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1. 发明授权

US11685922B2 Aptamer method 有权
公开(公告)号：US11685922B2
公开(公告)日：2023-06-27
申请号：US16916305
申请日：2020-06-30
申请人： Oxford Nanopore Technologies PLC
发明人： Daniel John Turner , Daniel George Fordham , Roger Charles Gill , Clive Gavin Brown , Stuart Reid , James Anthony Clarke , James White
IPC分类号： G01N33/00 , G01N33/543 , G01N33/53 , C12N15/115 , C07H21/04
CPC分类号： G01N33/54386 , C12N15/115 , G01N33/5308 , G01N2333/36 , G01N2333/49 , G01N2333/705 , G01N2333/96463
摘要： The invention relates to a new method of determining in a sample the presence or absence of one or more analyte members of a group of two or more analytes. The invention therefore relates to a multiplex assay for determining the presence or absence of each analyte in a group of multiple analytes. The assay uses aptamers and transmembrane pores.

2. 发明申请

US20180042850A1 Pharmaceutical Composition of Killed Cells with Substantially Retained Immunogenicity 审中-公开
公开(公告)号：US20180042850A1
公开(公告)日：2018-02-15
申请号：US15722511
申请日：2017-10-02
申请人： Cadila Pharmaceuticals Ltd.
发明人： Bakulesh Mafatlal Khamar , Satinder Singh , Nirav Manojkumar Desai , Rajiv Indravadan Modi
IPC分类号： A61K9/19 , A61K39/00 , C12N1/20 , A61K47/32 , A61K47/36 , A61K39/39 , A61K47/26
CPC分类号： A61K9/19 , A01N1/0221 , A61K35/13 , A61K39/0011 , A61K39/39 , A61K47/26 , A61K47/32 , A61K47/36 , A61K2039/5152 , C07H3/04 , C08F26/10 , C12N1/20 , G01N2333/36
摘要： The present invention relates to a lyophilized composition comprising killed cancer cells with substantially retained immunogenicity and morphology, an intracellular cryopreservative such as trehalose and an extracellular cryopreservative such as polyvinylpyrrolidone. The present invention also relates to a process for the preparation of said lyophilized composition. The lyophilized composition of the present invention can be used for cancer immunotherapy.

3. 发明授权

US08586322B2 Sandwich assay for immunosuppressant drugs 有权
标题翻译：免疫抑制药物的三明治测定
公开(公告)号：US08586322B2
公开(公告)日：2013-11-19
申请号：US13413925
申请日：2012-03-07
申请人： Tie Quan Wei
发明人： Tie Quan Wei
IPC分类号： G01N33/53 , G01N33/553
CPC分类号： G01N33/9493 , G01N2333/36
摘要： Methods are disclosed for determining an immunosuppressant drug in a sample suspected of containing an immunosuppressant drug. The method includes providing in combination in a medium the sample, a first monoclonal antibody for the immunosuppressant drug, and a second monoclonal antibody for the immunosuppressant drug. The second monoclonal antibody binds to a portion of the immunosuppressant drug other than the portion to which the first monoclonal antibody binds to the immunosuppressant drug. The medium is incubated under conditions for binding of the first monoclonal antibody and the second monoclonal antibody to the immunosuppressant drug. The medium is examined for the presence of an immunocomplex comprising the immunosuppressant drug, the first monoclonal antibody and the second monoclonal antibody. The presence and/or amount of the immunocomplex indicates the presence and/or amount of the immunosuppressant drug in the sample.
摘要翻译：公开了用于确定怀疑含有免疫抑制剂药物的样品中的免疫抑制剂药物的方法。该方法包括在培养基中组合提供样品，用于免疫抑制剂药物的第一单克隆抗体和用于免疫抑制剂药物的第二单克隆抗体。第二单克隆抗体结合一部分免疫抑制剂药物，而不是第一单克隆抗体与免疫抑制剂药物结合的部分。将培养基在第一单克隆抗体和第二单克隆抗体与免疫抑制剂药物结合的条件下孵育。检查介质是否存在包含免疫抑制剂药物，第一单克隆抗体和第二单克隆抗体的免疫复合物。免疫复合物的存在和/或量表示样品中免疫抑制剂药物的存在和/或量。

4. 发明申请

US20120149054A1 MEASUREMENT METHOD FOR VIABLE CELL COUNT, AND CULTURE MEDIUM 有权
标题翻译：可视电池计数和文化媒质的测量方法
公开(公告)号：US20120149054A1
公开(公告)日：2012-06-14
申请号：US13390859
申请日：2011-03-25
申请人： Masimichi Muto , Fumiaki Abe , Tomoko Yaeshima
发明人： Masimichi Muto , Fumiaki Abe , Tomoko Yaeshima
IPC分类号： C12Q1/02
CPC分类号： C12Q1/045 , C12N1/20 , C12Q1/06 , G01N2333/36
摘要： There are provided a method of identifying the longum species alone, such as Bifidobacterium longum subsp. longum alone, and measuring the viable cell count thereof, amongst the bacterial cells to be tested which include a microorganism belonging to the genus Bifidobacterium by using a culture medium that contains L-arabinose as a sole sugar source; and also a culture medium which is useful as a selective medium for the above measurement method and which is also easy to prepare.
摘要翻译：提供了一种识别长单独物种的方法，例如长双歧杆菌（Bifidobacterium longum subsp。）并且通过使用含有L-阿拉伯糖作为唯一糖源的培养基，测量其中包含属于双歧杆菌属的微生物的待测试细菌细胞中的活细胞数; 以及作为上述测定方法的选择培养基有用的培养基，也容易制备。

5. 发明授权

US07989610B2 Protein, a gene encoding therefor and a method of using the same 有权
标题翻译：蛋白质，其编码基因及其使用方法
公开(公告)号：US07989610B2
公开(公告)日：2011-08-02
申请号：US12942978
申请日：2010-11-09
申请人： Yoshimitsu Takakura
发明人： Yoshimitsu Takakura
IPC分类号： C07H21/04
CPC分类号： A01N63/04 , C07K14/375 , C12N15/8282 , G01N2333/36
摘要： An object of the present invention is to search and identify novel antifungal proteins capable of inhibiting the growth of plant pathogenic microorganisms including Magnaporthe grisea and Rhizoctonia solani causing two major rice diseases at relatively low concentrations, and further to clone a gene for said protein. The present invention provides an antifungal protein which can be obtained from fraction(s) precipitated by ammonium sulfate precipitation using an aqueous extract from Pleurotus cornucopiae, wherein said protein has an antifungal activity against at least rice blast, and exhibits existence of a component having a molecular weight of about 15 kDa as determined by SDS-PAGE method; a gene encoding said protein and uses thereof.
摘要翻译：本发明的目的是搜索并鉴定能够抑制植物病原微生物生长的新型抗真菌蛋白质，包括稻瘟病菌和丝核丝杆菌，其以相对低的浓度引起两种主要的水稻病害，并进一步克隆所述蛋白质的基因。本发明提供了一种抗真菌蛋白质，其可以从使用来自白头翁聚合物的水提取物沉淀的级分获得，其中所述蛋白质具有至少抗稻瘟病的抗真菌活性，并且表现出存在具有通过SDS-PAGE法测定分子量约15kDa; 编码所述蛋白质的基因及其用途。

6. 发明申请

US20100145626A1 Systems for rapid forensic analysis of mitochondrial DNA and characterization of mitochondrial DNA heteroplasmy 审中-公开
标题翻译：线粒体DNA的快速法医分析系统和线粒体DNA异质性的表征
公开(公告)号：US20100145626A1
公开(公告)日：2010-06-10
申请号：US12605628
申请日：2009-10-26
申请人： David J. Ecker , Richard H. Griffey , Rangarajan Sampath , Steven A. Hofstadler , John McNeil , Stanley T. Crooke , Lawrence B. Blyn , Thomas A. Hall , Yun Jiang , James C. Hannis , Neill White , Vivek Samant , Mark W. Eshoo , Jared J. Drader
发明人： David J. Ecker , Richard H. Griffey , Rangarajan Sampath , Steven A. Hofstadler , John McNeil , Stanley T. Crooke , Lawrence B. Blyn , Thomas A. Hall , Yun Jiang , James C. Hannis , Neill White , Vivek Samant , Mark W. Eshoo , Jared J. Drader
IPC分类号： G06F19/00 , B01D59/44 , G01N33/48
CPC分类号： C12Q1/686 , C12Q1/6806 , C12Q1/6844 , C12Q1/6858 , C12Q1/6872 , C12Q1/6888 , C12Q1/689 , C12Q2600/156 , G01N2333/28 , G01N2333/32 , G01N2333/35 , G01N2333/36 , C12Q2563/167 , C12Q2545/101 , C12Q2531/113 , C12Q2565/627 , C12Q2545/113
摘要： The present invention provides methods for rapid forensic analysis of mitochondrial DNA and methods for characterizing heteroplasmy of mitochondrial DNA, which can be used to assess the progression of mitochondrial diseases.
摘要翻译：本发明提供线粒体DNA的快速法医分析方法和线粒体DNA异质性表征的方法，可用于评估线粒体疾病的进展。

7. 发明授权

US07666588B2 Methods for rapid forensic analysis of mitochondrial DNA and characterization of mitochondrial DNA heteroplasmy 有权
标题翻译：线粒体DNA快速法医分析方法及线粒体DNA异质性表征
公开(公告)号：US07666588B2
公开(公告)日：2010-02-23
申请号：US10660998
申请日：2003-09-12
申请人： David J. Ecker , Richard H. Griffey , Rangarajan Sampath , Steven A. Hofstadler , John McNeil , Stanley T. Crooke , Lawrence B. Blyn , Thomas A. Hall , Yun Jiang , James C. Hannis , Neil White , Vivek Samant , Mark W. Eshoo , Jared J. Drader
发明人： David J. Ecker , Richard H. Griffey , Rangarajan Sampath , Steven A. Hofstadler , John McNeil , Stanley T. Crooke , Lawrence B. Blyn , Thomas A. Hall , Yun Jiang , James C. Hannis , Neil White , Vivek Samant , Mark W. Eshoo , Jared J. Drader
IPC分类号： C12Q1/68 , C12P19/34 , C07H21/04
CPC分类号： C12Q1/686 , C12Q1/6806 , C12Q1/6844 , C12Q1/6858 , C12Q1/6872 , C12Q1/6888 , C12Q1/689 , C12Q2600/156 , G01N2333/28 , G01N2333/32 , G01N2333/35 , G01N2333/36 , C12Q2563/167 , C12Q2545/101 , C12Q2531/113 , C12Q2565/627 , C12Q2545/113
摘要： The present invention provides methods for rapid forensic analysis of mitochondrial DNA and methods for characterizing heteroplasmy of mitochondrial DNA, which can be used to assess the progression of mitochondrial diseases.
摘要翻译：本发明提供线粒体DNA的快速法医分析方法和线粒体DNA异质性表征的方法，可用于评估线粒体疾病的进展。

8. 发明申请

US20090069401A1 MARINE ACTINOMYCETE TAXON FOR DRUG AND FERMENTATION PRODUCT DISCOVERY 有权
公开(公告)号：US20090069401A1
公开(公告)日：2009-03-12
申请号：US11966787
申请日：2007-12-28
申请人： William Fenical , Paul R. Jensen , Tracy J. Mincer
发明人： William Fenical , Paul R. Jensen , Tracy J. Mincer
IPC分类号： C07D491/044 , A61K31/407
CPC分类号： C12Q1/18 , C12N1/10 , C12P17/188 , C12R1/01 , G01N2333/36
摘要： The invention is the discovery of an actinomycete genus, given the name Salinospora gen. nov., that displays an obligate requirement of seawater (Na+) for growth and unique 16S rRNA signature nucleotides. The invention is also the use of the genus for the production and discovery of active biomolecules such as pharmaceutical agents, agrichemicals, immunomodifiers, enzymes and enzyme inhibitors.

9. 发明申请

US20050089983A1 Novel protein, genes encoding the same and method of using the same 有权
标题翻译：新型蛋白质，编码基因的基因和使用方法相同
公开(公告)号：US20050089983A1
公开(公告)日：2005-04-28
申请号：US10471422
申请日：2002-03-12
申请人： Yoshimitsu Takakura
发明人： Yoshimitsu Takakura
IPC分类号： A01N63/04 , C07K14/375 , C12N1/15 , C12N1/19 , C12N1/21 , C12N15/82 , C12N9/24
CPC分类号： A01N63/04 , C07K14/375 , C12N15/8282 , G01N2333/36
摘要： An object of the present invention is to search and identify novel antifungal proteins capable of inhibiting the growth of plant pathogenic microorganisms including Magnaporthe grisea and Rhizoctonia solani causing two major rice diseases at relatively low concentrations, and further to clone a gene for said protein. The present invention provides an antifungal protein which can be obtained from fraction(s) precipitated by ammonium sulfate precipitation using an aqueous extract from Pleurotus cornucopiae, wherein said protein has an antifungal activity against at least rice blast, and exhibits existence of a component having a molecular weight of about 15 kDa as determined by SDS-PAGE method; a gene encoding said protein and uses thereof.
摘要翻译：本发明的目的是搜索并鉴定能够抑制植物病原微生物生长的新型抗真菌蛋白质，包括稻瘟病菌和丝核丝杆菌，其以相对低的浓度引起两种主要的水稻病害，并进一步克隆所述蛋白质的基因。本发明提供了一种抗真菌蛋白质，其可以从使用来自白头翁聚合物的水提取物沉淀的级分获得，其中所述蛋白质具有至少抗稻瘟病的抗真菌活性，并且表现出存在具有通过SDS-PAGE法测定分子量约15kDa; 编码所述蛋白质的基因及其用途。

10. 发明授权

US06727076B2 Comparative phenotype analysis 有权
标题翻译：比较表型分析
公开(公告)号：US06727076B2
公开(公告)日：2004-04-27
申请号：US10226436
申请日：2002-08-23
申请人： Barry Bochner
发明人： Barry Bochner
IPC分类号： C12Q104
CPC分类号： C12Q1/04 , C12Q2304/20 , C12Q2304/22 , C12Q2304/24 , G01N2035/00148 , G01N2333/36 , Y10S435/81 , Y10S435/822 , Y10S435/911 , Y10S435/975
摘要： The present invention relates to growing and testing microorganisms in a multitest format which utilizes a gel forming matrix for the rapid screening of clinical and environmental cultures. The present invention is suited for the characterization of commonly encountered microorganisms (e.g., E. coli, S. aureus, etc.), as well as commercially and industrially important organisms from various and diverse environments (e.g., the present invention is particularly suited for the growth and characterization of the actinomycetes and fungi). The present invention is also particularly suited for comparative analysis of phenotypic differences between cell types, including strains of microorganisms that have been designated as the same genus and species, as well as other cell types (e.g., mammalian, insect, and plant cells).
摘要翻译：本发明涉及利用凝胶形成基质以快速筛选临床和环境培养物来培养和测试多种格式的微生物。本发明适用于常见的微生物（例如，大肠杆菌，金黄色葡萄球菌等）的表征，以及来自各种和各种环境的商业和工业上重要的生物体（例如，本发明特别适用于放线菌和真菌的生长和表征）。本发明还特别适用于细胞类型之间的表型差异的比较分析，包括已被指定为相同属和物种的微生物以及其它细胞类型（例如哺乳动物，昆虫和植物细胞）的菌株。

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