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1. 发明申请

US20090047688A1 REAGENTS, KITS AND METHODS FOR DETECTING BIOLOGICAL MOLECULES BY ENERGY TRANSFER FROM AN ACTIVATED CHEMILUMINESCENT SUBSTRATE TO AN ENERGY ACCEPTOR DYE 有权
标题翻译：通过能量转移从激活的CHEMILUMINESCENT底物到能量受体染料检测生物分子的试剂，试剂盒和方法
公开(公告)号：US20090047688A1
公开(公告)日：2009-02-19
申请号：US12126094
申请日：2008-05-23
申请人： Rouh-Rong Juo , John C. Voyta , Brooks Edwards
发明人： Rouh-Rong Juo , John C. Voyta , Brooks Edwards
IPC分类号： G01N33/53 , G01N21/76 , C12Q1/42
CPC分类号： G01N33/543 , G01N33/533 , G01N33/542 , G01N33/54313 , G01N33/573 , G01N33/581 , G01N2333/916
摘要： Reagents, kits and methods for detecting biological molecules by energy transfer from an activated chemiluminescent substrate to an energy acceptor dye such as a J-aggregated dye are described.
摘要翻译：描述了通过从活性化学发光底物到能量受体染料如J-聚集染料的能量转移来检测生物分子的试剂，试剂盒和方法。

2. 发明申请

US20060286561A1 PROPARGYLETHOXYAMINO NUCLEOTIDES 审中-公开
标题翻译：丙基胆碱胺核苷酸
公开(公告)号：US20060286561A1
公开(公告)日：2006-12-21
申请号：US11277481
申请日：2006-03-24
申请人： Shaheer Khan , Steven Menchen , Barnett Rosenblum
发明人： Shaheer Khan , Steven Menchen , Barnett Rosenblum
IPC分类号： C12Q1/68 , C07H19/04 , C12P19/34 , C07H21/04
CPC分类号： C07H21/00 , C07H19/04 , C07H21/04 , C12Q1/686
摘要： Propargylethoxyamino nucleosides are disclosed having the structure wherein R1 and R2 are —H lower alkyl, or label; B is a 7-deazapurine, purine, or pyrimidine nucleoside base; W1 is —H or —H; W2 is —H or a moiety which renders the nucleoside incapable of forming a phosphodiester bond at the 3′-position; and W3 is —PO4, —P2O7, —P3O10, phosphate analog, or —OH. Additionaly, a primer extension method is provided employing the above propargylethoxyamino nucleosides.
摘要翻译：公开了具有其中R 1和R 2为-H低级烷基或标记的结构的丙炔乙氧基氨基核苷; B是7-脱氮嘌呤，嘌呤或嘧啶核苷碱基; W 1是-H或-H; W 2是-H或使核苷不能在3'-位形成磷酸二酯键的部分; 和W 3是-PO 4，-P 2 O 7，-P 3，或磷酸酯类似物或-OH。另外，使用上述炔丙氧基氨基核苷提供引物延伸方法。

3. 发明申请

US20070038387A1 Methods and systems for mass defect filtering of mass spectrometry data 有权
标题翻译：质谱数据质谱缺陷过滤方法与系统
公开(公告)号：US20070038387A1
公开(公告)日：2007-02-15
申请号：US11474128
申请日：2006-06-23
申请人： Xunming Chen , Philip Savickas , Marvin Vestal
发明人： Xunming Chen , Philip Savickas , Marvin Vestal
IPC分类号： G01N31/00
CPC分类号： H01J49/0036
摘要： The present teachings relate to a method of filtering mass spectrometer data using a variable filter window. The width of the window can depend on the mass itself and the mass defects for a family of compounds. The teachings can be used with a plurality of compounds including but not limited to peptides and can be utilized on a brood range of mass spectrometers.
摘要翻译：本教导涉及使用可变过滤器窗口过滤质谱仪数据的方法。窗口的宽度可以取决于质量本身和一系列化合物的质量缺陷。该教导可以与多种化合物一起使用，包括但不限于肽，并且可以在质谱仪的亲本范围上使用。

4. 发明申请

US20080241838A1 METHODS AND SYSTEMS FOR DETECTING NUCLEIC ACIDS 审中-公开
标题翻译：检测核酸的方法和系统
公开(公告)号：US20080241838A1
公开(公告)日：2008-10-02
申请号：US11965837
申请日：2007-12-28
申请人： Kristian Scaboo , Vissarion Aivazachvili , Timothy Liu , Robert Eason , Konrad Faulstich
发明人： Kristian Scaboo , Vissarion Aivazachvili , Timothy Liu , Robert Eason , Konrad Faulstich
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6834 , C12Q1/6823 , C12Q1/6825 , C12Q2531/113 , C12Q2521/307 , C12Q2525/204 , C12Q2565/607 , C12Q2561/109 , C12Q2565/519
摘要： Methods and kits for detecting a target nucleic acid in a sample are described. In some embodiments, the sample to be analyzed includes a primer which hybridizes to at least a portion of the target nucleic acid, a probe having a first region which hybridizes to at least a portion of the target nucleic acid and a second region having a detectable label, a polymerase which extends the hybridized primer and an enzyme comprising nuclease activity that can cleave the hybridized hybridization probe to thereby release a labeled probe fragment. In some embodiments, the sample can then be contacted with a solid support comprising surface bound capture probes which can hybridize to the labeled probe fragment(s). These capture probes more readily bind to the probe fragment(s) than to the intact hybridization probe. The label can then be detected on the support surface. In this manner, improved discrimination between the probe fragments and the intact hybridization probes can be achieved.
摘要翻译：描述了用于检测样品中靶核酸的方法和试剂盒。在一些实施方案中，待分析的样品包括与靶核酸的至少一部分杂交的引物，具有与靶核酸的至少一部分杂交的第一区的探针和具有可检测的第二区标记，扩增杂交引物的聚合酶和包含核酸酶活性的酶，其可以切割杂交的杂交探针，从而释放标记的探针片段。在一些实施方案中，然后可以将样品与包含可以与标记的探针片段杂交的表面结合捕获探针的固体支持物接触。这些捕获探针比完整的杂交探针更容易与探针片段结合。然后可以在支撑表面上检测标签。以这种方式，可以实现探针片段与完整杂交探针之间的改善的区别。

5. 发明申请

US20070254298A1 ATROPISOMERS OF ASYMMETRIC XANTHENE FLUORESCENT DYES AND METHOD OF DNA SEQUENCING AND FRAGMENT ANALYSIS 审中-公开
标题翻译：不对称XANENENE荧光染料的染色体和DNA测序和片段分析方法
公开(公告)号：US20070254298A1
公开(公告)日：2007-11-01
申请号：US11733014
申请日：2007-04-09
申请人： Linda Lee , Meng Taing , Barnett Rosenblum
发明人： Linda Lee , Meng Taing , Barnett Rosenblum
IPC分类号： C12Q1/68 , C07H21/04
CPC分类号： C07H19/10 , C07H19/20 , C07H21/00 , C07H21/04 , C09B11/08 , C09B11/24 , G01N33/533
摘要： Atropisomeric energy-transfer dye compounds are disclosed. A variety of molecular biology applications utilize atropisomeric xanthene fluorescent dyes as labels for substrates such as nucleotides, nucleosides, polynucleotides, polypeptides and carbohydrates. Methods include DNA sequencing, DNA fragment analysis, PCR, SNP analysis, oligonucleotide ligation, amplification, minisequencing, and primer extension.
摘要翻译：公开了异转移能量转移染料化合物。各种分子生物学应用利用无异构呫吨荧光染料作为底物的标记，例如核苷酸，核苷，多核苷酸，多肽和碳水化合物。方法包括DNA测序，DNA片段分析，PCR，SNP分析，寡核苷酸连接，扩增，minisequencing和引物延伸。

6. 发明申请

US20090246763A1 ELECTROCHEMICAL LABELS DERIVED FROM SIDEROPHORES 有权
标题翻译：电子标签衍生自SIDEROPHORES
公开(公告)号：US20090246763A1
公开(公告)日：2009-10-01
申请号：US12059744
申请日：2008-03-31
申请人： Robert G. Eason
发明人： Robert G. Eason
IPC分类号： C12Q1/68 , C07D259/00 , C07H15/26 , C07F15/00
CPC分类号： C07H15/26 , C12Q1/6816 , C12Q2563/137
摘要： Disclosed are tri-nuclear metal complexes and salts thereof, such as tri-nuclear osmium or ruthenium complexes or salts thereof, suitable for use as electrochemical labels. Also disclosed are oligonucleotide probes with an attached electrochemical label, methods of nucleic acid amplification, methods of sequencing, and kits for nucleic acid amplification and sequencing having oligonucleotide probes including an electrochemical label. The electrochemical labels are synthesized from siderophores.
摘要翻译：公开了适合用作电化学标记的三核金属络合物及其盐，例如三核锇或钌络合物或其盐。还公开了具有附加的电化学标记的寡核苷酸探针，核酸扩增方法，测序方法，以及用于核酸扩增和测序的试剂盒，其具有包含电化学标记的寡核苷酸探针。电化学标记由铁载体合成。

7. 发明申请

US20080193940A1 SYSTEMS AND METHODS FOR DETECTING NUCLEIC ACIDS 审中-公开
标题翻译：用于检测核酸的系统和方法
公开(公告)号：US20080193940A1
公开(公告)日：2008-08-14
申请号：US11965807
申请日：2007-12-28
申请人： Vissarion Aivazachvili , Kristian Scaboo , Eugene Spier
发明人： Vissarion Aivazachvili , Kristian Scaboo , Eugene Spier
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6823 , C12Q1/6825 , C12Q1/6827 , C12Q2531/113 , C12Q2521/307 , C12Q2525/161 , C12Q2525/301 , C12Q2565/607 , C12Q2565/519 , C12Q2521/301 , C12Q2561/109
摘要： A method and kit for detecting a target nucleic acid in a sample is described. The sample to be analyzed may include a primer which hybridizes to at least a portion of the target nucleic acid, a probe having a first region which hybridizes to at least a portion of the target nucleic acid and a second region having a detectable label, a polymerase which extends the hybridized primer and an enzyme comprising exonuclease activity that can cleave the hybridized hybridization probe to thereby generate a labeled probe fragment. At least one portion of the hybridization probe hybridizes to another portion of the hybridization probe to thereby form a folded structure. The method can involve melting the sample, reducing the temperature of the sample to allow primer and probe to each hybridize to at least a portion of single stranded target nucleic acid in the sample, elongating the primer and releasing the labeled probe fragment. The sample can be contacted with a solid support comprising surface bound capture probes which hybridize to the labeled probe fragments. The label can then be detected.
摘要翻译：描述了用于检测样品中靶核酸的方法和试剂盒。要分析的样品可以包括与靶核酸的至少一部分杂交的引物，具有与靶核酸的至少一部分杂交的第一区的探针和具有可检测标记的第二区，扩增杂交引物的聚合酶和包含外切核酸酶活性的酶，其可以切割杂交的杂交探针，从而产生标记的探针片段。至少一部分杂交探针与杂交探针的另一部分杂交，从而形成折叠结构。该方法可以包括熔化样品，降低样品的温度以使引物和探针各自与样品中的至少一部分单链靶核酸杂交，延长引物并释放标记的探针片段。样品可以与包含与标记的探针片段杂交的表面结合捕获探针的固体支持物接触。然后可以检测标签。

8. 发明申请

US20060286581A1 Heteroconfigurational Polynucleotides and Methods of Use 审中-公开
公开(公告)号：US20060286581A1
公开(公告)日：2006-12-21
申请号：US11425788
申请日：2006-06-22
申请人： Stefan Matysiak , Benjamin Schroeder , Ravi Vinayak , I. Greenfield
发明人： Stefan Matysiak , Benjamin Schroeder , Ravi Vinayak , I. Greenfield
IPC分类号： C12Q1/68 , C07K14/47 , C07H21/02 , C12M1/34 , C07H21/04
CPC分类号： C12Q1/6837 , B82Y5/00 , B82Y10/00 , B82Y20/00 , C07H21/00
摘要： Methods, compositions and kits are disclosed that utilize heteroconfigurational polynucleotide comprising a D-form polynucleotide sequence portion and an L-form polynucleotide sequence portion that is covalently linked to the D-form polynucleotide sequence portion.

9. 发明申请

US20060063189A1 Methods of using sulfur nucleophiles as improved alternatives to sodium bisulfite for methylated DNA analysis 审中-公开
标题翻译：使用硫亲核试剂作为亚硫酸氢钠替代甲基化DNA分析的方法
公开(公告)号：US20060063189A1
公开(公告)日：2006-03-23
申请号：US11231480
申请日：2005-09-21
申请人： Gerald Zon
发明人： Gerald Zon
IPC分类号： C12Q1/68 , C07H21/04
CPC分类号： C07H21/04 , C12Q1/6806 , C12Q1/6827 , Y10T436/143333 , C12Q2523/125 , C12Q2527/125 , C12Q2525/117
摘要： The invention provides for the use of sulfur nucleophiles in analyzing methylated DNA and novel sulfur nucleophiles suitable for such us.
摘要翻译：本发明提供硫亲核试剂在分析适合于我们的甲基化DNA和新型硫亲核试剂的用途。

10. 发明授权

US07006215B2 Shaped illumination geometry and intensity using a diffractive optical element 失效
$Shaped illumination geometry and intensity using a diffractive optical element$
标题翻译：使用衍射光学元件形成照明几何形状和强度
公开(公告)号：US07006215B2
公开(公告)日：2006-02-28
申请号：US10837616
申请日：2004-05-04
申请人： Louis B. Hoff , Mark F. Oldham
发明人： Louis B. Hoff , Mark F. Oldham
IPC分类号： G01J3/30
CPC分类号： G02B27/0944 , G01J1/20 , G01J3/10 , G02B19/0014 , G02B19/0052 , G02B27/0927
摘要： A method and apparatus to illuminate a target. The apparatus can comprise a first lens configured to receive light from the light source, a diffractive optical element configured to receive the light from the first lens and to regulate the light into regulated light, and second lens configured to receive the regulated light and to direct the regulated light onto a selected area of the target.
摘要翻译：照明目标的方法和装置。该装置可以包括被配置为从光源接收光的第一透镜，被配置为接收来自第一透镜的光并将光调节为调节光的衍射光学元件，以及被配置为接收调节光并引导调节光到目标的选定区域。

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