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1. 发明公开

US20240359113A1 Blood Plasma Product 审中-公开
公开(公告)号：US20240359113A1
公开(公告)日：2024-10-31
申请号：US18604041
申请日：2024-03-13
申请人： Velico Medical, Inc.
发明人： Qiyong Peter Liu , Herman E. Snyder , Evan P. Ordway , William J. Merritt , Robert R. Andrews , Clair Strohl , Jihae Sohn , Lisa A. Buckley , Mark A. Popovsky
IPC分类号： B01D1/18 , A61J1/00 , A61J3/00 , A61K9/16 , A61K35/16 , B01D1/00 , B01D1/20 , B01J2/04
CPC分类号： B01D1/18 , A61J1/00 , A61J3/00 , A61K9/16 , A61K35/16 , B01D1/0082 , B01D1/20 , B01J2/04
摘要： The present invention relates to a spray dried plasma composition having one or more of the following characteristics: when reconstituted, largely amorphous and has no cholesterol crystals; when reconstituted, the number of large particulates is reduced; has low residual moisture; reconstitutes rapidly in under four minutes; highly stable when stored under refrigeration, at room temperature or at elevated temperatures and allows for storage for longer periods of time; when reconstituted, exhibits recovery of the most fragile of proteins, including von Willebrand's factor; when reconstituted with Sterile Water for Injection (SWFI), reconstituted plasma is at a pH that is near normal plasma pH, and does so without treatment or storage in CO2 or other pH adjustment; and when reconstituted, has reduced complement activation (C5A, C3A).

2. 发明授权

US11931809B2 Apparatus for the production of nanoparticles and method for producing nanoparticles 有权
公开(公告)号：US11931809B2
公开(公告)日：2024-03-19
申请号：US16828373
申请日：2020-03-24
申请人： Catalytic Instruments Gmbh & Co. KG
发明人： Adam Meyer Boies , Jacob John Swanson , Hans-Joachim Schulz
IPC分类号： B22F9/08 , B01J2/04 , B01L3/00 , B22F1/054 , B22F9/12 , B82Y40/00
CPC分类号： B22F9/12 , B01J2/04 , B01L3/00 , B01L3/5025 , B01L3/5027 , B22F1/054 , B22F1/056 , B22F9/082 , B22F2009/0832 , B22F2009/0896 , B22F2301/255 , B82Y40/00
摘要： An apparatus for the production of nanoparticles is provided. The apparatus includes a main tube that is closed at a bottom, an inlet channel arranged within the main tube and includes a first opening to the outside of the apparatus and a second opening to the main tube, and a main opening in the main tube. The main tube includes a sample position at the bottom, the cross section of the main tube at the sample position is smaller than at other positions of the main tube, and the second opening of the inlet channel is arranged closer to the sample position than the main opening. Furthermore, an arrangement for the production of nanoparticles and a method for producing nanoparticles are provided.

3. 发明授权

US11884596B2 Method for producing granules for ceramic production 有权
公开(公告)号：US11884596B2
公开(公告)日：2024-01-30
申请号：US17256114
申请日：2019-06-24
申请人： TOKUYAMA CORPORATION
发明人： Hironobu Fujimoto , Tsuyoshi Ikeda
IPC分类号： C04B35/626 , C04B35/581 , B01D1/18 , B01J2/04
CPC分类号： C04B35/62695 , C04B35/581 , C04B35/62625 , B01D1/18 , B01J2/04 , C04B2235/5436
摘要： The present invention aims to provide a method for producing granules for ceramic production, the method having high productivity and making it possible to obtain a ceramic which, when produced by press molding the granules and firing the resulting press molded product, has physical properties kept from lowering. The present invention is characterized by including: a slurry preparation step of preparing a slurry including a mixture containing a powder of an inorganic compound, a binder, and a solvent; a granulation step of introducing the slurry into a spray drying device to form a granulated substance containing the inorganic compound; an exhaust step of exhausting an atmospheric gas within the spray drying device via a cyclone having a surface made of ceramic; and a step of mixing a fine powder, which has been recovered by the cyclone during the exhaust step, with the granulated substance obtained in the granulation step.

4. 发明授权

US11794158B2 Microparticle production process and apparatus 有权
公开(公告)号：US11794158B2
公开(公告)日：2023-10-24
申请号：US17204676
申请日：2021-03-17
申请人： MIDATECH PHARMA (WALES) LIMITED
发明人： Paul Seaman , Huw Jones , Liam McAleer
IPC分类号： B01J2/08 , B01J2/04 , B01J2/18 , B01J2/06
CPC分类号： B01J2/08 , B01J2/04 , B01J2/06 , B01J2/18
摘要： Provided is an apparatus for producing solid polymeric microparticles, the apparatus comprising a plurality of liquid droplet generators for forming liquid droplets of a first liquid, and a nozzle for forming a jet of a second liquid, wherein the plurality of liquid droplet generators and the nozzle are arranged relative to each other such that, in use, liquid droplets from the plurality of liquid droplet generators pass through a gas into said jet of second liquid. Also provided is a process for producing solid microparticles, the process comprising: providing a first liquid comprising a solute and a solvent, the solute comprising a biocompatible polymer, the concentration of polymer in the first liquid being at least 10% w/v, ‘w’ being the weight of the polymer and ‘v’ being the volume of the solvent, providing a plurality of liquid droplet generators operable to generate liquid droplets, providing a jet of a second liquid, causing the plurality of liquid droplet generators to form liquid droplets of the first liquid, passing the liquid droplets through a gas to contact the jet of the second liquid so as to cause the solvent to exit the droplets, thus forming solid microparticles, the solubility of the solvent in the second liquid being at least 5 g of solvent per 100 ml of second liquid, the solvent being substantially miscible with the second liquid.

5. 发明授权

US11794155B2 Mechanical system that fluidizes, mixes, coats, dries, combines, chemically reacts, and segregates materials 有权
公开(公告)号：US11794155B2
公开(公告)日：2023-10-24
申请号：US17464370
申请日：2021-09-01
申请人： Resodyn Corporation
发明人： Peter A. Lucon , Lawrence C. Farrar
IPC分类号： B01F31/24 , B01J2/18 , B01F31/25 , B01J2/00 , B01J2/04 , B01F33/30 , B01F35/90 , B01F35/213 , B01F35/21 , B01F35/221 , B01F35/71 , B01F31/20
CPC分类号： B01F31/25 , B01F31/24 , B01F33/30 , B01F35/213 , B01F35/2115 , B01F35/2213 , B01F35/7179 , B01F35/90 , B01J2/006 , B01J2/04 , B01J2/18 , B01F31/265 , B01F2035/98
摘要： The present application is directed towards systems and methods for adding components to materials being fluidized in a vibratory mixer by use of atomizers or sprayers. A mechanical system can fluidizes, mix, coat, dry, combine, or segregate materials. The system may comprise a vibratory mixer, mixing vessel containing a first material and a sprayer to introduce a second material. The vibratory mixer may generate a fluidized bed of a first material and the sprayer, coupled to the mixing vessel, may introduce a second material onto the fluidized bed to mix the materials in a uniform and even fashion.

6. 发明授权

US11766650B2 System and method to produce particles of organic substances 有权
公开(公告)号：US11766650B2
公开(公告)日：2023-09-26
申请号：US17796189
申请日：2020-11-17
申请人： NANOFORM FINLAND OYJ
发明人： Ilkka Lassila
IPC分类号： B01J2/04 , A61K9/16 , A61K9/51 , B01J3/00 , B01J3/08
CPC分类号： B01J2/04 , A61K9/1682 , A61K9/5192 , B01J3/008 , B01J3/08
摘要： Disclosed are systems and methods for producing particles of organic substances, in particular nanoparticles and microparticles of active pharmaceutical ingredients, wherein the particles are collected in the aid of an extension member engaged to a collection chamber and positioning a nozzle.

7. 发明授权

US11708463B2 Spray drying process for low aspect ratio particles comprising poly[(methyl methacrylate)-co-(methacrylic acid)] 有权
公开(公告)号：US11708463B2
公开(公告)日：2023-07-25
申请号：US17044712
申请日：2019-04-01
申请人： Capsugel Belgium NV
发明人： Kimberly Shepard , Michael Morgen
IPC分类号： C08J3/12 , B01J2/04 , A61K9/16 , C08F220/06 , C08F220/14
CPC分类号： C08J3/122 , B01J2/04 , C08F220/06 , C08F220/14 , A61K9/1635 , A61K9/1682
摘要： Embodiments of a spray-drying process for producing low aspect ratio particles of poly[(methyl methacrylate)-co-(methacrylic acid)] (PMMAMA) are disclosed. In some examples, at least 95% of PMMAMA-containing particles made by the process have an aspect ratio

8. 发明授权

US10843100B2 Spray drier assembly for automated spray drying 有权
公开(公告)号：US10843100B2
公开(公告)日：2020-11-24
申请号：US15603699
申请日：2017-05-24
申请人： Velico Medical, Inc.
发明人： Abdul Wahid Khan , Dennis Brian Hubbard
IPC分类号： B01D1/18 , B01J2/04
CPC分类号： B01D1/18 , B01J2/04
摘要： A spray drier system is provided for spray drying a liquid sample such as blood plasma. The spray drier system may include a spray drier device adapted to couple with a spray drier assembly. The assembly may include an enclosure mounted to a frame. The assembly may receive a flow of drying gas which is directed by the enclosure shape towards a spray drying head mounted within the enclosure to the frame. Flows of a liquid sample may be further received by the head, which aerosolizes the liquid sample. Aerosolized liquid sample and drying air may be mixed within a drying chamber of the enclosure to produce dried sample and humid air. The dried sample and humid air may also be separated in a collection chamber of the enclosure, with the humid air exhausted from the enclosure.

9. 发明授权

US10625281B2 Ultrahigh efficiency spray drying apparatus and process 有权
公开(公告)号：US10625281B2
公开(公告)日：2020-04-21
申请号：US16695883
申请日：2019-11-26
申请人： ZoomEssence, Inc.
发明人： Charles Pershing Beetz , Jason Andrew Beetz
IPC分类号： B05B5/03 , B01D1/18 , B01J2/04 , B05B12/00 , B01D1/00
CPC分类号： B05B5/032 , B01D1/0082 , B01D1/18 , B01J2/04 , B05B12/00
摘要： The disclosure relates to ultrahigh efficiency spray drying systems and processes, utilizing induction of localized turbulence in a drying fluid flow stream to produce spray dried product, having particular utility for low temperature spray drying operations. In a specific implementation, a method of processing a spray dryable liquid composition to form a spray dried product includes the steps of: generating a spray of the spray dryable liquid composition; contacting the spray of spray dryable liquid composition in a spray drying contact zone with a stream of primary drying fluid; injecting pressurized secondary drying fluid into the stream of primary drying fluid in the spray drying contact zone at multiple loci thereof to provide localized turbulence at said multiple loci; and recovering the spray dried product from the spray drying contact zone. Systems of the present disclosure are effective in achieving high-rate production of dry powder spray dried products, with substantially reduced capital equipment costs, energy requirements, and operating expenditures.

10. 发明授权

US10625229B2 Device for preparing nano-carbon urea 有权
公开(公告)号：US10625229B2
公开(公告)日：2020-04-21
申请号：US16088812
申请日：2017-09-29
申请人： BEIJING NANO HI-TECH MATERIAL CO., LTD.
发明人： Wenying Xing , Ligang Zuo , Lele Zuo , Kaisheng Li
IPC分类号： B01D1/18 , B01J2/04 , C05C9/00 , B82Y30/00
CPC分类号： B01J2/04 , B01D1/18 , C05C9/005 , B82Y30/00
摘要： A device for preparing nano-carbon urea comprising: the urea inlet pipe is connected to the conical nozzle above the urea granulation tower, install the spray device under the natural ventilation window of the urea granulation tower, the spray device is connected to the atomizing nozzle through the spray manifold, the spray manifold is connected to the atomizing nozzle, they are all located inner the urea granulation tower above the urea rotary sweep, urea discharge funnel is set on the bottom of urea granulation tower; urea discharge funnel is connected to the drum drying device, an atomizer is arranged between the drum drying device and the urea discharge funnel. This utility model comprises two stages which combines tower internal, external spray absorption and drying, the content of urea nano-carbon is increased.

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