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    • 5. 发明申请
    • FORMATION AND CONTROL OF FLUIDIC SPECIES
    • 流体物种的形成与控制
    • US20150283546A1
    • 2015-10-08
    • US14662668
    • 2015-03-19
    • President and Fellows of Harvard College
    • Darren Roy LinkDavid A. WeitzManuel Marquez-SanchezZhengdong Cheng
    • B01L3/00
    • B01L3/502784B01F5/0682B01F13/0062B01F13/0071B01F13/0076B01F2215/0431B01J2/04B01L3/502715B01L3/50273B01L2200/0673B01L2300/0867B01L2400/02B01L2400/0415B01L2400/0424B05B5/03B05B7/061
    • This invention generally relates to systems and methods for the formation and/or control of fluidic species, and articles produced by such systems and methods. In some cases, the invention involves unique fluid channels, systems, controls, and/or restrictions, and combinations thereof. In certain embodiments, the invention allows fluidic streams (which can be continuous or discontinuous, i.e., droplets) to be formed and/or combined, at a variety of scales, including microfluidic scales. In one set of embodiments, a fluidic stream may be produced from a channel, where a cross-sectional dimension of the fluidic stream is smaller than that of the channel, for example, through the use of structural elements, other fluids, and/or applied external fields, etc. In some cases, a Taylor cone may be produced. In another set of embodiments, a fluidic stream may be manipulated in some fashion, for example, to create tubes (which may be hollow or solid), droplets, nested tubes or droplets, arrays of tubes or droplets, meshes of tubes, etc. In some cases, droplets produced using certain embodiments of the invention may be charged or substantially charged, which may allow their further manipulation, for instance, using applied external fields. Non-limiting examples of such manipulations include producing charged droplets, coalescing droplets (especially at the microscale), synchronizing droplet formation, aligning molecules within the droplet, etc. In some cases, the droplets and/or the fluidic streams may include colloids, cells, therapeutic agents, and the like.
    • 本发明一般涉及用于形成和/或控制流体物质的系统和方法,以及由这些系统和方法生产的制品。 在一些情况下,本发明涉及独特的流体通道,系统,控制和/或限制及其组合。 在某些实施方案中,本发明允许流体流(其可以是连续的或不连续的,即液滴)以各种尺度形成和/或组合,包括微流体尺度。 在一组实施例中,流体流可以从通道产生,其中流体流的横截面尺寸小于通道的横截面尺寸,例如通过使用结构元件,其它流体和/或 应用外场等。在某些情况下,可能产生泰勒锥。 在另一组实施例中,可以以某种方式操纵流体流,例如以产生管(其可以是中空或固体),液滴,嵌套管或液滴,管或液滴阵列,管的网格等。 在一些情况下,使用本发明的某些实施方案产生的液滴可能被充电或基本上带电,这可能允许它们进一步操作,例如使用外部应用场。 这种操作的非限制性实例包括产生带电液滴,聚集液滴(特别是微量级),同步液滴形成,使液滴中的分子对齐等。在一些情况下,液滴和/或流体流可包括胶体,细胞 ,治疗剂等。