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1. 发明申请

US20170050924A1 INHIBITORS OF CREATINE TRANSPORT AND USES THEREOF 审中-公开
标题翻译：运输运输的抑制剂及其用途
公开(公告)号：US20170050924A1
公开(公告)日：2017-02-23
申请号：US15307178
申请日：2015-04-30
申请人： Rgenix, Inc.
发明人： Eduardo J. MARTINEZ , Sohail F. TAVAZONE
IPC分类号： C07C279/14 , C07D233/46 , A61K31/4168 , C07D239/14 , A61K31/505 , C07D233/52 , C07D253/06 , A61K31/53 , A61K31/155 , C07D213/74 , A61K31/4402 , C07C275/70 , C07D207/16 , A61K31/40 , C07D205/08 , A61K31/397 , C07D401/04 , A61K31/4427 , C07H19/06 , A61K31/7068 , A61K45/06
CPC分类号： C07C279/14 , A61K31/00 , A61K31/155 , A61K31/337 , A61K31/397 , A61K31/40 , A61K31/4168 , A61K31/4402 , A61K31/4427 , A61K31/505 , A61K31/53 , A61K31/704 , A61K31/7068 , A61K31/7105 , A61K45/06 , C07B2200/05 , C07C257/14 , C07C259/14 , C07C275/70 , C07C279/16 , C07C279/26 , C07C279/36 , C07C281/16 , C07C281/18 , C07C309/15 , C07C313/34 , C07C2601/02 , C07C2601/04 , C07D205/04 , C07D205/08 , C07D207/16 , C07D207/22 , C07D213/74 , C07D213/76 , C07D231/12 , C07D233/26 , C07D233/46 , C07D233/52 , C07D233/64 , C07D233/88 , C07D239/06 , C07D239/14 , C07D249/08 , C07D249/14 , C07D253/06 , C07D257/08 , C07D295/32 , C07D401/04 , C07D405/04 , C07D487/04 , C07F9/097 , C07F9/2458 , C07F9/3808 , C07F9/4006 , C07F9/48 , C07F9/568 , C07F9/572 , C07F9/6506 , C07H19/06 , A61K2300/00
摘要： This invention relates to compounds that inhibit creatine transport and/or creatine kinase, pharmaceutical compositions including such compounds, and methods of utilizing such compounds and compositions for the treatment of cancer.
摘要翻译：本发明涉及抑制肌酸转运和/或肌酸激酶的化合物，包括这些化合物的药物组合物，以及利用这些化合物和组合物治疗癌症的方法。

2. 发明授权

US09499480B2 Methods, compounds, compositions and vehicles for delivering 3-amino-1-propanesulfonic acid 有权
标题翻译：用于递送3-氨基-1-丙磺酸的方法，化合物，组合物和载体
公开(公告)号：US09499480B2
公开(公告)日：2016-11-22
申请号：US14246894
申请日：2014-04-07
申请人： BHI Limited Partnership
发明人： Xianqi Kong , Mohamed Atfani , Benoit Bachand , Abderrahim Bouzide , Stephane Ciblat , Sophie Levesque , David Migneault , Isabelle Valade , Xinfu Wu , Daniel Delorme
IPC分类号： C07D285/36 , C07D323/02 , C07D285/38 , C07D333/24 , C07D217/24 , C07D291/02 , C07D233/64 , C07D209/20 , C07K5/068 , C07K5/062 , C07C309/24 , A61K47/48 , C07C309/19 , C12P13/00 , C07C309/18 , C07H15/12 , C07H7/02 , C07J9/00 , C12P11/00 , C07C309/15 , C07K5/083 , C07D207/16
CPC分类号： A61K31/145 , A61K47/54 , A61K47/542 , A61K47/545 , A61K47/549 , A61K47/554 , A61K47/64 , C07C309/15 , C07C309/18 , C07C309/19 , C07C309/24 , C07D207/16 , C07D209/20 , C07D217/24 , C07D233/64 , C07D285/36 , C07D285/38 , C07D291/02 , C07D323/02 , C07D333/24 , C07H7/02 , C07H15/12 , C07J9/005 , C07K5/06026 , C07K5/06052 , C07K5/0606 , C07K5/06069 , C07K5/06086 , C07K5/0806 , C07K5/081 , C12P11/00 , C12P13/001 , Y02P20/55
摘要： The invention relates to methods, compounds, compositions and vehicles for delivering 3-amino-1-propanesulfonic acid (3APS) in a subject, preferably a human subject. The invention encompasses compound that will yield or generate 3APS, either in vitro or in vivo. Preferred compounds include amino acid prodrugs of 3APS for use, including but not limited to the prevention and treatment of Alzheimer's disease.
摘要翻译：本发明涉及在受试者，优选人受试者中递送3-氨基-1-丙磺酸（3APS）的方法，化合物，组合物和载体。本发明包括在体外或体内产生或产生3APS的化合物。优选的化合物包括3APS的氨基酸前药，包括但不限于预防和治疗阿尔茨海默氏病。

3. 发明授权

US09440905B2 Polymerizable gemini dicarboxlate surfactants and lyotropic liquid crystals and membranes made therefrom 有权
标题翻译：可聚合的双晶二甲酸表面活性剂和溶致液晶以及由其制成的膜
公开(公告)号：US09440905B2
公开(公告)日：2016-09-13
申请号：US13747865
申请日：2013-01-23
申请人： Wisconsin Alumni Research Foundation
发明人： Mahesh Kalyana Mahanthappa , Gregory Paul Sorenson
IPC分类号： C07C57/13 , C09K19/02 , C07C309/15 , C09K19/04 , C09K19/52
CPC分类号： C07C57/13 , C07C309/15 , C09K19/0283 , C09K2019/0448 , C09K2019/528
摘要： The disclosure provides anionic Gemini surfactants comprising at least two carbonyl moieties and at least two aliphatic moieties. In some aspects, at least two of the aliphatic moieties comprise at least seven carbon atoms and at least one pair of conjugated carbon-to-carbon double bonds. The anionic Gemini surfactants are polymerizable and may be used to prepare triply periodic multiply continuous lyotropic phase and polymers thereof that substantially retain triply periodic multiply continuous lyotropic phase structure.
摘要翻译：本公开提供了包含至少两个羰基部分和至少两个脂族部分的阴离子Gemini表面活性剂。在一些方面，至少两个脂族部分包含至少七个碳原子和至少一对共轭碳 - 碳双键。阴离子双子表面活性剂是可聚合的，并且可以用于制备基本上保持三次周期性多次连续溶致相结构的三次定期多次连续溶致相及其聚合物。

4. 发明申请

US20160137596A1 METHOD FOR PURIFYING ACRYLAMIDE ALKYL SULFONIC ACID 有权
标题翻译：纯化丙烯酰胺磺酸的方法
公开(公告)号：US20160137596A1
公开(公告)日：2016-05-19
申请号：US14896387
申请日：2014-02-11
申请人： Longyi MEI
发明人： Longyuan MEI
IPC分类号： C07C303/44
CPC分类号： C07C303/44 , C07C309/15
摘要： A method for purifying acrylamide alkyl sulfonic acid comprises: (1) making a material A evenly mixed and contacted with a solvent C, an amount of the material A exceeding a solubility of the material A in the solvent C under the condition where the material A is located, therefore the material A is not completely dissolved by the solvent C; (2) keeping the material A even mixed and contacted with the solvent C for at least 5 minutes; (3) performing a solid-liquid separation to obtain a solid, namely, a purified product B with impurities reduced. In the purifying method according to the invention, the material does not need to be completely dissolved, therefore less solvent is used, and the steps of dissolving the material by increasing temperature, separating out by decreasing temperature or removing the solvent are eliminated, so cost is reduced, efficiency is improved, and operations are simplified.
摘要翻译：丙烯酰胺烷基磺酸的纯化方法包括：（1）将材料A均匀混合并与溶剂C接触，一定量的材料A超过材料A在溶剂C中的溶解度，在材料A 因此材料A不被溶剂C完全溶解; （2）保持材料A均匀混合并与溶剂C接触至少5分钟; （3）进行固液分离以获得固体，即具有杂质降低的纯化物B。在根据本发明的净化方法中，材料不需要完全溶解，因此使用较少的溶剂，并且消除了通过升高温度溶解材料，通过降低温度分离出来或除去溶剂的步骤，因此成本降低效率，提高效率，简化操作。

5. 发明申请

US20160122295A1 PREPARATION METHOD OF SOLID ACRYLAMIDEALKYL SULFONATE 有权
标题翻译：固体丙烯酰胺基磺酸盐的制备方法
公开(公告)号：US20160122295A1
公开(公告)日：2016-05-05
申请号：US14765315
申请日：2014-01-24
申请人： Longyi MEI
发明人： LONGYUAN MEI
IPC分类号： C07C303/32 , C07C303/44
CPC分类号： C07C303/32 , C07C303/44 , C07C309/15
摘要： The present invention provides a method for preparing a solid acrylamide alkyl sulfonate. Said method comprises: reacting 2-acrylamido-2-methylpropanesulfonic acid and analogs thereof with an alkaline substance in a solvent. The 2-acrylamido-2-methylpropanesulfonic acid and the analogs thereof and the alkaline substance are significant excess with respect to the solvent, so that the amount of the resulting acrylamido alkyl sulfonate exceeds the solubility under the reaction condition. The acrylamido alkyl sulfonate can be continuously generated and directly massively precipitated, and the precipitated solid product, i.e. the product, is collected. The method of the present invention can greatly improve production efficiency of products, save time, reduce cost, and easy to operate by leaving out the re-crystallization step and the like in the prior art.
摘要翻译：本发明提供一种制备固体丙烯酰胺烷基磺酸盐的方法。所述方法包括：使2-丙烯酰胺基-2-甲基丙磺酸及其类似物与碱性物质在溶剂中反应。 2-丙烯酰氨基-2-甲基丙磺酸及其类似物和碱性物质相对于溶剂显着过量，使得所得丙烯酰氨基烷基磺酸盐的量超过反应条件下的溶解度。丙烯酰氨基烷基磺酸酯可以连续生成并直接大量沉淀，并收集沉淀的固体产物，即产物。本发明的方法可以通过省略现有技术中的再结晶步骤等而大大提高产品的生产效率，节省时间，降低成本，并且易于操作。

6. 发明申请

US20160116840A1 COMPOUND, ACTIVE LIGHT SENSITIVE OR RADIATION SENSITIVE RESIN COMPOSITION, RESIST FILM USING SAME, RESIST-COATED MASK BLANK, PHOTOMASK, PATTERN FORMING METHOD, METHOD FOR MANUFACTURING ELECTRONIC DEVICE, AND ELECTRONIC DEVICE 有权
标题翻译：化合物，活性敏感性或辐射敏感性树脂组合物，使用其的耐光膜，耐光涂布掩模，光刻胶，图案形成方法，制造电子器件的方法和电子器件
公开(公告)号：US20160116840A1
公开(公告)日：2016-04-28
申请号：US14982759
申请日：2015-12-29
申请人： FUJIFILM Corporation
发明人： Tomotaka TSUCHIMURA
IPC分类号： G03F7/004 , H01L21/027 , C07C327/24 , C07C321/28 , C07D333/76 , C07C309/19 , C07C323/20 , C07C25/18 , C07C323/09 , C07D333/46 , C07D209/48 , C07C311/16 , C07D327/08 , C07J41/00 , G03F7/038 , G03F1/76 , H01L29/16
CPC分类号： G03F7/0045 , C07C25/18 , C07C309/15 , C07C309/19 , C07C311/14 , C07C311/16 , C07C311/48 , C07C311/51 , C07C321/28 , C07C323/09 , C07C323/20 , C07C327/22 , C07C327/24 , C07C327/26 , C07C381/12 , C07C2601/08 , C07C2601/14 , C07C2602/42 , C07C2603/18 , C07C2603/24 , C07C2603/74 , C07D209/48 , C07D327/08 , C07D333/46 , C07D333/76 , C07D335/16 , C07D339/08 , C07D347/00 , C07D493/08 , C07J31/006 , C07J41/0055 , C07J41/0061 , G03F1/76 , G03F7/038 , G03F7/0382 , G03F7/0392 , G03F7/0397 , H01L21/0271 , H01L21/0276 , H01L29/16
摘要： Provided is an active light sensitive or radiation sensitive resin composition which contains a compound (A) represented by General Formula (I) or (II): in the formulae, each of Y1 and Y2 represents a monovalent organic group; each of M1+ and M2+ represents an organic onium ion; each of X1 and X2 represents a group that is represented by —S—, —NH—, or —NR1—; R1 represents a monovalent organic group; each of n1 and n2 represents an integer of 1 or more; and R1 and Y1 or Y2 may bond with each other to form a ring.
摘要翻译：本发明提供含有由通式（I）或（II）表示的化合物（A））的有源光敏性或辐射敏感性树脂组合物：在该式中，Y1和Y2各自表示一价有机基团; M1 +和M2 +各自表示有机鎓离子; X1和X2各自表示由-S-，-NH-或-NR1-表示的基团; R1表示一价有机基团; n1和n2各自表示1以上的整数，并且R1和Y1或Y2可以彼此键合形成环。

7. 发明申请

US20150336916A1 EPOXYEICOSATRIENOIC ACID ANALOGS AND METHODS OF MAKING AND USING THE SAME 有权
标题翻译：环氧亚油酸类似物及其制备和使用方法
公开(公告)号：US20150336916A1
公开(公告)日：2015-11-26
申请号：US14813615
申请日：2015-07-30
申请人： THE MEDICAL COLLEGE OF WISCONSIN, INC. , THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM
发明人： John David Imig , William B. Campbell , John Russell Falck
IPC分类号： C07D291/04 , C07D285/08 , C07D271/07 , C07D277/34 , C07D257/04 , C07D249/12
CPC分类号： C07F9/40 , C07C233/46 , C07C233/47 , C07C233/56 , C07C237/22 , C07C275/20 , C07C309/15 , C07C311/18 , C07C311/19 , C07C311/51 , C07C317/28 , C07C323/44 , C07D249/12 , C07D257/04 , C07D271/06 , C07D271/07 , C07D277/34 , C07D277/593 , C07D277/82 , C07D285/08 , C07D291/04
摘要： Compounds and compositions comprising epoxyeicosatrienoic acid (EET) analogs that act as EET agonists and are useful as medications in the treatment of drug-induced nephrotoxicity, hypertension and other related conditions. Methods of making and using the compounds and compositions are further described.
摘要翻译：作为EET激动剂的环氧二十碳三烯酸（EET）类似物的化合物和组合物，可用作治疗药物诱导的肾毒性，高血压和其它相关病症的药物。进一步描述制备和使用化合物和组合物的方法。

8. 发明授权

US09127027B2 Epoxyeicosatrienoic acid analogs and methods of making and using the same 有权
标题翻译：环氧二十碳三烯酸类似物及其制备和使用方法
公开(公告)号：US09127027B2
公开(公告)日：2015-09-08
申请号：US14009658
申请日：2012-04-04
申请人： John David Imig , William B. Campbell , John Russell Falck
发明人： John David Imig , William B. Campbell , John Russell Falck
IPC分类号： A61K31/66 , C07F9/40 , C07C233/46 , C07C233/56 , C07C275/20 , C07C309/15 , C07C311/18 , C07C311/51 , C07C317/28 , C07C323/44 , C07D249/12 , C07D257/04 , C07D271/06 , C07D277/34 , C07D277/82 , C07D291/04 , C07C233/47 , C07C237/22 , C07C311/19 , C07D271/07 , C07D277/593 , C07D285/08
CPC分类号： C07F9/40 , C07C233/46 , C07C233/47 , C07C233/56 , C07C237/22 , C07C275/20 , C07C309/15 , C07C311/18 , C07C311/19 , C07C311/51 , C07C317/28 , C07C323/44 , C07D249/12 , C07D257/04 , C07D271/06 , C07D271/07 , C07D277/34 , C07D277/593 , C07D277/82 , C07D285/08 , C07D291/04
摘要： Compounds and compositions comprising epoxyeicosatrienoic acid (EET) analogs that act as EET agonists and are useful as medications in the treatment of drug-induced nephrotoxicity, hypertension and other related conditions. Methods of making and using the compounds and compositions are further described.
摘要翻译：作为EET激动剂的环氧二十碳三烯酸（EET）类似物的化合物和组合物，可用作治疗药物诱导的肾毒性，高血压和其它相关病症的药物。进一步描述制备和使用化合物和组合物的方法。

9. 发明申请

US20140220122A1 METHODS, COMPOUNDS, COMPOSITIONS AND VEHICLES FOR DELIVERING 3-AMINO-1-PROPANESULFONIC ACID 有权
标题翻译：方法，化合物，用于递送3-氨基-1-丙酸的酸的组合物和车辆
公开(公告)号：US20140220122A1
公开(公告)日：2014-08-07
申请号：US14246894
申请日：2014-04-07
申请人： BHI Limited Partnership
发明人： Xianqi KONG , Mohamed ATFANI , Benoit BACHAND , Abderrahim BOUZIDE , Stephane CIBLAT , Sophie LEVESQUE , David MIGNEAULT , Isabelle VALADE , Xinfu WU , Daniel DELORME
IPC分类号： C07C309/24 , C07D291/02 , C07H15/12 , C07H7/02 , C07D285/36 , C07C309/18 , C07D217/24 , C07D333/24 , C07D323/02 , C07J9/00 , C07C309/19 , C12P13/00 , C07D285/38
CPC分类号： A61K31/145 , A61K47/54 , A61K47/542 , A61K47/545 , A61K47/549 , A61K47/554 , A61K47/64 , C07C309/15 , C07C309/18 , C07C309/19 , C07C309/24 , C07D207/16 , C07D209/20 , C07D217/24 , C07D233/64 , C07D285/36 , C07D285/38 , C07D291/02 , C07D323/02 , C07D333/24 , C07H7/02 , C07H15/12 , C07J9/005 , C07K5/06026 , C07K5/06052 , C07K5/0606 , C07K5/06069 , C07K5/06086 , C07K5/0806 , C07K5/081 , C12P11/00 , C12P13/001 , Y02P20/55
摘要： The invention relates to methods, compounds, compositions and vehicles for delivering 3-amino-1-propanesulfonic acid (3APS) in a subject, preferably a human subject. The invention encompasses compound that will yield or generate 3APS, either in vitro or in vivo. Preferred compounds include amino acid prodrugs of 3APS for use, including but not limited to the prevention and treatment of Alzheimer's disease
摘要翻译：本发明涉及在受试者，优选人受试者中递送3-氨基-1-丙磺酸（3APS）的方法，化合物，组合物和载体。本发明包括在体外或体内产生或产生3APS的化合物。优选的化合物包括3APS的氨基酸前药，包括但不限于预防和治疗阿尔茨海默氏病

10. 再颁专利

USRE44988E1 Polymerizable sulfonate ionic liquids and liquid polymers therefrom 有权
标题翻译：可聚合的磺酸盐离子液体和液体聚合物
公开(公告)号：USRE44988E1
公开(公告)日：2014-07-01
申请号：US13763787
申请日：2013-02-11
申请人： The United States of America as represented by the Secretary of the Navy
发明人： Holly L. Ricks-Laskoski , Arthur W. Snow
IPC分类号： C07C309/00 , C07C303/32
CPC分类号： C07C303/32 , C07C217/08 , C07C309/15 , C07C309/21 , C08F2/02 , C08F220/60
摘要： Disclosed is a new ionic liquid monomer salt and methods of is synthesis and polymerization. The ionic liquid monomer salt is prepared by mixing equimolar amounts of an amine, such as tris[2-(2-methoxyethoxy)-ethyl]amine and an acid functionalized polymerizable monomer, such as 2-acrylamido-2-methyl-1-propanesulfonic acid (AMPS), which is stirred at ambient temperature until salt formation is complete. Also disclosed is a new ionic liquid polymer salts and method for making the same. The synthesis of AMPS-ammonium salt polymer is accomplished by adding 2,2′-azobisisobutyronitrile (AIBN) to the ionic liquid monomer salt and heating the homogeneous melt at 70° C. for 18 hr.
摘要翻译：公开了一种新的离子液体单体盐及其合成和聚合方法。离子液体单体盐通过混合等摩尔量的胺，如三[2-（2-甲氧基乙氧基） - 乙基]胺和酸官能化的可聚合单体，如2-丙烯酰胺基-2-甲基-1-丙磺酸酸（AMPS），其在环境温度下搅拌直到盐形成完成。还公开了一种新的离子液体聚合物盐及其制备方法。 AMPS-铵盐聚合物的合成通过向离子液体单体盐中加入2,2'-偶氮二异丁腈（AIBN）并在70℃加热均匀的熔体18小时来完成。

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