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1. 发明申请

US20050037424A1 Selectable length linear microarrays 审中-公开
标题翻译：可选长度线性微阵列
公开(公告)号：US20050037424A1
公开(公告)日：2005-02-17
申请号：US10640801
申请日：2003-08-13
申请人： Carol Schembri
发明人： Carol Schembri
IPC分类号： B01J19/00 , C40B40/06 , C40B40/10 , G01N33/53 , G01N33/543
CPC分类号： G01N33/54313 , B01J19/0046 , B01J2219/00513 , B01J2219/00518 , B01J2219/0052 , B01J2219/00533 , B01J2219/0054 , B01J2219/00576 , B01J2219/00657 , B01J2219/00702 , B01J2219/00722 , B01J2219/00725 , C40B40/06 , C40B40/10
摘要： Devices are disclosed comprising a substrate in the form of an elongated web having on a surface thereof a linear array of chemical compounds and markings on the elongated web indicating segments of the linear array comprising groups of one or more chemical compounds of the linear array. In certain embodiments the devices comprise a severable housing, a linear array of features within the housing, and markings on the housing indicating segments of the linear array comprising groups of one or more features of the linear array. Usually, the housing is an enclosed microchannel. The device may be employed for conducting an assay for one or more analytes suspected of being in a sample.
摘要翻译：公开的装置包括呈细长网状形式的基底，在其表面上具有在细长网上的化学化合物和标记的线性阵列，指示线性阵列的片段包含线性阵列的一种或多种化学化合物的组。在某些实施例中，装置包括可分离的壳体，壳体内的特征的线性阵列，以及壳体上的标记，指示线性阵列的线段阵列包括线性阵列的一个或多个特征的组。通常，外壳是封闭的微通道。该装置可用于对疑似在样品中的一种或多种分析物进行测定。

2. 发明申请

US20040248144A1 Arrays and methods of use 审中-公开
标题翻译：数组和使用方法
公开(公告)号：US20040248144A1
公开(公告)日：2004-12-09
申请号：US10664000
申请日：2003-09-16
发明人： Kalim Mir
IPC分类号： C12Q001/68 , G01N033/53 , C12M001/34 , B05D003/00
CPC分类号： C12N15/1065 , B01J2219/00497 , B01J2219/005 , B01J2219/00513 , B01J2219/0052 , B01J2219/00524 , B01J2219/00554 , B01J2219/00572 , B01J2219/00576 , B01J2219/00596 , B01J2219/00605 , B01J2219/0061 , B01J2219/00612 , B01J2219/00619 , B01J2219/00621 , B01J2219/00626 , B01J2219/0063 , B01J2219/00637 , B01J2219/00641 , B01J2219/00653 , B01J2219/00659 , B01J2219/0072 , B82Y10/00 , B82Y30/00 , C12Q1/6818 , C12Q1/6837 , C12Q1/6874 , C12Q1/6876 , C12Q2600/156 , C12Q2600/158 , G01N33/582 , C12Q2523/303 , C12Q2565/507 , C12Q2565/629
摘要： Methods are provided for producing a molecular array comprising a plurality of molecules immobilised to a solid substrate at a density which allows individual immobilised molecules to be individually resolved, wherein each individual molecule in the array is spatially addressable and the identity of each molecule is known or determined prior to immobilisation. The use of spatially addressable lowdensity molecular arrays in single molecule detection and analysis techniques is also provided. Novel assays and methods are also provided.
摘要翻译：提供了用于产生包含固定在固体底物上的多个分子的分子阵列，其密度以允许各个固定化分子单独分辨的密度，其中阵列中的每个单独的分子是空间可寻址的，并且每个分子的身份是已知的，或者在固定前确定。还提供了在单分子检测和分析技术中使用空间可寻址的低密度分子阵列。还提供了新的测定和方法。

3. 发明申请

US20040209376A1 Assemblies of differentiable segmented particles 审中-公开
标题翻译：可微分段颗粒的组件
公开(公告)号：US20040209376A1
公开(公告)日：2004-10-21
申请号：US10840604
申请日：2004-05-06
申请人： SURROMED, INC.
发明人： Michael J. Natan , Thomas E. Mallouk
IPC分类号： G01N037/00
CPC分类号： G01N33/54346 , B01J13/0047 , B01J13/0091 , B01J19/0046 , B01J2219/005 , B01J2219/00502 , B01J2219/00513 , B01J2219/00545 , B01J2219/00547 , B01J2219/00554 , B01J2219/00596 , B01J2219/00657 , B01J2219/0072 , B01J2219/00722 , B01L3/545 , B22F1/004 , B22F2999/00 , B82B1/00 , B82Y25/00 , B82Y30/00 , C25D1/04 , C40B40/06 , C40B70/00 , H01F1/0081 , Y10T436/13 , B22F2207/01
摘要： Freestanding particles comprising a plurality of segments, wherein the particle length is from 10 nm to 50 nullm and the particle width is form 5 nm to 50 nullm.
摘要翻译：包含多个片段的独立粒子，其中粒子长度为10nm至50μm，粒子宽度为5nm至50μm。

4. 发明申请

US20040142338A1 Method for producing an array for detecting constituents from a biological sample 失效
标题翻译：用于生成用于检测来自生物样品的成分的阵列的方法
公开(公告)号：US20040142338A1
公开(公告)日：2004-07-22
申请号：US10469167
申请日：2004-03-15
发明人： Werner Lehmann
IPC分类号： C12Q001/68 , G01N033/53 , B05D003/00
CPC分类号： B82Y30/00 , B01J19/0046 , B01J2219/00497 , B01J2219/00513 , B01J2219/00527 , B01J2219/00585 , B01J2219/00596 , B01J2219/00605 , B01J2219/0061 , B01J2219/00612 , B01J2219/00621 , B01J2219/00626 , B01J2219/0063 , B01J2219/00637 , B01J2219/00644 , B01J2219/00659 , B01J2219/00673 , B01J2219/00677 , B01J2219/0072 , B01J2219/00722 , B01J2219/00725 , B01J2219/0074 , B01J2219/00743 , C40B40/06 , C40B40/10 , G01N33/5436
摘要： The invention suggests a method of producing an array for the detection of components from a biological sample, wherein the detection molecules are immobilized on one or more supports, said support(s) is/are embedded and subjected to curing, the support is separated into sections, and the sections are applied on another support.
摘要翻译：本发明提出了一种制备用于检测来自生物样品的组分的阵列的方法，其中将检测分子固定在一个或多个载体上，所述载体被嵌入并固化，载体被分离成部分，部分应用于另一个支持。

5. 发明申请

US20020182117A1 Analytical biochemistry system with robotically carried bioarray 审中-公开
标题翻译：分析生物化学系统与机器人携带的生物阵列
公开(公告)号：US20020182117A1
公开(公告)日：2002-12-05
申请号：US10200720
申请日：2002-07-22
发明人： Peter J. Coassin , Jack D. Mc Neal , David B. Helphrey
IPC分类号： B01L003/02 , G01N035/00
CPC分类号： G01N35/0099 , B01J19/0046 , B01J2219/00292 , B01J2219/00315 , B01J2219/00378 , B01J2219/0043 , B01J2219/00432 , B01J2219/00513 , B01J2219/00527 , B01J2219/00585 , B01J2219/0059 , B01J2219/00596 , B01J2219/00605 , B01J2219/0061 , B01J2219/00612 , B01J2219/00626 , B01J2219/0063 , B01J2219/00657 , B01J2219/00659 , B01J2219/00691 , B01J2219/00711 , B01J2219/00722 , B01L3/0275 , B01L3/508 , B01L3/5085 , B01L2300/0636 , B82Y30/00 , C40B40/06 , C40B60/14 , G01N21/6452 , G01N35/00029 , G01N2035/00118 , G01N2035/00158 , G01N2035/1055 , G01N2035/1062 , Y10T436/11 , Y10T436/112499 , Y10T436/25
摘要： An analytical biochemistry system featuring a substrate with reactants immobilized thereon at fixed, known locations, a holder supporting the substrate and a manipulator for transporting the holder to a fixed sample and to an inspection station. The reactants are binding agents for a target biomolecule in a sample which forms a bound substance having a detectable characteristic. The holder may be a standard pipettor, optionally carried by a robot arm or hand as the manipulator to contact the sample for detection of the presence of target biomolecules within the sample. In one embodiment, the holder is a pipette tip within which the substrate is housed, or it may be a pipette adapter which bears the substrate and fits within the sample wells of a standard microtiter plate. After appropriate incubation, the substrate and holder may be moved from contact with the sample, and the substrate may be exposed to any necessary development steps before being moved by the manipulator to a location for probing, such as by a beam. Probing of the substrate is performed to identify binding or complexing of target biomolecules of the sample with the reactants immobilized on the substrate, and may be accomplished via fluorescence detection, light scattering, autoradiography, or some other detection method.
摘要翻译：一种分析生物化学系统，其特征在于在固定的已知位置处固定有反应物的基底，支撑基底的保持器和用于将保持器运送到固定样品的操纵器和检查站。反应物是样品中靶生物分子的结合剂，其形成具有可检测特征的结合物质。保持器可以是标准移液器，可选地由机器人手臂或手携带作为操纵器以接触样品以检测样品内目标生物分子的存在。在一个实施例中，保持器是其中容纳基底的移液管尖端，或者其可以是承载基底并且配合在标准微量滴定板的样品孔内的移液管适配器。在适当的温育之后，衬底和保持器可以与样品接触移动，并且衬底可以在被操纵器移动到用于探测的位置（例如通过光束）之前暴露于任何必要的显影步骤。进行底物的检测以鉴定样品的目标生物分子与固定在底物上的反应物的结合或络合，并且可以通过荧光检测，光散射，放射自显影或其它检测方法来实现。

6. 发明授权

US6146593A High density array fabrication and readout method for a fiber optic biosensor 失效
公开(公告)号：US6146593A
公开(公告)日：2000-11-14
申请号：US899000
申请日：1997-07-24
申请人： Daniel Pinkel , Joe Gray , Donna G. Albertson
发明人： Daniel Pinkel , Joe Gray , Donna G. Albertson
IPC分类号： C12Q1/68 , G01N21/77 , G01N33/543 , G02B6/04 , G01N15/06 , C07H21/02 , C07H21/04
CPC分类号： G01N21/6452 , C12Q1/6825 , G01N21/648 , G01N21/7703 , G01N33/54373 , B01J2219/00513 , B01J2219/00524 , B01J2219/00605 , B01J2219/00612 , B01J2219/00621 , B01J2219/00626 , B01J2219/00659 , G01N2201/0833 , G02B6/04
摘要： The invention relates to the fabrication and use of biosensors comprising a plurality of optical fibers each fiber having attached to its "sensor end" biological "binding partners" (molecules that specifically bind other molecules to form a binding complex such as antibody-antigen, lectin-carbohydrate, nucleic acid-nucleic acid, biotin-avidin, etc.). The biosensor preferably bears two or more different species of biological binding partner. The sensor is fabricated by providing a plurality of groups of optical fibers. Each group is treated as a batch to attach a different species of biological binding partner to the sensor ends of the fibers comprising that bundle. Each fiber, or group of fibers within a bundle, may be uniquely identified so that the fibers, or group of fibers, when later combined in an array of different fibers, can be discretely addressed. Fibers or groups of fibers are then selected and discretely separated from different bundles. The discretely separated fibers are then combined at their sensor ends to produce a high density sensor array of fibers capable of assaying simultaneously the binding of components of a test sample to the various binding partners on the different fibers of the sensor array. The transmission ends of the optical fibers are then discretely addressed to detectors--such as a multiplicity of optical sensors. An optical signal, produced by binding of the binding partner to its substrate to form a binding complex, is conducted through the optical fiber or group of fibers to a detector for each discrete test. By examining the addressed transmission ends of fibers, or groups of fibers, the addressed transmission ends can transmit unique patterns assisting in rapid sample identification by the sensor.

7. 发明授权

US5847105A Methods for performing multiple sequential reactions on a matrix 失效
标题翻译：在矩阵上执行多个连续反应的方法
公开(公告)号：US5847105A
公开(公告)日：1998-12-08
申请号：US910727
申请日：1997-08-13
申请人： John D. Baldeschwieler , Ronald C. Gamble , Thomas P. Theriault
发明人： John D. Baldeschwieler , Ronald C. Gamble , Thomas P. Theriault
IPC分类号： C12Q1/68 , B01J19/00 , C07H21/00 , C07K1/04 , C40B40/06 , C40B40/10 , C40B50/14 , C40B60/14 , G01N33/53 , G01N37/00
CPC分类号： B82Y30/00 , B01J19/0046 , C07H21/00 , C07K1/042 , C07K1/047 , B01J2219/00369 , B01J2219/00378 , B01J2219/00475 , B01J2219/00513 , B01J2219/00527 , B01J2219/00585 , B01J2219/0059 , B01J2219/00596 , B01J2219/00605 , B01J2219/0061 , B01J2219/00612 , B01J2219/00621 , B01J2219/00626 , B01J2219/00637 , B01J2219/00641 , B01J2219/00659 , B01J2219/00675 , B01J2219/0068 , B01J2219/00722 , B01J2219/00725 , C40B40/06 , C40B40/10 , C40B50/14 , C40B60/14
摘要： A method and apparatus are provided for preparing a substrate upon which is located microdrop-sized loci at which chemical compounds are synthesized or diagnostic tests are conducted. The loci are formed by applying microdrops from a dispenser from which a microdrop is pulse fed onto the surface of the substrate.
摘要翻译：提供了一种用于制备基底的方法和装置，其上定位有微小尺寸的位置，在该位置处合成化合物或进行诊断测试。通过将微滴从脉冲馈送到基底表面上的分配器施加微滴而形成位点。

8. 发明授权

US5690894A High density array fabrication and readout method for a fiber optic biosensor 失效
标题翻译：用于光纤生物传感器的高密度阵列制造和读出方法
公开(公告)号：US5690894A
公开(公告)日：1997-11-25
申请号：US448043
申请日：1995-05-23
申请人： Daniel Pinkel , Joe Gray
发明人： Daniel Pinkel , Joe Gray
IPC分类号： C12Q1/68 , G01N21/77 , G01N33/543 , G02B6/04 , G01N15/06 , C03B37/15 , G01N21/29
CPC分类号： G01N21/6452 , C12Q1/6825 , G01N21/648 , G01N21/7703 , G01N33/54373 , B01J2219/00513 , B01J2219/00524 , B01J2219/00605 , B01J2219/00612 , B01J2219/00621 , B01J2219/00626 , B01J2219/00659 , G01N2201/0833 , G02B6/04
摘要： The invention relates to the fabrication and use of biosensors comprising a plurality of optical fibers each fiber having attached to its "sensor end" biological "binding partners" (molecules that specifically bind other molecules to form a binding complex such as antibody-antigen, lectin-carbohydrate, nucleic acid-nucleic acid, biotin-avidin, etc.). The biosensor preferably bears two or more different species of biological binding partner. The sensor is fabricated by providing a plurality of groups of optical fibers. Each group is treated as a batch to attach a different species of biological binding partner to the sensor ends of the fibers comprising that bundle. Each fiber, or group of fibers within a bundle, may be uniquely identified so that the fibers, or group of fibers, when later combined in an array of different fibers, can be discretely addressed. Fibers or groups of fibers are then selected and discretely separated from different bundles. The discretely separated fibers are then combined at their sensor ends to produce a high density sensor array of fibers capable of assaying simultaneously the binding of components of a test sample to the various binding partners on the different fibers of the sensor array. The transmission ends of the optical fibers are then discretely addressed to detectors--such as a multiplicity of optical sensors. An optical signal, produced by binding of the binding partner to its substrate to form a binding complex, is conducted through the optical fiber or group of fibers to a detector for each discrete test. By examining the addressed transmission ends of fibers, or groups of fibers, the addressed transmission ends can transmit unique patterns assisting in rapid sample identification by the sensor.
摘要翻译：本发明涉及生物传感器的制造和使用，该生物传感器包括多个光纤，每个光纤各自连接到其“传感器端”生物“结合伙伴”（特异性结合其他分子以形成结合复合物如抗体抗原，凝集素碳水化合物，核酸 - 核酸，生物素 - 抗生物素蛋白等）。生物传感器优选具有两种或更多种不同种类的生物结合配偶体。通过提供多组光纤来制造传感器。将每组作为批次处理以将不同种类的生物结合配偶体附着到包含该束的纤维的传感器末端。束内的每个纤维或一组纤维可以被唯一地识别，使得当稍后组合在不同纤维阵列中时，纤维或纤维组可以离散地寻址。然后选择纤维或纤维组，并从不同的束离散分离。然后将离散分离的纤维在其传感器端组合以产生能够同时测定测试样品的组分与传感器阵列的不同纤维上的各种结合配偶体的结合的高密度纤维传感器阵列。然后将光纤的传输端离散地寻址到诸如多个光学传感器的检测器。通过将结合配偶体与其底物结合以形成结合复合物产生的光学信号通过光纤或纤维组进行到用于每个离散测试的检测器。通过检查光纤或光纤组的所寻址的传输端，所寻址的传输结束可以传输有助于传感器快速采样识别的独特模式。

9. 发明申请

US20160160272A1 Arrays and Methods of Use 审中-公开
标题翻译：数组和使用方法
公开(公告)号：US20160160272A1
公开(公告)日：2016-06-09
申请号：US15008100
申请日：2016-01-27
申请人： Singular Bio, Inc.
发明人： Kalim Mir
IPC分类号： C12Q1/68
CPC分类号： C12N15/1065 , B01J2219/00497 , B01J2219/005 , B01J2219/00513 , B01J2219/0052 , B01J2219/00524 , B01J2219/00554 , B01J2219/00572 , B01J2219/00576 , B01J2219/00596 , B01J2219/00605 , B01J2219/0061 , B01J2219/00612 , B01J2219/00619 , B01J2219/00621 , B01J2219/00626 , B01J2219/0063 , B01J2219/00637 , B01J2219/00641 , B01J2219/00653 , B01J2219/00659 , B01J2219/0072 , B82Y10/00 , B82Y30/00 , C12Q1/6818 , C12Q1/6837 , C12Q1/6874 , C12Q1/6876 , C12Q2600/156 , C12Q2600/158 , G01N33/582 , C12Q2523/303 , C12Q2565/507 , C12Q2565/629
摘要： Methods are provided for producing a molecular array comprising a plurality of molecules immobilised to a solid substrate at a density which allows individual immobilised molecules to be individually resolved, wherein each individual molecule in the array is spatially addressable and the identity of each molecule is known or determined prior to immobilization. The use of spatially addressable low density molecular arrays in single molecule detection and analysis techniques is also provided. Novel assays and methods are also provided.
摘要翻译：提供了用于产生包含固定在固体底物上的多个分子的分子阵列，其密度以允许各个固定化分子单独分辨的密度，其中阵列中的每个单独的分子是空间可寻址的，并且每个分子的身份是已知的，或者在固定前测定。还提供了在单分子检测和分析技术中使用空间可寻址的低密度分子阵列。还提供了新的测定和方法。

10. 发明申请

US20150337296A1 Arrays and Methods of Use 有权
标题翻译：数组和使用方法
公开(公告)号：US20150337296A1
公开(公告)日：2015-11-26
申请号：US14806096
申请日：2015-07-22
申请人： SINGULAR BIO, INC.
发明人： Kalim Mir
IPC分类号： C12N15/10 , C12Q1/68
CPC分类号： C12N15/1065 , B01J2219/00497 , B01J2219/005 , B01J2219/00513 , B01J2219/0052 , B01J2219/00524 , B01J2219/00554 , B01J2219/00572 , B01J2219/00576 , B01J2219/00596 , B01J2219/00605 , B01J2219/0061 , B01J2219/00612 , B01J2219/00619 , B01J2219/00621 , B01J2219/00626 , B01J2219/0063 , B01J2219/00637 , B01J2219/00641 , B01J2219/00653 , B01J2219/00659 , B01J2219/0072 , B82Y10/00 , B82Y30/00 , C12Q1/6818 , C12Q1/6837 , C12Q1/6874 , C12Q1/6876 , C12Q2600/156 , C12Q2600/158 , G01N33/582 , C12Q2523/303 , C12Q2565/507 , C12Q2565/629
摘要： Methods are provided for producing a molecular array comprising a plurality of molecules immoblised to a solid substrate at a density which allows individual immobilised molecules to be individually resolved, wherein each individual molecule in the array is spatially addressable and the identity of each molecule is known or determined prior to immobilization. The use of spatially addressable low density molecular arrays in single molecule detection and analysis techniques is also provided. Novel assays and methods are also provided.
摘要翻译：提供了用于产生分子阵列的方法，该分子阵列包含固定在固体底物上的多个分子，其密度可以使各个固定的分子被单独分辨，其中阵列中的每个单独的分子都是可空间寻址的，每个分子的身份是已知的，在固定前测定。还提供了在单分子检测和分析技术中使用空间可寻址的低密度分子阵列。还提供了新的测定和方法。

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