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1. 发明申请

US20130236918A1 SANDWICH ASSAY FOR IMMUNOSUPPRESSANT DRUGS 有权
标题翻译：用于免疫抑制剂的三明治测定
公开(公告)号：US20130236918A1
公开(公告)日：2013-09-12
申请号：US13413925
申请日：2012-03-07
申请人： Tie Quan Wei
发明人： Tie Quan Wei
IPC分类号： G01N33/566
CPC分类号： G01N33/9493 , G01N2333/36
摘要： Methods are disclosed for determining an immunosuppressant drug in a sample suspected of containing an immunosuppressant drug. The method includes providing in combination in a medium the sample, a first monoclonal antibody for the immunosuppressant drug, and a second monoclonal antibody for the immunosuppressant drug. The second monoclonal antibody binds to a portion of the immunosuppressant drug other than the portion to which the first monoclonal antibody binds to the immunosuppressant drug. The medium is incubated under conditions for binding of the first monoclonal antibody and the second monoclonal antibody to the immunosuppressant drug. The medium is examined for the presence of an immunocomplex comprising the immunosuppressant drug, the first monoclonal antibody and the second monoclonal antibody. The presence and/or amount of the immunocomplex indicates the presence and/or amount of the immunosuppressant drug in the sample.
摘要翻译：公开了用于确定怀疑含有免疫抑制剂药物的样品中的免疫抑制剂药物的方法。该方法包括在培养基中组合提供样品，用于免疫抑制剂药物的第一单克隆抗体和用于免疫抑制剂药物的第二单克隆抗体。第二单克隆抗体结合一部分免疫抑制剂药物，而不是第一单克隆抗体与免疫抑制剂药物结合的部分。将培养基在第一单克隆抗体和第二单克隆抗体与免疫抑制剂药物结合的条件下孵育。检查介质是否存在包含免疫抑制剂药物，第一单克隆抗体和第二单克隆抗体的免疫复合物。免疫复合物的存在和/或量表示样品中免疫抑制剂药物的存在和/或量。

2. 发明申请

US20100240073A1 DETECTION OF FALSE RESULTS IN ASSAYS 有权
标题翻译：检测结果在测试中
公开(公告)号：US20100240073A1
公开(公告)日：2010-09-23
申请号：US12409302
申请日：2009-03-23
申请人： Tie Quan Wei
发明人： Tie Quan Wei
IPC分类号： G01N33/53
CPC分类号： G01N33/9493 , Y10T436/106664 , Y10T436/107497 , Y10T436/25125 , Y10T436/25375
摘要： Methods and reagents are disclosed for detecting a false result in an assay for determining a concentration of an analyte in a whole blood sample suspected of containing the analyte. The method comprises determining by means of the assay a concentration of the analyte utilizing a hemolyzed portion of the blood sample to obtain concentration value 1 and determining by means of the assay a concentration of the analyte utilizing a non-hemolyzed portion of the blood sample and multiplying the concentration times a hematocrit factor to obtain concentration value 2. A ratio of concentration value 1 divided by concentration value 2 is determined and is compared to a predetermined ratio of known reliability. If the ratio is less than the predetermined ratio, a false result is indicated.
摘要翻译：公开了用于在用于确定怀疑含有分析物的全血样品中的分析物的浓度的测定中检测假结果的方法和试剂。该方法包括通过测定方法测定分析物的浓度，利用血液样品的溶血部分获得浓度值1，并通过测定法确定分析物的浓度，利用血液样品的非溶血部分，将浓度乘以血细胞比容因子以获得浓度值2.确定浓度值1除以浓度值2的比例，并将其与已知可靠性的预定比率进行比较。如果该比例小于预定比率，则指出错误结果。

3. 发明授权

US07488608B2 Reduction of non-specific binding in assays 有权
标题翻译：在测定中减少非特异性结合
公开(公告)号：US07488608B2
公开(公告)日：2009-02-10
申请号：US11619244
申请日：2007-01-03
申请人： Zhu Teng , Jeffrey L. Moore , Alan R. Craig , Gary Hickey , Carsten Schelp , Tie Quan Wei
发明人： Zhu Teng , Jeffrey L. Moore , Alan R. Craig , Gary Hickey , Carsten Schelp , Tie Quan Wei
IPC分类号： G01N33/548 , G01N33/544 , G01N33/547 , G01N33/53 , C07K17/10
CPC分类号： G01N33/548 , G01N33/54393
摘要： Methods and compositions are disclosed for reducing non-specific binding in a binding assay for the determination of an analyte in a sample where one of the reagents for conducting the binding assay comprises a solid support comprising a polysaccharide. The method comprises including in an assay medium for conducting the binding assay a soluble compound comprising a protein linked to a polysaccharide. Also disclosed are methods and compositions for determining the presence and/or amount of an analyte in a sample suspected of containing the analyte. The methods include as reagents a solid support comprising a polysaccharide and a soluble compound comprising a protein linked to a polysaccharide.
摘要翻译：公开了用于在用于测定样品中分析物的结合测定中的非特异性结合的方法和组合物，其中用于进行结合测定的试剂之一包含含有多糖的固体支持物。该方法包括在用于进行结合测定的测定培养基中包含可与多糖连接的蛋白质的可溶性化合物。还公开了用于确定疑似含有分析物的样品中分析物的存在和/或量的方法和组合物。所述方法包括作为试剂的固体支持物，其包含多糖和包含与多糖连接的蛋白质的可溶性化合物。

4. 发明授权

US08586322B2 Sandwich assay for immunosuppressant drugs 有权
标题翻译：免疫抑制药物的三明治测定
公开(公告)号：US08586322B2
公开(公告)日：2013-11-19
申请号：US13413925
申请日：2012-03-07
申请人： Tie Quan Wei
发明人： Tie Quan Wei
IPC分类号： G01N33/53 , G01N33/553
CPC分类号： G01N33/9493 , G01N2333/36
摘要： Methods are disclosed for determining an immunosuppressant drug in a sample suspected of containing an immunosuppressant drug. The method includes providing in combination in a medium the sample, a first monoclonal antibody for the immunosuppressant drug, and a second monoclonal antibody for the immunosuppressant drug. The second monoclonal antibody binds to a portion of the immunosuppressant drug other than the portion to which the first monoclonal antibody binds to the immunosuppressant drug. The medium is incubated under conditions for binding of the first monoclonal antibody and the second monoclonal antibody to the immunosuppressant drug. The medium is examined for the presence of an immunocomplex comprising the immunosuppressant drug, the first monoclonal antibody and the second monoclonal antibody. The presence and/or amount of the immunocomplex indicates the presence and/or amount of the immunosuppressant drug in the sample.
摘要翻译：公开了用于确定怀疑含有免疫抑制剂药物的样品中的免疫抑制剂药物的方法。该方法包括在培养基中组合提供样品，用于免疫抑制剂药物的第一单克隆抗体和用于免疫抑制剂药物的第二单克隆抗体。第二单克隆抗体结合一部分免疫抑制剂药物，而不是第一单克隆抗体与免疫抑制剂药物结合的部分。将培养基在第一单克隆抗体和第二单克隆抗体与免疫抑制剂药物结合的条件下孵育。检查介质是否存在包含免疫抑制剂药物，第一单克隆抗体和第二单克隆抗体的免疫复合物。免疫复合物的存在和/或量表示样品中免疫抑制剂药物的存在和/或量。

5. 发明申请

US20130295592A1 DETERMINATION OF TOTAL ANALYTE CONCENTRATION 有权
标题翻译：总分析浓度的确定
公开(公告)号：US20130295592A1
公开(公告)日：2013-11-07
申请号：US13465574
申请日：2012-05-07
申请人： Tie Quan Wei
发明人： Tie Quan Wei
IPC分类号： G01N21/76 , G01N33/53 , G06F19/00 , G01N21/64
CPC分类号： G01N33/5306 , G01N21/6428 , G01N21/76 , G01N33/9493 , G06F19/24
摘要： Methods and reagents are disclosed for determining a total amount of an analyte in an unknown sample suspected of containing the analyte in the presence of endogeneous interfering substances. The methods involve measuring an amount [Y] of the portion of the analyte in the unknown sample that is bound by endogeneous binding substances employing an assay for the analyte. An amount [Z] of analyte in the unknown sample that is not bound by endogeneous binding substances is determined by the formula: [Z]=a[Y]+b, wherein “a” and “b” are predetermined by conducting the assay on samples containing known amounts of the analyte but substantially free from endogeneous interfering substances. Adding [Y] and [Z] yields the total amount [X] of the analyte in the unknown sample.
摘要翻译：公开了用于确定在内分子干扰物质存在下怀疑含有分析物的未知样品中分析物的总量的方法和试剂。所述方法涉及通过使用分析物的测定法来测量未知样品中被分析物结合的部分的量[Y]。不结合未结合物质的未知样品中的分析物的量[Z]由下式确定：[Z] = a [Y] + b，其中“a”和“b”通过进行测定在含有已知量的分析物但基本上不含内源干扰物质的样品上。添加[Y]和[Z]得到未知样品中分析物的总量[X]。

6. 发明授权

US07039561B2 Outlier rejection method in an automatic clinical analyzer 失效
标题翻译：自动临床分析仪中异常排除方法
公开(公告)号：US07039561B2
公开(公告)日：2006-05-02
申请号：US10865081
申请日：2004-06-10
申请人： Tie Quan Wei
发明人： Tie Quan Wei
IPC分类号： G06F15/00 , H03F1/26 , H04B15/00
CPC分类号： G16H10/40 , G06F19/00
摘要： Automatically rejecting outlier measurements in an analytical method employing multiple photometric values by determining the photometric value that is involved in the pair of photometric values having the greatest variance between individual mean rates and the mean rate of all of the multiple photometric values.
摘要翻译：在采用多个光度值的分析方法中，通过确定在单个平均速率和所有多个测光值的平均速率之间具有最大差异的光度对对参与的光度值，自动拒绝异常值测量。

7. 发明授权

US06284472B1 Method for extending the range of an immunoassay 有权
标题翻译：扩展免疫测定范围的方法
公开(公告)号：US06284472B1
公开(公告)日：2001-09-04
申请号：US09294489
申请日：1999-04-20
申请人： Tie Quan Wei , Thomas John Pankratz , Victor Pichai Chu
发明人： Tie Quan Wei , Thomas John Pankratz , Victor Pichai Chu
IPC分类号： G01N3353
CPC分类号： C07K16/40 , G01N33/53 , Y10S435/962 , Y10S435/973 , Y10S436/80 , Y10S436/805 , Y10S436/808 , Y10S436/817 , Y10S436/901 , Y10T436/11 , Y10T436/115831
摘要： Calibrating an immunoassay by generating two reaction rate measuring curves, from samples having higher and lower relative levels of antigen, extrapolating a combination of the curves to cover sample concentrations known to contain an excess of antigen relative to an amount of capture reagent and combining the low end linear potion of the higher reaction rate measuring curve with the higher end portion of the extrapolated reaction rate measuring curve, thereby eliminating measuring inaccuracies otherwise arising from the hook effect. For antigen concentrations higher than the assay range, a high antigen signal utilizing the two rates avoids reporting false results.
摘要翻译：通过从具有较高和较低相对抗原水平的样品产生两个反应速率测量曲线来校准免疫测定，外推曲线的组合以覆盖已知含有相对于捕获试剂量的过量抗原的样品浓度，并结合低反应速率测量曲线的最终线性度与外推反应速率测量曲线的较高端部分相比较，从而消除了由钩效应引起的测量不准确度。对于高于测定范围的抗原浓度，使用两种速率的高抗原信号避免报告错误的结果。

8. 发明授权

US09658218B2 Determination of total analyte concentration 有权
公开(公告)号：US09658218B2
公开(公告)日：2017-05-23
申请号：US13465574
申请日：2012-05-07
申请人： Tie Quan Wei
发明人： Tie Quan Wei
IPC分类号： G01N33/566 , G01N33/53 , G01N21/76 , G01N21/64 , G01N33/94 , G06F19/24
CPC分类号： G01N33/5306 , G01N21/6428 , G01N21/76 , G01N33/9493 , G06F19/24
摘要： Methods and reagents are disclosed for determining a total amount of an analyte in an unknown sample suspected of containing the analyte in the presence of endogeneous interfering substances. The methods involve measuring an amount [Y] of the portion of the analyte in the unknown sample that is bound by endogeneous binding substances employing an assay for the analyte. An amount [Z] of analyte in the unknown sample that is not bound by endogeneous binding substances is determined by the formula: [Z]=a[Y]+b, wherein “a” and “b” are predetermined by conducting the assay on samples containing known amounts of the analyte but substantially free from endogeneous interfering substances. Adding [Y] and [Z] yields the total amount [X] of the analyte in the unknown sample.

9. 发明授权

US07172906B2 Reduction of non-specific binding in assays 有权
标题翻译：在测定中减少非特异性结合
公开(公告)号：US07172906B2
公开(公告)日：2007-02-06
申请号：US10989677
申请日：2004-11-16
申请人： Zhu Teng , Jeffrey L. Moore , Alan R. Craig , Gary Hickey , Carsten Schelp , Tie Quan Wei
发明人： Zhu Teng , Jeffrey L. Moore , Alan R. Craig , Gary Hickey , Carsten Schelp , Tie Quan Wei
IPC分类号： G01N33/548 , G01N33/544 , G01N33/547 , G01N33/53 , G01N1/17
CPC分类号： G01N33/548 , G01N33/54393
摘要： Methods and compositions are disclosed for reducing non-specific binding in a binding assay for the determination of an analyte in a sample where one of the reagents for conducting the binding assay comprises a solid support comprising a polysaccharide. The method comprises including in an assay medium for conducting the binding assay a soluble compound comprising a protein linked to a polysaccharide. Also disclosed are methods and compositions for determining the presence and/or amount of an analyte in a sample suspected of containing the analyte. The methods include as reagents a solid support comprising a polysaccharide and a soluble compound comprising a protein linked to a polysaccharide.
摘要翻译：公开了用于在用于测定样品中分析物的结合测定中的非特异性结合的方法和组合物，其中用于进行结合测定的试剂之一包含含有多糖的固体支持物。该方法包括在用于进行结合测定的测定培养基中包含可与多糖连接的蛋白质的可溶性化合物。还公开了用于确定疑似含有分析物的样品中分析物的存在和/或量的方法和组合物。所述方法包括作为试剂的固体支持物，其包含多糖和包含与多糖连接的蛋白质的可溶性化合物。

10. 发明授权

US06277584B1 Method for calibrating a chemical analyzer with improved accuracy at low signal levels 失效
标题翻译：在低信号水平下以更高的精度校准化学分析仪的方法
公开(公告)号：US06277584B1
公开(公告)日：2001-08-21
申请号：US09212641
申请日：1998-12-16
申请人： Victor Pichai Chu , Connie Mary Sanders , James Floyd Pierson-Perry , Tie Quan Wei
发明人： Victor Pichai Chu , Connie Mary Sanders , James Floyd Pierson-Perry , Tie Quan Wei
IPC分类号： G01N3353
CPC分类号： G01N21/274 , G01N33/53 , G01N35/00594 , G01N35/00693 , G01N2035/00702 , Y10S435/967 , Y10S436/811 , Y10S436/815
摘要： Calibration of an assay by converting an analyzer's normal signal response through an arithmetic function prior to performing the curve fit, thereby improving the accuracy of the curve fit in a region of greatest diagnostic interest.
摘要翻译：通过在执行曲线拟合之前通过算术函数转换分析仪的正常信号响应来校准测定，由此提高在最大诊断兴趣的区域中曲线拟合的精度。

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