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1. 发明授权

US11884678B2 Method for producing a spirooxindole derivative 有权
公开(公告)号：US11884678B2
公开(公告)日：2024-01-30
申请号：US17081452
申请日：2020-10-27
申请人： Daiichi Sankyo Company, Limited
发明人： Motoshi Yamauchi , Keiji Nakayama
IPC分类号： C07D487/10 , C07D491/20 , B01J31/02 , B01J31/04 , B01J31/22 , C07B53/00 , B01J31/24 , B01J31/18 , B01J31/14
CPC分类号： C07D487/10 , B01J31/02 , B01J31/04 , B01J31/143 , B01J31/189 , B01J31/22 , B01J31/226 , B01J31/2295 , B01J31/2409 , B01J31/2414 , B01J31/2452 , B01J31/2457 , B01J31/2476 , C07B53/00 , C07D491/20 , B01J2231/32 , B01J2231/328 , B01J2531/0205 , B01J2531/0263 , B01J2531/0266 , B01J2531/0272 , B01J2531/16 , B01J2531/17 , B01J2531/842 , B01J2540/10 , B01J2540/40
摘要： The present disclosure provides a method for efficiently producing and providing compounds having a spirooxindole skeleton, for example compounds having a spirooxindole skeleton and having antitumor activity that inhibit the interaction between Mdm2 protein and p53 protein, or intermediates thereof, using an asymmetric catalyst. Compounds having optically active tricyclic dispiroindole skeletons are obtained through catalytic asymmetric 1,3-dipolar cycloaddition reaction using ketimine as a reaction substrate and using a chiral ligand and a Lewis acid.

2. 发明授权

US3836602A Method of cyclotrimerizing 1-buten-3-yne to form 1,2,4-trivinylbenzene 失效
标题翻译：将1-丁-3-烯旋转形成1,2,4-三乙基苯的方法
公开(公告)号：US3836602A
公开(公告)日：1974-09-17
申请号：US41671573
申请日：1973-11-16
申请人： GOODYEAR TIRE & RUBBER
发明人： WIDEMAN L
IPC分类号： B01J31/14 , B01J31/18 , C07C2/48 , C07C3/04 , C07C15/10
CPC分类号： B01J31/143 , B01J31/1805 , B01J2231/328 , B01J2531/842 , C07C2/48 , C07C2531/12 , C07C2531/16 , C07C2531/22 , C07C15/44
摘要： THERE IS DISCLOSED A METHOD OF PREPARING 1,2,4-TRIVINYLBENZENE BY CYCLOTRIMERIZING 1-BUTEN-3-YNE. THE CATALYST EMPLOYED IN THIS CYCLOTRIMERIZATION COMPRISES (1) IRON SALTS OR IRON COMPLEXEX, (2) AN ORGANOMETALLIC REDUCING AGENT AND (3) CERTAIN LIGANDS CONTAINING NITROGEN.

3. 发明授权

US3823196A Production of cyclic trimers of 1,3-dienes 失效
标题翻译：生产1,3-二氧化碳的循环回旋剂
公开(公告)号：US3823196A
公开(公告)日：1974-07-09
申请号：US15080271
申请日：1971-06-07
申请人： MITSUBISHI PETROCHEMICAL CO
发明人： MORIKAWA H , SAITO T
IPC分类号： B01J31/00 , B01J31/02 , B01J31/14 , C07C1/00 , C07C2/46 , C07C13/277 , C07C67/00 , C08F4/64 , C07C3/00
CPC分类号： B01J31/0212 , B01J31/143 , B01J2231/328 , C07C2/465 , C07C2531/02 , C07C2531/14 , C07C2601/20 , C07C13/277
摘要： A 1,3-DIENE IS CAUSED TO CONTACT A CATALYST SYSTEM COMPRISING, IN COMBINATION: A TITANIUM COMPOUND

TI(O-R-CL)NCL4-N

(WHERE R IS AN ALKYLENE, CYCLOALKYLENE, CHLOROALKYLENE OR CHLOROCYLOALKYLENE GROUP OF C2 TO C15, AND N IS 1 OR 2); AN ORGANOALUMINUM COMPOUND AIR''MCL3-M (WHERE R'' IS AN ALKYL GROUP OF C1 TO C10, AND M IS 2 OR 1.5); AND AN ADDITIVE WHICH IS A SULFOXIDE SOR"2 (WHERE R" IS AN ALKYL OR ARALKYL GROUP OF C1 TO C10) OR A MIXTURE THEREOF AND A PHOSPHINE OXIDE POR''"3 (WHERE R" IS AN ALKYL, ARALKYL, OR ALKOXY GROUP OF C1 TO C10), THE 1,3-DIENE THERBY UNDERGOING CYCLIC TRIMERIZAYION WHEREBY A CYCLIC TRIMER OF LOW CONTENT OF HIGH POLYMERS IS PRODUCED AT HGIH REACTION VELOCITY AND WITH HIGH SELECTIVITY.

4. 发明授权

US3462376A Catalyst and preparation thereof 失效
标题翻译：催化剂及其制备
公开(公告)号：US3462376A
公开(公告)日：1969-08-19
申请号：US3462376D
申请日：1965-06-14
申请人： COLUMBIAN CARBON
发明人： KIRK JAMES C
IPC分类号： B01J31/20 , C07C2/46 , C08F4/64 , B01J11/06
CPC分类号： B01J31/121 , B01J31/122 , B01J31/143 , B01J31/20 , B01J2231/324 , B01J2231/328 , B01J2531/847 , C07C2/465 , C07C2531/12 , C07C2531/14 , C07C2531/20

5. 发明授权

US3352931A Catalytic oligomerization of butadiene 失效
标题翻译：丁二烯的催化低聚
公开(公告)号：US3352931A
公开(公告)日：1967-11-14
申请号：US48014465
申请日：1965-08-16
申请人： PHILLIPS PETROLEUM CO
发明人： ZUECH ERNEST A
IPC分类号： B01J31/20 , C07C2/46
CPC分类号： C07C2/465 , B01J31/04 , B01J31/121 , B01J31/14 , B01J31/28 , B01J2231/20 , B01J2231/326 , B01J2231/328 , C07C2531/04 , C07C2531/12

6. 发明授权

US3157708A Process for making cyclododecatriene 失效
标题翻译：制备环十二碳三烯的方法
公开(公告)号：US3157708A
公开(公告)日：1964-11-17
申请号：US1918460
申请日：1960-04-01
申请人： EXXON RESEARCH ENGINEERING CO
发明人： MUNLEY JR WILLIAM J , WIESE HERBERT K
IPC分类号： B01J31/38 , C07C2/46
CPC分类号： B01J31/143 , B01J27/10 , B01J31/122 , B01J31/26 , B01J31/38 , B01J2231/328 , B01J2531/0205 , B01J2531/31 , B01J2531/46 , C07C2/465 , C07C2527/135 , C07C2531/14 , C07C2531/38 , C07C2601/20 , C07C13/277

7. 发明申请

US20170327532A1 METHODS, COMPOSITIONS, AND KITS USING HETEROGENEOUS CATALYSTS 审中-公开
公开(公告)号：US20170327532A1
公开(公告)日：2017-11-16
申请号：US15664926
申请日：2017-07-31
申请人： OCCIDENTAL COLLEGE
发明人： Michael HILL , Andrew UDIT
IPC分类号： C07K1/107 , B01J35/00 , B01J27/138 , B01J37/04 , B01J31/08 , B01J23/06 , B01J31/26 , B01J31/18 , C07H21/04 , B01J35/02
CPC分类号： C07H21/04 , B01J23/06 , B01J23/72 , B01J27/138 , B01J31/08 , B01J31/183 , B01J31/26 , B01J35/0006 , B01J35/0073 , B01J35/02 , B01J37/04 , B01J37/16 , B01J2231/328 , B01J2531/16 , C07K1/1077
摘要： Described herein are methods, compositions and kits utilizing heterogeneous metal catalysts for the preparation of cycloaddition compounds, such as triazoles and biomolecules.

8. 发明授权

US06894172B2 Chiral cheating agent and chiral catalyst 有权
标题翻译：手性螯合剂和手性催化剂
公开(公告)号：US06894172B2
公开(公告)日：2005-05-17
申请号：US10612609
申请日：2003-07-01
申请人： Kwunmin Chen , Kung-Shou Yang , Wei-Der Lee , Jia-Fu Pan
发明人： Kwunmin Chen , Kung-Shou Yang , Wei-Der Lee , Jia-Fu Pan
IPC分类号： B01J31/18 , B01J31/22 , C07C45/72 , C07C67/343 , C07C235/40 , C07C251/18 , C07C251/88 , C07C311/10 , C07D275/06 , C07F5/00 , C07C69/74 , C07C233/57
CPC分类号： C07C251/18 , B01J31/1805 , B01J31/223 , B01J31/2243 , B01J31/2295 , B01J2231/324 , B01J2231/326 , B01J2231/328 , B01J2231/341 , B01J2231/72 , B01J2231/74 , B01J2531/0266 , B01J2531/37 , B01J2531/38 , B01J2540/34 , C07B2200/07 , C07C45/72 , C07C67/343 , C07C235/40 , C07C251/88 , C07C311/10 , C07C2601/14 , C07C2602/42 , C07D275/06 , C07F5/003 , C07C69/732 , C07C69/734
摘要： Chiral chelating agents and chiral catalysts, which are formed from the chiral chelating agents and metal, are described. One chiral chelating agent has a general formula (1) as illustrated below: wherein R represents H, methyl, ethyl, a primary, secondary or tertiary straight, branched or cyclic alkyl group having 3-7 carbon atoms, a heterocyclic or aromatic group, an aromatic group substituted at the 2-, 3- or 4-position, an aromatic-like group, or a naphthyl or naphthyl-derived group, and n is an integer between 0 and 4.
摘要翻译：描述了由手性螯合剂和金属形成的手性螯合剂和手性催化剂。一种手性螯合剂具有如下所示的通式（1）：其中R表示H，甲基，乙基，具有3-7个碳原子的伯，仲或叔直链，支链或环状烷基，杂环或芳族基团，在2-，3-或4-位取代的芳族基团，芳香族基团或萘基或萘基衍生基团，n为0至4的整数。

9. 发明授权

US3878258A Preparation of cyclododecatriene 失效
标题翻译：环十二碳三烯的制备
公开(公告)号：US3878258A
公开(公告)日：1975-04-15
申请号：US48781274
申请日：1974-07-11
申请人： DU PONT
发明人： RAPOPORT MORRIS , SULLIVAN DAVID LEE
IPC分类号： B01J31/00 , B01J31/38 , B01J37/22 , C07B61/00 , C07C1/00 , C07C2/46 , C07C13/277 , C07C67/00 , C07C3/00
CPC分类号： B01J31/0207 , B01J27/10 , B01J31/0208 , B01J31/0212 , B01J31/04 , B01J31/143 , B01J31/2213 , B01J31/38 , B01J37/22 , B01J2231/328 , C07C2/465 , C07C2527/135 , C07C2531/02 , C07C2531/14 , C07C2601/20 , C07C13/277
摘要： Process for preparing 1,5,9-cyclododecatriene by contacting butadiene with a catalyst system resulting from the mixing of an aluminum composition of the structure Z(2.5 3.5)Al2Cl(3.5 2.5) wherein Z is selected from the group consisting of alkyl radicals containing from 2 to 4 carbon atoms and the phenyl radical; a titanium compound of the formula TiA4 wherein A is selected from the class consisting of Cl, Br, I and OR wherein R is an organic radical of from 1 to 20 carbon atoms; and a promoter for the catalyst system wherein the promoter is selected from the group consisting of water, oxygen and oxygen-containing organic compounds, at a temperature in the range of 20* to 120*C. and at a pressure of 0.5 to 50 atmospheres and recovering cyclododecatriene-1,5,9 along with by-products 1,5-cyclooctadiene and 4-vinylcyclohexene, the improvement which comprises adding an iodide-containing composition or compound selected from the group consisting of Z(2.5 3.5)Al2I(3.5 2.5), Z2AlI, ZAlI2, and I2 wherein Z is selected from the group consisting of alkyl radicals containing from 2 to 4 carbon atoms and the phenyl radical, the molar ratio of iodine or iodide-containing composition or compound to aluminum composition being in the range of 0.05:10 to 5:10.
摘要翻译：通过使丁二烯与由Z（2.5-3.5）Al 2 Cl（3.5-2.5）结构的铝组合物混合而得到的催化剂体系制备1,5,9-环十二碳三烯的方法，其中Z选自烷基含有2至4个碳原子的基团和苯基; 式TiA 4的钛化合物，其中A选自Cl，Br，I和OR，其中R是1至20个碳原子的有机基团; 和催化剂体系的助催化剂，其中助催化剂选自水，氧和含氧有机化合物，温度范围为20-120℃，压力为0.5至50大气压并且与副产物1,5-环辛二烯和4-乙烯基环己烯一起回收环十二碳三烯-1,5,9，其改进包括加入选自Z（2.5-3.5）Al 2 I的含碘化物的组合物或化合物 3.5-2.5），Z2AlI，ZAlI2和I2，其中Z选自含有2至4个碳原子的烷基和苯基，碘或含碘化合物或化合物与铝组成的摩尔比为在0.05：10至5:10的范围内。

10. 发明授权

US3634528A Process for preparing 1 5 9-cyclo-dodecatrienes 失效
标题翻译：制备1 5个9-环十二烷基醚的方法
公开(公告)号：US3634528A
公开(公告)日：1972-01-11
申请号：US84742469
申请日：1969-08-04
申请人： TOA GOSEI CHEM IND
发明人： ITAKURA JO , ITO HIROO
IPC分类号： B01J31/14 , B01J31/22 , C07C2/46 , C08F4/64 , C07C13/00 , C07C3/10
CPC分类号： B01J31/2234 , B01J31/143 , B01J2231/328 , B01J2531/46 , C07C2/465 , C07C2531/14 , C07C2531/22 , C07C2601/20 , C07C13/277
摘要： 1,5,9-CYCLODODECATRIENES ARE PREPARED BY SUBJECTING CONJUGATED DIOLEFINS TO CYCLIZATION TRIMERIZATION IN THE PRESENCE OF A CATALYST COMPOSITION OBTAINED BY MIXING AN ORGANIC GROUP-CONTAINING CHLOROTITANIUM COMPOUND WITH AN ALKYLALUMIMUM CHLORIDE.

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