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1. 发明授权

US10642056B2 Multispectral or hyperspectral imaging and imaging system based on birefringent subwavelength resonating structure 有权
公开(公告)号：US10642056B2
公开(公告)日：2020-05-05
申请号：US15787002
申请日：2017-10-18
申请人： CSEM Centre Suisse d'Electronique et de Microtechnique SA—Recherche et Développement
发明人： Luc Dümpelmann , Benjamin Gallinet
IPC分类号： G02B27/28 , G01J3/02 , G01J3/28 , G02B1/08 , G02B5/00 , G02B5/30 , G02B5/20 , G02F1/137 , G02B26/00 , G02F1/01 , G02B5/18 , G02B5/28 , G01J3/12
CPC分类号： G02B27/288 , G01J3/0224 , G01J3/0256 , G01J3/2803 , G01J3/2823 , G02B1/08 , G02B5/008 , G02B5/203 , G02B5/3083 , G01J2003/1269 , G01J2003/1291 , G01J2003/2826 , G01J2003/2866 , G01J2003/2873 , G02B5/1809 , G02B5/285 , G02B26/007 , G02F1/0136 , G02F1/137
摘要： An angle-stable, miniaturized and integrate-able imaging system based on plasmon resonances or dielectric resonances for multispectral imaging maintaining full spatial resolution of the image sensor. Active tunability of the filter allows color recording, estimation of unknown spectra and determination of spectral singularities, for example laser lines, with the use of a conventional B/W camera. The system is characterized by high angular acceptance, cost-efficient fabrication and ease-of-use. This system can be used in conjunction with other commercial multispectral imaging systems such as RGB cameras to further enhance the spectral resolution. It can be adapted to different spectral ranges, depending on the application.

2. 发明申请

US20160278678A1 METHOD AND APPARATUS FOR QUANTITATIVE AND DEPTH RESOLVED HYPERSPECTRAL FLUORESCENCE AND REFLECTANCE IMAGING FOR SURGICAL GUIDANCE 审中-公开
标题翻译：定量和深度分析手术指导的超视距荧光和反射成像的方法和装置
公开(公告)号：US20160278678A1
公开(公告)日：2016-09-29
申请号：US15044097
申请日：2016-02-15
申请人： The Trustees of Dartmouth College
发明人： Pablo Valdes , Frederic Leblone , Keith D. Paulsen , Brian Campbell Wilson , David W. Roberts , Michael Jermyn
IPC分类号： A61B5/1455 , A61B5/00 , A61B1/04 , A61B5/055 , A61B5/1495 , A61B1/06 , A61B1/00 , A61B5/1459 , A61B5/145
CPC分类号： A61B5/14556 , A61B1/00009 , A61B1/00165 , A61B1/00193 , A61B1/042 , A61B1/043 , A61B1/05 , A61B1/0646 , A61B1/0669 , A61B1/0684 , A61B1/07 , A61B1/3132 , A61B5/0071 , A61B5/0077 , A61B5/055 , A61B5/14546 , A61B5/14553 , A61B5/1459 , A61B5/1495 , A61B5/4836 , A61B5/7264 , G01J3/0229 , G01J3/1256 , G01J3/2823 , G01J2003/1269 , G01J2003/2826
摘要： An imaging system, such as a surgical microscope, laparoscope, or endoscope or integrated with these devices, includes an illuminator providing patterned white light and/or fluorescent stimulus light. The system receives and images light hyperspectrally, in embodiments using a hyperspectral imaging array, and/or using narrowband tunable filters for passing filtered received light to an imager. Embodiments may construct a 3-D surface model from stereo images, and will estimate optical properties of the target using images taken in patterned light or using other approximations obtained from white light exposures. Hyperspectral images taken under stimulus light are displayed as fluorescent images, and corrected for optical properties of tissue to provide quantitative maps of fluorophore concentration. Spectral information from hyperspectral images is processed to provide depth of fluorophore below the tissue surface. Quantitative images of fluorescence at depth are also prepared. The images are displayed to a surgeon for use in surgery.
摘要翻译：诸如手术显微镜，腹腔镜或内窥镜或与这些装置集成的成像系统包括提供图案化的白光和/或荧光激发光的照明器。在使用高光谱成像阵列的实施例中，系统接收并高光图像光，并且/或使用窄带可调滤波器将滤波的接收光传递到成像器。实施例可以从立体图像构造3-D表面模型，并且将使用在图案化光线中拍摄的图像或使用从白光曝光获得的其它近似来估计目标的光学性质。在激发光下拍摄的高光谱图像显示为荧光图像，并对组织的光学性质进行校正，以提供荧光团浓度的定量图谱。处理来自高光谱图像的光谱信息，以提供组织表面下方的荧光团的深度。还准备了深度荧光的定量图像。图像显示给外科医生用于手术。

3. 发明授权

US4856897A Raman spectrometer having Hadamard electrooptical mask and diode detector 失效
标题翻译：拉曼光谱仪具有Hadamard电光掩模和二极管检测器
公开(公告)号：US4856897A
公开(公告)日：1989-08-15
申请号：US85530
申请日：1987-08-14
申请人： William G. Fateley , David C. Tilotta
发明人： William G. Fateley , David C. Tilotta
IPC分类号： G01J3/12 , G01J3/28 , G01J3/44 , G02F1/13
CPC分类号： G01J3/2846 , G01J3/44 , G02F1/1313 , G01J2003/1269 , G01J2003/285 , G01J3/0229
摘要： An improved Raman spectrometer device is provided which provides useful spectral information in situations where Raman spectroscopy has heretofore been unworkable. The spectrometer of the invention makes use of a stationary electrooptical masking device in lieu of conventional slit scanning optics, with the mask being computer controlled to provide a multiplexing function, typically employing Hadamard mathematics. The stationary encoding mask permits use of a relatively inexpensive photodiode detector, as compared with photomultiplier tubes conventionally used in Raman instrumentation. Advantageously, unwanted Rayleigh scattered radiation can be completely eliminated, either by blanking those zones of the mask receiving such radiation, or physically locating the device in such orientation that the Rayleigh scattered radiation does not pass through operative portions of the mask.
摘要翻译：提供了一种改进的拉曼光谱仪装置，其在拉曼光谱迄今为止不能工作的情况下提供有用的光谱信息。本发明的光谱仪利用固定的电光掩模装置代替传统的狭缝扫描光学器件，其掩模被计算机控制以提供通常采用Hadamard数学的复用功能。与常规用于拉曼仪器的光电倍增管相比，固定编码掩模允许使用相对便宜的光电二极管检测器。有利的是，可以通过对接收这种辐射的掩模的那些区域进行消隐，或者将该器件物理地定位成使得瑞利散射辐射不通过掩模的可操作部分的方向，来完全消除不需要的瑞利散射辐射。

4. 发明申请

US20170264835A1 LIQUID CRYSTAL FOURIER TRANSFORM IMAGING SPECTROMETER 审中-公开
公开(公告)号：US20170264835A1
公开(公告)日：2017-09-14
申请号：US15605642
申请日：2017-05-25
申请人： PALO ALTO RESEARCH CENTER INCORPORATED
发明人： ALEX HEGYI , JOERG MARTINI
IPC分类号： H04N5/33 , G01J3/00
CPC分类号： H04N5/332 , G01J3/00 , G01J3/0208 , G01J3/0224 , G01J3/0229 , G01J3/0272 , G01J3/0291 , G01J3/28 , G01J3/2803 , G01J3/2823 , G01J3/44 , G01J3/4531 , G01J2003/1269 , G01J2003/1291 , G01J2003/2826 , G02F1/13
摘要： A method of operating a hyperspectral imaging device includes receiving a light beam at a liquid crystal retarding device, and driving the liquid crystal retarding device with a pre-computed voltage waveform, wherein the voltage waveform is selected to reach a target optical retardance over time for the liquid crystal retarding device.

5. 发明申请

US20170264834A1 LIQUID CRYSTAL FOURIER TRANSFORM IMAGING SPECTROMETER 审中-公开
公开(公告)号：US20170264834A1
公开(公告)日：2017-09-14
申请号：US15605625
申请日：2017-05-25
申请人： PALO ALTO RESEARCH CENTER INCORPORATED
发明人： ALEX HEGYI , JOERG MARTINI
IPC分类号： H04N5/33 , G01J3/00
CPC分类号： H04N5/332 , G01J3/00 , G01J3/0208 , G01J3/0224 , G01J3/0229 , G01J3/0272 , G01J3/0291 , G01J3/28 , G01J3/2803 , G01J3/2823 , G01J3/44 , G01J3/4531 , G01J2003/1269 , G01J2003/1291 , G01J2003/2826 , G02F1/0136 , G02F1/13 , G02F1/13306 , G02F1/13471 , G02F1/1395
摘要： A method of calibrating a hyperspectral imaging device includes illuminating a hyperspectral imaging sensor with a light source having known spectral properties, sampling the light from the light source with the hyperspectral imaging sensor to obtain sampled spectral properties, and calibrating a performance characteristic of the hyperspectral imaging sensor based upon comparing the sampled spectral properties of the light source to the known spectral properties.

6. 发明授权

US07317526B2 System and method for dynamic chemical imaging 有权
标题翻译：动态化学成像系统和方法
公开(公告)号：US07317526B2
公开(公告)日：2008-01-08
申请号：US11399032
申请日：2006-04-06
申请人： Thomas C. Voigt , David Tuschel , John S. Maier
发明人： Thomas C. Voigt , David Tuschel , John S. Maier
IPC分类号： G01J3/44 , G01N21/65
CPC分类号： G01N21/6456 , G01J3/12 , G01J3/1256 , G01J3/2823 , G01J3/32 , G01J3/44 , G01J2003/1269 , G01N21/3563 , G01N21/3577 , G01N21/65
摘要： A system and method for detecting dynamic changes that occur in a sample between a first time interval and a second time interval using a series of at least first and second sequential chemical images of the sample. During the first time interval: (i) the sample is illuminated with a plurality of photons to thereby produce photons scattered or emitted by the sample; (ii) a two-dimensional array of detection elements is used to simultaneously detect scattered or emitted photons in a first predetermined wavelength band from different locations on or within the sample; and (iii) the two-dimensional array of detection elements is thereafter used one or more further times to simultaneously detect scattered or emitted photons in one or more further predetermined wavelength band(s) from different locations on or within the sample. The outputs of the two-dimensional array of detection elements during the first time interval are then combined to generate the first chemical image of the sample. The process is repeated during the second time interval to generate the second chemical image of the sample. Dynamic changes occurring in the sample between the first time interval and the second time interval are detected based on one or more differences between the first and second chemical images.
摘要翻译：一种系统和方法，用于使用所述样本的至少第一和第二顺序化学图像的一系列来检测在第一时间间隔和第二时间间隔之间在样本中发生的动态变化。在第一时间间隔期间：（i）样品用多个光子照射，从而产生样品散射或发射的光子; （ii）检测元件的二维阵列用于同时从样品上或样品内的不同位置检测来自第一预定波长带的散射或发射的光子; 然后，（iii）检测元件的二维阵列此后再被使用一次或多次，以同时检测来自样品上或样品内的不同位置的一个或多个另外的预定波长带中的散射或发射的光子。然后组合在第一时间间隔期间检测元件的二维阵列的输出以产生样本的第一化学图像。该过程在第二时间间隔期间重复以产生样品的第二化学图像。基于第一和第二化学图像之间的一个或多个差异来检测在第一时间间隔和第二时间间隔之间在样本中发生的动态变化。

7. 发明授权

US5598267A Optical sensor for orthogonal radiation modes 失效
标题翻译：用于正交辐射模式的光学传感器
公开(公告)号：US5598267A
公开(公告)日：1997-01-28
申请号：US384591
申请日：1995-02-03
申请人： John R. Sambles , Guy P. Bryan-Brown
发明人： John R. Sambles , Guy P. Bryan-Brown
IPC分类号： G01J3/12 , G01N21/21 , G01N21/55 , G01N21/77 , G01N30/74 , G11B11/105 , G01J4/00
CPC分类号： G01N21/554 , G01J3/12 , G01N21/553 , G11B11/10547 , G01J2003/1269 , G01N21/21 , G01N30/74
摘要： An optical sensing device that incorporates either a surface plasmon-polariton or guided mode apparatus for converting radiation between s and p modes together with a sensor for detecting a maximum in conversion between the s and p modes.
摘要翻译：一种光学感测装置，其包括用于在s和p模式之间转换辐射的表面等离子体激元或引导模式装置以及用于检测s和p模式之间的最大转换的传感器。

8. 发明授权

US5412469A Optical spectrum analyzer and encoder using a modulated phase grating wherein said grating diffracts the wavelength as a function of the magnetic field 失效
$Optical spectrum analyzer and encoder using a modulated phase grating wherein said grating diffracts the wavelength as a function of the magnetic field$
标题翻译：光谱分析仪和使用调制相位光栅的编码器，其中所述光栅将波长衍射为磁场的函数
公开(公告)号：US5412469A
公开(公告)日：1995-05-02
申请号：US976605
申请日：1992-11-16
申请人： William B. Spillman, Jr.
发明人： William B. Spillman, Jr.
IPC分类号： G01J3/18 , G01D5/26 , G01J3/12 , G01J3/28 , G01J9/00 , G01R33/032 , G02F1/09 , G02F1/29
CPC分类号： G01R33/0322 , G01D5/26 , G01J3/12 , G01J2003/1269 , G01J3/2803 , G01J9/00 , G02F1/09 , G02F1/292
摘要： An apparatus and method of wavelength detection and parameter sensing uses a variable magnetic field applied to a Faraday effect thin magnetizable film to perform spectral analysis based on detected intensity distribution of diffracted light for known magnetic field strengths. The strength of the applied magnetic field can also be varied by change in a physical parameter relative to a fixed magnet in a magnetic circuit which generates a magnetic field about the grating to produce diffracted wavelengths which correspond to the parameter which influences the magnetic circuit.
摘要翻译：波长检测和参数检测的装置和方法使用施加到法拉第效应薄磁化膜的可变磁场，以基于已知磁场强度的衍射光的检测强度分布进行光谱分析。所施加的磁场的强度也可以通过在磁路中相对于固定磁体的物理参数的变化来改变，所述磁路产生围绕光栅的磁场，以产生对应于影响磁路的参数的衍射波长。

9. 发明授权

US11857317B2 Method and apparatus for quantitative and depth resolved hyperspectral fluorescence and reflectance imaging for surgical guidance 有权
公开(公告)号：US11857317B2
公开(公告)日：2024-01-02
申请号：US17961480
申请日：2022-10-06
申请人： The Trustees of Dartmouth College
发明人： Pablo Valdes , Frederic Leblond , Keith D. Paulsen , Brian Campbell Wilson , David W. Roberts , Michael Jermyn
IPC分类号： A61B5/1455 , A61B5/1459 , A61B1/04 , A61B5/145 , A61B5/00 , A61B5/1495 , A61B1/06 , A61B5/055 , G01J3/28 , A61B1/05 , G01J3/12 , G01J3/02 , A61B1/00 , A61B1/07 , A61B1/313
CPC分类号： A61B5/14556 , A61B1/00009 , A61B1/000094 , A61B1/00165 , A61B1/00193 , A61B1/00194 , A61B1/042 , A61B1/043 , A61B1/05 , A61B1/0646 , A61B1/0669 , A61B1/0684 , A61B1/07 , A61B5/0071 , A61B5/0077 , A61B5/055 , A61B5/1459 , A61B5/1495 , A61B5/14546 , A61B5/14553 , A61B5/7264 , G01J3/0229 , G01J3/1256 , G01J3/2823 , A61B1/3132 , G01J2003/1269 , G01J2003/2826
摘要： An imaging system, such as a surgical microscope, laparoscope, or endoscope or integrated with these devices, includes an illuminator providing patterned white light and/or fluorescent stimulus light. The system receives and images light hyperspectrally, in embodiments using a hyperspectral imaging array, and/or using narrowband tunable filters for passing filtered received light to an imager. Embodiments may construct a 3-D surface model from stereo images, and will estimate optical properties of the target using images taken in patterned light or using other approximations obtained from white light exposures. Hyperspectral images taken under stimulus light are displayed as fluorescent images, and corrected for optical properties of tissue to provide quantitative maps of fluorophore concentration. Spectral information from hyperspectral images is processed to provide depth of fluorophore below the tissue surface. Quantitative images of fluorescence at depth are also prepared. The images are displayed to a surgeon for use in surgery.

10. 发明申请

US20180143074A1 SPECTROMETER AND SPECTROMETER MODULE 有权
公开(公告)号：US20180143074A1
公开(公告)日：2018-05-24
申请号：US15442851
申请日：2017-02-27
申请人： SAMSUNG ELECTRONICS CO., LTD.
发明人： Jesada UNGNAPATANIN
IPC分类号： G01J3/12 , G01J3/26 , G02F1/133 , G02F1/139 , G01J3/28
CPC分类号： G01J3/12 , G01J3/26 , G01J3/28 , G01J3/32 , G01J3/36 , G01J2003/1213 , G01J2003/1269 , G02F1/13306 , G02F1/133553 , G02F1/139 , G02F2203/055
摘要： A spectrometer and a spectrometer module are disclosed. The spectrometer includes a liquid crystal (LC) filter including an LC layer configured to pass light having a wavelength that is tunable based on an electrical stimulus that is applied to the LC layer, and a photodetector configured to detect the light passed through the LC filter.

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