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1. 发明授权

US10640817B2 Multiplex methods for detection and quantification of minor variants 有权
公开(公告)号：US10640817B2
公开(公告)日：2020-05-05
申请号：US15568701
申请日：2016-04-22
申请人： Agena Bioscience, Inc.
发明人： Anders Olof Herman Nygren
IPC分类号： C12Q1/68 , C12Q1/6853 , C12Q1/6827
CPC分类号： C12Q1/6853 , C12Q1/6827 , C12Q2600/16 , C12Q1/6827 , C12Q2525/186 , C12Q2527/143 , C12Q2537/143 , C12Q2545/114 , C12Q2565/518 , C12Q2565/537 , C12Q1/6853 , C12Q2525/186 , C12Q2537/143 , C12Q2545/114 , C12Q2563/167 , C12Q2565/518
摘要： Provided herein are multiplex methods for detecting the presence or absence and amount of variants of a plurality of target nucleic acid species having low-abundance variants and high-abundance variants.

2. 发明申请

US20180230535A1 METHODS OF TAGGING PARTICLES FOR MULTIPLEXED FUNCTIONAL SCREENING 审中-公开
公开(公告)号：US20180230535A1
公开(公告)日：2018-08-16
申请号：US15944564
申请日：2018-04-03
申请人： Verily Life Sciences LLC
发明人： Jerrod Joseph SCHWARTZ , Vikram Singh BAJAJ , Alberto Clemente VITARI
IPC分类号： C12Q1/6876
CPC分类号： C12Q1/6876 , C12N15/1068 , C12N15/11 , C12Q1/6804 , C12Q2600/158 , C12Q2563/131 , C12Q2563/149 , C12Q2563/167 , C12Q2563/179
摘要： The present invention relates generally to the fields of cell biology and laboratory diagnostics, and particularly to general compositions and of uniquely tagged particles linked to moieties of known properties and methods of making tagged, functionalized particles. Additionally, the invention relates to methods of screening a collection of tagged functionalized particles.

3. 发明授权

US09752184B2 Methods for rapid forensic analysis of mitochondrial DNA and characterization of mitochondrial DNA heteroplasmy 有权
公开(公告)号：US09752184B2
公开(公告)日：2017-09-05
申请号：US14456806
申请日：2014-08-11
申请人： IBIS BIOSCIENCES, INC. , Nina M. Hofstadler
发明人： David J. Ecker , Richard H. Griffey , Rangarajan Sampath , Steven A. Hofstadler , John McNeil , Stanley T. Crooke , Lawrence B. Blyn , Thomas A. Hall , Yun Jiang , James C. Hannis , Neill K. White , Vivek Samant , Mark W. Eshoo , Jared J. Drader
IPC分类号： C12Q1/68
CPC分类号： C12Q1/686 , C12Q1/6806 , C12Q1/6844 , C12Q1/6858 , C12Q1/6872 , C12Q1/6888 , C12Q1/689 , C12Q2600/156 , G01N2333/28 , G01N2333/32 , G01N2333/35 , G01N2333/36 , C12Q2563/167 , C12Q2545/101 , C12Q2531/113 , C12Q2565/627 , C12Q2545/113
摘要： The present invention provides methods for rapid forensic analysis of mitochondrial DNA and methods for characterizing heteroplasmy of mitochondrial DNA, which can be used to assess the progression of mitochondrial diseases.

4. 发明申请

US20150284783A1 METHODS AND COMPOSITIONS FOR ANALYZING NUCLEIC ACID 审中-公开
标题翻译：用于分析核酸的方法和组合物
公开(公告)号：US20150284783A1
公开(公告)日：2015-10-08
申请号：US14402658
申请日：2013-05-16
申请人： Agena Bioscience, Inc.
发明人： Charles R. Canton
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6825 , C12Q1/68 , C12Q2525/101 , C12Q2525/204 , C12Q2563/101 , C12Q2563/167 , C12Q2565/627
摘要： Technology provided herein relates in part to methods, processes, compositions and apparatuses for analyzing nucleic acid.
摘要翻译：本文提供的技术部分地涉及用于分析核酸的方法，方法，组合物和装置。

5. 发明授权

US09149473B2 Targeted whole genome amplification method for identification of pathogens 有权
标题翻译：用于鉴定病原体的全基因组扩增方法
公开(公告)号：US09149473B2
公开(公告)日：2015-10-06
申请号：US12441329
申请日：2007-09-14
申请人： David J. Ecker , Mark W. Eshoo
发明人： David J. Ecker , Mark W. Eshoo
IPC分类号： C12Q1/68 , C12P19/34 , A61K31/4741
CPC分类号： C12Q1/6806 , A61K31/4741 , C12P19/34 , C12Q1/68 , C12Q1/6848 , C12Q1/686 , C12Q1/689 , H01J49/0027 , H01J49/40 , Y02A50/473 , C12Q2565/627 , C12Q2537/143 , C12Q2531/119 , C12Q2565/513 , C12Q2563/167
摘要： The methods disclosed herein relate to methods and compositions for amplifying nucleic acid sequences, more specifically, from nucleic acid sequences of pathogens by targeted whole genome amplification.
摘要翻译：本文公开的方法涉及用于通过靶向全基因组扩增来扩增核酸序列，更具体地从病原体的核酸序列扩增的方法和组合物。

6. 发明授权

US08945940B2 Mass- and property-tuned variable mass labeling reagents and analytical methods for simultaneous peptide sequencing and multiplexed protein quantification using thereof 有权
标题翻译：质谱和质量调整的可变质量标记试剂以及使用其同时进行肽测序和多重蛋白质定量的分析方法
公开(公告)号：US08945940B2
公开(公告)日：2015-02-03
申请号：US12601512
申请日：2009-07-10
申请人： Seung Koo Shin , Jongcheol Seo , Min-Soo Suh , Hye-Joo Yoon
发明人： Seung Koo Shin , Jongcheol Seo , Min-Soo Suh , Hye-Joo Yoon
IPC分类号： C07K5/04 , C07K5/06 , G01R3/00 , C07B59/00 , C07C237/22 , C07K1/13 , C07K5/062 , C07K5/065 , C07K5/072 , C07K5/078 , G01N33/68 , G01N30/72 , C40B20/04
CPC分类号： G01R3/00 , C07B59/008 , C07C237/22 , C07K1/13 , C07K5/06026 , C07K5/06052 , C07K5/06069 , C07K5/06078 , C07K5/06095 , C07K5/06104 , C07K5/06139 , C12Q2563/167 , C40B20/04 , G01N33/6851 , G01N2458/15 , Y10S930/01 , Y10T436/24
摘要： The present invention provides variable mass labeling reagents, a set of the variable mass labeling reagents, and a multiplexed set of variable mass labeling reagents.
摘要翻译：本发明提供可变质量标记试剂，一组可变质量标记试剂和多组可变质量标记试剂。

7. 发明授权

US08802372B2 Methods for rapid forensic analysis of mitochondrial DNA and characterization of mitochondrial DNA heteroplasmy 有权
标题翻译：线粒体DNA快速法医分析方法及线粒体DNA异质性表征
公开(公告)号：US08802372B2
公开(公告)日：2014-08-12
申请号：US11929930
申请日：2007-10-30
申请人： David J. Ecker , Richard H. Griffey , Rangarajan Sampath , Steven A. Hofstadler , John McNeil , Stanley T. Crooke , Lawrence Blyn , Thomas A. Hall , Yun Jiang , James C. Hannis , Neill White , Vivek Samant , Mark W. Eshoo , Jared James Drader
发明人： David J. Ecker , Richard H. Griffey , Rangarajan Sampath , Steven A. Hofstadler , John McNeil , Stanley T. Crooke , Lawrence Blyn , Thomas A. Hall , Yun Jiang , James C. Hannis , Neill White , Vivek Samant , Mark W. Eshoo , Jared James Drader
IPC分类号： C12Q1/68 , C12P19/34 , C07H21/04
CPC分类号： C12Q1/686 , C12Q1/6806 , C12Q1/6844 , C12Q1/6858 , C12Q1/6872 , C12Q1/6888 , C12Q1/689 , C12Q2600/156 , G01N2333/28 , G01N2333/32 , G01N2333/35 , G01N2333/36 , C12Q2563/167 , C12Q2545/101 , C12Q2531/113 , C12Q2565/627 , C12Q2545/113
摘要： The present invention provides methods for rapid forensic analysis of mitochondrial DNA and methods for characterizing heteroplasmy of mitochondrial DNA, which can be used to assess the progression of mitochondrial diseases.
摘要翻译：本发明提供线粒体DNA的快速法医分析方法和线粒体DNA异质性表征的方法，可用于评估线粒体疾病的进展。

8. 发明申请

US20140080126A1 QUANTIFICATION OF NUCLEIC ACIDS AND PROTEINS USING OLIGONUCLEOTIDE MASS TAGS 审中-公开
标题翻译：使用寡核苷酸质量标签对核酸和蛋白质进行定量
公开(公告)号：US20140080126A1
公开(公告)日：2014-03-20
申请号：US13863839
申请日：2013-04-16
申请人： TRUSTEES OF BOSTON UNIVERSITY
发明人： Charles R. Cantor , Lingang Zhang , Simon Kasif
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6816 , C12Q1/6809 , C12Q2565/627 , C12Q2563/167 , C12Q2545/114
摘要： The invention provides a method for detecting and quantifying the amount of target molecules, such as nucleic acids or proteins in a sample. The target molecules are first recognized and bounded by target-specific probes, generally nucleic acids or proteins that bind specifically to the targets, each of which is labeled with a short single-stranded nucleic acid probe, either DNA or RNA, with distinct molecular weight. This label is called an oligonucleotide mass tag. One or several standard oligonucleotide sequences can be designed with similar sequence but distinct molecular weight to those oligonucleotide mass tags. Then the oligonucleotide mass tags associated with bounded probes and the standard sequences are co-amplified using a pair of common primers. The presence and/or amount of each oligonucleotide mass tag, which corresponds to the amount of corresponding target molecule, is determined by a primer extension reaction and quantification of the primer extension product.
摘要翻译：本发明提供了用于检测和定量样品中靶分子如核酸或蛋白质的量的方法。目标分子首先被目标特异性探针识别并限制，通常是与靶标特异性结合的核酸或蛋白质，其中每个标记有短单链核酸探针，DNA或RNA，具有不同的分子量。该标签称为寡核苷酸质量标签。可以设计一个或几个标准寡核苷酸序列，其具有与那些寡核苷酸质量标签相似的序列但分子量不同。然后使用一对普通引物共同扩增与有界探针和标准序列相关的寡核苷酸质粒标签。通过引物延伸反应和引物延伸产物的定量来确定对应于相应靶分子量的每个寡核苷酸质粒标签的存在和/或量。

9. 发明授权

US08563250B2 Methods for identifying bioagents 有权
标题翻译：识别生物标签的方法
公开(公告)号：US08563250B2
公开(公告)日：2013-10-22
申请号：US11682259
申请日：2007-03-05
申请人： David J. Ecker , Richard H. Griffey , Rangarajan Sampath , Steven Hofstadler , John McNeil , Stanley T. Crooke , James C. Hannis
发明人： David J. Ecker , Richard H. Griffey , Rangarajan Sampath , Steven Hofstadler , John McNeil , Stanley T. Crooke , James C. Hannis
IPC分类号： C12Q1/68 , C07H21/04
CPC分类号： C12Q1/689 , C12Q1/6813 , C12Q1/6858 , C12Q1/686 , C12Q1/6888 , C12Q2600/156 , Y02A50/59 , Y02A50/60 , Y02A90/24 , C12Q2565/627 , C12Q2545/113 , C12Q2563/167
摘要： The present invention provides methods for rapid forensic investigations by identification of bioagents associated with biowarfare and acts of terrorism or crime. The methods are also useful for epidemiological investigations by genotyping of bioagents.
摘要翻译：本发明提供了通过识别与生物武器相关的生物标签和恐怖主义或犯罪行为进行快速法医调查的方法。该方法也可用于通过基因分型生物学的流行病学调查。

10. 发明授权

US08455202B2 Affinity selector based recognition and quantification system and method for multiple analytes in a single analysis 有权
标题翻译：基于亲和选择器的识别和量化系统和方法在多个分析物中进行单一分析
公开(公告)号：US08455202B2
公开(公告)日：2013-06-04
申请号：US12721173
申请日：2010-03-10
申请人： Fred E. Regnier , Nicholas B. Herold , Kevin W. Meyer
发明人： Fred E. Regnier , Nicholas B. Herold , Kevin W. Meyer
IPC分类号： G01N33/53
CPC分类号： G01N33/53 , C12Q1/6816 , G01N33/6842 , G01N33/6848 , C12Q2525/107 , C12Q2537/143 , C12Q2563/167
摘要： A multi-dimensional method for simultaneously analyzing multiple analytes within a sample solution, comprising adding affinity selectors to a sample solution containing analytes to be measured, the affinity selectors having an affinity for one or more of the analytes within the sample solution; allowing immune complexes to form between the affinity selectors and the analytes; partially or totally resolving the formed immune complexes from non-analyte substances within the sample solution; dissociating the resolved immune complexes; separating the analytes and the affinity selectors of the dissociated immune complexes from one another by capturing the analytes through a surface adsorption process; transferring the captured analytes to a detection means; and resolving the analytes with the detection means in accordance with their mass-to-charge ratios.
摘要翻译：一种用于同时分析样品溶液中的多种分析物的多维方法，包括将亲和选择剂添加到含有待测量待分析物的样品溶液中，所述亲和选择剂对样品溶液中的一种或多种分析物具有亲和力; 允许在亲和选择剂和分析物之间形成免疫复合物; 形成的免疫复合物部分或全部从样品溶液中的非分析物质中分离出来; 解离分离的免疫复合物; 通过表面吸附过程捕获分析物，将解离的免疫复合物的分析物和亲和选择剂彼此分离; 将捕获的分析物转移到检测装置; 并根据其质荷比，用检测装置分析分析物。

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