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    • 2. 发明授权
    • Autosampler for high-performance liquid chromatography
    • 自动进样器用于高效液相色谱
    • US08196456B2
    • 2012-06-12
    • US12331228
    • 2008-12-09
    • Hermann HochgraeberGervin Ruegenberg
    • Hermann HochgraeberGervin Ruegenberg
    • G01N30/84
    • G01N30/20G01N30/22G01N35/1097G01N2030/201G01N2030/202
    • An autosampler for high-performance liquid chromatography (HPLC) with a high-pressure injection valve (1, 2) having improved life, particularly in high pressure operation. The geometry of the valve components and the connections of the high-pressure injection valve are provided such that the switching processes do not take place in a deleterious direction. The grooves in rotor (2) and/or the port opening cross sections (131, 151) in stator (1) and the rotational direction are selected such that fluid flows from grooves under high pressure in the direction of narrow, substantially pressure-free ports are avoided. This applies in particular to the switching process from INJECT to LOAD, since the sample loop contains a relatively large dead volume of compressed fluid. In addition, the valve can be controlled according to the invention in such a manner that an appropriate time is available for reducing harmful or undesired pressure differences.
    • 一种用于高效液相色谱(HPLC)的自动进样器,其具有改善寿命的高压注射阀(1,2),特别是在高压操作中。 提供了阀部件的几何形状和高压喷射阀的连接,使得切换过程不会在有害的方向上发生。 选择转子(2)中的槽和/或定子(1)中的端口开口横截面(131,151)和旋转方向,使得流体在窄的,基本上无压力的方向从高压槽流出 端口被避免。 这特别适用于从INJECT到LOAD的切换过程,因为样品回路包含相对大的死体积的压缩流体。 此外,根据本发明可以以适当的时间可用于减少有害或不期望的压力差的方式来控制阀门。
    • 7. 发明申请
    • CONTROL ARRANGEMENT FOR CONTROLLING A PISTON PUMP UNIT FOR LIQUID CHROMATOGRAPHY
    • 用于控制用于液相色谱的活塞泵单元的控制装置
    • US20130336803A1
    • 2013-12-19
    • US13917963
    • 2013-06-14
    • Gervin RUEGENBERGRichard SCHLODERERWerner TUCHAN
    • Gervin RUEGENBERGRichard SCHLODERERWerner TUCHAN
    • F04B49/22
    • F04B49/22F04B23/06F04B49/20G01N30/22G01N30/32G01N2030/326
    • A control arrangement for controlling a piston pump unit for liquid chromatography, in particular high-performance liquid chromatography, is described. The piston pump unit has at least two piston-cylinder units which operate cyclically in a phase-offset manner and generate, at an outlet port, a predetermined flow of a liquid medium to be delivered. A system pressure is established at the outlet port, irrespective of an associated fluid load resistance. The control arrangement is configured to record the pressure in the cylinder volume of at least a first of the at least two piston-cylinder units. During a measurement phase of the compression phase of the first piston-cylinder unit or during a measurement phase of the decompression phase of the first piston-cylinder unit, the control arrangement stops the drive device for the first piston-cylinder unit for a predetermined time period and in the process records measurement data which characterize the time profile of the pressure.
    • 描述了用于控制用于液相色谱的活塞泵单元,特别是高效液相色谱的控制装置。 活塞泵单元具有至少两个活塞 - 气缸单元,其以相位偏移方式周期性地操作,并在出口处产生待输送的液体介质的预定流量。 在出口处建立系统压力,不管相关的流体负载阻力如何。 控制装置构造成记录至少两个活塞 - 气缸单元中的至少一个的气缸体积中的压力。 在第一活塞 - 气缸单元的压缩阶段的测量阶段期间或在第一活塞 - 气缸单元的减压阶段的测量阶段期间,控制装置将用于第一活塞 - 气缸单元的驱动装置停止预定时间 期间和过程记录表征压力时间曲线的测量数据。
    • 8. 发明授权
    • Method and device for providing defined fluid flow, especially for use in liquid chromatography
    • 用于提供限定流体流动的方法和装置,特别用于液相色谱
    • US07454959B2
    • 2008-11-25
    • US10583435
    • 2004-11-23
    • Gervin RuegenbergHermann Hochgraeber
    • Gervin RuegenbergHermann Hochgraeber
    • G01N30/00B01D53/02
    • G01N30/32G01N30/36G01N2030/324G01N2030/342G01N30/10
    • The invention relates to a method for providing a defined fluid flow, especially for use in liquid chromatography. According to the method, a constant total flow (f0) is subdivided into an internal excess flow (fie) in an excess branch and into an internal working flow (fiw) in a working branch. The ratio of subdivision of the internal working flow (fiw) and the internal excess flow (fie) depends on the reverse ratio of a fluidic resistance provided in the working branch and a fluidic resistance in the excess branch. The excess branch and the working branch are interlinked at the respective outputs of the two fluidic outputs of the fluidic resistances by a cross-branch. The equalizing flow occurring between the outputs of the fluidic resistances is measured by means of a flow sensor. A desired, external working flow in the further course of the working branch can be fed to a working device, for example a chromatography column mounted downstream of the device. Further down the excess branch a variable fluidic resistance device is arranged. The resistance value of the variable fluidic resistance device is controlled, thereby controlling the equalizing flow in such a manner that the equalizing flow, preferably in the temporal mean, is substantially zero or equals a defined offset value whose amount is small compared to the internal working flow (fiw). The invention also relates to a device for carrying out the inventive method.
    • 本发明涉及一种用于提供限定的流体流动的方法,特别是用于液相色谱。 根据该方法,将恒定的总流量(f 0> 0)细分为过量分支中的内部过量流(f),并分成内部工作流程(f iw )。 内部工作流程(f)的细分比和内部过剩流量(f )取决于工作分支中提供的流体阻力的反比 和多余分支中的流体阻力。 多余分支和工作分支通过交叉分支在流体电阻的两个流体输出的相应输出处相互连接。 通过流量传感器测量在流体电阻的输出之间产生的均衡流。 在工作分支的进一步过程中所需的外部工作流程可以被馈送到工作装置,例如安装在装置下游的色谱柱。 在多余的分支下方设置可变流体阻力装置。 控制可变流体阻力装置的电阻值,从而以均衡流量(优选在时间平均值)基本上为零或等于限定的偏移值来控制均衡流量,其量相对于内部工作 流(f> w w)。 本发明还涉及一种用于实施本发明的方法的装置。
    • 9. 发明申请
    • Method and device for providing defined fluid flow, especially for use in liquid chromatography
    • 用于提供限定流体流动的方法和装置,特别用于液相色谱
    • US20070056357A1
    • 2007-03-15
    • US10583435
    • 2004-11-23
    • Gervin RuegenbergHermann Hochgraeber
    • Gervin RuegenbergHermann Hochgraeber
    • G01N11/00
    • G01N30/32G01N30/36G01N2030/324G01N2030/342G01N30/10
    • The invention relates to a method for providing a defined fluid flow, especially for use in liquid chromatography. According to the method, a constant total flow (f0) is subdivided into an internal excess flow (fie) in an excess branch and into an internal working flow (fiw) in a working branch. The ratio of subdivision of the internal working flow (fiw) and the internal excess flow (fie) depends on the reverse ratio of a fluidic resistance provided in the working branch and a fluidic resistance in the excess branch. The excess branch and the working branch are interlinked at the respective outputs of the two fluidic outputs of the fluidic resistances by a cross-branch. The equalizing flow occurring between the outputs of the fluidic resistances is measured by means of a flow sensor. A desired, external working flow in the further course of the working branch can be fed to a working device, for example a chromatography column mounted downstream of the device. Further down the excess branch a variable fluidic resistance device is arranged. The resistance value of the variable fluidic resistance device is controlled, thereby controlling the equalizing flow in such a manner that the equalizing flow, preferably in the temporal mean, is substantially zero or equals a defined offset value whose amount is small compared to the internal working flow (fiw). The invention also relates to a device for carrying out the inventive method.
    • 本发明涉及一种用于提供限定的流体流动的方法,特别是用于液相色谱。 根据该方法,将恒定的总流量(f 0> 0)细分为过量分支中的内部过量流(f),并分成内部工作流程(f iw )。 内部工作流程(f)的细分比和内部过剩流量(f )取决于工作分支中提供的流体阻力的反比 和多余分支中的流体阻力。 多余分支和工作分支通过交叉分支在流体电阻的两个流体输出的相应输出处相互连接。 通过流量传感器测量在流体电阻的输出之间产生的均衡流。 在工作分支的进一步过程中所需的外部工作流程可以被馈送到工作装置,例如安装在装置下游的色谱柱。 在多余的分支下方设置可变流体阻力装置。 控制可变流体阻力装置的电阻值,从而以均衡流量(优选在时间平均值)基本上为零或等于限定的偏移值来控制均衡流量,其量相对于内部工作 流(f> w w)。 本发明还涉及一种用于实施本发明的方法的装置。