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1. 发明授权

US10060887B2 Field sampling kit and methods for collecting and detecting alkyl methylphosphonic acids 有权
公开(公告)号：US10060887B2
公开(公告)日：2018-08-28
申请号：US13885634
申请日：2011-11-15
申请人： Richard J. Lawrence , J. Richard Smith , Benedict R. Capacio
发明人： Richard J. Lawrence , J. Richard Smith , Benedict R. Capacio
IPC分类号： G01N30/02 , B01J20/281 , G01N1/10 , G01N1/02 , G01N1/00 , G01N1/14 , G01N1/28
CPC分类号： G01N30/482 , G01N1/10 , G01N2001/005 , G01N2001/022 , G01N2001/149 , G01N2001/2826 , Y10T436/163333
摘要： The invention relates to kits and methods of collecting and detecting alkyl methylphosphonic acids from environmental or biological liquids using a sorbent material. The sorbent material may be transported, desorbed and tested for alkyl methylphosphonic acids.

2. 发明申请

US20170299597A1 COMBINED ANTICANCER DRUG SENSITIVITY-DETERMINING MARKER 审中-公开
公开(公告)号：US20170299597A1
公开(公告)日：2017-10-19
申请号：US15635293
申请日：2017-06-28
申请人： KEIO UNIVERSITY , KABUSHIKI KAISHA YAKULT HONSHA
发明人： Yusuke TANIGAWARA , Akito NISHIMUTA , Junya TSUZAKI , Hiroyuki TAKAHASHI
IPC分类号： G01N33/574
CPC分类号： G01N33/57484 , A61K31/282 , A61K31/513 , A61K31/555 , A61K45/06 , A61K47/18 , A61K47/183 , A61K47/26 , G01N33/574 , G01N33/6848 , G01N2560/00 , G01N2570/00 , G01N2800/52 , Y10T436/143333 , Y10T436/147777 , Y10T436/163333 , Y10T436/173845 , Y10T436/201666 , A61K2300/00
摘要： To provide an anti-cancer agent sensitivity determination marker, which marker can determine whether or not the patient has a therapeutic response to the anti-cancer agent, and novel cancer therapeutic means employing the marker.The anti-cancer agent sensitivity determination marker, the anti-cancer agent including oxaliplatin or a salt thereof and fluorouracil or a salt thereof, contains one or more substances selected from among an amino-acid-metabolism-related substance, a nucleic-acid-metabolism-related substance, a substance in the pentose phosphate pathway, a substance in the glycolytic pathway, a substance in the TCA cycle, a polyamine-metabolism-related substance, 7,8-dihydrobiopterin, 6-phosphogluconic acid, butyric acid, triethanolamine, 1-methylnicotinamide, NADH, NAD+, and a substance involved in the metabolism of any of these substances.

3. 发明授权

US09752185B2 Microfluidic devices 有权
公开(公告)号：US09752185B2
公开(公告)日：2017-09-05
申请号：US14824333
申请日：2015-08-12
申请人： IntegenX Inc.
发明人： Allen Boronkay , Stevan Bogdan Jovanovich , Iuliu Ioan Blaga
IPC分类号： C12M1/00 , C12M1/34 , G01N15/06 , B01J19/08 , B01J19/12 , B01D21/00 , C12Q1/68 , B01F11/00 , B01F13/00 , C12Q1/24 , C12Q1/70 , C12N15/10 , B01L3/00 , B01L7/00 , B01L9/00 , G01N35/00
CPC分类号： C12Q1/6869 , B01F11/0071 , B01F13/0059 , B01L3/5025 , B01L3/5027 , B01L3/502715 , B01L3/502738 , B01L3/502753 , B01L3/502761 , B01L7/52 , B01L9/527 , B01L2200/027 , B01L2200/028 , B01L2200/0668 , B01L2200/10 , B01L2300/0627 , B01L2300/0636 , B01L2300/0654 , B01L2300/0803 , B01L2300/0816 , B01L2300/0864 , B01L2300/0867 , B01L2300/087 , B01L2300/0874 , B01L2300/0887 , B01L2300/1822 , B01L2300/1827 , B01L2300/1844 , B01L2400/0415 , B01L2400/0421 , B01L2400/0481 , B01L2400/0655 , C12N15/1003 , C12N15/1013 , C12Q1/24 , C12Q1/6806 , C12Q1/6844 , C12Q1/686 , C12Q1/70 , G01N2035/00514 , Y10T436/163333 , Y10T436/25875
摘要： Methods and devices for the interfacing of microchips to various types of modules are disclosed. The technology disclosed can be used as sample preparation and analysis systems for various applications, such as DNA sequencing and genotyping, proteomics, pathogen detection, diagnostics and biodefense. Also disclosed in the present disclosure is a flow through, traveling-wave, bead-beating device which comprises a rotating pole piece, a flow through tube, and a magnetic piece. Rotation of the rotating pole piece may create a magnetic wave down the flow through tube, thereby producing sufficient acceleration of beads through the tube to disrupt or lyse target analytes flowing through the tube.

4. 发明授权

US09733256B2 Combined anticancer drug sensitivity-determining marker 有权
公开(公告)号：US09733256B2
公开(公告)日：2017-08-15
申请号：US14379945
申请日：2013-02-22
申请人： KEIO UNIVERSITY , KABUSHIKI KAISHA YAKULT HONSHA
发明人： Yusuke Tanigawara , Akito Nishimuta , Junya Tsuzaki , Hiroyuki Takahashi
IPC分类号： A61K31/282 , A61K31/513 , G01N33/68 , G01N33/574 , A61K45/06 , A61K31/555 , A61K47/18 , A61K47/26
CPC分类号： G01N33/57484 , A61K31/282 , A61K31/513 , A61K31/555 , A61K45/06 , A61K47/18 , A61K47/183 , A61K47/26 , G01N33/574 , G01N33/6848 , G01N2560/00 , G01N2570/00 , G01N2800/52 , Y10T436/143333 , Y10T436/147777 , Y10T436/163333 , Y10T436/173845 , Y10T436/201666 , A61K2300/00
摘要： To provide an anti-cancer agent sensitivity determination marker, which marker can determine whether or not the patient has a therapeutic response to the anti-cancer agent, and novel cancer therapeutic means employing the marker.The anti-cancer agent sensitivity determination marker, the anti-cancer agent including oxaliplatin or a salt thereof and fluorouracil or a salt thereof, contains one or more substances selected from among an amino-acid-metabolism-related substance, a nucleic-acid-metabolism-related substance, a substance in the pentose phosphate pathway, a substance in the glycolytic pathway, a substance in the TCA cycle, a polyamine-metabolism-related substance, 7,8-dihydrobiopterin, 6-phosphogluconic acid, butyric acid, triethanolamine, 1-methylnicotinamide, NADH, NAD+, and a substance involved in the metabolism of any of these substances.

5. 发明申请

US20170131258A1 PERSONAL SUBSTANCE DETECTION FIELD TEST KIT 审中-公开
公开(公告)号：US20170131258A1
公开(公告)日：2017-05-11
申请号：US15412719
申请日：2017-01-23
申请人： LINDON GROUP, INC.
发明人： Dalita Tomellini , Melinda Penney , Phil Brooks
IPC分类号： G01N33/22 , G01N21/78
CPC分类号： G01N33/227 , A45C13/02 , A45C13/1084 , G01N21/78 , G01N21/8483 , G01N2201/0221 , G01N2201/0222 , Y10T436/142222 , Y10T436/145555 , Y10T436/147777 , Y10T436/163333 , Y10T436/170769 , Y10T436/171538 , Y10T436/173076 , Y10T436/173845
摘要： A personal-sized, portable explosive detection field test kit (ETK) and related methods of use. Embodiments of the disclosed ETK include a case having a closing system featuring three levels of closure which retain the case cover securely in a closed position until ready for use, while being easily opened when necessary. The ETK instructions are permanently attached to the case to prevent loss. The case includes retention features which retain the kit components until needed and protects them against loss or damage. The ETK includes one or more test tubes that are color coded and include abbreviated instructions.

6. 发明申请

US20150153353A1 METHODS FOR DIAGNOSING CHRONIC VALVULAR DISEASE 审中-公开
标题翻译：诊断慢性病变的方法
公开(公告)号：US20150153353A1
公开(公告)日：2015-06-04
申请号：US14405325
申请日：2013-06-04
申请人： NESTEC SA
发明人： Qinghong Li , Dorothy P. Laflamme , Steven S. Hannah
IPC分类号： G01N33/68 , G01N33/92
CPC分类号： G01N33/6812 , G01N33/50 , G01N33/92 , G01N2570/00 , G01N2800/326 , Y10T436/142222 , Y10T436/143333 , Y10T436/163333 , Y10T436/201666
摘要： The invention provides methods for diagnosing chronic valvular disease in an animal. The methods comprise obtaining a sample from the animal; analyzing the sample for the presence of one or more metabolites associated with chronic valvular disease; comparing the amount of each such metabolite identified in the sample to a corresponding amount of the same metabolite present in a sample from one or more comparable control animals that do not suffer from chronic valvular disease; and using said comparison to diagnose chronic valvular disease in the animal if the metabolites found in the animal's sample is greater than or less than the amount present in the control animal's sample.
摘要翻译：本发明提供用于诊断动物中慢性瓣膜疾病的方法。所述方法包括从动物获得样品; 分析样品中存在与慢性瓣膜疾病相关的一种或多种代谢物; 将样品中鉴定的每种这样的代谢物的量与来自不患有慢性瓣膜疾病的一种或多种可比对照动物的样品中存在的相同代谢物的相应量相比较; 并且如果动物样品中发现的代谢物大于或小于对照动物样品中存在的量，则使用所述比较来诊断动物中的慢性瓣膜病。

7. 发明申请

US20150111302A1 Method for Measuring Acid Strength in Reaction Medium 有权
标题翻译：测定反应介质中酸强度的方法
公开(公告)号：US20150111302A1
公开(公告)日：2015-04-23
申请号：US14498332
申请日：2014-09-26
申请人： ExxonMobil Chemical Patents Inc.
发明人： Kun Wang , Roberto Garcia
IPC分类号： G01N24/08 , G01N31/22
CPC分类号： G01N24/088 , C07C37/08 , C07C45/53 , C07C2601/14 , G01N24/085 , G01N31/221 , G01R33/46 , Y10T436/163333 , C07C39/04 , C07C49/403
摘要： A method to determine the strength of an acid in a medium is disclosed. The method includes (I) providing multiple samples comprising trimethylphosphine oxide (TMPO), the acid, and the medium, wherein the multiple samples have different [H+]/[TMPO] ratios, [H+] is the concentration of hydrons in the sample in mole.liter−1, and [TMPO] is the concentration of TMPO in the sample in mole.liter−1. (II) The 31P chemical shifts of the multiple samples are measured by 31P NMR and compared to standardized samples to determine the acid strength of the medium.
摘要翻译：公开了确定介质中酸的强度的方法。该方法包括（I）提供包含三甲基氧化膦（TMPO），酸和介质的多个样品，其中多个样品具有不同的[H +] / [TMPO]比，[H +]是样品中氢化物的浓度摩尔比1，[TMPO]是样品中TMPO的浓度，摩尔数l-1。（II）通过31P NMR测量多个样品的31P化学位移，并与标准样品进行比较，以确定培养基的酸强度。

8. 发明授权

US08945932B2 Methods and compositions for detecting and isolating phosphorylated molecules using hydrated metal oxides 有权
标题翻译：使用水合金属氧化物检测和分离磷酸化分子的方法和组合物
公开(公告)号：US08945932B2
公开(公告)日：2015-02-03
申请号：US11571687
申请日：2005-07-06
申请人： Wayne F. Patton , Alvydas Mikulskis , Eva Golenko
发明人： Wayne F. Patton , Alvydas Mikulskis , Eva Golenko
IPC分类号： G01N33/52 , C12Q1/68 , C07K1/22 , G01N33/68
CPC分类号： C12Q1/6818 , C07K1/22 , G01N33/6842 , Y10T436/163333 , Y10T436/25 , Y10T436/25375 , Y10T436/255 , C12Q2563/137 , C12Q2563/107 , C12Q2563/167
摘要： The invention provides methods for detecting and isolating phosphomolecules using phosphoaffinity materials that comprise a hydrated metal oxide. In an embodiment, a method for detecting a phosphomolecule in a sample involves (a) contacting a sample with a phosphoaffinity material comprising a hydrated metal oxide, under conditions wherein a phosphomolecule is capable of binding to the phosphoaffinity material to form a phosphomolecule-phosphoaffinity material complex, and (b) detecting formation of a phosphomolecule-phosphoaffinity material complex, thereby detecting a phosphomolecule in the sample. In another embodiment, a method for isolating a phosphomolecule from a sample involves (a) contacting a sample with a phosphoaffinity material comprising a hydrated metal oxide, under conditions wherein a phosphomolecule is capable of binding to the phosphoaffinity material to form a phosphomolecule-phosphoaffinity material complex, wherein the hydrated metal oxide comprises yttrium, and (b) separating the phosphomolecule-phosphoaffinity material complex from the sample, thereby isolating the phosphomolecule from the sample.
摘要翻译：本发明提供了使用包含水合金属氧化物的磷酸亲和物质来检测和分离磷酸分子的方法。在一个实施方案中，用于检测样品中的磷酸分子的方法包括（a）使样品与包含水合金属氧化物的磷脂质材料接触，条件是其中磷分子能够结合磷酸亲和物质以形成磷酸分子 - 磷酸亲和物质复合物，和（b）检测磷酸分子 - 磷酸亲和性物质复合物的形成，从而检测样品中的磷酸分子。在另一个实施方案中，从样品中分离磷酸分子的方法包括（a）使样品与包含水合金属氧化物的磷脂质材料接触，条件是其中磷分子能够结合磷酸亲和物质以形成磷酸分子 - 磷酸亲和物质复合物，其中所述水合金属氧化物包含钇，和（b）从所述样品中分离所述磷酸分子 - 磷酸亲和性材料配合物，从而从所述样品中分离出所述磷酸分子。

9. 发明授权

US08810417B2 Beverage immersate with detection capability 有权
标题翻译：饮料浸入检测能力
公开(公告)号：US08810417B2
公开(公告)日：2014-08-19
申请号：US12584054
申请日：2009-08-28
申请人： Leroy E. Hood , Edward K. Y. Jung , Elizabeth A. Sweeney , Clarence T. Tegreene , Lowell L. Wood, Jr.
发明人： Leroy E. Hood , Edward K. Y. Jung , Elizabeth A. Sweeney , Clarence T. Tegreene , Lowell L. Wood, Jr.
IPC分类号： G08B21/00 , G01N33/14
CPC分类号： A61B5/0002 , A61B5/00 , A61B5/411 , G01N33/14 , G06F19/00 , G06Q50/24 , Y02A90/22 , Y02A90/26 , Y10T436/163333
摘要： Methods and systems described herein include beverage immersates and methods of their use. Systems include: at least one beverage immersate, wherein the at least one beverage immersate includes at least one sensor configured to detect at least one analyte in a fluid within a personal use beverage container; and at least one signal transmitter configured to transmit a signal responsive to the at least one beverage immersate. Methods include: detecting one or more analyte in fluid within a personal use beverage container with at least one sensor integral to at least one beverage immersate; and communicating data from the at least one beverage immersate to at least one device external to the beverage immersate.
摘要翻译：本文所述的方法和系统包括饮料浸渍及其使用方法。系统包括：至少一种饮料浸泡，其中所述至少一种饮料浸入物包括至少一个传感器，所述传感器被配置为检测个人使用饮料容器内的流体中的至少一种分析物; 以及至少一个信号发射器，被配置为响应于所述至少一个饮料浸没而传输信号。方法包括：在个人使用的饮料容器内检测流体中的一种或多种分析物，其中至少一个传感器与至少一种饮料浸入一体; 以及将来自所述至少一个饮料的数据传送到所述饮料外部的至少一个装置，所述装置浸没。

10. 发明申请

US20140127822A1 Electro-Mechanical Switches and Methods of Use Thereof 有权
标题翻译：机电开关及其使用方法
公开(公告)号：US20140127822A1
公开(公告)日：2014-05-08
申请号：US13893699
申请日：2013-05-14
申请人： William Jay Arora , Karen K. Gleason , George Barbastathis , Wyatt E. Tenhaeff
发明人： William Jay Arora , Karen K. Gleason , George Barbastathis , Wyatt E. Tenhaeff
IPC分类号： G01N33/00
CPC分类号： G01N33/0057 , G01N27/128 , Y10T436/147777 , Y10T436/163333 , Y10T436/173076 , Y10T436/173845
摘要： One aspect of the invention relates to an ultrathin micro-electromechanical chemical sensing device which uses swelling or straining of a reactive organic material for sensing. In certain embodiments, the device comprises a contact on-off switch chemical sensor. For example, the device can comprises a small gap separating two electrodes, wherein the gap can be closed as a result of the swelling or stressing of an organic polymer coating on one or both sides of the gap. In certain embodiments, the swelling or stressing is due to the organic polymer reacting with a target analyte.
摘要翻译：本发明的一个方面涉及使用用于感测的反应性有机材料的溶胀或应变的超薄微机电化学感测装置。在某些实施例中，该装置包括接触开 - 关开关化学传感器。例如，该装置可以包括分开两个电极的小间隙，其中间隙可以由于间隙的一侧或两侧上的有机聚合物涂层的膨胀或应力而封闭。在某些实施方案中，溶胀或应激是由于有机聚合物与靶分析物反应。

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