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1. 发明授权

US08772519B2 Process for preparing mono-allyl-functionalized dialkylphosphinic acids, salts and esters thereof with allylic compounds, and the use thereof 失效
标题翻译：用烯丙基化合物制备单烯丙基官能化二烷基次膦酸，其盐和酯的方法及其用途
公开(公告)号：US08772519B2
公开(公告)日：2014-07-08
申请号：US13127110
申请日：2009-10-06
申请人： Michael Hill , Werner Krause , Martin Sicken
发明人： Michael Hill , Werner Krause , Martin Sicken
IPC分类号： C07F9/30 , C07F9/32 , C07F5/06
CPC分类号： C09K21/12 , C07F9/302 , C07F9/3217 , C08K5/5313
摘要： The invention relates to a process for preparing mono-allyl-functionalized dialkylphosphinic acids, esters and salts with allylic compounds, characterized in that a) a phosphinic acid source (I) is reacted with olefins (IV) in the presence of a catalyst A to give an alkylphosphonous acid, or salt or ester thereof (II), b) the alkylphosphonous acid, or salt or ester thereof (II) thus formed is reacted with allylic compounds of the formula (V) in the presence of a catalyst B and of a base to give a mono-allyl-functionalized dialkylphosphinic acid derivative (III), where R1, R2, R3, R4, R5, R6, R7, R8, R9 are the same or different and are each independently, inter alia, H, C1-C18-alkyl, C6-C18-aryl, C6-C18-aralkyl, C6-C18-alkylaryl, and X is H, C1-C18-alkyl, C6-C18-aryl, C6-C18-aralkyl, C6-C18-alkylaryl, Mg, Ca, Al, Sb, Sn, Ge, Ti, Fe, Zr, Zn, Ce, Bi, Sr, Mn, Cu, Ni, Li, Na, K and/or a protonated nitrogen base, and the catalysts A and B are transition metals and/or transition metal compounds and/or catalyst systems which are composed of a transition metal and/or a transition metal compound and at least one ligand.
摘要翻译：本发明涉及用烯丙基化合物制备单烯丙基官能化二烷基次膦酸，酯和盐的方法，其特征在于a）在催化剂A存在下，使次膦酸源（I）与烯烃（Ⅳ）反应，得到烷基亚磷酸或其盐或酯（II），b）将如此形成的烷基亚膦酸或其盐或酯（II）与式（Ⅴ）的烯丙基化合物在催化剂B的存在下反应，和得到单烯丙基官能化的二烷基次膦酸衍生物（III）的碱，其中R 1，R 2，R 3，R 4，R 5，R 6，R 7，R 8，R 9相同或不同，并且各自独立地为H， C 1 -C 18烷基，C 6 -C 18芳基，C 6 -C 18芳烷基，C 6 -C 18烷基芳基，X是H，C 1 -C 18烷基，C 6 -C 18芳基，C 6 -C 18芳烷基，C 6 -C 18 - 烷基芳基，Mg，Ca，Al，Sb，Sn，Ge，Ti，Fe，Zr，Zn，Ce，Bi，Sr，Mn，Cu，Ni，Li，Na，K和/或质子化氮碱，催化剂A和B是过渡金属和/或过渡金属 nds和/或由过渡金属和/或过渡金属化合物和至少一种配体组成的催化剂体系。

2. 发明授权

US5099063A Certain phosphinic acid derivatives having antibacterial activity 失效
标题翻译：某些具有抗菌活性的次膦酸衍生物
公开(公告)号：US5099063A
公开(公告)日：1992-03-24
申请号：US541167
申请日：1990-06-21
申请人： William H. Parsons , Arthur A. Patchett , William R. Schoen , Masao Taniguchi
发明人： William H. Parsons , Arthur A. Patchett , William R. Schoen , Masao Taniguchi
IPC分类号： A61K31/40 , C07F9/30 , C07F9/32 , C07F9/58
CPC分类号： C07F9/582 , A61K31/40 , C07F9/301 , C07F9/302 , C07F9/303 , C07F9/306 , C07F9/3211 , C07F9/3217 , C07F9/3241
摘要： New 3-(1-aminoalkylphosphinyl)-(2-substituted)propionic acids are described which display antibacterial activity and potentiate carbapenem antibiotics.
摘要翻译：描述了新的3-（1-氨基烷基氧膦基） - （2-取代的）丙酸，其显示出抗菌活性和增强碳青霉烯类抗生素。

3. 发明授权

US4988681A Phosphinic acid derivatives 失效
标题翻译：次膦酸衍生物
公开(公告)号：US4988681A
公开(公告)日：1991-01-29
申请号：US370190
申请日：1989-06-22
申请人： Kiyofumi Ishikawa , Takehiro Fukami , Hiroshi Naganuma , Kyoko Nakamichi
发明人： Kiyofumi Ishikawa , Takehiro Fukami , Hiroshi Naganuma , Kyoko Nakamichi
IPC分类号： C07F9/30 , C07F9/32 , C07F9/58 , C07F9/6506 , C07F9/6518
CPC分类号： C07F9/65182 , C07F9/302 , C07F9/303 , C07F9/3217 , C07F9/3223 , C07F9/582 , C07F9/65062
摘要： A phosphinic acid derivative represented by the general formula [I], or a pharmaceutically acceptable salt thereof, ##STR1## wherein R.sup.1 represents an alkyl, cycloalkyl or aralkyl group which may be substituted; R.sup.2 and R.sup.5 may be identical or different, and each represents a hydrogen atom, or an ester residue capable of forming a non-toxic ester hydrolyzable in vivo; and A represents a group of the formula ##STR2## wherein R.sup.3 represents an alkyl group, a group of the formula ##STR3## wherein R.sup.30 represents a halogen atom, a carboxyl group, a hydroxyl group, a cycloalkyl group which may be substituted, an aryl group which may be substituted, an arylthio group, a heteroarylthio group which may be substituted, an alkylthio group which may be substituted, an amino group which may be substituted, or a lower alkoxycarbonyl group; R.sup.31 represents a hydrogen atom or a lower alkyl group; and n represents an integer of 0 to 6, a cycloalkyl group which may be substituted or an aryl group which may be substituted; and the double bond at A has a Z-configuration, or a group of the formula ##STR4## wherein R.sup.4 represents a cycloalkyl group which may be substituted. Said phosphinic acid derivative is useful for reducing renal toxicity induced by a carbapenem or penem antibiotic and for inhibiting dipeptidase.

4. 发明授权

US08835674B2 Conjugated diene phosphinate compounds, preparation method and use thereof 有权
标题翻译：共轭二烯次膦酸盐化合物，其制备方法和用途
公开(公告)号：US08835674B2
公开(公告)日：2014-09-16
申请号：US13502901
申请日：2009-10-30
申请人： Zhaoqing Liu , Floryan De Campo
发明人： Zhaoqing Liu , Floryan De Campo
IPC分类号： C07F9/30
CPC分类号： C07F9/4825 , C07F9/302 , C07F9/3217 , C08K5/5313 , C09K21/12
摘要： This invention relates to conjugated diene phosphinate compounds for making halogen free phosphinate-containing flame retardants, inimer and metal extractants, method for preparing said compounds from unsaturated ketones or aldehydes, and the 5 use thereof. The compounds of the present invention having the following formula (III), wherein R1, R2, R3, R4, R5 and R6 represent, independently, hydrogen, alkyl, aryl, alkaryl, aralkyl, cycloalkyl, heterocycloalkyl, or alkenyl groups; R7 represents hydrogen, alkyl, aryl, alkaryl, aralkyl, cycloalkyl, alkenyl groups, or metals selected from the group consisting of Na, Li, Ca.
摘要翻译：本发明涉及用于制备无卤素的含有次膦酸盐的阻燃剂的共轭二烯次膦酸盐化合物，非对称和金属萃取剂，由不饱和酮或醛制备所述化合物的方法及其用途。具有下式（III）的本发明化合物，其中R 1，R 2，R 3，R 4，R 5和R 6独立地表示氢，烷基，芳基，烷芳基，芳烷基，环烷基，杂环烷基或烯基; R 7表示氢，烷基，芳基，烷芳基，芳烷基，环烷基，烯基或选自Na，Li，Ca的金属。

5. 发明申请

US20110009662A1 PROCESS FOR PRODUCING PHOSPHORUS-CONTAINING DEHYDROAMINO ACID 有权
标题翻译：生产含磷酸脱氢山梨醇酸的方法
公开(公告)号：US20110009662A1
公开(公告)日：2011-01-13
申请号：US12529953
申请日：2008-03-19
申请人： Kenichi Kurihara , Nobuto Minowa , Nozomu Nakanishi , Masaaki Mitomi
发明人： Kenichi Kurihara , Nobuto Minowa , Nozomu Nakanishi , Masaaki Mitomi
IPC分类号： C07C227/14
CPC分类号： C07F9/4006 , C07F9/3217
摘要： A process for efficiently producing through a small number of steps an N-substituted 2-amino-4-(substituted-oxymethylphosphinyl)-2-butenoic ester which is an intermediate for herbicide L-AMPB. The process comprises reacting a compound represented by the following formula (1): (where R1 represents C1-4 alkyl group) with a compound represented by the following formula (2): (wherein R2, R2′, and R3 each represents C1-4 alkyl and R4 represents benzyloxycarbonyl) in the presence of a base.
摘要翻译：通过少量步骤有效地制备作为除草剂L-AMPB的中间体的N-取代的2-氨基-4-（取代的 - 氧甲基氧膦基）-2-丁烯酸酯的方法。该方法包括使由下式（1）表示的化合物（其中R 1表示C 1-4烷基）与下式（2）表示的化合物反应：（其中R2，R2'和R3各自表示C1- 4烷基，R 4表示苄氧基羰基）。

6. 发明授权

US5175344A Unsaturated amino acids 失效
标题翻译：不饱和氨基酸
公开(公告)号：US5175344A
公开(公告)日：1992-12-29
申请号：US731580
申请日：1991-07-17
申请人： Christof Angst , Derek E. Brundish , John G. Dingwall , Graham E. Fagg , Hans Allgeier , Guido Bold , Rudolf Duthaler , Roland Heckendorn , Antonio Togni
发明人： Christof Angst , Derek E. Brundish , John G. Dingwall , Graham E. Fagg , Hans Allgeier , Guido Bold , Rudolf Duthaler , Roland Heckendorn , Antonio Togni
IPC分类号： C07F9/30 , C07F9/32 , C07F9/38 , C07F9/40 , C07F9/48
CPC分类号： C07F9/4825 , C07F9/302 , C07F9/3217 , C07F9/3826 , C07F9/4015
摘要： The invention relates to unsaturated amino acids of the formula I ##STR1## in which R.sup.1 represents hydroxy or etherified hydroxy, R.sup.2 represents hydrogen, alkyl, hydroxy or etherified hydroxy, R.sup.3 represents hydrogen, alkyl, haloalkyl, hydroxyalkyl, lower alkoxyalkyl, arylalkyl, lower alkenyl, halogen or aryl, R.sup.4 represents hydrogen, alkyl or aryl, R.sup.5 represents hydrogen or alkyl, R.sup.6 represents carboxy or esterified or amidated carboxy, R.sup.7 represents amino or amino substituted by alkyl or acyl, A represents unsubstituted or alkyl-substituted .alpha.,.omega.-alkylene having from 1 to 3 carbon atoms or represents a bond, and B represents methylene or a bond, with the proviso that A is other than a bond when B represents a bond, and salts thereof. They can be manufactured, for example, in accordance with the Michaelis-Arbuzov reaction and can be used as pharmacologically active substances.
摘要翻译：本发明涉及式I（I）的不饱和氨基酸，其中R 1表示羟基或醚化羟基，R 2表示氢，烷基，羟基或醚化羟基，R 3表示氢，烷基，卤代烷基，羟基烷基，低级烷氧基烷基，芳基烷基，低级烯基，卤素或芳基，R 4表示氢，烷基或芳基，R 5表示氢或烷基，R 6表示羧基或酯化或酰胺化羧基，R 7表示氨基或被烷基或酰基取代的氨基，A表示未取代或烷基取代具有1至3个碳原子的α，ω-亚烷基或表示键，并且B表示亚甲基或键，条件是当B表示键时A不是键，以及其盐。它们可以例如根据Michaelis-Arbuzov反应制造，并且可以用作药理活性物质。

7. 发明授权

US5068298A Alkenyl-phosphonic and -phosphinic esters, process for their preparation, their use and hydrogels prepared using them 失效
标题翻译：烯基 - 膦酸和 - 膦酸酯，它们的制备方法，它们的用途和使用它们制备的水凝胶
公开(公告)号：US5068298A
公开(公告)日：1991-11-26
申请号：US542763
申请日：1990-06-25
申请人： Friedrich Engelhardt , Ulrich Riegel , Joachim Gersdorf , Hans-Jerg Kleiner
发明人： Friedrich Engelhardt , Ulrich Riegel , Joachim Gersdorf , Hans-Jerg Kleiner
IPC分类号： B01J13/00 , C07F9/32 , C07F9/40 , C07F9/655 , C07F9/6561 , C08F30/02
CPC分类号： C07F9/6561 , C07F9/3217 , C07F9/3264 , C07F9/4015 , C07F9/4075 , Y10S524/916
摘要： The present invention relates to compounds of the general formula I ##STR1## in which R.sup.1, R.sup.1', R.sup.2, A and n are as defined in the description, a process for their preparation, their use and also hydrogels prepared using them.
摘要翻译：本发明涉及通式I（I）的化合物，其中R 1，R 1'，R 2，A和n如说明书中所定义，其制备方法及其用途，以及使用它们制备的水凝胶。

8. 发明授权

US4715994A Novel antibacterial agents and potentiators of carbapenem antibiotics 失效
标题翻译：新型抗菌药物和碳青霉烯类抗生素的增效剂
公开(公告)号：US4715994A
公开(公告)日：1987-12-29
申请号：US927028
申请日：1986-11-05
申请人： William H. Parsons , William R. Schoen , Arthur A. Patchett , Masao Taniguchi
发明人： William H. Parsons , William R. Schoen , Arthur A. Patchett , Masao Taniguchi
IPC分类号： C07F9/30 , C07F9/32 , C07F9/58 , A01N31/02 , A01N57/12
CPC分类号： C07F9/582 , C07F9/301 , C07F9/302 , C07F9/3211 , C07F9/3217
摘要： New 3-(1-aminoalkylphosphinyl)-(2-substituted)propionic acids are described which display antibacterial activity and potentiate carbapenem antibiotics.
摘要翻译：描述了新的3-（1-氨基烷基氧膦基） - （2-取代的）丙酸，其表现出抗菌活性并增强碳青霉烯类抗生素。

9. 发明授权

US3972877A Butadiene derivatives, process for their preparation and their use as optical brighteners 失效
标题翻译：丁二烯衍生物，其制备方法及其作为荧光增白剂的用途
公开(公告)号：US3972877A
公开(公告)日：1976-08-03
申请号：US431047
申请日：1974-01-07
申请人： Erich Schinzel , Wilfried Sahm , Gunter Rosch
发明人： Erich Schinzel , Wilfried Sahm , Gunter Rosch
IPC分类号： C08K5/00 , C07D307/79 , C07D307/80 , C07F9/32 , C07F9/40 , C07F9/655 , C08K5/1535 , C08L1/00 , C08L27/00 , C08L67/00 , C08L77/00 , C09B23/10 , C09B57/00 , D06L3/12
CPC分类号： C07D307/79 , C07D307/80 , C07F9/3217 , C07F9/40 , C07F9/65517 , C09B23/107 , D06L3/12 , D06L3/1228
摘要： 1,3-BUTADIENES CONTAINING AT LEAST ONE TERMINAL 2-BENZOFURANYL GROUP ARE OBTAINABLE BY HORNER syntheses. The products are optical brighteners.
摘要翻译：至少有一个终端的2-BENZOFURANYL组的1,3-BUTADIENES可以通过HORNER合成来获得。产品是荧光增白剂。

10. 发明授权

US3673284A 2-hydrocarbyl aminovinyl phosphonates or phosphinates 失效
标题翻译： 2-氨基亚氨基二磷酸盐或磷酸盐
公开(公告)号：US3673284A
公开(公告)日：1972-06-27
申请号：US3673284D
申请日：1969-02-27
申请人： SHIONOGI & CO
发明人： NAGATA WATARU , HAYASE YOSHIO
IPC分类号： C07F9/32 , C07F9/40 , C07F9/38 , C07C45/00
CPC分类号： C07C45/516 , C07F9/3217 , C07F9/40 , C07F9/4015 , C07J1/0025 , C07J7/002 , C07J13/007 , C07J61/00
摘要： Reagents particularly useful for the preparation of Alpha Beta -unsaturated aldehydes are provided herein, which reagents consist of compounds of the general formula: WHEREIN R1 is a lower alkyl group, R2 is a member selected from the group consisting of R1O, a lower alkyl group, an aralkyl group of seven to eight carbon atoms and an aryl group of six to seven carbon atoms, R3 is a member selected from the group consisting of an acyclic or cyclic alkyl group of one to six carbon atoms and an aryl group of six to seven carbon atoms, and R4 is a member selected from the group consisting of a hydrogen atom, a lower alkyl group, an aralkyl group of seven to eight carbon atoms, and a halogen atom. These compounds react with carbonyl compounds to form unsaturated aldehydes and are especially useful in the synthesis of various pharmaceutical compounds such as various steroids, vitamin A, vitamin D, etc.
摘要翻译：本文提供了特别可用于制备αβ-不饱和醛的试剂，该试剂由以下通式的化合物组成：

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