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1. 发明授权

US07564546B2 Dynamic imaging of biological cells and other subjects 有权
标题翻译：生物细胞和其他科目的动态成像
公开(公告)号：US07564546B2
公开(公告)日：2009-07-21
申请号：US10556038
申请日：2005-06-30
申请人： John S. Maier , Patrick J. Treado , David Tuschel , Thomas C. Voigt
发明人： John S. Maier , Patrick J. Treado , David Tuschel , Thomas C. Voigt
IPC分类号： G01J3/44 , G01N21/65
CPC分类号： G01N21/6456 , G01J3/2803 , G01J3/32 , G01J3/36 , G01J3/44 , G01N21/359 , G01N21/6486 , G01N21/65 , G01N21/658 , G01N2021/656
摘要： The invention relates to methods of dynamic chemical imaging, including methods of cellular imaging. The method comprises illuminating at least a portion of a cell with substantially monochromatic light and assessing Raman-shifted light scattered from the illuminated portion at a plurality of discrete times. The Raman-shifted light can be assessed at a plurality of Raman shift (RS) values at each of the discrete times, and the RS values can be selected to be characteristic of a pre-selected component at each of the discrete times. Multivariate analysis of Raman spectral features of the images thus obtained can yield the location and chemical identity of components in the field of view. This information can be combined or overlaid with other spectral data (e.g., a visible microscopic image) obtained from the field of view.
摘要翻译：本发明涉及动态化学成像方法，包括细胞成像方法。该方法包括以基本上单色的光照亮电池的至少一部分，并且在多个离散时间评估从照射部分散射的拉曼偏移光。可以在每个离散时间处以多个拉曼位移（RS）值评估拉曼移位的光，并且可以将每个离散时间的RS值选择为预选择的分量的特征。如此获得的图像的拉曼光谱特征的多变量分析可以产生视场中部件的位置和化学特性。该信息可以与从视野获得的其他光谱数据（例如，可见显微镜图像）组合或覆盖。

2. 发明授权

US07317526B2 System and method for dynamic chemical imaging 有权
标题翻译：动态化学成像系统和方法
公开(公告)号：US07317526B2
公开(公告)日：2008-01-08
申请号：US11399032
申请日：2006-04-06
申请人： Thomas C. Voigt , David Tuschel , John S. Maier
发明人： Thomas C. Voigt , David Tuschel , John S. Maier
IPC分类号： G01J3/44 , G01N21/65
CPC分类号： G01N21/6456 , G01J3/12 , G01J3/1256 , G01J3/2823 , G01J3/32 , G01J3/44 , G01J2003/1269 , G01N21/3563 , G01N21/3577 , G01N21/65
摘要： A system and method for detecting dynamic changes that occur in a sample between a first time interval and a second time interval using a series of at least first and second sequential chemical images of the sample. During the first time interval: (i) the sample is illuminated with a plurality of photons to thereby produce photons scattered or emitted by the sample; (ii) a two-dimensional array of detection elements is used to simultaneously detect scattered or emitted photons in a first predetermined wavelength band from different locations on or within the sample; and (iii) the two-dimensional array of detection elements is thereafter used one or more further times to simultaneously detect scattered or emitted photons in one or more further predetermined wavelength band(s) from different locations on or within the sample. The outputs of the two-dimensional array of detection elements during the first time interval are then combined to generate the first chemical image of the sample. The process is repeated during the second time interval to generate the second chemical image of the sample. Dynamic changes occurring in the sample between the first time interval and the second time interval are detected based on one or more differences between the first and second chemical images.
摘要翻译：一种系统和方法，用于使用所述样本的至少第一和第二顺序化学图像的一系列来检测在第一时间间隔和第二时间间隔之间在样本中发生的动态变化。在第一时间间隔期间：（i）样品用多个光子照射，从而产生样品散射或发射的光子; （ii）检测元件的二维阵列用于同时从样品上或样品内的不同位置检测来自第一预定波长带的散射或发射的光子; 然后，（iii）检测元件的二维阵列此后再被使用一次或多次，以同时检测来自样品上或样品内的不同位置的一个或多个另外的预定波长带中的散射或发射的光子。然后组合在第一时间间隔期间检测元件的二维阵列的输出以产生样本的第一化学图像。该过程在第二时间间隔期间重复以产生样品的第二化学图像。基于第一和第二化学图像之间的一个或多个差异来检测在第一时间间隔和第二时间间隔之间在样本中发生的动态变化。

3. 发明申请

US20070152032A1 Method and apparatus for counterfeiting protection 审中-公开
公开(公告)号：US20070152032A1
公开(公告)日：2007-07-05
申请号：US11641667
申请日：2006-12-20
申请人： David Tuschel , Thomas C. Voigt
发明人： David Tuschel , Thomas C. Voigt
IPC分类号： G06F17/00
CPC分类号： G06K19/10
摘要： The disclosure relates generally to methods and apparatus for protecting against counterfeit products and for methods and apparatus for providing counterfeiting protection for an object. In one embodiment, the method includes the steps of: (a) accessing an object including an identifying mark having a first portion and a second portion wherein said second portion includes an encrypted feature; (b) reading the first portion to thereby obtain a first set of information; (c) transmitting the first set of information to a remote location; (d) receiving from the remote location a second set of information; and (e) reading the second portion using the second set of information to thereby determine the authenticity of the object.

4. 发明授权

US07815117B2 Method and apparatus for counterfeiting protection 有权
公开(公告)号：US07815117B2
公开(公告)日：2010-10-19
申请号：US11641671
申请日：2006-12-20
申请人： David Tuschel , Wesley H. Hutchison , Thomas C. Voigt
发明人： David Tuschel , Wesley H. Hutchison , Thomas C. Voigt
IPC分类号： G06K15/00 , G06F19/00 , G06Q30/00
CPC分类号： G06K15/00 , G06K19/06028 , G06K19/10 , G06K2017/0064
摘要： The disclosure relates generally to methods and apparatus for protecting against counterfeit products and for methods and apparatus for providing counterfeiting protection for an object. In one embodiment, the method includes the steps of: (a) accessing an object including an identifying mark having a first portion and a second portion wherein said second portion includes an encrypted feature; (b) reading the first portion to thereby obtain a first set of information; (c) transmitting the first set of information to a remote location; (d) receiving from the remote location a second set of information; and (e) reading the second portion using the second set of information to thereby determine the authenticity of the object.

5. 发明授权

US07046359B2 System and method for dynamic chemical imaging 有权
公开(公告)号：US07046359B2
公开(公告)日：2006-05-16
申请号：US10882082
申请日：2004-06-30
申请人： Thomas C. Voigt , David Tuschel , John Maier
发明人： Thomas C. Voigt , David Tuschel , John Maier
IPC分类号： G01J3/44 , G01N21/65
CPC分类号： G01N21/6456 , G01J3/12 , G01J3/1256 , G01J3/2823 , G01J3/32 , G01J3/44 , G01J2003/1269 , G01N21/3563 , G01N21/3577 , G01N21/65
摘要： A system and method for detecting dynamic changes that occur in a sample between a first time interval and a second time interval using a series of at least first and second sequential chemical images of the sample. During the first time interval: (i) the sample is illuminated with a plurality of photons to thereby produce photons scattered or emitted by the sample; (ii) a two-dimensional array of detection elements is used to simultaneously detect scattered or emitted photons in a first predetermined wavelength band from different locations on or within the sample; and (iii) the two-dimensional array of detection elements is thereafter used one or more further times to simultaneously detect scattered or emitted photons in one or more further predetermined wavelength band(s) from different locations on or within the sample. The outputs of the two-dimensional array of detection elements during the first time interval are then combined to generate the first chemical image of the sample. The process is repeated during the second time interval to generate the second chemical image of the sample. Dynamic changes occurring in the sample between the first time interval and the second time interval are detected based on one or more differences between the first and second chemical images.

6. 发明申请

US20090059220A1 System and Method for Chemical Imaging of Microarrays 有权
标题翻译：微阵列化学成像系统与方法
公开(公告)号：US20090059220A1
公开(公告)日：2009-03-05
申请号：US11918487
申请日：2005-04-08
申请人： David Tuschel , Thomas C. Voigt
发明人： David Tuschel , Thomas C. Voigt
IPC分类号： G01J3/00
CPC分类号： G01J3/42 , G01J3/2823 , G01J3/44 , G01N21/253 , G01N21/6452 , G01N21/65
摘要： The disclosure relates to systems and method for chemical imaging of microarrays. In one embodiment, the disclosure relates to a system for simultaneous spectral imaging of a plurality of samples arranged on an array. The system includes an illumination source for providing illuminating photons to said plurality of samples, the illuminating photons interacting with each of the plurality of samples to emit interacted photons; an array for receiving said plurality of samples, the array having an external dimension such that the samples are within a simultaneous field of view of the optical device; an optical device for collecting the interacted photons and directing the photons to an imaging device, the imaging device simultaneously forming a plurality of images corresponding to each of the plurality of samples.
摘要翻译：本公开涉及用于微阵列的化学成像的系统和方法。在一个实施例中，本公开涉及一种用于同时对阵列上布置的多个样本进行光谱成像的系统。该系统包括用于向所述多个样本提供照明光子的照明源，所述照明光子与所述多个样本中的每一个相互作用以发射相互作用的光子; 用于接收所述多个样本的阵列，所述阵列具有使得所述样本在所述光学装置的同时视野内的外部尺寸; 用于收集相互作用的光子并将光子引导到成像装置的光学装置，成像装置同时形成对应于多个样本中的每一个的多个图像。

7. 发明授权

US07757952B2 Method and apparatus for counterfeiting protection 有权
标题翻译：防伪方法及装置
公开(公告)号：US07757952B2
公开(公告)日：2010-07-20
申请号：US11641668
申请日：2006-12-20
申请人： David Tuschel , Wesley H. Hutchison , Thomas C. Voigt
发明人： David Tuschel , Wesley H. Hutchison , Thomas C. Voigt
IPC分类号： G06K15/00 , G06F19/00 , G06Q30/00 , G06Q90/00
CPC分类号： G06K15/00 , G06K19/06037 , G06K19/06046 , G06K19/10 , G06K19/14
摘要： The disclosure relates generally to methods and apparatus for protecting against counterfeit products and for methods and apparatus for providing counterfeiting protection for an object. In one embodiment, the method includes the steps of: (a) accessing an object including an identifying mark having a first portion and a second portion wherein said second portion includes an encrypted feature; (b) reading the first portion to thereby obtain a first set of information; (c) transmitting the first set of information to a remote location; (d) receiving from the remote location a second set of information; and (e) reading the second portion using the second set of information to thereby determine the authenticity of the object.
摘要翻译：本公开总体上涉及用于防止假冒产品的方法和装置以及用于为对象提供假冒保护的方法和装置。在一个实施例中，该方法包括以下步骤：（a）访问包括具有第一部分和第二部分的识别标记的对象，其中所述第二部分包括加密特征; （b）读取第一部分，从而获得第一组信息; （c）将第一组信息发送到远程位置; （d）从远程位置接收第二组信息; 和（e）使用第二组信息读取第二部分，从而确定对象的真实性。

8. 发明授权

US07701572B2 System and method for chemical imaging of microarrays 有权
标题翻译：微阵列化学成像系统和方法
公开(公告)号：US07701572B2
公开(公告)日：2010-04-20
申请号：US11918487
申请日：2005-04-08
申请人： David Tuschel , Thomas C. Voigt
发明人： David Tuschel , Thomas C. Voigt
IPC分类号： G01N21/64 , G01N21/65 , G01J3/51 , G01J3/44
CPC分类号： G01J3/42 , G01J3/2823 , G01J3/44 , G01N21/253 , G01N21/6452 , G01N21/65
摘要： The disclosure relates to systems and method for chemical imaging of microarrays. In one embodiment, the disclosure relates to a system for simultaneous spectral imaging of a plurality of samples arranged on an array. The system includes an illumination source for providing illuminating photons to said plurality of samples, the illuminating photons interacting with each of the plurality of samples to emit interacted photons; an array for receiving said plurality of samples, the array having an external dimension such that the samples are within a simultaneous field of view of the optical device; an optical device for collecting the interacted photons and directing the photons to an imaging device, the imaging device simultaneously forming a plurality of images corresponding to each of the plurality of samples.
摘要翻译：本公开涉及用于微阵列的化学成像的系统和方法。在一个实施例中，本公开涉及一种用于同时对阵列上布置的多个样本进行光谱成像的系统。该系统包括用于向所述多个样本提供照明光子的照明源，所述照明光子与所述多个样本中的每一个相互作用以发射相互作用的光子; 用于接收所述多个样本的阵列，所述阵列具有使得所述样本在所述光学装置的同时视野内的外部尺寸; 用于收集相互作用的光子并将光子引导到成像装置的光学装置，成像装置同时形成对应于多个样本中的每一个的多个图像。

9. 发明授权

US07283241B2 Method and apparatus for a microscope image selector 有权
标题翻译：显微镜图像选择器的方法和装置
公开(公告)号：US07283241B2
公开(公告)日：2007-10-16
申请号：US11045080
申请日：2005-01-31
申请人： Xinghua Wang , Thomas C. Voigt , David Tuschel , Chenhui Wang , Patrick J. Treado
发明人： Xinghua Wang , Thomas C. Voigt , David Tuschel , Chenhui Wang , Patrick J. Treado
IPC分类号： G01N21/25
CPC分类号： G01N21/65 , G01J3/02 , G01J3/0291 , G01J3/36 , G01J3/44 , G01N21/359 , G01N21/59 , G01N21/6458 , G01N2021/6419 , G01N2021/6421 , G01N2021/656
摘要： The disclosure generally relates to a multimode imaging apparatus for simultaneously obtaining multiple wavelength-discriminative spectral images of a sample. In one embodiment, the apparatus includes an image selector having a rotator assembly, the rotator assembly housing a first plurality of optical components, the image selector adapted to receive a illuminating photons having a first wavelength and direct the illuminating photons to the sample, the image selector adapted to receive illuminating photons interacted with the sample and selectively direct said interacted photons to one of a plurality of detection sources; a microscope turret housing a second plurality of components, the microscope turret adapted to receive illuminating photons having a second wavelength and direct the photons to the sample; the microscopic turret adapted to receive illuminating photons interacted with the sample and selectively direct said interacted photons to one of a plurality of detection sources; wherein substantially all of the interacted photons are selectively directed one of a plurality of detection sources to form multiple wavelength discriminative spectral images of the sample simultaneously.
摘要翻译：本公开总体上涉及用于同时获得样本的多个波长鉴别光谱图像的多模式成像装置。在一个实施例中，该装置包括具有旋转器组件的图像选择器，旋转体组件容纳第一多个光学部件，图像选择器适于接收具有第一波长的照明光子并将照射光子引导到样本，图像选择器，适于接收与样本相互作用的照明光子，并选择性地将所述相互作用的光子引导到多个检测源之一; 显微镜转台，其容纳第二多个部件，所述显微镜转台适于接收具有第二波长并且将所述光子引导到所述样品的照明光子; 适于接收与样品相互作用的照明光子并且选择性地将所述相互作用的光子引导到多个检测源中的一个的微观炮塔; 其中基本上所有相互作用的光子被选择性地指向多个检测源中的一个，以同时形成样品的多个波长鉴别光谱图像。

10. 发明授权

US07486395B2 System and method for a chemical imaging threat assessor with a probe 有权
标题翻译：具有探针的化学成像威胁评估者的系统和方法
公开(公告)号：US07486395B2
公开(公告)日：2009-02-03
申请号：US11544648
申请日：2006-10-10
申请人： Patrick J. Treado , Thomas C. Voigt , Wesley H. Hutchison
发明人： Patrick J. Treado , Thomas C. Voigt , Wesley H. Hutchison
IPC分类号： G01J3/44
CPC分类号： G01N21/65 , G01J3/02 , G01J3/0205 , G01J3/0218 , G01J3/0224 , G01J3/0227 , G01J3/0256 , G01J3/0264 , G01J3/027 , G01J3/0272 , G01J3/0283 , G01J3/0286 , G01J3/0289 , G01J3/0291 , G01J3/10 , G01J3/26 , G01J3/2803 , G01J3/2823 , G01J3/44 , G01J3/4406 , G01J3/447 , G01N2021/656 , G01N2201/0846
摘要： The disclosure relates to a portable and/or handheld bioagent detector and methodology described herein that is based in part on advanced Raman Chemical Imaging (“RCI”) technology. According to one embodiment of the present disclosure, the detection system may include a fiber array spectral translator (“FAST”) and may also include a probe which may include a complementary metal oxide semiconductor (CMOS) camera. The probe alleviates the need to place the main instrument close to an unconfined release of a potentially hazardous material and facilitates analysis of a sample that is situated in a hard-to-reach location while minimizing contamination of the detector and operator.
摘要翻译：本公开涉及部分基于先进的拉曼化学成像（“RCI”）技术的本文描述的便携式和/或手持式生物代谢检测器和方法。根据本公开的一个实施例，检测系统可以包括光纤阵列光谱转换器（“FAST”），并且还可以包括可以包括互补金属氧化物半导体（CMOS）照相机的探针。探头减轻了将主仪器置于非限制性释放潜在危险物质的需要，并有助于分析位于难以到达的位置的样品，同时最大限度地减少检测器和操作者的污染。

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