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1. 发明申请

US20220413404A1 ELECTROPHOTOGRAPHIC PHOTOSENSITIVE MEMBER, PROCESS CARTRIDGE, AND IMAGE FORMING APPARATUS 有权
公开(公告)号：US20220413404A1
公开(公告)日：2022-12-29
申请号：US17752454
申请日：2022-05-24
申请人： KYOCERA Document Solutions Inc.
发明人： Tomofumi SHIMIZU , Makoto SHISHIDO
IPC分类号： G03G5/05 , C07C211/54 , C07F15/00 , C07D259/00 , C07D231/22 , C07C50/10 , C07C50/12 , C07D471/04 , C07C245/06 , G03G5/06
摘要： A photosensitive layer of an electrophotographic photosensitive member is a single layer and contains a charge generating material, a hole transport material, a first electron transport material, a second electron transport material, and a binder resin. The binder resin includes a polyarylate resin. The polyarylate resin includes repeating units (1), (2), (3), and (4). A percentage of the number of repeats of the repeating unit (3) relative to the total of the number of repeats of the repeating units (1) and the number of repeats of the repeating unit (3) is greater than 0% and less than 20%. The first electron transport material includes a compound represented by formula (A15) or (A16). The second electron transport material includes a compound represented by formula (B10), (B11), (B12), (B13), or (B14)

2. 发明申请

US20200017454A1 MACROCYCLIC COMPOUNDS 审中-公开
公开(公告)号：US20200017454A1
公开(公告)日：2020-01-16
申请号：US16491379
申请日：2018-03-15
申请人： Ziylo Limited
发明人： Anthony Davis , Robert Tromans , Miriam Ruth Wilson , Michael Glen Orchard , Andrew Michael Chapman , Michael Roger Tomsett , Johnathan Vincent Matlock
IPC分类号： C07D259/00 , C07D493/10 , G01N33/66 , G01N33/58
摘要： The present invention relates to macrocyclic compounds which are capable of selective binding to a target saccharide (e.g. glucose), making them particularly well suited for use in saccharide sensing applications. The present invention also relates to processes for the preparation of said compounds, to compositions and devices comprising them, and to their use in the detection of a target saccharide.

3. 发明授权

US10350193B2 Super-oxide dismutase mimetics 有权
公开(公告)号：US10350193B2
公开(公告)日：2019-07-16
申请号：US15160055
申请日：2016-05-20
申请人： Galera Labs, LLC
发明人： Dennis P. Riley
IPC分类号： A61K31/395 , C07D471/08 , C07D259/00 , A61K31/4353 , A61K31/555
摘要： The present invention relates to compounds which are effective as catalysts for dismutating superoxide and, more particularly, the manganese or iron complexes of substituted, unsaturated heterocyclic 16-membered macrocyclic complexes that catalytically dismutate superoxide. It also relates to methods of using these complexes to reduce the concentration or the effects of superoxide, pharmaceutical compositions comprising these compounds or their metal complexes, and methods of treating conditions associated with excessive superoxide activity.

4. 发明授权

US09439984B2 Macrocycles 有权
标题翻译：大型循环
公开(公告)号：US09439984B2
公开(公告)日：2016-09-13
申请号：US14403401
申请日：2013-03-14
申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
发明人： Kenneth N. Raymond , Jide Xu , Tiffany A. Pham
IPC分类号： A61K51/04 , C07D259/00 , C07B59/00 , C07D401/14
CPC分类号： A61K51/0482 , C07B59/004 , C07D259/00 , C07D401/14
摘要： The invention provides macrocycles useful in chelating metal ions, particularly radionuclides, to provide metal ion complexes. The invention also provides methods of using the compounds and complexes of the invention, such as in therapeutic and diagnostic applications.
摘要翻译：本发明提供了可用于螯合金属离子，特别是放射性核素以提供金属离子络合物的大环化合物。本发明还提供了使用本发明的化合物和复合物的方法，例如在治疗和诊断应用中。

5. 发明授权

US09233971B2 Lipomacrocycles and uses thereof 有权
标题翻译：脂多糖及其用途
公开(公告)号：US09233971B2
公开(公告)日：2016-01-12
申请号：US13819147
申请日：2011-08-26
申请人： Kunyuan Cui , Dong Liang
发明人： Kunyuan Cui , Dong Liang
IPC分类号： C07D487/22 , C07D257/02 , C07D255/02 , C07D259/00 , A61K47/48 , C12N15/87 , C07D295/13
CPC分类号： C07D487/22 , A61K47/544 , A61K47/549 , A61K47/55 , C07D255/02 , C07D257/02 , C07D259/00 , C07D295/13 , C12N15/87
摘要： What is described are macrocyclic compounds formed by reaction of a cyclic compound, which contains an amine, with an epoxide. The macrocyclic compound has the following structure: When substituents R and R′ that are hydrophobic substituents, the macrocyclic compound functions as a lipid and is compatible with lipid systems, including liposomes and lipid particles. When present in certain lipid systems, the macrocyclic compound enhances the ability of the lipid system to facilitate delivery of therapeutic molecules to target cells in a mammalian subject.
摘要翻译：所描述的是通过含有胺的环状化合物与环氧化物反应形成的大环化合物。大环化合物具有以下结构：当作为疏水取代基的取代基R和R'时，大环化合物起脂质的作用，并且与脂质体系（包括脂质体和脂质）相容。当存在于某些脂质体系中时，大环化合物增强了脂质系统促进治疗分子向哺乳动物受试者中的靶细胞递送的能力。

6. 发明授权

US08507199B2 Multi-color time resolved fluorophores based on macrocyclic lanthanide complexes 有权
标题翻译：基于大环镧系元素复合物的多色时间分辨荧光团
公开(公告)号：US08507199B2
公开(公告)日：2013-08-13
申请号：US12521910
申请日：2008-01-25
申请人： Nathaniel G. Butlin , Todd M. Corneillie , Jide Xu
发明人： Nathaniel G. Butlin , Todd M. Corneillie , Jide Xu
IPC分类号： C12Q1/68 , C07D259/00
CPC分类号： C07D487/18 , A61K49/0043 , A61K49/0052 , C09B11/24 , C09B57/10 , C09K11/06 , C09K2211/145 , C09K2211/1466 , C09K2211/182 , G01N33/533
摘要： The present invention provides a novel class of macrocyclic compounds as well as complexes formed between a metal (e.g., lanthanide) ion and the compounds of the invention. Preferred complexes exhibit high stability as well as high quantum yields of lanthanide ion luminescence in aqueous media without the need for secondary activating agents. Preferred compounds incorporate hydroxy-isophthalamide moieties within their macrocyclic structure and are characterized by surprisingly low, non-specific binding to a variety of polypeptides such as antibodies and proteins as well as high kinetic stability. These characteristics distinguish them from known, open-structured ligands.
摘要翻译：本发明提供了一类新的大环化合物以及在金属（例如镧系元素）离子和本发明的化合物之间形成的络合物。优选的配合物在水性介质中表现出高稳定性以及镧系元素离子发光的高量子产率，而不需要第二活化剂。优选的化合物在其大环结构内掺入羟基间苯二酰胺部分，其特征在于与各种多肽例如抗体和蛋白质以及高动力学稳定性令人惊奇的低非特异性结合。这些特征将它们与已知的开放结构的配体区分开来。

7. 发明授权

US08350027B2 Dual-acting pyrazole antihypertensive agents 有权
标题翻译：双效吡唑抗高血压药
公开(公告)号：US08350027B2
公开(公告)日：2013-01-08
申请号：US13346237
申请日：2012-01-09
申请人： Brooke Blair , Paul R. Fatheree , Melissa Fleury , Roland Gendron , Ryan Hudson , Robert Murray McKinnell , Michael Wilson
发明人： Brooke Blair , Paul R. Fatheree , Melissa Fleury , Roland Gendron , Ryan Hudson , Robert Murray McKinnell , Michael Wilson
IPC分类号： C07D413/14 , C07D401/14 , C07D259/00 , C07D271/06 , C07D231/10
CPC分类号： C07D403/10 , C07D231/12 , C07D231/14 , C07D401/06 , C07D401/14 , C07D403/06 , C07D403/14 , C07D405/14 , C07D409/14 , C07D413/10
摘要： In one aspect, the invention relates to compounds having the formula: wherein: Ar, Z, R3, R4 and R5 are as defined in the specification, or a pharmaceutically acceptable salt thereof. These compounds have AT1 receptor antagonist activity and neprilysin inhibition activity. In another aspect, the invention relates to pharmaceutical compositions comprising such compounds; methods of using such compounds; and process and intermediates for preparing such compounds.
摘要翻译：一方面，本发明涉及具有下式的化合物：其中：Ar，Z，R 3，R 4和R 5如说明书中所定义，或其药学上可接受的盐。这些化合物具有AT1受体拮抗剂活性和neprilysin抑制活性。另一方面，本发明涉及包含这些化合物的药物组合物; 使用这些化合物的方法; 以及制备这些化合物的方法和中间体。

8. 发明申请

US20110177002A1 CYLIC POLYAMINES FOR BINDING PHOSPHATIDYLSERINE 审中-公开
标题翻译：用于结合磷脂酰胆碱的CYLIC POLYAMINES
公开(公告)号：US20110177002A1
公开(公告)日：2011-07-21
申请号：US13054606
申请日：2009-07-14
申请人： Sabine Zitzmann-Kolbe , Ulrike Bauder-Wuest , Michael Eisenhut , Doerte Oltmanns
发明人： Sabine Zitzmann-Kolbe , Ulrike Bauder-Wuest , Michael Eisenhut , Doerte Oltmanns
IPC分类号： A61K49/06 , A61K49/00 , C12N9/96 , A61K31/395 , C07K14/00 , C07K16/00 , C07D255/02 , C07D257/02 , C07D259/00
CPC分类号： C07D405/12 , A61K49/0043 , A61K49/0052 , A61K51/0482 , C07D257/02
摘要： The invention pertains to a compound for detecting cell death. According to the invention, the compound comprises a cyclic polyamine unit for the complexation of a bi- or trivalent metal ion. The compound of the invention may contain a reporting tag like fluorescein or a radioisotope including substituent.
摘要翻译：本发明涉及用于检测细胞死亡的化合物。根据本发明，化合物包含用于使二价或三价金属离子络合的环状多胺单元。本发明的化合物可以含有报告标签如荧光素或包含取代基的放射性同位素。

9. 发明申请

US20100168415A1 Process for preparation of Caspofungin acetate 审中-公开
标题翻译：乙酸卡泊芬净的制备方法
公开(公告)号：US20100168415A1
公开(公告)日：2010-07-01
申请号：US12653914
申请日：2009-12-22
申请人： Kwang-Chung Lee , Yen-Shih Tung , Hao-Ling Fang
发明人： Kwang-Chung Lee , Yen-Shih Tung , Hao-Ling Fang
IPC分类号： C07D259/00
CPC分类号： C07K7/56
摘要： A process for making caspofungin acetate comprising the steps of: A. selectively dehydrating pneumocandin Bo to obtain a nitrile; B. reducing the nitrile to primary amine; C. reacting the primary amine with an arylthiol in a suitable solvent to obtain a thioether; and D. reacting the thioether with ethylenediamine to obtain the caspofungin acetate having a formula as shown below:
摘要翻译：一种制备醋酸卡泊芬净的方法，包括以下步骤：A.选择性脱水肺炎球菌素Bo得到腈; B.将腈还原成伯胺; C.使伯胺与芳硫醇在合适的溶剂中反应得到硫醚; 和D.将硫醚与乙二胺反应，得到具有如下结构式的卡泊芬净乙酸酯：

10. 发明申请

US20090170218A1 METHODS FOR DETECTION OF CYCLOSPORIN A 审中-公开
标题翻译：检测环磷酰胺A的方法
公开(公告)号：US20090170218A1
公开(公告)日：2009-07-02
申请号：US11968349
申请日：2008-01-02
申请人： Yi Feng Zheng , Deb K. Vickery , Susan C. Swann
发明人： Yi Feng Zheng , Deb K. Vickery , Susan C. Swann
IPC分类号： G01N33/566 , C07D259/00
CPC分类号： G01N33/9493 , C07K7/645 , G01N33/542
摘要： Methods and reagents are disclosed for determining the presence and/or amount of cyclosporin A in a medium suspected of containing cyclosporin A. In the method a combination is provided in a medium. The combination comprises (i) the sample, (ii) a first member of a signal producing system (sps) associated with a first support wherein the first sps member is capable of activating a second member of the sps and wherein the first support is associated with a first member of a specific binding pair, and (iii) the second sps member associated with a second support wherein the second sps member is activatable by the first sps member. The second support comprises either (I) cyclosporin C or cyclosporin A and the combination further comprises a conjugate of an antibody for cyclosporin A and a second member of the specific binding pair or (II) antibody for cyclosporin A and the combination further comprises a conjugate of cyclosporin A and a second member of the specific binding pair. The combination is subjected to conditions for binding of cyclosporin A to the antibody for cyclosporin A. The first sps member is activated and the amount of signal generated by the second sps member is detected. The amount of signal is related to the presence and/or amount of cyclosporin A in the sample.
摘要翻译：公开了用于确定怀疑含有环孢菌素A的培养基中环孢菌素A的存在和/或量的方法和试剂。在该方法中，在培养基中提供组合。该组合包括（i）样品，（ii）与第一支撑件相关联的信号产生系统（sps）的第一构件，其中第一sp构件能够激活sp的第二构件，并且其中第一支撑件相关联具有特定装订对的第一成员，以及（iii）与第二支撑件相关联的第二sps构件，其中第二sp构件可由第一sp构件激活。第二种载体包括（I）环孢菌素C或环孢菌素A，并且该组合还包含环孢菌素A的抗体和特异性结合对的第二个成员或环孢菌素A的（II）抗体的缀合物，并且该组合还包含缀合物的环孢菌素A和特异性结合对的第二个成员。该组合经受环孢菌素A与环孢菌素A的抗体结合的条件。第一个sps成员被激活，并且检测由第二个sps成员产生的信号量。信号量与样品中环孢菌素A的存在和/或量有关。

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