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1. 发明授权

US09775900B2 Photodynamic diagnosis, formulations usable as photosensitizers for this purpose, method for the production and use thereof 有权
公开(公告)号：US09775900B2
公开(公告)日：2017-10-03
申请号：US15469602
申请日：2017-03-27
申请人： Sanochemia Pharmazeutika AG
发明人： Stefan Welzig , Beate Kälz , József Gungl , Klaus Gerdes , Werner Frantsits , Christina Abrahamsberg
IPC分类号： A61K9/00 , A61K41/00 , A61K31/121 , A61K36/38 , C07C50/36 , C07C50/00
CPC分类号： A61K41/00 , A61K9/0009 , A61K9/08 , A61K31/121 , A61K36/38 , A61K41/0057 , A61K47/32 , A61K49/0021 , A61K49/0054 , A61K49/0071 , C07C50/00 , C07C50/36
摘要： In the early detection of cancer, in particular bladder cancer, a photodynamic diagnosis uses, as a photosensitizer, a formulation that contains sodium hypericinate that is bonded to polyvinylpyrrolidone or complexed with polyvinylpyrrolidone.

2. 发明授权

US08629302B2 Methods for preparing hypericin 有权
标题翻译：金丝桃素的制备方法
公开(公告)号：US08629302B2
公开(公告)日：2014-01-14
申请号：US13496340
申请日：2010-09-15
申请人： Alfonso J. Tobia , Bernard E. Cabana , Venkata Vadlapatla , Ronald H. Connolly
发明人： Alfonso J. Tobia , Bernard E. Cabana , Venkata Vadlapatla , Ronald H. Connolly
IPC分类号： C07C45/61 , C07C45/81
CPC分类号： C07C50/36 , C07C46/00 , C07C46/02
摘要： The present invention provides a method for making hypericin comprising the steps of converting a protohypericin to a protohypericin salt, and irradiating the protohypericin salt with visible light to form hypericin. The present invention also provides an apparatus comprising a transparent column having a top end and a bottom end, an inlet attached to the column at the top end to flow reactants into the column, a container attached to the column at the bottom end; and a visible light source positioned to cast light on to the column. The present invention further provides a method for making hypericin using said apparatus.
摘要翻译：本发明提供一种制备金丝桃素的方法，其包括将原肌原蛋白转化为原肌原蛋白盐的步骤，以及用可见光照射原生精蛋白盐以形成金丝桃素。本发明还提供了一种装置，其包括具有顶端和底端的透明柱，在顶端连接到塔的入口以将反应物流入塔中，在底端附接到塔的容器; 以及定位成将光投射到柱上的可见光源。本发明还提供了使用所述装置制备金丝桃素的方法。

3. 发明申请

US20120245392A1 METHODS FOR PREPARING HYPERICIN 有权
标题翻译：制备高胰高血糖素的方法
公开(公告)号：US20120245392A1
公开(公告)日：2012-09-27
申请号：US13496340
申请日：2010-09-15
申请人： Alfonso J. Tobia , Bernard E. Cabana , Venkata Vadlapatla , Ronald H. Connolly
发明人： Alfonso J. Tobia , Bernard E. Cabana , Venkata Vadlapatla , Ronald H. Connolly
IPC分类号： C07C45/61 , C07C45/81 , B01J19/08 , C07C49/665
CPC分类号： C07C50/36 , C07C46/00 , C07C46/02
摘要： The present invention provides a method for making hypericin comprising the steps of converting a protohypericin to a protohypericin salt, and irradiating the protohypericin salt with visible light to form hypericin. The present invention also provides an apparatus comprising a transparent column having a top end and a bottom end, an inlet attached to the column at the top end to flow reactants into the column, a container attached to the column at the bottom end; and a visible light source positioned to cast light on to the column. The present invention further provides a method for making hypericin using said apparatus.
摘要翻译：本发明提供一种制备金丝桃素的方法，其包括将原肌原蛋白转化为原肌原蛋白盐的步骤，以及用可见光照射原生精蛋白盐以形成金丝桃素。本发明还提供了一种装置，其包括具有顶端和底端的透明柱，在顶端连接到塔的入口以将反应物流入塔中，在底端附接到塔的容器; 以及定位成将光投射到柱上的可见光源。本发明还提供了使用所述装置制备金丝桃素的方法。

4. 发明授权

US06828450B2 Triptycene analogs 失效
标题翻译：单体类似物
公开(公告)号：US06828450B2
公开(公告)日：2004-12-07
申请号：US09974716
申请日：2001-10-09
申请人： Duy Hua , Jean-Pierre Perchellet
发明人： Duy Hua , Jean-Pierre Perchellet
IPC分类号： C07C5012
CPC分类号： C07D473/00 , C07B2200/07 , C07C43/23 , C07C49/665 , C07C49/753 , C07C50/22 , C07C50/36 , C07C225/32 , C07C229/14 , C07C229/26 , C07C323/58 , C07C2603/00 , C07C2603/90 , C07D473/34 , C07H15/12
摘要： This invention provides analogs of triptycene which are useful as anticancer drugs, as well as for other uses. The potency of these compounds is in a similar magnitude as daunomycin, a currently used anticancer drug. Each compound of the invention produces one or more desired effects (blocking nucleoside transport, inhibiting nucleic acid or protein syntheses, decreasing the proliferation and viability of cancer cells, inducing DNA fragmentation or retaining their effectiveness against multidrug-resistant tumor cells).
摘要翻译：本发明提供了可用作抗癌药物的triptycene类似物以及用于其它用途。这些化合物的效力与目前使用的抗癌药物道诺霉素的剂量类似。本发明的每种化合物产生一种或多种所需效果（阻断核苷转运，抑制核酸或蛋白质合成，降低癌细胞的增殖和存活力，诱导DNA断裂或保持其对多药耐药性肿瘤细胞的有效性）。

5. 发明授权

US6017470A Substituted [6]helicene compounds that show enhanced nonlinear optical rotatory power and uses thereof 失效
标题翻译：取代的[6]甲苯化合物，显示增强的非线性旋光性及其用途
公开(公告)号：US6017470A
公开(公告)日：2000-01-25
申请号：US631777
申请日：1996-04-12
申请人： Thomas J. Katz , Colin P. Nuckolls
发明人： Thomas J. Katz , Colin P. Nuckolls
IPC分类号： C07C50/36 , C07C69/00 , G02F1/361 , F21V9/00 , C07C41/00 , C09K19/32 , F21V9/14
CPC分类号： C07C69/00 , C07C50/36 , G02F1/361 , G02F1/3612 , G02F1/3616 , G02F1/3617 , C07C2103/00
摘要： This invention provides a compound having the structure: ##STR1## wherein rings A and B represent independent electron accepting ring systems and wherein R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5, R.sub.6, R.sub.7 and R.sub.8 are the same or different and are H, substituted or unsubstituted, saturated or unsaturated alkyl, alkenyl, cycloalkyl, aryl, or arylalkyl, --SR, --NRR', --OR, --OC(O)R, SC(O)R, --SCR, wherein R and R' are independently substituted or unsubstituted, saturated or unsaturated alkyl, alkenyl, cycloalkyl, aryl, or arylalkyl.This invention also provides thin films comprising a compound having the above structure or suitable derivatives thereof.This invention further provides liquid crystal display devices and non-linear optical devises comprising a compound having the above structure or a suitable derivative thereof.Finally, this invention provides a method for achieving a high order non-linear electrooptical response comprising contacting a suitable sample of the inventive compound or a derivative thereof with an appropriate light source.
摘要翻译：本发明提供具有以下结构的化合物：其中环A和B表示独立的电子接受环体系，其中R1，R2，R3，R4，R5，R6，R7和R8相同或不同，为H，取代或未取代的，饱和或不饱和的烷基，烯基，环烷基，芳基或芳基烷基，-SR，-NRR'，-OR，-OC（O）R，SC（O）R，-SCR，其中R和R'独立地是取代或未取代的，饱和或不饱和的烷基，烯基，环烷基，芳基或芳基烷基。本发明还提供了包含具有上述结构的化合物或其合适的衍生物的薄膜。本发明还提供了包含具有上述结构的化合物或其合适的衍生物的液晶显示装置和非线性光学装置。最后，本发明提供了一种实现高阶非线性电光响应的方法，包括将本发明化合物或其衍生物的合适样品与合适的光源接触。

6. 发明授权

US5140044A UCN-1028D derivatives 失效
标题翻译： UCN-1028D衍生物
公开(公告)号：US5140044A
公开(公告)日：1992-08-18
申请号：US500245
申请日：1990-03-27
申请人： Teruo Kishi , Hiromitsu Saito , Hiroshi Sano , Isami Takahashi , Tatsuya Tamaoki
发明人： Teruo Kishi , Hiromitsu Saito , Hiroshi Sano , Isami Takahashi , Tatsuya Tamaoki
IPC分类号： A61K31/12 , A61K31/255 , A61K31/265 , A61K31/44 , A61K31/4409 , A61K31/495 , A61P35/00 , A61P43/00 , C07C46/00 , C07C49/755 , C07C50/36 , C07C69/00 , C07C69/025 , C07C69/734 , C07C69/96 , C07C205/57 , C07C229/08 , C07C229/36 , C07C255/57 , C07C271/12 , C07C271/28 , C07C309/66 , C07C309/73 , C07C327/22 , C07C327/32 , C07D207/16 , C07D207/327 , C07D213/79 , C07D241/24 , C07D307/68 , C07D521/00
CPC分类号： C07D213/79 , C07C205/57 , C07C229/08 , C07C229/36 , C07C255/57 , C07C271/12 , C07C271/28 , C07C309/66 , C07C309/73 , C07C327/32 , C07C50/36 , C07C69/00 , C07C69/96 , C07D207/16 , C07D241/24 , C07D307/68 , C07C2101/14 , C07C2103/00 , C07C2103/52
摘要： A UCN-1028D derivative represented by the formula: ##STR1## has protein kinase C inhibitory activity and is expected to be used as an active ingredient in anti-tumor agents, etc.

7. 发明授权

US5112977A Substituted naphthacene-5,12-diones 失效
标题翻译：取代的萘醌-5,12-二酮
公开(公告)号：US5112977A
公开(公告)日：1992-05-12
申请号：US356830
申请日：1989-05-24
申请人： Walter Fischer , Marcus Baumann , Jurgen Finter , Vratislav Kvita , Carl W. Mayer , Wolfgang Wernet
发明人： Walter Fischer , Marcus Baumann , Jurgen Finter , Vratislav Kvita , Carl W. Mayer , Wolfgang Wernet
IPC分类号： G03F7/028 , B05D1/20 , C07C45/00 , C07C50/24 , C07C50/36 , C07C66/00 , C07C67/00 , C07C69/00 , C07C69/738 , C07C201/00 , C07C205/46 , C07C205/48 , C07C211/61 , C07C225/32 , C07C235/40 , C07C255/40 , C07C255/41 , C07C255/56 , C07C255/57 , C07C317/24 , C07C323/20 , C07C323/22 , C07D295/10 , C07D295/116 , C07D307/12 , C07F7/08 , C08F2/50 , C08G61/12 , C08K5/08 , C08K5/10 , C08K5/13 , C08K5/36 , C09B3/58 , H01B1/12
CPC分类号： C07D295/116 , B05D1/202 , B82Y30/00 , B82Y40/00 , C07C205/48 , C07C225/32 , C07C255/40 , C07C255/41 , C07C255/56 , C07C323/20 , C07C323/22 , C07C50/24 , C07C50/36 , C07C69/00 , C07D307/12 , C07F7/0818 , C08F2/50 , C08G61/123 , H01B1/121 , C07C2101/02 , C07C2103/00 , C07C2103/44
摘要： Substituted naphthacenediones of the formula I ##STR1## in which R.sup.1 to R.sup.8 are H and at least one of R.sup.1 to R.sup.8, for example R.sup.2 and R.sup.3 or R.sup.2 and R.sup.6, are, for example, C.sub.1 -C.sub.20 alkoxy, C.sub.1 -C.sub.20 alkenoxy, C.sub.1 -C.sub.20 -alkylsulfinyl, --CN, --CF.sub.3, --NO.sub.2, --Si(CH.sub.3).sub.3 or --COO(C.sub.1 -C.sub.12 alkyl), are suitable, when incorporated into polymers having hydroxyalkyl groups, for currentless deposition of metals onto the polymer surface. They are in some cases suitable as photoinitiators.
摘要翻译：其中R 1至R 8为H并且R 1至R 8中的至少一个，例如R 2和R 3或R 2和R 6的取代的对映体萘并吖啶为例如C 1 -C 20烷氧基，C 1 -C 20链烯氧基，当C 1 -C 20烷基亚磺酰基，-CN，-CF 3，-NO 2，-Si（CH 3）3或-COO（C 1 -C 12烷基）掺入到具有羟烷基的聚合物中时，适用于金属在聚合物上无电沉积表面。在某些情况下，它们适合作为光引发剂。

8. 发明授权

US4409391A Process to produce anthracycline compounds 失效
标题翻译：生产蒽环类化合物的方法
公开(公告)号：US4409391A
公开(公告)日：1983-10-11
申请号：US318522
申请日：1981-11-05
申请人： Michael J. Broadhurst , Cedric H. Hassall , Gareth J. Thomas
发明人： Michael J. Broadhurst , Cedric H. Hassall , Gareth J. Thomas
IPC分类号： C07C39/17 , C07C41/26 , C07C43/21 , C07C43/23 , C07C45/56 , C07C46/00 , C07C49/563 , C07C49/573 , C07C49/577 , C07C49/755 , C07C50/10 , C07C50/22 , C07C50/32 , C07C50/36 , C07C50/38 , C07C62/34 , C07D319/08 , C07D339/06 , C07F5/02 , C07D317/72
CPC分类号： C07C62/34 , C07C39/17 , C07C41/26 , C07C45/56 , C07C46/00 , C07C49/563 , C07C49/573 , C07C49/577 , C07C49/755 , C07C50/10 , C07C50/22 , C07C50/32 , C07C50/36 , C07C50/38 , C07D319/08 , C07D339/06 , C07F5/025 , C07C2102/10
摘要： There is presented a process for the manufacture of hexahydronaphthacene derivatives of the general formula ##STR1## wherein one of R.sup.1 and R.sup.2 represents a hydrogen atom and the other represents a hydrogen atom or a hydroxy group or R.sup.1 and R.sup.2 together represent a protected oxo group, R.sup.3 represents a hydrogen atom or a hydroxy or acyloxy group and R.sup.4 represents a lower alkyl or esterified carboxy group or a group of the formula ##STR2## wherein R.sup.5 and R.sup.6 together form an oxo group or a protected oxo group and X represents a hydrogen atom or a hydroxy or acyloxy group or--(CH.sub.2).sub.n --OY bin which n stands for 1 or 2 and Y represents a hydrogen atom or an alkyl or acyl group.Also presented are certain of the novel derivatives per se and various novel intermediates in the process.

9. 发明公开

US20230227393A1 IRON CATALYZED HIGHLY ENANTIOSELECTIVE CIS-DIHYDROXYLATION OF QUINONES 审中-公开
公开(公告)号：US20230227393A1
公开(公告)日：2023-07-20
申请号：US18155431
申请日：2023-01-17
申请人： Versitech Limited , Laboratory for Synthetic Chemistry and Chemical Biology Limited
发明人： Chi Ming Che , Tingting Wang , Haixu Wang
IPC分类号： C07C50/04 , C07C50/30 , C07C50/12 , C07C50/36 , C07C50/34 , B01J31/40
CPC分类号： C07C50/04 , C07C50/30 , C07C50/12 , C07C50/36 , C07C50/34 , B01J31/4023
摘要： Methods for asymmetric cis-dihydroxylation (“AD”) of quinones to produce cis-diols of quinones with high yield (i.e. a yield ≥30%) and high enantioselectivity (i.e. an enantiometric excess ≥30%) are disclosed. The method uses an iron-based catalyst, such as one or more Fe(II) complexes, as the catalyst, and can be performed under mild reaction conditions (e.g. a temperature ≤50° C. at 1 atom in open air). The method generally includes: (i) maintaining a reaction mixture at a temperature for a period of time sufficient to form a product, where the reaction mixture contains a quinone, one or more iron-based catalyst(s), and a solvent, and where the product contains a chiral cis-diol. Optionally, the method also includes adding an oxidant into the reaction mixture prior to and/or during step (i), such as a hydrogen peroxide solution.

10. 发明申请

US20190135724A1 Systems And Methods For Producing Synthetic Hypericin 审中-公开
公开(公告)号：US20190135724A1
公开(公告)日：2019-05-09
申请号：US16107047
申请日：2018-08-21
申请人： Soligenix, Inc.
发明人： Rasappa Arumugham , Christopher Schaber , Holger Rauter , Silvia Werner
IPC分类号： C07C46/10
CPC分类号： C07C46/10 , C07C2603/54 , C07C50/36
摘要： Improved systems and methods for producing synthetic hypericin at high volume and high purity.

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