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1. 发明授权

US11236078B2 Heterocyclic inhibitors of the sodium channel 有权
公开(公告)号：US11236078B2
公开(公告)日：2022-02-01
申请号：US16579803
申请日：2019-09-23
申请人： Mark G. DeGiacomo
发明人： Glenn F. Short, III , Donna L. Romero , Margaret S. Lee
IPC分类号： C07D417/12 , C07C311/51 , C07C235/40 , C07C237/24 , C07D237/20 , C07D239/42 , C07D207/16 , C07D285/08 , C07C311/04 , C07C233/66 , C07C233/58 , C07C311/10 , C07D277/52 , C07D307/24
摘要： The invention relates to compounds useful in treating conditions associated with voltage-gated ion channel function, particularly conditions associated with sodium channel activity. More specifically, the invention concerns heterocyclic compounds (e.g., compounds according to any of Formulas (I)-(III) or Compounds (1)-(65) of Table 1) that are that are useful in treatment of conditions such as epilepsy, cancer, pain, migraine, Parkinson's Disease, mood disorders, schizophrenia, psychosis, tinnitus, amyotropic lateral sclerosis, glaucoma, ischaemia, spasticity disorders, obsessive compulsive disorder, restless leg syndrome and Tourette syndrome.

2. 发明授权

US11091428B2 Antiviral compounds 有权
公开(公告)号：US11091428B2
公开(公告)日：2021-08-17
申请号：US16333159
申请日：2017-09-12
申请人： HAPLOGEN GMBH
发明人： Wolfgang Fischl , Mark Whittaker , Christopher John Yarnold , Jean-Francois Pons , Mark Anthony Kerry , Patricia Leonie Amouzegh , Inaki Morao , Peter Neville Ingram , Ewa Iwona Chudyk
IPC分类号： C07D207/27 , C07D207/26 , C07D261/18 , C07D211/26 , C07D405/06 , C07D309/04 , C07D309/14 , C07D403/06 , C07D403/12 , C07D307/14 , C07D215/14 , C07D233/64 , C07D401/12 , C07D417/12 , C07D205/04 , C07D241/12 , C07C311/10 , C07C311/13 , C07C311/14 , C07C311/06 , C07C311/03 , C07C237/22 , C07C235/74 , C07C271/24 , C07C311/19 , C07C311/29 , A61P31/14
摘要： The present invention relates to novel compounds of general formula (I) wherein the groups X, and R1 to R4 have the meanings given in the description and claims, process for preparing these compounds and their use as for treating, preventing or ameliorating viral infections and their use for treating, preventing or ameliorating diseases which are associated with PLA2G16.

3. 发明授权

US10752644B2 Modulators of Sestrin-GATOR2 interaction and uses thereof 有权
公开(公告)号：US10752644B2
公开(公告)日：2020-08-25
申请号：US16515788
申请日：2019-07-18
申请人： Navitor Pharmaceuticals, Inc.
发明人： Kristina Michelle Fetalvero , Sridhar Narayan , David John O'Neill , Eddine Saiah , Shomit Sengupta
IPC分类号： C07F7/08 , A61K38/00 , A61K31/198 , A61K31/223 , C07C261/04 , C07C311/13 , C07C311/19 , C07C229/28 , C07C233/40 , C07C233/83 , C07C237/06 , C07C237/12 , C07C237/30 , A61K31/197 , A61K31/221 , A61K31/275 , A61K31/341 , A61K31/41 , A61K31/695 , A61K45/06 , C07C229/12 , C07C229/14 , C07C229/18 , C07C229/20 , C07C233/07 , C07C233/47 , C07C233/49 , C07C233/51 , C07C233/63 , C07C255/61 , C07C311/06 , C07C311/10 , C07C311/14 , C07D257/04 , C07D307/33 , C07C311/51
摘要： The present invention provides compounds, compositions thereof, and methods of using the same.

4. 发明授权

US10464889B2 Sulfonylaminobenzamide compounds as anthelmintics 有权
公开(公告)号：US10464889B2
公开(公告)日：2019-11-05
申请号：US16037396
申请日：2018-07-17
申请人： ELANCO Tiergesundheit AG
发明人： Noelle Gauvry , Chouaib Tahtaoui
IPC分类号： C07C311/08 , C07D277/62 , C07D213/61 , C07D213/84 , C07D231/12 , C07D231/20 , C07D231/56 , C07C307/10 , C07D333/24 , C07D333/28 , C07C311/10 , C07C311/14 , C07C311/21 , C07C311/29 , C07D239/26 , C07D239/30 , C07D239/34 , C07D249/12 , C07D277/30 , C07D277/64 , C07D279/12 , C07D295/155 , C07D295/185 , C07D295/26 , C07D213/26 , C07D213/64 , C07D213/65 , C07C311/09 , C07C235/56 , C07F5/02 , C07F7/08 , C07D209/08 , C07D213/56 , C07D215/06 , C07D237/26 , C07D249/08 , C07D263/50 , C07D275/03 , C07D277/46 , C07D277/54 , C07D277/56 , C07D277/60 , C07D285/135 , C07D309/06 , C07D317/66 , C07D333/78 , C07D487/04
摘要： The present invention relates to a new compound of formula (I) wherein the variables have the meaning as indicated in the claims; or an enantiomer or salt thereof. The compounds of formula (I) are useful in the control of parasites, in particular endoparasites, in and on vertebrates.

5. 发明授权

US10414782B2 Modulators of sestrin-GATOR2 interaction and uses thereof 有权
公开(公告)号：US10414782B2
公开(公告)日：2019-09-17
申请号：US15974734
申请日：2018-05-09
申请人： Navitor Pharmaceuticals, Inc.
发明人： Kristina Michelle Fetalvero , Sridhar Narayan , David John O'Neill , Eddine Saiah , Shomit Sengupta
IPC分类号： C07F7/08 , A61K31/197 , A61K31/198 , A61K38/00 , C07D307/33 , A61K31/275 , A61K31/41 , A61K31/695 , A61K45/06 , C07C229/12 , C07C229/18 , C07C229/20 , C07C233/49 , C07C233/63 , C07C311/06 , C07C311/14 , C07D257/04 , C07C237/30 , C07C237/12 , C07C237/06 , C07C233/83 , C07C233/40 , C07C229/28 , C07C311/51 , C07C311/19 , C07C311/13 , C07C261/04 , A61K31/221 , A61K31/341 , C07C229/14 , C07C233/07 , C07C233/47 , C07C233/51 , C07C255/61 , C07C311/10 , A61K31/223
摘要： The present invention provides compounds, compositions thereof, and methods of using the same.

6. 发明授权

US08865893B2 Method for preparing 2-morpholinoisobornane-10-thiol and intermediates formed therein 有权
标题翻译：制备2-吗啉代异硼烷-10-硫醇的方法及其中形成的中间体
公开(公告)号：US08865893B2
公开(公告)日：2014-10-21
申请号：US12901117
申请日：2010-10-08
申请人： Biing-Jiun Uang , Yu-Han Tsao , Ping-Yu Wu
发明人： Biing-Jiun Uang , Yu-Han Tsao , Ping-Yu Wu
IPC分类号： C07D265/30 , C07C311/10 , C07D295/26 , C07C323/26 , C07D295/096
CPC分类号： C07D295/096 , C07C311/10 , C07C323/26 , C07C2602/42 , C07D295/26
摘要： A method for preparing 2-morpholinoisobornane-10-thiol is disclosed, which has simplified steps and avoids the use of Na metal. Accordingly, it is advantageous to apply the method in a mass production.
摘要翻译：公开了制备2-吗啉代异硼烷-10-硫醇的方法，其具有简化的步骤并避免使用Na金属。因此，在大规模生产中应用该方法是有利的。

8. 发明授权

US07816397B2 Phenylcarboxylic acid derivatives and use thereof for the treatment of diabetes 有权
标题翻译：苯基羧酸衍生物及其用于治疗糖尿病的用途
公开(公告)号：US07816397B2
公开(公告)日：2010-10-19
申请号：US11630892
申请日：2005-06-01
申请人： Gérard Moinet , Gérard Botton , Micheline Kergoat
发明人： Gérard Moinet , Gérard Botton , Micheline Kergoat
IPC分类号： C07C311/21 , C07C311/46 , C07C311/08 , C07C311/29 , C07C311/13 , C07C311/44 , C07C311/10 , C07D333/34 , A61P3/04 , A61P3/10
CPC分类号： C07C311/21 , C07C233/25 , C07C233/26 , C07C233/27 , C07C233/29 , C07C233/48 , C07C233/54 , C07C233/55 , C07C233/63 , C07C233/75 , C07C233/81 , C07C235/16 , C07C235/24 , C07C235/38 , C07C235/48 , C07C235/56 , C07C237/42 , C07C311/08 , C07C311/10 , C07C311/13 , C07C311/29 , C07C311/44 , C07C311/46 , C07C2601/02 , C07C2601/08 , C07C2601/14 , C07C2602/42 , C07D215/36 , C07D277/46 , C07D307/68 , C07D333/34 , C07D333/38 , C07D333/62
摘要： The invention relates to compounds of general formula (1): in which R1, R2, R3, R4, R5, A, B, D and E are as defined in Claim 1, and also to the preparation process therefor and the therapeutic use thereof. These compounds can be used in the treatment of pathologies associated with hyperglycaemia.
摘要翻译：本发明涉及通式（1）的化合物：其中R 1，R 2，R 3，R 4，R 5，A，B，D和E如权利要求1所定义，以及其制备方法及其治疗用途。这些化合物可用于治疗与高血糖相关的病理学。

9. 发明申请

US20100144762A1 NOVEL SULFONAMIDES AS L-CPT1 INHIBITORS 审中-公开
标题翻译：新型磺酰胺作为L-CPT1抑制剂
公开(公告)号：US20100144762A1
公开(公告)日：2010-06-10
申请号：US12701769
申请日：2010-02-08
申请人： Konrad Bleicher , Simona Maria Ceccarelli , Odile Chomienne , Patrizio Mattei , Tanja Schulz-Gasch , Christoph Martin Stahl
发明人： Konrad Bleicher , Simona Maria Ceccarelli , Odile Chomienne , Patrizio Mattei , Tanja Schulz-Gasch , Christoph Martin Stahl
IPC分类号： A61K31/506 , C07C317/06 , C07C311/10 , C07D261/06 , C07D401/04 , C07D409/04 , A61K31/195 , A61K31/24 , A61K31/42 , A61K31/40 , A61P9/10 , A61P3/10 , A61P9/12
CPC分类号： C07D413/04 , C07C311/21 , C07C311/29 , C07D257/04 , C07D271/07 , C07D291/04 , C07D409/04
摘要： The invention is concerned with novel sulfonamide derivatives of formula (I) wherein R2, R3, R4, A, X, Y1, Y2, Y3, Y4 and Z1 are as defined in the description and in the claims, as well as physiologically acceptable salts and esters thereof. These compounds inhibit L-CPT1 and can be used as medicaments.
摘要翻译：本发明涉及式（I）的新型磺酰胺衍生物，其中R2，R3，R4，A，X，Y1，Y2，Y3，Y4和Z1如说明书和权利要求书中所定义，以及生理上可接受的盐及其酯。这些化合物抑制L-CPT1，可用作药物。

10. 发明授权

US6046236A Carbocyclic sulfonamides 失效
标题翻译：碳环磺酰胺
公开(公告)号：US6046236A
公开(公告)日：2000-04-04
申请号：US848833
申请日：1997-05-05
申请人： Nobuyuki Hamanaka , Tsumoru Miyamoto
发明人： Nobuyuki Hamanaka , Tsumoru Miyamoto
IPC分类号： A61K31/557 , A61P43/00 , C07C303/38 , C07C303/40 , C07C311/07 , C07C311/10 , C07C311/11 , C07C311/12 , C07C311/13 , C07C311/14 , C07C311/19 , C07C311/20 , C07C311/27 , C07C311/29 , C07D493/08 , A01N37/12 , A01N37/44 , A61K31/24
CPC分类号： C07C311/19 , C07C311/07 , C07C311/10 , C07C311/11 , C07C311/13 , C07C311/14 , C07C311/20 , C07C311/27 , C07C311/29
摘要： (1) Prostaglandin (PG) E.sub.2 antagonist or agonist containing carbocyclic sulfonamides represented by the compound of the formula (I): ##STR1## cyclodextrin clathrates thereof, non-toxic salts thereof as active ingredient,(2) carbocyclic sulfonamides represented by the compound of the formula (II): ##STR2## cyclodextrin clathrates thereof, non-toxic salts thereof, (3) process for the preparation of the compound represented by the compound of the formula (II) described hereinbefore,(4) PGE.sub.2 antagonist or agonist containing the compound represented by the compound of the formula (II) as active ingredient.The compounds represented by the compounds of the formula (I) and (II) can be adapted to medicines which possess an inhibitory effect of uterine contraction, an analgetic action, an inhibitory effect of digestive peristalsis, a sleep-inducing effect as PGE.sub.2 antagonists, and an uterine contractile activity, a promoting effect of digestive peristalsis, a suppressive effect of gastric acid secretion, a hypotensive activity as PGE.sub.2 agonists, because they bind onto PGE.sub.2 receptor and have an activity of antagonist or agonist against the action thereof.
摘要翻译：（1）由式（I）化合物表示的前列腺素（PG）E2拮抗剂或含有碳环磺酰胺的激动剂：其环糊精包合物，其无毒性盐作为活性成分，（2）由下式表示的碳环磺酰胺（II）：其环糊精包合物，其无毒盐，（3）由上述式（II）化合物表示的化合物的制备方法，（4）PGE2拮抗剂或含有由式（II）的化合物作为活性成分。由式（I）和（II）化合物表示的化合物可适用于具有子宫收缩抑制作用，止痛作用，消化性蠕动抑制作用，睡眠诱导作用PGE2拮抗剂的药物，因为它们结合PGE2受体并且具有针对其作用的拮抗剂或激动剂的活性，因此其作为PGE2激动剂具有低血压活性，作为消化道蠕动的促进作用，胃酸分泌的抑制作用。

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