream.

7. 发明申请

US20160279587A1 PACKING FOR REACTION TUBE, REACTION TUBE, AND REACTION METHOD USING SAME 审中-公开
标题翻译：用于反应管的包装，反应管和使用该反应管的反应方法
公开(公告)号：US20160279587A1
公开(公告)日：2016-09-29
申请号：US15033749
申请日：2014-10-30
申请人： NIPPON SHOKUBAI CO., LTD.
发明人： Yuuji SHIMASAKI
IPC分类号： B01J7/00 , C07C51/25 , C07D301/08 , B01J8/06 , C07C37/58
CPC分类号： B01J7/00 , B01J8/067 , B01J19/30 , B01J2208/065 , B01J2219/30223 , B01J2219/30226 , B01J2219/30253 , B01J2219/30408 , B01J2219/30416 , C07C37/58 , C07C51/252 , C07D301/08 , C07D307/60
摘要： In a fixed-bed flow reaction using a multitubular heat exchange type reactor, an object of the present invention is to provide a novel packing for a reaction tube, which can control the reaction ratio in the vicinity of the reaction tube inlet, reduce the load unevenly placed on the catalyst in the reaction region, and distribute the load on the entire catalyst layer, a heat exchange type reactor, and a reaction method using the reaction tube. The packing for a reaction tube of the present invention is characterized in that the volume is continuously or step-by-step decreased from one end part or midway toward the other end part.
摘要翻译：在使用多管式热交换型反应器的固定床流动反应器中，本发明的目的是提供一种用于反应管的新型填料，其可以控制反应管入口附近的反应比，减少负载不均匀地放置在反应区域中的催化剂上，并且将负载分布在整个催化剂层上，热交换型反应器和使用反应管的反应方法。本发明的反应管的填料的特征在于，其体积从一个端部或中途向另一端部连续地或逐步地减小。

8. 发明申请

US20160272605A1 Disubstituted Maleic Anhydrides with Altered Kinetics of Ring Closure 审中-公开
标题翻译：具有改变闭环动力学的二取代马来酸酐
公开(公告)号：US20160272605A1
公开(公告)日：2016-09-22
申请号：US15166482
申请日：2016-05-27
申请人： Arrowhead Madison Inc.
发明人： Andrei V. Blokhin , David B. Rozema , Jonathan D. Benson , Jeffrey C. Carlson
IPC分类号： C07D307/66 , C07H15/26 , C07D307/88
CPC分类号： C07D307/89 , C07D307/60 , C07D307/66 , C07D307/88 , C07H15/08 , C07H15/26
摘要： We describe anhydride compounds suitable for physiologically labile modification of amine-containing molecules. The described anhydrides form reversible linkages having desirable kinetics for in vivo delivery of biologically active molecules. Also described are endosomolytic polymers formed by modification of membrane active polyamines with the described anhydrides.
摘要翻译：我们描述适用于含胺分子的生理不稳定修饰的酸酐化合物。所述的酸酐形成具有用于体内递送生物活性分子的所需动力学的可逆连接。还描述了通过用所述酸酐修饰膜活性多胺而形成的内体分解聚合物。

9. 发明授权

US09403788B2 Process for the production of acid anhydrides from epoxides 有权
标题翻译：从环氧化物生产酸酐的方法
公开(公告)号：US09403788B2
公开(公告)日：2016-08-02
申请号：US14378290
申请日：2013-02-12
申请人： Novomer, Inc.
发明人： Han Lee , Michael A. Slowik
IPC分类号： C07D307/60 , C07D303/12 , B01J31/22 , C07D305/12
CPC分类号： C07D307/60 , B01J31/2295 , B01J2231/48 , B01J2531/31 , B01J2531/845 , C07D303/12 , C07D305/12
摘要： A method of making acid anhydrides from epoxide and carbon monoxide feedstocks is presented. In various aspects, the method includes steps of reacting the contents of a feed stream comprising an epoxide, a solvent, a carbonylation catalyst and carbon monoxide to produce a first carbonylation product stream comprising a beta-lactone, then reacting the contents of the first carbonylation product stream with additional carbon monoxide to produce a second carbonylation product stream comprising an acid anhydride, and separating at least a portion of the acid anhydride from the second carbonylation product stream to produce: i) an acid anhydride product stream comprising the separated portion of acid anhydride; and ii) a recycling stream comprising the carbonylation catalyst, and finally adding the recycling stream to the feed stream.
摘要翻译：提出了一种从环氧化物和一氧化碳原料制备酸酐的方法。在各个方面，该方法包括使包含环氧化物，溶剂，羰基化催化剂和一氧化碳的进料流的内容物反应以产生包含β-内酯的第一羰基化产物流，然后使第一羰基化反应的内容物产生含有一氧化碳的产物流以产生包含酸酐的第二羰基化产物流，并将至少一部分酸酐与第二羰基化产物流分离以产生：i）包含酸的分离部分的酸酐产物流酐; 和ii）包含羰基化催化剂的再循环流，最后将再循环流加入进料流中。

10. 发明申请

US20160130216A1 COMPOUNDS FOR PROMOTING LIPOSOMAL AND CELLULAR ADHESION AND COMPOSITIONS AND METHODS OF USE THEREOF 有权
标题翻译：用于促进脂质和细胞粘附和组合物的化合物及其使用方法
公开(公告)号：US20160130216A1
公开(公告)日：2016-05-12
申请号：US14896069
申请日：2014-06-11
申请人： Muhammad YOUSAF
发明人： Muhammad Naveed Yousaf
IPC分类号： C07C235/20 , C12N15/88 , A61K9/127
CPC分类号： C07C235/20 , A61K9/127 , C07C43/14 , C07C43/172 , C07C49/175 , C07C50/28 , C07C217/08 , C07C239/20 , C07C243/14 , C07C247/04 , C07C323/12 , C07C2601/10 , C07D207/46 , C07D307/60 , C07D495/04 , C07F9/4084 , C07F9/5022 , C12N5/0006 , C12N15/88
摘要： The present application describes amphiphatic compounds like compound IIa below, compositions and methods for incorporating chemoselective and bio-orthogonal complementary functional groups into liposomes. Such compounds are incorporated in greater numbers in liposome and fused cell surfaces, leading to greater adhesion and conjugation efficiency. The present application also describes various uses of these modified liposomes including for tethering the chemoselective and bioorthogonal complementary functional groups from cell surfaces by liposome delivery toward the goal of rewiring the cell surface.
摘要翻译：本申请描述了下文化合物IIa的两性脂族化合物，将化学选择性和生物正交互补官能团掺入脂质体的组合物和方法。这些化合物在脂质体和融合细胞表面中更多地并入，导致更大的粘附和共轭效率。本申请还描述了这些修饰的脂质体的各种用途，包括通过脂质体递送将细胞表面的化学选择性和生物正交互补官能团连接到重新接线细胞表面的目的。

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