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1. 发明申请

US20130060042A1 PROCESS FOR PRODUCING PYRIPYROPENE DERIVATIVES 有权
标题翻译：生产吡啶衍生物的方法
公开(公告)号：US20130060042A1
公开(公告)日：2013-03-07
申请号：US13581857
申请日：2010-11-10
申请人： Yoshimasa Fukuda , Takashi Ando , Kimihiko Goto , Nozomu Nakanishi , Takashi Watanabe , Kenichi Kurihara , Nobuto Minowa , Masaaki Mitomi
发明人： Yoshimasa Fukuda , Takashi Ando , Kimihiko Goto , Nozomu Nakanishi , Takashi Watanabe , Kenichi Kurihara , Nobuto Minowa , Masaaki Mitomi
IPC分类号： C07D493/04
CPC分类号： C07D493/04
摘要： Disclosed is a process for efficiently producing pyripyropene derivatives having acyloxy at the 1-position and 11-position and hydroxyl at the 7-position. The process comprises selectively acylating hydroxyl at the 1-position and 11-position of a compound represented by formula B1 through one to three steps with an acylating agent in the presence or absence of a base.
摘要翻译：公开了一种有效生产在1-位和11位上具有酰氧基并在7-位具有羟基的吡啶并苯衍生物的方法。该方法包括在存在或不存在碱的情况下用酰化剂选择性地将式B1化合物的1位和11位羟基选择性酰化1-3步。

2. 发明申请

US20110009662A1 PROCESS FOR PRODUCING PHOSPHORUS-CONTAINING DEHYDROAMINO ACID 有权
标题翻译：生产含磷酸脱氢山梨醇酸的方法
公开(公告)号：US20110009662A1
公开(公告)日：2011-01-13
申请号：US12529953
申请日：2008-03-19
申请人： Kenichi Kurihara , Nobuto Minowa , Nozomu Nakanishi , Masaaki Mitomi
发明人： Kenichi Kurihara , Nobuto Minowa , Nozomu Nakanishi , Masaaki Mitomi
IPC分类号： C07C227/14
CPC分类号： C07F9/4006 , C07F9/3217
摘要： A process for efficiently producing through a small number of steps an N-substituted 2-amino-4-(substituted-oxymethylphosphinyl)-2-butenoic ester which is an intermediate for herbicide L-AMPB. The process comprises reacting a compound represented by the following formula (1): (where R1 represents C1-4 alkyl group) with a compound represented by the following formula (2): (wherein R2, R2′, and R3 each represents C1-4 alkyl and R4 represents benzyloxycarbonyl) in the presence of a base.
摘要翻译：通过少量步骤有效地制备作为除草剂L-AMPB的中间体的N-取代的2-氨基-4-（取代的 - 氧甲基氧膦基）-2-丁烯酸酯的方法。该方法包括使由下式（1）表示的化合物（其中R 1表示C 1-4烷基）与下式（2）表示的化合物反应：（其中R2，R2'和R3各自表示C1- 4烷基，R 4表示苄氧基羰基）。

3. 发明授权

US08853413B2 Process for producing pyripyropene derivatives 有权
公开(公告)号：US08853413B2
公开(公告)日：2014-10-07
申请号：US13266671
申请日：2010-05-12
申请人： Yoshimasa Fukuda , Takashi Ando , Kimihiko Goto , Nozomu Nakanishi , Takashi Watanabe , Kenichi Kurihara , Nobuto Minowa , Masaaki Mitomi
发明人： Yoshimasa Fukuda , Takashi Ando , Kimihiko Goto , Nozomu Nakanishi , Takashi Watanabe , Kenichi Kurihara , Nobuto Minowa , Masaaki Mitomi
IPC分类号： C07D401/04
CPC分类号： C07D493/04
摘要： Disclosed is a process for efficiently producing pyripyropene derivatives having acyloxy at the 1-position and 11-position and hydroxyl at the 7-position. The process comprises selectively acylating hydroxyl at the 1-position and 11-position of a compound represented by formula B1 through one to three steps with an acylating agent in the presence or absence of a base.

4. 发明申请

US20120046470A1 PROCESS FOR PRODUCING PYRIPYROPENE DERIVATIVES 有权
标题翻译：生产吡啶衍生物的方法
公开(公告)号：US20120046470A1
公开(公告)日：2012-02-23
申请号：US13266671
申请日：2010-05-12
申请人： Yoshimasa Fukuda , Takashi Ando , Kimihiko Goto , Nozomu Nakanishi , Takashi Watanabe , Kenichi Kurihara , Nobuto Minowa , Masaaki Mitomi
发明人： Yoshimasa Fukuda , Takashi Ando , Kimihiko Goto , Nozomu Nakanishi , Takashi Watanabe , Kenichi Kurihara , Nobuto Minowa , Masaaki Mitomi
IPC分类号： C07D493/04
CPC分类号： C07D493/04
摘要： Disclosed is a process for efficiently producing pyripyropene derivatives having acyloxy at the 1-position and 11-position and hydroxyl at the 7-position. The process comprises selectively acylating hydroxyl at the 1-position and 11-position of a compound represented by formula B1 through one to three steps with an acylating agent in the presence or absence of a base.
摘要翻译：公开了一种有效生产在1-位和11位上具有酰氧基并在7-位具有羟基的吡啶并苯衍生物的方法。该方法包括在存在或不存在碱的情况下用酰化剂选择性地将式B1化合物的1位和11位羟基选择性酰化1-3步。

5. 发明授权

US08853414B2 Process for producing pyripyropene derivatives 有权
标题翻译：生产拟南芥衍生物的方法
公开(公告)号：US08853414B2
公开(公告)日：2014-10-07
申请号：US13581857
申请日：2010-11-10
申请人： Yoshimasa Fukuda , Takashi Ando , Kimihiko Goto , Nozomu Nakanishi , Takashi Watanabe , Kenichi Kurihara , Nobuto Minowa , Masaaki Mitomi
发明人： Yoshimasa Fukuda , Takashi Ando , Kimihiko Goto , Nozomu Nakanishi , Takashi Watanabe , Kenichi Kurihara , Nobuto Minowa , Masaaki Mitomi
IPC分类号： C07D401/04 , C07D493/04
CPC分类号： C07D493/04
摘要： Disclosed is a process for efficiently producing pyripyropene derivatives having acyloxy at the 1-position and 11-position and hydroxyl at the 7-position. The process comprises selectively acylating hydroxyl at the 1-position and 11-position of a compound represented by formula B1 through one to three steps with an acylating agent in the presence or absence of a base.
摘要翻译：公开了一种有效生产在1-位和11位上具有酰氧基并在7-位具有羟基的吡啶并苯衍生物的方法。该方法包括在存在或不存在碱的情况下用酰化剂选择性地将式B1化合物的1位和11位羟基选择性酰化1至3个步骤。

6. 发明授权

US08329935B2 Process for producing phosphorus-containing dehydroamino acid 有权
标题翻译：生产含磷脱氢氨基酸的方法
公开(公告)号：US08329935B2
公开(公告)日：2012-12-11
申请号：US12529953
申请日：2008-03-19
申请人： Kenichi Kurihara , Nobuto Minowa , Nozomu Nakanishi , Masaaki Mitomi
发明人： Kenichi Kurihara , Nobuto Minowa , Nozomu Nakanishi , Masaaki Mitomi
IPC分类号： C07F9/28
CPC分类号： C07F9/4006 , C07F9/3217
摘要： A process for efficiently producing through a small number of steps an N-substituted 2-amino-4-(substituted-oxymethylphosphinyl)-2-butenoic ester which is an intermediate for herbicide L-AMPB. The process comprises reacting a compound represented by the following formula (1): (where R1 represents C1-4 alkyl group) with a compound represented by the following formula (2): (wherein R2, R2′, and R3 each represents C1-4 alkyl and R4 represents benzyloxycarbonyl) in the presence of a base.
摘要翻译：通过少量步骤有效地制备作为除草剂L-AMPB的中间体的N-取代的2-氨基-4-（取代的 - 氧甲基氧膦基）-2-丁烯酸酯的方法。该方法包括使由下式（1）表示的化合物（其中R 1表示C 1-4烷基）与下式（2）表示的化合物反应：（其中R2，R2'和R3各自表示C1- 4烷基，R 4表示苄氧基羰基）。

7. 发明申请

US20130131091A1 HARMFUL ORGANISM CONTROL AGENT 审中-公开
标题翻译：有害有机体控制剂
公开(公告)号：US20130131091A1
公开(公告)日：2013-05-23
申请号：US13699367
申请日：2011-05-23
申请人： Kimihiko Goto , Ryo Horikoshi , Kazuhiko Oyama , Yoshimasa Fukuda , Nozomu Nakanishi , Masato Tani , Nobuto Minowa , Masaaki Mitomi , Satoshi Omura , Toshiaki Sunazuka , Hiroshi Tomoda
发明人： Kimihiko Goto , Ryo Horikoshi , Kazuhiko Oyama , Yoshimasa Fukuda , Nozomu Nakanishi , Masato Tani , Nobuto Minowa , Masaaki Mitomi , Satoshi Omura , Toshiaki Sunazuka , Hiroshi Tomoda
IPC分类号： A01N43/90 , C07D498/04 , C07D493/04
CPC分类号： A01N43/90 , C07D491/04 , C07D493/04 , C07D498/04
摘要： The present invention provides a composition for use as a harmful organism control agent comprising as an active ingredient one or more of compounds represented by formula (I) or salts thereof and an agriculturally or zootechnically acceptable carrier. wherein Het represents pyridyl; X represents an oxygen atom; R1, R2, R3, R7, R10a, R10b, R11, and R12 represent a hydrogen atom; R4, R5, and R6 represent a hydrogen atom, hydroxyl, optionally substituted C1-18 alkylcarbonyloxy, optionally substituted C1-18 alkylsulfonyloxy, optionally substituted arylcarbonyloxy, C1-6 alkyloxy-C1-6 alkyloxy, C1-6 alkyloxy-C1-6 alkyloxy-C1-6 alkyloxy; R8 represents a hydrogen atom; and R13a, R13b, and R13c represent methyl.
摘要翻译：本发明提供一种用作有害生物体控制剂的组合物，其包含作为活性成分的一种或多种式（I）表示的化合物或其盐以及农业或动物技术上可接受的载体。其中Het表示吡啶基; X表示氧原子; R1，R2，R3，R7，R10a，R10b，R11和R12表示氢原子; R4，R5和R6表示氢原子，羟基，任选取代的C 1-18烷基羰基氧基，任选取代的C 1-18烷基磺酰氧基，任选取代的芳基羰氧基，C 1-6烷氧基-C 1-6烷氧基，C 1-6烷氧基-C 1-6烷氧基 -C 1-6烷氧基; R8表示氢原子; R13a，R13b和R13c表示甲基。

8. 发明申请

US20090221851A1 PROCESS FOR PRODUCTION OF OPTICALLY ACTIVE AMINOPHOSPHINYLBUTANOIC ACIDS 有权
标题翻译：生产光学活性氨基磷酰胆碱的方法
公开(公告)号：US20090221851A1
公开(公告)日：2009-09-03
申请号：US12298067
申请日：2007-09-03
申请人： Nobuto Minowa , Nozomu Nakanishi , Masaaki Mitomi , Hideki Nara , Tohru Yokozawa
发明人： Nobuto Minowa , Nozomu Nakanishi , Masaaki Mitomi , Hideki Nara , Tohru Yokozawa
IPC分类号： C07F9/28
CPC分类号： C07B53/00 , C07F9/301 , C07F9/3211
摘要： The present invention is a process for producing optically active aminophosphinylbutanoic acids represented by the formula (2) (in the formula (2), R1 represents an alkyl group having 1 to 4 carbon atom(s), R2 represents hydrogen atom or an alkyl group having 1 to 4 carbon atom(s), R3 represents an alkyl group having 1 to 4 carbon atom(s), an alkoxy group having 1 to 4 carbon atom(s), an aryl group, an aryloxy group, or a benzyloxy group, and R4 represents hydrogen atom or an alkyl group having 1 to 4 carbon atom(s); and * represents an asymmetric carbon atom), wherein a compound represented by the formula (1) (in the formula (1), R1 represents an alkyl group having 1 to 4 carbon atom(s), R2 represents hydrogen atom or an alkyl group having 1 to 4 carbon atom(s), R3 represents an alkyl group having 1 to 4 carbon atom(s), an alkoxy group having 1 to 4 carbon atom(s), an aryl group, an aryloxy group, or a benzyloxy group, and R4 represents hydrogen atom or an alkyl group having 1 to 4 carbon atom(s)) is asymmetrically hydrogenated in the presence of a ruthenium-optically active phosphine complex. With the process for the production, a compound useful in a herbicide such as L-AHPB can be produced with good efficiency and high asymmetric yield.
摘要翻译：本发明是一种由式（2）表示的光学活性氨基氧膦基丁酸的制备方法（式（2）中，R 1表示碳原子数1〜4的烷基，R 2表示氢原子或烷基具有1至4个碳原子，R 3表示具有1至4个碳原子的烷基，具有1至4个碳原子的烷氧基，芳基，芳氧基或苄氧基 R4表示氢原子或碳原子数1〜4的烷基，*表示不对称碳原子），式（1）表示的化合物（式（1）中，R 1表示具有1至4个碳原子的烷基，R 2表示氢原子或具有1至4个碳原子的烷基，R 3表示具有1至4个碳原子的烷基，具有1个至4个碳原子，芳基，芳氧基或苄氧基，R 4表示氢原子或1-4个碳原子的烷基在一种钌光学活性膦配合物的存在下，不对称氢化。通过制备方法，可以以高效率和高不对称产率制备可用于除草剂如L-AHPB的化合物。

9. 发明授权

US08076503B2 Process for production of optically active aminophosphinylbutanoic acids 有权
标题翻译：光学活性氨基氧膦基丁酸生产方法
公开(公告)号：US08076503B2
公开(公告)日：2011-12-13
申请号：US12298067
申请日：2007-09-03
申请人： Nobuto Minowa , Nozomu Nakanishi , Masaaki Mitomi , Hideki Nara , Tohru Yokozawa
发明人： Nobuto Minowa , Nozomu Nakanishi , Masaaki Mitomi , Hideki Nara , Tohru Yokozawa
IPC分类号： C07C229/04 , C07F9/28
CPC分类号： C07B53/00 , C07F9/301 , C07F9/3211
摘要： The present invention is a process for producing optically active aminophosphinylbutanoic acids represented by the formula (2), comprising asymmetrically hydrogenating a compound represented by the formula (1) in the presence of a ruthenium-optically active phosphine complex, a process for the production thereof, and a compound useful in a herbicide such as L-AHPB that can be produced with good efficiency and high asymmetric yield.
摘要翻译：本发明是一种制备由式（2）表示的光学活性氨基氧膦基丁酸的方法，包括在钌 - 光学活性膦配合物的存在下不对称地氢化由式（1）表示的化合物，其制备方法，以及可以以高效率和高不对称产率生产的用于除草剂如L-AHPB的化合物。

10. 发明授权

US07772426B2 Method for producing L-2-amino-4-(hydroxymethylphosphinyl)-butanoic acid 有权
标题翻译：制备L-2-氨基-4-（羟甲基氧膦基） - 丁酸的方法
公开(公告)号：US07772426B2
公开(公告)日：2010-08-10
申请号：US11909839
申请日：2006-03-28
申请人： Nobuto Minowa , Nozomu Nakanishi , Masaaki Mitomi
发明人： Nobuto Minowa , Nozomu Nakanishi , Masaaki Mitomi
IPC分类号： C07C227/32
CPC分类号： C07B53/00 , C07F9/301 , C07F9/65683
摘要： Disclosed is a method for efficiently and highly selectively producing L-2-amino-4-(hydroxymethylphosphinyl)-butanoic acid, which is useful as a herbicide, through a catalytic asymmetric synthesis reaction. Specifically disclosed is a method for producing L-2-amino-4-(hydroxymethylphosphinyl)-butanoic acid which is characterized in that a dehydroamino acid is subjected to an asymmetric hydrogenation by using a rhodium catalyst represented by the formula (2) below and having an optically active cyclic phosphine ligand, and then the resulting product is subjected to hydrolysis: [Rh(R4)(L)]X (2) [where R4 represents 1,5-cyclooctadien or norbornadien; L represents a substance represented by the following formula (6): (wherein R5 and R8 respectively represent a C1-4 alkyl group; R6 and R7 respectively represent hydrogen atom or hydroxyl group; and Y represents a group selected from groups represented by the following formula (7): (where Me represents methyl group)).].
摘要翻译：公开了通过催化不对称合成反应有效和高选择性地生产可用作除草剂的L-2-氨基-4-（羟甲基氧膦基） - 丁酸的方法。具体公开了一种生产L-2-氨基-4-（羟甲基氧膦基） - 丁酸的方法，其特征在于，使用下式（2）表示的铑催化剂对脱氢氨基酸进行不对称氢化，光学活性环膦配体，然后使所得产物水解：[Rh（R 4）（L）] X（2）[其中R 4表示1,5-环辛二烯或降冰片素; L表示由下式（6）表示的物质：（其中，R 5和R 8分别表示C 1-4烷基; R 6和R 7分别表示氢原子或羟基，Y表示选自下述式（7）：（Me表示甲基））。

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