会员体验
专利管家(专利管理)
工作空间(专利管理)
风险监控(情报监控)
数据分析(专利分析)
侵权分析(诉讼无效)
联系我们
交流群
官方交流:
QQ群: 891211   
微信请扫码    >>>
现在联系顾问~
热词
    • 1. 发明申请
    • Novel benzimidazole derivatives
    • US20060205750A1
    • 2006-09-14
    • US11431274
    • 2006-05-10
    • Norikazu OtakeMinoru MoriyaYoshio OginoKenji MatsudaYoshikazu NagaeAkio KanataniTakehiro Fukami
    • Norikazu OtakeMinoru MoriyaYoshio OginoKenji MatsudaYoshikazu NagaeAkio KanataniTakehiro Fukami
    • A61K31/4747A61K31/4184C07D487/10
    • C07D473/30C07D405/04C07D471/04C07D471/10C07D473/00C07D491/04
    • The present invention relates to a compound of the formula (I): (wherein A, B, C and D are independently nitrogen or optionally substituted methine; E is nitrogen, methine or hydroxy substituted methine; n is 0 or 1; T, U, V and W are independently nitrogen or optionally substituted methine; X is —N(SO2R4)—, —N(COR5)— or —CO—; Y is —C(R6)(R7)—, —O— or —N(R8)—, provided that the compound (I) when E is nitrogen, n is 0, X is —CO—, and Y is —O— is excluded) and the like, which are useful as an agent for the treatment of various diseases related to NPY, for example cardiovascular disorders such as angina, acute or congestive heart failure, myocardial infarction, hypertension, nephropathy, electrolyte abnormality, vasospasm, arteriosclerosis, etc., central nervous system disorders such as bulimia, depression, anxiety, seizure, epilepsy, dementia, pain, alcoholism, drug withdrawal, circadian rhythm disorders, schizophrenia, memory impairment, sleep disorders, cognitive impairment, etc., metabolic diseases such as obesity, diabetes, hormone abnormality, hypercholesterolemia, hyperlipidemia, gout, fatty liver, etc., genital or reproductive disorders such as infertility, preterm labor, sexual dysfunction, etc., gastro-intestinal disorders, respiratory disorder, inflammatory diseases or glaucoma, and the like, also for example, atherosclerosis, hypogonadism, hyperandrogenism, polycystic ovary syndrome (Pickwickian syndrome), hirsutism, gastro-intestinal motility disorder, obesity-related gastro-esophageal reflux, obesity hypoventilation, sleep apnea, inflammation, systemic inflammation of the vasculature, osteoarthritis, insulin resistance, bronchoconstriction, alcohol preference, metabolic syndrome, Alzheimer's disease, cardiac hypertrophy, left ventricular hypertrophy, hypertriglyceridemia, low HDL cholesterol, cardiovascular disorders such as coronary heart disease (CHD), cerebrovascular disease, stroke, peripheral vascular disease, sudden death, gallbladder diseases, cancer (breast, endometrial, colon), breathlessness, hyperuricemia, impaired fertility, low back pain, or increased anesthetic risk, and the like.
    • 8. 发明授权
    • Spiro compounds
    • 螺环化合物
    • US06649624B2
    • 2003-11-18
    • US10226225
    • 2002-08-23
    • Takehiro FukamiAkio KanataniAkane IshiharaYasuyuki IshiiToshiyuki TakahashiYuji HagaToshihiro SakamotoTakahiro Itoh
    • Takehiro FukamiAkio KanataniAkane IshiharaYasuyuki IshiiToshiyuki TakahashiYuji HagaToshihiro SakamotoTakahiro Itoh
    • A61K31438
    • C07D405/12C07D213/61C07D307/94C07D471/10C07D491/10
    • A method for treating a central nervous system disorder, which involves administering to a patient in need a therapeutically effective amount of a compound of formula (I): wherein Ar1 represents an aryl or heteroaryl which may be substituted, the substituent being selected from the group consisting of halogen, nitro, lower alkyl, halo(lower) alkyl, hydroxy(lower) alkyl, cyclo(lower) alkyl, lower alkenyl, lower alkoxy, halo(lower) alkoxy, lower alkylthio, carboxyl, lower alkanoyl, lower alkoxycarbonyl, lower alkylene optionally substituted with oxo, and a group represented by the formula —Q—Ar2; Ar2 represents an aryl or heteroaryl which may be substituted, the substituent being selected from the group consisting of halogen, cyano, lower alkyl, halo(lower) alkyl, hydroxy(lower) alkyl, hydroxy, lower alkoxy, halo(lower) alkoxy, lower alkylamino, di-lower alkylamino, lower alkanoyl and aryl: n represents 0 or 1; Q represents a single bond or carbonyl; T, U, V and W each independently represent a nitrogen atom or a methine group which may have a substituent selected from the group consisting of halogen, lower alkyl, hydroxy and lower alkoxy, wherein at least two of which represent said methine group; X represents methine; Y represents an imino which may be substituted with lower alkyl, or oxygen; or a salt or ester thereof
    • 一种治疗中枢神经系统疾病的方法,其涉及向需要的患者施用治疗有效量的式(I)化合物:其中Ar 1表示可被取代的芳基或杂芳基,所选择的取代基 卤代低级烷基,羟基(低级)烷基,环(低级)烷基,低级烯基,低级烷氧基,卤代(低级)烷氧基,低级烷硫基,羧基,低级烷酰基, 低级烷氧基羰基,任选被氧代取代的低级亚烷基和由式-Q-Ar 2表示的基团; Ar 2表示可被取代的芳基或杂芳基,该取代基选自卤素, 氰基,低级烷基,卤代(低级)烷基,羟基(低级)烷基,羟基,低级烷氧基,卤代(低级)烷氧基,低级烷基氨基,二低级烷基氨基,低级烷酰基和芳基:n表示0或1; Q表示 单键或羰基; T,U,V和W各自独立地表示 反应可以具有选自卤素,低级烷基,羟基和低级烷氧基的取代基的氮原子或次甲基,其中至少两个表示所述次甲基; X表示次甲基; Y表示亚氨基, 被低级烷基或氧取代; 或其盐或酯