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1. 发明授权

US08147775B2 Self-cleaning and mixing microfluidic elements 有权
标题翻译：自清洁和混合微流体元件
公开(公告)号：US08147775B2
公开(公告)日：2012-04-03
申请号：US12552914
申请日：2009-09-02
申请人： Sivaramakrishnan Krishnamoorthy , Jianiun Feng
发明人： Sivaramakrishnan Krishnamoorthy , Jianiun Feng
IPC分类号： B01F15/00
CPC分类号： B08B7/0064 , B01F13/0079 , B01F13/0081 , B01L3/5027 , B01L99/00 , B01L2300/1833 , B01L2400/0415 , B01L2400/0442 , B01L2400/0493 , B08B9/00 , F04B19/006 , F04B19/24 , Y10S366/04 , Y10T137/0329 , Y10T137/034 , Y10T137/0391
摘要： Apparatus and methods are disclosed for mixing and self-cleaning elements in microfluidic systems based on electrothermally induced fluid flow. The apparatus and methods provide for the control of fluid flow in and between components in a microfluidic system to cause the removal of unwanted liquids and particulates or mixing of liquids. The geometry and position of electrodes is adjusted to generate a temperature gradient in the liquid, thereby causing a non-uniform distribution of dielectric properties within the liquid. The dielectric non-uniformity produces a body force and flow in the solution, which is controlled by element and electrode geometries, electrode placement, and the frequency and waveform of the applied voltage.
摘要翻译：公开了用于基于电热诱导流体流动的微流体系统中的混合和自清洁元件的装置和方法。该装置和方法提供了在微流体系统中的组件之间和之间的流体流动的控制，以便除去不期望的液体和微粒或混合液体。调节电极的几何形状和位置，以在液体中产生温度梯度，从而导致液体内介电性质的不均匀分布。电介质非均匀性在溶液中产生体力和流动，其由元件和电极几何形状，电极布置以及施加电压的频率和波形控制。

2. 发明授权

US07189578B1 Methods and systems employing electrothermally induced flow for mixing and cleaning in microsystems 有权
标题翻译：在微系统中采用电热诱导流混合和清洗的方法和系统
公开(公告)号：US07189578B1
公开(公告)日：2007-03-13
申请号：US10307907
申请日：2002-12-02
申请人： Jianjun Feng , Sivaramakrishnan Krishnamoorthy , Vinod Bhagwan Makhijani
发明人： Jianjun Feng , Sivaramakrishnan Krishnamoorthy , Vinod Bhagwan Makhijani
IPC分类号： G01N1/00 , G01N1/10 , G01N35/00 , H05F3/00 , B01D57/02
CPC分类号： B08B9/00 , B01F13/0079 , B01F13/0081 , B01L3/5027 , B01L99/00 , B01L2300/1833 , B01L2400/0415 , B01L2400/0442 , B01L2400/0493 , B08B7/0064 , F04B19/006 , F04B19/24 , Y10T29/49 , Y10T29/49002 , Y10T436/11 , Y10T436/25 , Y10T436/2575
摘要： A method and system for controlling flow motion in a channel/cavity in a microfluidic system includes positioning at least one pair of electrodes in and/or proximate to the channel/cavity. A buffer solution is placed in the channel/cavity, the buffer solution having at least one dielectric property that varies in response to changes in temperature of the solution. An AC/DC voltage is applied to the electrodes to generate an electric field in the channel/cavity; the AC voltage having a known magnitude and frequency and the DC voltage having a known magnitude. The magnitude of the AC/DC voltage is adjusted to cause Joule heating of the buffer solution in the channel/cavity. The geometry and position of the electrodes is adjusted to generate a temperature gradient in the buffer solution, thereby causing a non-uniform distribution of the dielectric property within the solution in the channel/cavity. The dielectric non-uniformity produces a body force and flow in the solution. Also, the frequency of the AC voltage is adjusted to generate flow of the buffer solution in the channel/cavity in response to the non-uniform distribution of the dielectric property.
摘要翻译：用于控制微流体系统中的通道/空腔中的流动的方法和系统包括将至少一对电极定位在通道/空腔中和/或接近通道/空腔。将缓冲溶液放置在通道/空腔中，缓冲溶液具有响应于溶液温度变化而变化的至少一种介电特性。 AC / DC电压施加到电极以在通道/空腔中产生电场; AC电压具有已知的幅度和频率，并且DC电压具有已知的幅度。调整AC / DC电压的大小，使通道/腔中的缓冲溶液焦耳加热。调节电极的几何形状和位置以在缓冲溶液中产生温度梯度，从而导致溶液中的介电性质在通道/空腔中的不均匀分布。电介质非均匀性会在溶液中产生体力和流动。此外，响应于介电性质的不均匀分布，调节AC电压的频率以产生通道/空腔中的缓冲溶液的流动。

3. 发明授权

US09878090B2 Miniaturized electrothermal flow induced infusion pump 有权
公开(公告)号：US09878090B2
公开(公告)日：2018-01-30
申请号：US14971715
申请日：2015-12-16
申请人： CFD Research Corporation
发明人： Sivaramakrishnan Krishnamoorthy , Guiren Wang , Jianjun Feng , Yi Wang
IPC分类号： A61M5/142 , B01F13/00 , B01L3/00 , B01L99/00 , B08B7/00 , B08B9/00 , F04B19/00 , F04B19/24 , G01N30/00
CPC分类号： A61M5/14244 , A61M2205/0244 , B01F13/0079 , B01F13/0081 , B01L3/5027 , B01L99/00 , B01L2300/1833 , B01L2400/0415 , B01L2400/0442 , B01L2400/0493 , B01L2400/0496 , B08B7/0064 , B08B9/00 , F04B19/006 , F04B19/24 , G01N2030/0035 , G01N2030/0065
摘要： A micropump that pumps liquid using electrothermally-induced flow is described, along with a corresponding self-regulating pump and infusion pump. The micropump has applications in microfluidic systems, such as biochips. The self-regulating infusion pump is useful for administration of large and small volumes of liquids such as drugs to patients and can be designed for a wide range of flow rates by combining multiple micropumps in one infusion pump system. The micropump uses electrode sequences on opposing surfaces of a flow chamber that are staggered with respect to each other. The opposing surfaces include staggered electrodes that have the same phase and same electrode sequence. As such electrodes with the same phase are staggered and not eclipsed.

4. 发明授权

US08316643B2 Method of driving and drive mechanism utilizing surface tension difference convection generated in two fluids having an interface 有权
标题翻译：利用在具有界面的两种流体中产生的表面张力差对流的驱动和驱动机构的方法
公开(公告)号：US08316643B2
公开(公告)日：2012-11-27
申请号：US11033800
申请日：2005-01-13
申请人： Masato Sakurai , Shoichi Yoshihara , Mitsuru Onishi
发明人： Masato Sakurai , Shoichi Yoshihara , Mitsuru Onishi
IPC分类号： F01K1/00
CPC分类号： F03G7/00 , B01F13/0081 , F03B5/00 , F05D2250/82 , F05D2250/84 , Y02E10/20
摘要： An object of the present invention is to provide a method of driving a micromachine and a drive mechanism whereby the required drive force can be obtained and that avoid excessive load to the machine, the mechanism not being of large size and not being troublesome in terms of energy supply. In a micromachine rotary drive mechanism according to the present invention, a micro-turbine is floated on the liquid surface of Fluorinert, silicone oil is attached onto faces respectively directed in the same direction of this micro-turbine, thereby drive force of the micro-turbine is obtained from the surface tension difference convection generated at the two-fluid interface. Also, in a unidirectional drive mechanism of a micromachine according to the present invention, a minute thin sheet is floated on a Fluorinert liquid surface, silicone oil is attached to one end of this minute thin sheet, thereby drive force of this minute thin sheet is obtained from the surface tension difference convection generated at the two-fluid interface.
摘要翻译：本发明的目的是提供一种驱动微型机械和驱动机构的方法，由此可以获得所需的驱动力，并且避免了对机器的过度负载，该机构不具有大尺寸并且不会麻烦能源供应。在根据本发明的微型机械旋转驱动机构中，微型涡轮机漂浮在Fluorinert的液体表面上，硅油被附着到分别指向该微型涡轮机的相同方向的面上，从而驱动微型涡轮机的力，涡轮机是从在两流体界面处产生的表面张力差对流获得的。此外，在根据本发明的微型机器的单向驱动机构中，将微小的薄片漂浮在Fluorinert液体表面上，硅油附着在该分片薄片的一端，因此该分片薄片的驱动力为从在两流体界面处产生的表面张力差对流获得。

5. 发明授权

US07604394B2 Self-cleaning and mixing microfluidic elements 有权
标题翻译：自清洁和混合微流体元件
公开(公告)号：US07604394B2
公开(公告)日：2009-10-20
申请号：US11516358
申请日：2006-09-06
申请人： Sivaramakrishnan Krishnamoorthy , Jianjun Feng
发明人： Sivaramakrishnan Krishnamoorthy , Jianjun Feng
IPC分类号： B01F13/00 , H02K44/00 , C12Q1/68 , B03C5/02
CPC分类号： B08B7/0064 , B01F13/0079 , B01F13/0081 , B01L3/5027 , B01L99/00 , B01L2300/1833 , B01L2400/0415 , B01L2400/0442 , B01L2400/0493 , B08B9/00 , F04B19/006 , F04B19/24 , Y10S366/04 , Y10T137/0329 , Y10T137/034 , Y10T137/0391
摘要： Apparatus and methods are disclosed for mixing and self-cleaning elements in microfluidic systems based on electrothermally induced fluid flow. The apparatus and methods provide for the control of fluid flow in and between components in a microfluidic system to cause the removal of unwanted liquids and particulates or mixing of liquids. The geometry and position of electrodes is adjusted to generate a temperature gradient in the liquid, thereby causing a non-uniform distribution of dielectric properties within the liquid. The dielectric non-uniformity produces a body force and flow in the solution, which is controlled by element and electrode geometries, electrode placement, and the frequency and waveform of the applied voltage.
摘要翻译：公开了用于基于电热诱导流体流动的微流体系统中的混合和自清洁元件的装置和方法。该装置和方法提供了在微流体系统中的组件之间和之间的流体流动的控制，以便除去不期望的液体和微粒或混合液体。调节电极的几何形状和位置，以在液体中产生温度梯度，从而导致液体内介电性质的不均匀分布。电介质非均匀性在溶液中产生体力和流动，其由元件和电极几何形状，电极布置以及施加电压的频率和波形控制。

6. 发明授权

US09283597B2 Miniaturized electrothermal flow induced infusion pump 有权
标题翻译：小型电热流感诱导输液泵
公开(公告)号：US09283597B2
公开(公告)日：2016-03-15
申请号：US11516269
申请日：2006-09-06
申请人： Sivaramakrishnan Krishnamoorthy , Guiren Wang , Jianjun Feng , Yi Wang
发明人： Sivaramakrishnan Krishnamoorthy , Guiren Wang , Jianjun Feng , Yi Wang
IPC分类号： G01N30/00 , B08B7/00 , B01F13/00 , B08B9/00 , F04B19/00 , F04B19/24 , B01L99/00 , B01L3/00
CPC分类号： A61M5/14244 , A61M2205/0244 , B01F13/0079 , B01F13/0081 , B01L3/5027 , B01L99/00 , B01L2300/1833 , B01L2400/0415 , B01L2400/0442 , B01L2400/0493 , B01L2400/0496 , B08B7/0064 , B08B9/00 , F04B19/006 , F04B19/24 , G01N2030/0035 , G01N2030/0065
摘要： A micropump that pumps liquid using electrothermally-induced flow is described, along with a corresponding self-regulating pump and infusion pump. The micropump has applications in microfluidic systems such as biochips. The self-regulating infusion pump is useful for the administration of large and small volumes of liquids such as drugs to patients and can be designed for a wide range of flow rates by combining multiple micropumps in one infusion pump system.
摘要翻译：描述了使用电热诱导流体泵送液体的微型泵，以及相应的自调节泵和输液泵。微型泵应用于微流体系统，如生物芯片。自调节输液泵可用于向患者施用大量和小体积的液体如药物，并且可以通过在一个输液泵系统中组合多个微泵来设计用于各种流量的流量。

7. 发明申请

US20070110625A1 Miniaturized electrothermal flow induced infusion pump 有权
标题翻译：小型电热流感诱导输液泵
公开(公告)号：US20070110625A1
公开(公告)日：2007-05-17
申请号：US11516269
申请日：2006-09-06
申请人： Sivaramakrishnan Krishnamoorthy , Guiren Wang , Jianjun Feng , Yi Wang
发明人： Sivaramakrishnan Krishnamoorthy , Guiren Wang , Jianjun Feng , Yi Wang
IPC分类号： B01L3/00
CPC分类号： A61M5/14244 , A61M2205/0244 , B01F13/0079 , B01F13/0081 , B01L3/5027 , B01L99/00 , B01L2300/1833 , B01L2400/0415 , B01L2400/0442 , B01L2400/0493 , B01L2400/0496 , B08B7/0064 , B08B9/00 , F04B19/006 , F04B19/24 , G01N2030/0035 , G01N2030/0065
摘要： A micropump that pumps liquid using electrothermally-induced flow is described, along with a corresponding self-regulating pump and infusion pump. The micropump has applications in microfluidic systems such as biochips. The self-regulating infusion pump is useful for the administration of large and small volumes of liquids such as drugs to patients and can be designed for a wide range of flow rates by combining multiple micropumps in one infusion pump system.
摘要翻译：描述了使用电热诱导流体泵送液体的微型泵，以及相应的自调节泵和输液泵。微型泵应用于微流体系统，如生物芯片。自调节输液泵可用于向患者施用大量和小体积的液体如药物，并且可以通过在一个输液泵系统中组合多个微泵来设计用于各种流量的流量。

8. 发明申请

US20050214110A1 Method of driving and drive mechanism utilizing surface tension difference convection generated in two fluids having an interface 有权
标题翻译：利用在具有界面的两种流体中产生的表面张力差对流的驱动和驱动机构的方法
公开(公告)号：US20050214110A1
公开(公告)日：2005-09-29
申请号：US11033800
申请日：2005-01-13
申请人： Masato Sakurai , Shoichi Yoshihara , Mitsuru Onishi
发明人： Masato Sakurai , Shoichi Yoshihara , Mitsuru Onishi
IPC分类号： G01N1/00 , B81B5/00 , F03B5/00 , F03G7/00 , G01N1/36 , G01N35/02 , G01N35/08 , G01N37/00
CPC分类号： F03G7/00 , B01F13/0081 , F03B5/00 , F05D2250/82 , F05D2250/84 , Y02E10/20
摘要： An object of the present invention is to provide a method of driving a micromachine and a drive mechanism whereby the required drive force can be obtained and that avoid excessive load to the machine, the mechanism not being of large size and not being troublesome in terms of energy supply. In a micromachine rotary drive mechanism according to the present invention, a micro-turbine is floated on the liquid surface of Fluorinert, silicone oil is attached onto faces respectively directed in the same direction of this micro-turbine, thereby drive force of the micro-turbine is obtained from the surface tension difference convection generated at the two-fluid interface. Also, in a unidirectional drive mechanism of a micromachine according to the present invention, a minute thin sheet is floated on a Fluorinert liquid surface, silicone oil is attached to one end of this minute thin sheet, thereby drive force of this minute thin sheet is obtained from the surface tension difference convection generated at the two-fluid interface.
摘要翻译：本发明的目的是提供一种驱动微型机械和驱动机构的方法，由此可以获得所需的驱动力，并且避免了对机器的过度负载，该机构不具有大尺寸并且不会麻烦能源供应。在根据本发明的微型机械旋转驱动机构中，微型涡轮机漂浮在Fluorinert的液体表面上，硅油被附着到分别指向该微型涡轮机的相同方向的面上，从而驱动微型涡轮机的力，涡轮机是从在两流体界面处产生的表面张力差对流获得的。此外，在根据本发明的微型机器的单向驱动机构中，将微小的薄片漂浮在Fluorinert液体表面上，硅油附着在该分钟薄片的一端，从而驱动该分片薄片的力从在两流体界面处产生的表面张力差对流获得。

9. 发明申请

US20160235912A1 MINIATURIZED ELECTROTHERMAL FLOW INDUCED INFUSION PUMP 有权
标题翻译：微型电热流感诱导泵
公开(公告)号：US20160235912A1
公开(公告)日：2016-08-18
申请号：US14971715
申请日：2015-12-16
申请人： CFD Research Corporation
发明人： Sivaramakrishnan Krishnamoorthy , Guiren Wang , Jianjun Feng , Yi Wang
IPC分类号： A61M5/142 , A61M5/168
CPC分类号： A61M5/14244 , A61M2205/0244 , B01F13/0079 , B01F13/0081 , B01L3/5027 , B01L99/00 , B01L2300/1833 , B01L2400/0415 , B01L2400/0442 , B01L2400/0493 , B01L2400/0496 , B08B7/0064 , B08B9/00 , F04B19/006 , F04B19/24 , G01N2030/0035 , G01N2030/0065
摘要： A micropump that pumps liquid using electrothermally-induced flow is described, along with a corresponding self-regulating pump and infusion pump. The micropump has applications in microfluidic systems, such as biochips. The self-regulating infusion pump is useful for administration of large and small volumes of liquids such as drugs to patients and can be designed for a wide range of flow rates by combining multiple micropumps in one infusion pump system. The micropump uses electrode sequences on opposing surfaces of a flow chamber that are staggered with respect to each other. The opposing surfaces include staggered electrodes that have the same phase and same electrode sequence. As such electrodes with the same phase are staggered and not eclipsed.
摘要翻译：描述了使用电热诱导流体泵送液体的微型泵，以及相应的自调节泵和输液泵。微型泵在微流体系统中具有应用，如生物芯片。自调节输液泵可用于向患者施用大量和小体积的液体，例如药物，并且可以通过在一个输液泵系统中组合多个微泵来设计用于各种流量的流量。微型泵使用相对于彼此交错的流动室的相对表面上的电极序列。相对表面包括具有相同相位和相同电极序列的交错电极。因为具有相同相位的电极是交错的并且不会被淹没。

10. 发明申请

US20070209940A1 Self-cleaning and mixing microfluidic elements 有权
标题翻译：自清洁和混合微流体元件
公开(公告)号：US20070209940A1
公开(公告)日：2007-09-13
申请号：US11516358
申请日：2006-09-06
申请人： Sivaramakrishnan Krishnamoorthy , Jianjun Feng
发明人： Sivaramakrishnan Krishnamoorthy , Jianjun Feng
IPC分类号： B01D57/02 , B03C5/00
CPC分类号： B08B7/0064 , B01F13/0079 , B01F13/0081 , B01L3/5027 , B01L99/00 , B01L2300/1833 , B01L2400/0415 , B01L2400/0442 , B01L2400/0493 , B08B9/00 , F04B19/006 , F04B19/24 , Y10S366/04 , Y10T137/0329 , Y10T137/034 , Y10T137/0391
摘要： Apparatus and methods are disclosed for mixing and self-cleaning elements in microfluidic systems based on electrothermally induced fluid flow. The apparatus and methods provide for the control of fluid flow in and between components in a microfluidic system to cause the removal of unwanted liquids and particulates or mixing of liquids. The geometry and position of electrodes is adjusted to generate a temperature gradient in the liquid, thereby causing a non-uniform distribution of dielectric properties within the liquid. The dielectric non-uniformity produces a body force and flow in the solution, which is controlled by element and electrode geometries, electrode placement, and the frequency and waveform of the applied voltage.
摘要翻译：公开了用于基于电热诱导流体流动的微流体系统中的混合和自清洁元件的装置和方法。该装置和方法提供了在微流体系统中的组件之间和之间的流体流动的控制，以便除去不期望的液体和微粒或混合液体。调节电极的几何形状和位置，以在液体中产生温度梯度，从而导致液体内介电性质的不均匀分布。电介质非均匀性在溶液中产生体力和流动，其由元件和电极几何形状，电极布置以及施加电压的频率和波形控制。

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