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1. 发明授权

US09091693B2 Plug unit and connection system for connecting capillary tubes, especially for high-performance liquid chromatography 有权
标题翻译：用于连接毛细管的插头单元和连接系统，特别适用于高效液相色谱
公开(公告)号：US09091693B2
公开(公告)日：2015-07-28
申请号：US13321156
申请日：2010-03-19
申请人： Hermann Hochgraeber , Adolf Satzinger , Daniel Bürger , Andreas Unger
发明人： Hermann Hochgraeber , Adolf Satzinger , Daniel Bürger , Andreas Unger
IPC分类号： F16L17/00 , G01N30/60
CPC分类号： G01N30/6026 , F16L25/0018 , F16L37/02 , G01N2030/027
摘要： A plug unit for connecting capillary tubes includes a plug housing that has an axial borehole, a plug capillary tube that projects through the axial borehole, and a sealing element that surrounds the plug capillary tube. The front end of the plug capillary tube is sealed by an elastic and/or plastic deformation of the sealing element against the capillary tube receptacle opening of a bushing unit. A hollow cylindrical pressure piece is provided that surrounds the sealing element in an axial region facing away from the end surface of the plug capillary tube, and the pressure piece has a rearward end side that faces away from the end surface of the plug capillary tube and that can be loaded by the plug housing with an axial pressure force when the plug unit and bushing unit are connected.
摘要翻译：用于连接毛细管的塞子单元包括具有轴向钻孔的塞子壳体，通过轴向孔眼突出的塞子毛细管和围绕塞子毛细管的密封元件。插塞毛细管的前端通过密封元件的弹性和/或塑性变形抵靠衬套单元的毛细管插座开口密封。提供一个中空的圆柱形压片，其在远离插塞毛细管的端面的轴向区域中围绕密封元件，并且压片具有背离插头毛细管的端面的后端侧，当插头单元和衬套单元连接时，可以通过插头壳体以轴向压力加载。

2. 发明申请

US20070056357A1 Method and device for providing defined fluid flow, especially for use in liquid chromatography 失效
标题翻译：用于提供限定流体流动的方法和装置，特别用于液相色谱
公开(公告)号：US20070056357A1
公开(公告)日：2007-03-15
申请号：US10583435
申请日：2004-11-23
申请人： Gervin Ruegenberg , Hermann Hochgraeber
发明人： Gervin Ruegenberg , Hermann Hochgraeber
IPC分类号： G01N11/00
CPC分类号： G01N30/32 , G01N30/36 , G01N2030/324 , G01N2030/342 , G01N30/10
摘要： The invention relates to a method for providing a defined fluid flow, especially for use in liquid chromatography. According to the method, a constant total flow (f0) is subdivided into an internal excess flow (fie) in an excess branch and into an internal working flow (fiw) in a working branch. The ratio of subdivision of the internal working flow (fiw) and the internal excess flow (fie) depends on the reverse ratio of a fluidic resistance provided in the working branch and a fluidic resistance in the excess branch. The excess branch and the working branch are interlinked at the respective outputs of the two fluidic outputs of the fluidic resistances by a cross-branch. The equalizing flow occurring between the outputs of the fluidic resistances is measured by means of a flow sensor. A desired, external working flow in the further course of the working branch can be fed to a working device, for example a chromatography column mounted downstream of the device. Further down the excess branch a variable fluidic resistance device is arranged. The resistance value of the variable fluidic resistance device is controlled, thereby controlling the equalizing flow in such a manner that the equalizing flow, preferably in the temporal mean, is substantially zero or equals a defined offset value whose amount is small compared to the internal working flow (fiw). The invention also relates to a device for carrying out the inventive method.
摘要翻译：本发明涉及一种用于提供限定的流体流动的方法，特别是用于液相色谱。根据该方法，将恒定的总流量（f 0> 0）细分为过量分支中的内部过量流（f），并分成内部工作流程（f _{iw ）。内部工作流程（f）的细分比和内部过剩流量（f ）取决于工作分支中提供的流体阻力的反比和多余分支中的流体阻力。多余分支和工作分支通过交叉分支在流体电阻的两个流体输出的相应输出处相互连接。通过流量传感器测量在流体电阻的输出之间产生的均衡流。在工作分支的进一步过程中所需的外部工作流程可以被馈送到工作装置，例如安装在装置下游的色谱柱。在多余的分支下方设置可变流体阻力装置。控制可变流体阻力装置的电阻值，从而以均衡流量（优选在时间平均值）基本上为零或等于限定的偏移值来控制均衡流量，其量相对于内部工作流（f> w w）。本发明还涉及一种用于实施本发明的方法的装置。}

3. 发明授权

US09400265B2 Switching valve for high-performance liquid chromatography 有权
标题翻译：高效液相色谱切换阀
公开(公告)号：US09400265B2
公开(公告)日：2016-07-26
申请号：US13961637
申请日：2013-08-07
申请人： Joachim Wiechers , Hermann Hochgraeber
发明人： Joachim Wiechers , Hermann Hochgraeber
IPC分类号： F16K25/00 , G01N30/26 , G01N30/22 , F16K3/10 , F16K11/074 , G01N30/20
CPC分类号： G01N30/26 , F16K3/10 , F16K11/0743 , G01N30/22 , G01N2030/202
摘要： A switching valve is described that has a stator which is arranged in a housing and which has multiple connection ports. The switching valve also has a rotatable rotor which is arranged in the housing and which, in predetermined switching positions defined by associated angular positions, interacts with the stator for the fluidic connection or separation of predetermined connection ports. The rotor is rotatably mounted, and acted on with a predefined pressing force in the direction of the stator, by means of a bearing and pressing device arranged in the housing. The bearing and pressing device has a spring device which exerts a load on the rotor or on an element that is capable of performing a wobbling movement.
摘要翻译：描述了具有布置在壳体中并且具有多个连接端口的定子的切换阀。切换阀还具有可转动的转子，该转子布置在壳体中，并且在由关联的角位置限定的预定切换位置中与定子相互作用以进行流体连接或预定连接端口的分离。转子通过设置在壳体中的轴承和加压装置可旋转地安装并以预定的按压力在定子的方向上作用。轴承和加压装置具有弹簧装置，该弹簧装置对转子或能够进行摆动运动的元件施加负载。

4. 发明申请

US20080092553A1 Device for the Refrigerated Storage and Delivery of Samples and an Integrated Liquid Cooling Unit That is Suitable Therefor 审中-公开
标题翻译：用于冷藏存储和运送样品的装置以及适用于其的集成液体冷却装置
公开(公告)号：US20080092553A1
公开(公告)日：2008-04-24
申请号：US11573083
申请日：2005-07-18
申请人： Hermann Hochgraeber , Adolf Satzinger , Gerhard Martens
发明人： Hermann Hochgraeber , Adolf Satzinger , Gerhard Martens
IPC分类号： F25B21/02 , G01N30/00
CPC分类号： F25B21/02 , B01L7/00 , B01L2300/1822 , B01L2300/185 , B01L2300/1894 , F04D29/5826 , G01N30/24 , G01N30/30 , G01N2030/3092 , G01N2030/303
摘要： The invention relates to a device for the refrigerated storage and dispensing of substance samples, in particular a sample dispenser that is used in chromatography. Said device comprises a holder (7) for receiving one or more substance samples (3), at least one section of the holder (7) comprising at least one cavity (13) that is traversed by a liquid coolant (29), said cavity or cavities (13) being connected to a feed connection for supplying the coolant (29) and a return connection for evacuating the coolant (29). The device also comprises a liquid refrigeration unit (21), the feed connection of which is connected to the feed connection of the cavity or cavities (13) and the return connection of which is connected to the return connection of the cavity or cavities (13), a pump (23) for transporting the coolant (29) through the cavity or cavities (13) and a Peltier refrigeration unit (27) for cooling the coolant (29). In addition, the invention relates to an integrated liquid refrigeration unit (21) for a device of this type.
摘要翻译：本发明涉及用于冷藏储存和分配物质样品的装置，特别是用于色谱法的样品分配器。所述装置包括用于接收一个或多个物质样品（3）的保持器（7），所述保持器（7）的至少一个部分包括由液体冷却剂（29）穿过的至少一个空腔（13），所述腔或空腔（13）连接到用于供应冷却剂（29）的进料连接件和用于抽空冷却剂（29）的返回连接件。该装置还包括液体制冷单元（21），其进料连接件连接到空腔或空腔（13）的进料连接件，并且其返回连接件连接到空腔（13）的返回连接件），用于将冷却剂（29）输送通过空腔（13）的泵（23）和用于冷却冷却剂（29）的珀尔帖制冷单元（27）。此外，本发明涉及一种用于这种装置的集成液体制冷单元（21）。

5. 发明授权

US08806922B2 Sample injector for liquid chromatography, particularly for high performance liquid chromatography 有权
标题翻译：用于液相色谱的样品注射器，特别是用于高效液相色谱
公开(公告)号：US08806922B2
公开(公告)日：2014-08-19
申请号：US12863976
申请日：2009-01-07
申请人： Hermann Hochgraeber
发明人： Hermann Hochgraeber
IPC分类号： G01N13/00 , G01N30/24
CPC分类号： G01N30/20 , G01N30/24 , G01N30/32 , G01N35/1097 , G01N2030/027 , G01N2030/201 , G01N2030/207
摘要： A sample injector for liquid chromatography includes an injection valve having a waste port, two sample loop ports, and two high-pressure ports. One high-pressure port can be connected to a pump and the other high-pressure port can be connected to a chromatography column. A sample loop is connected to one of the sample loop ports on one end and to a pump volume of a sample conveying device on the other end. A section of the sample loop can be separated to facilitate receiving a sample fluid in the sample loop. A control unit controls the injection valve and the sample conveying device. The sample injector allows a sample to be loaded into the sample loop and then pressurized to an operating pressure prior to injecting the sample into the chromatography column. The sample loop may also be isolated from the operating pressure for facilitating depressurization of the loop.
摘要翻译：用于液相色谱的样品注射器包括具有废物口，两个样品环端口和两个高压端口的注射阀。一个高压端口可以连接到泵，另一个高压端口可以连接到色谱柱。样品回路连接到一端的一个样品回路端口和另一端的样品输送装置的泵体积。样品回路的一部分可以分开，以便于在样品回路中接收样品流体。控制单元控制喷射阀和样品输送装置。样品注射器允许将样品装载到样品环中，然后在将样品注入色谱柱之前加压至操作压力。样品回路也可以与操作压力隔离，以便于循环的减压。

6. 发明申请

US20140042350A1 SWITCHING VALVE FOR LIQUID CHROMATOGRAPHY 有权
标题翻译：用于液相色谱的开关阀
公开(公告)号：US20140042350A1
公开(公告)日：2014-02-13
申请号：US13961618
申请日：2013-08-07
申请人： Hermann HOCHGRAEBER , Burkhard SEYFERTH , Robert SPRINGER
发明人： Hermann HOCHGRAEBER , Burkhard SEYFERTH , Robert SPRINGER
IPC分类号： F16K31/04
CPC分类号： G01N30/26 , F16K11/0743 , F16K31/041 , F16K31/043 , F16K37/0025 , G01N2030/202
摘要： A switching valve includes a stator and a rotor. The stator includes multiple connection ports. The rotor having predetermined switching positions and interacts with the stator to form a fluidic connection or a fluidic disconnection of predetermined connection ports. The rotor being mounted rotatably via a bearing and pressing device, where the bearing and pressing device is arranged in the housing and loaded with a predefined pressing force in a direction of the stator. The bearing and pressing device includes a spring unit, being supported against a receiving part mounted to rotate about a rotor axis. The receiving part is coupled rotationally conjointly to the rotor and has a drive region which faces away from the stator and is coupled to an output of a drive device.
摘要翻译：切换阀包括定子和转子。定子包括多个连接端口。转子具有预定的切换位置并与定子相互作用以形成预定连接端口的流体连接或流体断开。转子通过轴承和加压装置可旋转地安装，其中轴承和加压装置布置在壳体中并且在定子的方向上加载预定的按压力。轴承和加压装置包括弹簧单元，其被支撑在安装成围绕转子轴线旋转的接收部件上。接收部分旋转地联接到转子并且具有驱动区域，该驱动区域远离定子并耦合到驱动装置的输出端。

7. 发明申请

US20120061955A1 PLUG UNIT AND CONNECTION SYSTEM FOR CONNECTING CAPILLARY TUBES, ESPECIALLY FOR HIGH-PERFORMANCE LIQUID CHROMATOGRAPHY 有权
公开(公告)号：US20120061955A1
公开(公告)日：2012-03-15
申请号：US13321156
申请日：2010-03-19
申请人： Hermann Hochgraeber , Adolf Satzinger , Daniel Bürger , Andreas Unger
发明人： Hermann Hochgraeber , Adolf Satzinger , Daniel Bürger , Andreas Unger
IPC分类号： F16L19/06
CPC分类号： G01N30/6026 , F16L25/0018 , F16L37/02 , G01N2030/027
摘要： The invention relates to a plug unit for connecting capillary tubes, especially for high-performance liquid chromatography, with a plug housing that has an axial borehole, with a plug capillary tube that projects through the axial borehole of the plug housing, and with a sealing element that has an annular cross section and that surrounds the plug capillary tube, and the front end of the plug capillary tube is sealed by an elastic and/or plastic deformation of the sealing element against the capillary tube receptacle opening of the bushing unit, wherein the plug housing is constructed so that it can be connected detachably to a bushing unit, wherein the front end of the plug capillary tube projects into a capillary tube receptacle opening of the bushing unit when the plug unit and bushing unit are connected and with its end surface essentially aligned opposite a front end of a bushing capillary tube or a bushing capillary tube opening of the bushing unit, and the sealing element is loaded directly or indirectly with an axial contact force when the plug unit and bushing unit are connected. According to the invention, the sealing element surrounds a front end region of the plug capillary tube that can be inserted into the capillary tube receptacle opening of the bushing unit, wherein the end surface of the sealing element is flush with the end surface of the front end region of the plug capillary tube, or projects past this surface when the plug unit and bushing unit are not connected, a hollow cylindrical pressure piece is provided that surrounds the sealing element in an axial region facing away from the end surface of the plug capillary tube, and the pressure piece has a rearward end side that faces away from the end surface of the plug capillary tube and that can be loaded by the plug housing with an axial pressure force when the plug unit and bushing unit are connected. The pressure piece and the sealing element are rigidly connected to the plug capillary tube such that the axial pressure force can be transmitted to the end surface of the sealing element without there being relative movement between the pressure piece and sealing element, on the one hand, and the plug capillary tube, on the other hand

8. 发明申请

US20090145205A1 AUTOSAMPLER FOR HIGH-PERFORMANCE LIQUID CHROMATOGRAPHY 有权
标题翻译：用于高性能液相色谱的自动清洗机
公开(公告)号：US20090145205A1
公开(公告)日：2009-06-11
申请号：US12331228
申请日：2008-12-09
申请人： Hermann Hochgraeber , Gervin Ruegenberg
发明人： Hermann Hochgraeber , Gervin Ruegenberg
IPC分类号： G01N30/04
CPC分类号： G01N30/20 , G01N30/22 , G01N35/1097 , G01N2030/201 , G01N2030/202
摘要： The invention relates to an autosampler for high-performance liquid chromatography (HPLC) with a high-pressure injection valve (1, 2) that has a considerably improved service life in comparison to the prior art, particularly in operation at very high pressures. This objective is achieved according to the invention by adapting the geometry of the valve components in such a manner and establishing the connections of the high-pressure injection valve in such a manner that the switching processes do not take place in a direction that reduces the service life. The grooves (81, 83, 85; 61, 63, 65; 21, 23, 25) in rotor (2) and/or the port opening cross sections (131, 151) in stator (1) and the rotational direction are selected such that fluid flows from grooves (81, 83, 85; 61, 63, 65; 21, 23, 25) under high pressure in the direction of narrow, substantially pressure-free ports (11, 12, 13, 16) are avoided. This applies in particular to the switching process from INJECT to LOAD, since the sample loop (50, 501/502) contains a relatively large dead volume of compressed fluid. In addition, the valve can be controlled according to the invention in such a manner that an appropriate time is available for reducing harmful or undesired pressure differences. The service life of a high-pressure injection valve (1, 2) according to the invention is limited only by the unavoidable abrasion between rotor (2) and stator (1) and possibly by the abrasive effect of particles such as contaminants or sample materials.
摘要翻译：本发明涉及一种用于高效液相色谱（HPLC）的自动进样器，其具有与现有技术相比具有显着改善的使用寿命的高压喷射阀（1,2），特别是在非常高的压力下操作。根据本发明，通过以这种方式适应阀部件的几何形状并建立高压喷射阀的连接，使得切换过程不会在减少服务的方向上发生，从而实现了该目的生活。选择转子（2）中的凹槽（81,83,85; 61,63,65; 21,23,25）和/或定子（1）中的开口开口横截面（131,151）和旋转方向使得流体在窄的，基本上无压力的端口（11,12,13,16）的方向上在高压下从槽（81,83,85; 61,63,65; 21,23,25）流出。。这特别适用于从INJECT到LOAD的切换过程，因为样品回路（50,501 / 502）包含相对较大的死体积的压缩流体。此外，根据本发明可以以适当的时间可用于减少有害或不期望的压力差的方式来控制阀门。根据本发明的高压喷射阀（1,2）的使用寿命仅受到转子（2）和定子（1）之间的不可避免的磨损的限制，并且可能受到污染物或样品材料等颗粒的磨损作用的限制。

9. 发明授权

US09329157B2 Switching valve for liquid chromatography 有权
标题翻译：液相色谱切换阀
公开(公告)号：US09329157B2
公开(公告)日：2016-05-03
申请号：US13961555
申请日：2013-08-07
申请人： Hermann Hochgraeber , Burkhard Seyferth
发明人： Hermann Hochgraeber , Burkhard Seyferth
IPC分类号： F16K25/00 , G01N30/26 , F16K31/04 , F16K37/00 , F16K11/074 , G01N30/20
CPC分类号： G01N30/26 , F16K11/0743 , F16K31/041 , F16K31/043 , F16K37/0025 , G01N2030/202
摘要： The invention relates to a switching valve for liquid chromatography having a stator in which multiple ports are formed. Each port is formed by in each case one duct which is connected at one end to in each case one connection port and which, at the other end, has a predetermined port opening cross section at a stator face surface of the stator. The switching valve includes a rotor which has a rotor face surface which interacts with the stator face surface and in which are formed at least one or more grooves. Depending on the rotational position of the rotor with respect to the stator, in at least one predetermined switching position, the switching valve connects respective predetermined port opening cross sections in a pressure-tight manner. The switching valve further includes a drive device for driving the rotor in rotation, and a device for detecting the rotational position of the rotor, which device generates a signal corresponding to the absolute or relative position of the rotor.
摘要翻译：本发明涉及一种液相色谱转换阀，其具有形成多个端口的定子。每个端口在每个情况下形成一个管道，其一端连接到每个壳体中的一个连接端口，另一端在定子的定子面上具有预定的开口横截面。切换阀包括具有与定子面表面相互作用并且形成有至少一个或多个槽的转子面表面的转子。根据转子相对于定子的旋转位置，在至少一个预定的切换位置中，切换阀以不透气的方式连接各个预定的开口横截面。切换阀还包括用于驱动转子旋转的驱动装置和用于检测转子的旋转位置的装置，该装置产生对应于转子的绝对位置或相对位置的信号。

10. 发明授权

US09134283B2 Plug unit and connection system for connecting capillary tubes, especially for high-performance liquid chromatography 有权
标题翻译：用于连接毛细管的插头单元和连接系统，特别适用于高效液相色谱
公开(公告)号：US09134283B2
公开(公告)日：2015-09-15
申请号：US13132578
申请日：2009-11-27
申请人： Hermann Hochgraeber , Adolf Satzinger
发明人： Hermann Hochgraeber , Adolf Satzinger
IPC分类号： F16L19/06 , G01N30/60
CPC分类号： F16L21/04 , F16L19/00 , F16L19/061 , F16L21/035 , G01N30/6026 , G01N30/6039 , G01N30/6091
摘要： A plug unit and system for connecting capillary tubes, especially for high-performance liquid chromatography, with a plug capillary tube projecting through a hole of a plug housing, which is detachably connectable to a bushing unit. The plug capillary tube front end projects into a capillary tube receptacle in the bushing unit with its end face essentially aligned opposite a front end of a bushing capillary tube or a bushing capillary passage opening of the bushing unit, the end face of which is butted against. The plug housing applies a force, with its end face facing the plug capillary tube end, directly or indirectly on an annular sealing element surrounding the plug capillary tube in the region of the front end of the plug capillary tube such that the front end of the plug capillary tube is sealed through deformation of the sealing element against the capillary tube receptacle opening.
摘要翻译：一种插头单元和系统，用于连接毛细管，特别是用于高效液相色谱，其中插塞毛细管突出穿过插头壳体的孔，该插头毛细管可拆卸地连接到衬套单元。塞子毛细管前端突出到衬套单元中的毛细管插座中，其端面基本上对准衬套毛细管的前端或衬套单元的衬套毛细管通道开口，其端面对接。插头壳体将其端面面向塞子毛细管端部的力直接或间接地施加在塞子毛细管前端的区域周围的环形密封元件上，使得前端插塞毛细管通过密封元件相对于毛细管插座开口的变形而被密封。

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