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1. 发明申请

US20050218532A1 Method of preparing organomagnesium compounds 有权
标题翻译：制备有机镁化合物的方法
公开(公告)号：US20050218532A1
公开(公告)日：2005-10-06
申请号：US11097707
申请日：2005-04-01
申请人： Paul Knochel , Arkady Krasovskiy
发明人： Paul Knochel , Arkady Krasovskiy
IPC分类号： C07D333/16 , C07B49/00 , C07C1/32 , C07C15/58 , C07C17/263 , C07C25/24 , C07C29/40 , C07C33/18 , C07C33/24 , C07C33/46 , C07C41/26 , C07C43/23 , C07C45/45 , C07C45/68 , C07C49/697 , C07C49/813 , C07C49/84 , C07C67/343 , C07C69/616 , C07C69/76 , C07C253/30 , C07C255/50 , C07C255/53 , C07C255/56 , C07C319/14 , C07C323/20 , C07D213/16 , C07D213/61 , C07D277/24 , C07D333/56 , C07F3/02 , C07F3/04 , C07F9/53
CPC分类号： C07B49/00 , C07F3/02
摘要： The present invention is directed to a reagent for use in the preparation of organomagnesium compounds as well as to a method of preparing such organomagnesium compounds. The present invention furthermore provides a method of preparing functionalized or unfunctionalized organic compounds as well as the use of the reagents of the present invention in the preparation of organometallic compounds and their reaction with electrophiles. Finally, the present invention is directed to the use of lithium salts—LiY in the preparation of organometallic compounds and their reactions with electrophiles and to an organometallic compound which is obtainable by the disclosed method.
摘要翻译：本发明涉及用于制备有机镁化合物的试剂以及制备这种有机镁化合物的方法。本发明还提供了制备官能化或未官能化的有机化合物的方法以及本发明的试剂在制备有机金属化合物中的用途及其与亲电体的反应。最后，本发明涉及锂盐-LYY在制备有机金属化合物中的用途及其与亲电体的反应以及通过所公开的方法可获得的有机金属化合物。

2. 发明授权

US08470982B2 Solutions of anhydrous lanthanide salts and its preparation 有权
公开(公告)号：US08470982B2
公开(公告)日：2013-06-25
申请号：US11991131
申请日：2006-09-01
申请人： Paul Knochel , Arkady Krasovskiy , Felix Kopp
发明人： Paul Knochel , Arkady Krasovskiy , Felix Kopp
IPC分类号： C07F5/00
CPC分类号： C07C29/40 , C01F17/0012 , C01F17/0031 , C07B49/00 , C07C29/143 , C07C67/343 , C07C205/59 , C07C217/84 , C07C2601/08 , C07C2601/14 , C07C2601/16 , C07C2602/10 , C07C2602/42 , C07C69/76 , C07C33/20 , C07C33/24 , C07C35/06 , C07C35/08 , C07C35/18 , C07C35/21 , C07C35/30 , C07C35/36
摘要： The present invention relates to anhydrous solutions of MX3-Z LiA in a solvent, wherein M is a lanthanide including lanthanum, or yttrium or indium; z>0; and X and A are independently or both monovalent anions, preferably Cl, Br or I. The solution is readily prepared by dissolving or suspending MX3 or its hydrate and z equiv LiA in water or hydrophilic solvents, or mixtures thereof, removing the solvent under vacuum and dissolving the resulting powder in another solvent. The solution of MX3-Z LiA can advantageously be used e.g. in addition reactions of Grignard reagents to ketones and imines. Even the catalytic use of MX3-Z LiA is possible.

3. 发明授权

US08134005B2 Preparation and use of magnesium amides 有权
标题翻译：制备和使用镁酰胺
公开(公告)号：US08134005B2
公开(公告)日：2012-03-13
申请号：US12087351
申请日：2007-01-18
申请人： Paul Knochel , Arkady Krasovskiy , Valeria Krasovskaya , Christoph Josef Rohbogner , Giuliano Cesar Clososki
发明人： Paul Knochel , Arkady Krasovskiy , Valeria Krasovskaya , Christoph Josef Rohbogner , Giuliano Cesar Clososki
IPC分类号： C07D295/027 , C07D207/00 , C07F7/02 , C07C211/01
CPC分类号： C07B49/00 , C07F3/003 , C07F3/02
摘要： The present application relates to mixed Mg/Li amides of the general formula R1R2N—Mg(NR3R4)mX,.m zLiY (II) wherein R1, R2, R3, and R4 are, independently, selected from H, substituted or unsubstituted aryl or heteroaryl containing one or more heteroatoms, linear, branched or cyclic, substituted or unsubstituted alkyl, alkenyl, alkynyl, or silyl derivatives thereof; and R1 and R2 together, or R3 and R4 together can be part of a cyclic or polymeric structure; and wherein at least one of R1 and R2 and at least one of R3 and R is other than H; X and Y are, independently, selected from the group consisting of F; Cl; Br; I; CN; SCN; NCO; HaIOn, wherein n=3 or 4 and Hal is selected from Cl, Br and I; NO3; BF4; PF6; H; a carboxylate of the general formula RXCO2; an alcoholate of the general formula ORX; a thiolate of the general formula SRX; RXP(O)O2; or SCORX; or SCSRX; OnSRx, wherein n=2 or 3; or NOn, wherein n=2 or 3; and a derivative thereof; wherein Rx is a substituted or unsubstituted aryl or heteroaryl containing one or more heteroatoms, linear, branched or cyclic, substituted or unsubstituted alkyl, alkenyl, alkynyl, or derivatives thereof, or H; m is O or 1; and z>O; as well as a process for the preparation of the mixed Mg/Li amides and the use of these amides, e.g. as bases.
摘要翻译：本申请涉及通式为R 1 R 2 N-Mg（NR 3 R 4）m X，m z L i Y（II）的混合Mg / Li酰胺，其中R 1，R 2，R 3和R 4独立地选自H，取代或未取代的芳基或含有一个或多个杂原子的杂芳基，其直链，支链或环状的取代或未取代的烷基，烯基，炔基或甲硅烷基衍生物; R 1和R 2一起，或者R 3和R 4一起可以是环状或聚合物结构的一部分; 并且其中R 1和R 2以及R 3和R R中的至少一个不是H; X和Y独立地选自F; Cl; Br; 一世; CN; SCN; NCO; 其中n = 3或4，Hal选自Cl，Br和I; NO3; BF4; PF6; H; 通式为RXCO2的羧酸酯; 通式ORX的醇化物; 通式SRX的硫醇盐; RXP（O）O2; 或SCORX; 或SCSRX; OnSRx，其中n = 2或3; 或NO n，其中n = 2或3; 及其衍生物; 其中Rx是取代或未取代的芳基或含有一个或多个杂原子的直链，支链或环状取代或未取代的烷基，烯基，炔基或衍生物，或H; m为O或1; 和z> O; 以及制备混合的Mg / Li酰胺的方法和这些酰胺的使用，例如。作为基础。

4. 发明申请

US20110084230A1 Process for Synthesizing Organoelemental Compounds 审中-公开
标题翻译：合成有机化合物的方法
公开(公告)号：US20110084230A1
公开(公告)日：2011-04-14
申请号：US12225647
申请日：2007-04-03
申请人： Paul Knochel , Andrei Gavryushin , Vladimir Malakhov , Arkady Krasovskiy
发明人： Paul Knochel , Andrei Gavryushin , Vladimir Malakhov , Arkady Krasovskiy
IPC分类号： C07F3/06 , C07C69/76 , C07C255/50 , C07C49/303 , C07C251/00 , C07C15/02 , C07D307/02 , C07D307/34 , C07C1/32 , C09K3/00
CPC分类号： C07F3/06 , C07F13/00
摘要： The present application discloses a process for preparing a compound of the general formula R1-M1-Ad.zLiX (I) by reacting a compound R1-A (III) with an element M1 in the presence of lithium salts. The application also discloses a process for preparing a compound of the general formula R1m-M3-Tm.zLiX (II) by reacting a compound R1-A (III) with an M3-containing compound in the presence of lithium salts and in the presence of an elemental metal M2. The metal M3 may be selected from Al, Mn, Cu, Zn, Sn, Ti, In, La, Ce, Nd, Y, Li, Sm, Bi, Mg, B, Si and S.
摘要翻译：本申请公开了通过在锂盐存在下使化合物R1-A（III）与元素M1反应来制备通式为R 1 -M1-Ad.zLiX（I）的化合物的方法。本申请还公开了在锂盐存在下使化合物R1-A（III）与含M3化合物反应制备通式为R1m-M3-Tm.zLiX（II）的化合物的方法，的元素金属M2。金属M3可以选自Al，Mn，Cu，Zn，Sn，Ti，In，La，Ce，Nd，Y，Li，Sm，Bi，Mg，B，Si和S.

5. 发明申请

US20090326235A1 Solutions of anhydrous lanthanide salts and its preparation 有权
标题翻译：无水镧系盐的溶液及其制备方法
公开(公告)号：US20090326235A1
公开(公告)日：2009-12-31
申请号：US11991131
申请日：2006-09-01
申请人： Paul Knochel , Arkady Krasovskiy , Felix Kopp
发明人： Paul Knochel , Arkady Krasovskiy , Felix Kopp
IPC分类号： C07D213/30 , C07C29/143 , C07C67/30 , C07C253/30 , B01J27/08 , B01J27/02 , B01J27/055
CPC分类号： C07C29/40 , C01F17/0012 , C01F17/0031 , C07B49/00 , C07C29/143 , C07C67/343 , C07C205/59 , C07C217/84 , C07C2601/08 , C07C2601/14 , C07C2601/16 , C07C2602/10 , C07C2602/42 , C07C69/76 , C07C33/20 , C07C33/24 , C07C35/06 , C07C35/08 , C07C35/18 , C07C35/21 , C07C35/30 , C07C35/36
摘要： The present invention relates to anhydrous solutions of MX3-Z LiA in a solvent, wherein M is a lanthanide including lanthanum, or yttrium or indium; z>0; and X and A are independently or both monovalent anions, preferably Cl, Br or I. The solution is readily prepared by dissolving or suspending MX3 or its hydrate and z equiv LiA in water or hydrophilic solvents, or mixtures thereof, removing the solvent under vacuum and dissolving the resulting powder in another solvent. The solution of MX3-Z LiA can advantageously be used e.g. in addition reactions of Grignard reagents to ketones and imines. Even the catalytic use of MX3-Z LiA is possible.
摘要翻译：本发明涉及MX3-ZLiA在溶剂中的无水溶液，其中M是包含镧或钇或铟的镧系元素; z> 0; X和A独立地是两个一价阴离子，优选Cl，Br或I.通过将MX3或其水合物和z当量LiA溶解或悬浮在水或亲水溶剂或其混合物中，容易地制备溶液，在真空下除去溶剂并将所得粉末溶解在另一种溶剂中。 MX3-Z LiA的溶液可以有利地例如使用。另外还有格氏试剂对酮和亚胺的反应。甚至可以使用MX3-Z LiA催化剂。

6. 发明申请

US20090176988A1 Preparation and Use of Magnesium Amides 有权
标题翻译：制备和使用镁酰胺
公开(公告)号：US20090176988A1
公开(公告)日：2009-07-09
申请号：US12087351
申请日：2007-01-18
申请人： Paul Knochel , Arkady Krasovskiy , Valeria Krasovskaya , Christoph Josef Rohbogner , Giuliano Cesar Clososki
发明人： Paul Knochel , Arkady Krasovskiy , Valeria Krasovskaya , Christoph Josef Rohbogner , Giuliano Cesar Clososki
IPC分类号： C07D211/06 , C07D403/02 , C07F7/02
CPC分类号： C07B49/00 , C07F3/003 , C07F3/02
摘要： The present application relates to mixed Mg/Li amides of the general formula R1R2N—Mg(NR3R4)mX,m zLiY (II) wherein R1, R2, R3, and R4 are, independently, selected from H, substituted or unsubstituted aryl or heteroaryl containing one or more heteroatoms, linear, branched or cyclic, substituted or unsubstituted alkyl, alkenyl, alkynyl, or silyl derivatives thereof; and R1 and R2 together, or R3 and R4 together can be part of a cyclic or polymeric structure; and wherein at least one of R1 and R2 and at least one of R3 and R is other than H; X and Y are, independently, selected from the group consisting of F; Cl; Br; I; CN; SCN; NCO; HalOn, wherein n=3 or 4 and Hal is selected from Cl, Br and I; NO3; BF4; PF6; H; a carboxylate of the general formula RXCO2; an alcoholate of the general formula ORX; a thiolate of the general formula SRX; RXP(O)O2; or SCORX; or SCSRX; OnSRx, wherein n=2 or 3; or NOn, wherein n=2 or 3; and a derivative thereof; wherein Rx is a substituted or unsubstituted aryl or heteroaryl containing one or more heteroatoms, linear, branched or cyclic, substituted or unsubstituted alkyl, alkenyl, alkynyl, or derivatives thereof, or H; m is O or 1; and z>O; as well as a process for the preparation of the mixed Mg/Li amides and the use of these amides, e.g. as bases.
摘要翻译：本申请涉及通式为R 1 R 2 N-Mg（NR 3 R 4）m X，m z L i Y（II）的混合Mg / Li酰胺，其中R 1，R 2，R 3和R 4独立地选自H，取代或未取代的芳基或杂芳基含有一个或多个直链，支链或环状的取代或未取代的烷基，烯基，炔基或甲硅烷基衍生物的杂原子; R 1和R 2一起，或者R 3和R 4一起可以是环状或聚合物结构的一部分; 并且其中R 1和R 2以及R 3和R R中的至少一个不是H; X和Y独立地选自F; Cl; Br; 一世; CN; SCN; NCO; HalOn，其中n = 3或4，Hal选自Cl，Br和I; NO3; BF4; PF6; H; 通式为RXCO2的羧酸酯; 通式ORX的醇化物; 通式SRX的硫醇盐; RXP（O）O2; 或SCORX; 或SCSRX; OnSRx，其中n = 2或3; 或NO n，其中n = 2或3; 及其衍生物; 其中Rx是取代或未取代的芳基或含有一个或多个杂原子的直链，支链或环状取代或未取代的烷基，烯基，炔基或衍生物，或H; m为O或1; 和z> O; 以及制备混合的Mg / Li酰胺的方法和这些酰胺的使用，例如。作为基础。

7. 发明授权

US07387751B2 Method of preparing organomagnesium compounds 有权
公开(公告)号：US07387751B2
公开(公告)日：2008-06-17
申请号：US11787974
申请日：2007-04-18
申请人： Paul Knochel , Arkady Krasovskiy
发明人： Paul Knochel , Arkady Krasovskiy
IPC分类号： C07F3/04
CPC分类号： C07B49/00 , C07F3/02
摘要： The present invention is directed to a reagent for use in the preparation of organomagnesium compounds as well as to a method of preparing such organomagnesium compounds. The present invention furthermore provides a method of preparing functionalized or unfunctionalized organic compounds as well as the use of the reagents of the present invention in the preparation of organometallic compounds and their reaction with electrophiles. Finally, the present invention is directed to the use of lithium salts—LiY in the preparation of organometallic compounds and their reactions with electrophiles and to an organometallic compound which is obtainable by the disclosed method.

8. 发明授权

US07384580B2 Method of preparing organomagnesium compounds 有权
标题翻译：制备有机镁化合物的方法
公开(公告)号：US07384580B2
公开(公告)日：2008-06-10
申请号：US11097707
申请日：2005-04-01
申请人： Paul Knochel , Arkady Krasovskiy
发明人： Paul Knochel , Arkady Krasovskiy
IPC分类号： C07F3/04
CPC分类号： C07B49/00 , C07F3/02
摘要： The present invention is directed to a reagent for use in the preparation of organomagnesium compounds as well as to a method of preparing such organomagnesium compounds. The present invention furthermore provides a method of preparing functionalized or unfunctionalized organic compounds as well as the use of the reagents of the present invention in the preparation of organometallic compounds and their reaction with electrophiles. Finally, the present invention is directed to the use of lithium salts—LiY in the preparation of organometallic compounds and their reactions with electrophiles and to an organometallic compound which is obtainable by the disclosed method.
摘要翻译：本发明涉及用于制备有机镁化合物的试剂以及制备这种有机镁化合物的方法。本发明还提供了制备官能化或未官能化的有机化合物的方法以及本发明的试剂在制备有机金属化合物中的用途及其与亲电体的反应。最后，本发明涉及锂盐-LYY在制备有机金属化合物中的用途及其与亲电体的反应以及通过所公开的方法可获得的有机金属化合物。

9. 发明申请

US20070194468A1 Method of preparing organomagnesium compounds 有权
标题翻译：制备有机镁化合物的方法
公开(公告)号：US20070194468A1
公开(公告)日：2007-08-23
申请号：US11787974
申请日：2007-04-18
申请人： Paul Knochel , Arkady Krasovskiy
发明人： Paul Knochel , Arkady Krasovskiy
IPC分类号： C07F3/02
CPC分类号： C07B49/00 , C07F3/02
摘要： The present invention is directed to a reagent for use in the preparation of organomagnesium compounds as well as to a method of preparing such organomagnesium compounds. The present invention furthermore provides a method of preparing functionalized or unfunctionalized organic compounds as well as the use of the reagents of the present invention in the preparation of organometallic compounds and their reaction with electrophiles. Finally, the present invention is directed to the use of lithium salts—LiY in the preparation of organometallic compounds and their reactions with electrophiles and to an organometallic compound which is obtainable by the disclosed method.
摘要翻译：本发明涉及用于制备有机镁化合物的试剂以及制备这种有机镁化合物的方法。本发明还提供了制备官能化或未官能化的有机化合物的方法以及本发明的试剂在制备有机金属化合物中的用途及其与亲电体的反应。最后，本发明涉及锂盐-LYY在制备有机金属化合物中的用途及其与亲电体的反应以及通过所公开的方法可获得的有机金属化合物。

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