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1. 发明授权

US08404491B2 Luminescent chemical sensor integrated with at least one molecular trap 有权
标题翻译：与至少一个分子陷阱集成的发光化学传感器
公开(公告)号：US08404491B2
公开(公告)日：2013-03-26
申请号：US12916299
申请日：2010-10-29
申请人： Zhiyong Li , Michael Josef Stuke , Shih-Yuan Wang , Huei Pei Kuo
发明人： Zhiyong Li , Michael Josef Stuke , Shih-Yuan Wang , Huei Pei Kuo
IPC分类号： G01N21/76
CPC分类号： G01N33/5438 , B82Y15/00 , G01N21/648 , G01N21/658 , Y10T436/25
摘要： A luminescent chemical sensor integrated with at least one molecular trap. The luminescent chemical sensor includes at least one molecular trap and at least one metallic-nanofinger device integrated with at least one molecular trap. The molecular trap includes a plurality of electrodes that trap at least one analyte molecule. The metallic-nanofinger device includes a substrate, and a plurality of nanofingers coupled with the substrate. A nanofinger of the plurality includes a flexible column, and a metallic cap coupled to an apex of the flexible column. At least the nanofinger and a second nanofinger of the plurality of nanofingers are to self-arrange into a close-packed configuration with the analyte molecule. A method for using, and a chemical-analysis apparatus including the luminescent chemical sensor are also provided.
摘要翻译：与至少一个分子阱集成的发光化学传感器。发光化学传感器包括至少一个分子阱和至少一个与至少一个分子陷阱集成的金属纳米酮装置。分子阱包括捕获至少一种分析物分子的多个电极。金属纳米装置包括衬底和与衬底耦合的多个纳米器件。多个纳米针板包括柔性柱和联接到柔性柱的顶点的金属帽。至少纳米角蛋白和多个纳米针的第二纳米梳理器将自分配成与分析物分子紧密堆积的构型。还提供了使用方法和包括发光化学传感器的化学分析装置。

2. 发明申请

US20110188033A1 MOLECULE DETECTION USING RAMAN LIGHT DETECTION 失效
标题翻译：使用拉曼光检测的分子检测
公开(公告)号：US20110188033A1
公开(公告)日：2011-08-04
申请号：US12696853
申请日：2010-01-29
申请人： Min Hu , Alexandre M. Bratkovski , Jingjing Li , Huei Pei Kuo , Zhiyong Li , Fung Suong Ou , Michael Josef Stuke , Michael Renne Ty Tan , Shih-Yuan Wang , Wei Wu
发明人： Min Hu , Alexandre M. Bratkovski , Jingjing Li , Huei Pei Kuo , Zhiyong Li , Fung Suong Ou , Michael Josef Stuke , Michael Renne Ty Tan , Shih-Yuan Wang , Wei Wu
IPC分类号： G01J3/44
CPC分类号： G01J3/44
摘要： An apparatus for detecting at least one molecule using Raman light detection includes a substrate for supporting a sample containing the at least one molecule, a laser source for emitting a laser beam to cause Raman light emission from the at least one molecule, a modulating element for modulating a spatial relationship between the laser beam and the substrate at an identified frequency to cause the Raman light to be emitted from the at least one molecule at the identified frequency, at least one detector for detecting the Raman light emitted from the at least one molecule, and a post-signal processing unit configured to process the detected Raman light emission at the identified frequency to detect the at least one molecule.
摘要翻译：用于使用拉曼光检测检测至少一个分子的装置包括用于支撑含有至少一个分子的样品的基底，用于发射激光束以产生来自至少一个分子的拉曼光发射的激光源，以识别的频率调制激光束和衬底之间的空间关系，以使所述拉曼光以所识别的频率从所述至少一个分子发射;至少一个检测器，用于检测从所述至少一个分子发射的拉曼光以及后信号处理单元，被配置为处理所识别的频率处的所检测的拉曼光发射以检测所述至少一个分子。

3. 发明申请

US20120107948A1 LUMINESCENT CHEMICAL SENSOR INTEGRATED WITH AT LEAST ONE MOLECULAR TRAP 有权
标题翻译： LUMINESCENT化学传感器与最少的一个分子轨迹集成
公开(公告)号：US20120107948A1
公开(公告)日：2012-05-03
申请号：US12916299
申请日：2010-10-29
申请人： Zhiyong LI , Michael Josef Stuke , Shih-Yuan Wang , Huei Pei Kuo
发明人： Zhiyong LI , Michael Josef Stuke , Shih-Yuan Wang , Huei Pei Kuo
IPC分类号： G01N21/75 , G01N33/48 , C40B60/00 , G01N1/00
CPC分类号： G01N33/5438 , B82Y15/00 , G01N21/648 , G01N21/658 , Y10T436/25
摘要： A luminescent chemical sensor integrated with at least one molecular trap. The luminescent chemical sensor includes at least one molecular trap and at least one metallic-nanofinger device integrated with at least one molecular trap. The molecular trap includes a plurality of electrodes that trap at least one analyte molecule. The metallic-nanofinger device includes a substrate, and a plurality of nanofingers coupled with the substrate. A nanofinger of the plurality includes a flexible column, and a metallic cap coupled to an apex of the flexible column. At least the nanofinger and a second nanofinger of the plurality of nanofingers are to self-arrange into a close-packed configuration with the analyte molecule. A method for using, and a chemical-analysis apparatus including the luminescent chemical sensor are also provided.
摘要翻译：与至少一个分子阱集成的发光化学传感器。发光化学传感器包括至少一个分子阱和至少一个与至少一个分子陷阱集成的金属纳米酮装置。分子阱包括捕获至少一种分析物分子的多个电极。金属纳米装置包括衬底和与衬底耦合的多个纳米器件。多个纳米针板包括柔性柱和联接到柔性柱的顶点的金属帽。至少纳米角蛋白和多个纳米针的第二纳米梳理器将自分配成与分析物分子紧密堆积的构型。还提供了使用方法和包括发光化学传感器的化学分析装置。

4. 发明授权

US08208137B2 Molecule detection using Raman light detection 失效
标题翻译：使用拉曼光检测的分子检测
公开(公告)号：US08208137B2
公开(公告)日：2012-06-26
申请号：US12696853
申请日：2010-01-29
申请人： Min Hu , Alexandre M. Bratkovski , Jingjing Li , Huei Pei Kuo , Zhiyong Li , Fung Suong Ou , Michael Josef Stuke , Michael Renne Ty Tan , Shih-Yuan Wang , Wei Wu
发明人： Min Hu , Alexandre M. Bratkovski , Jingjing Li , Huei Pei Kuo , Zhiyong Li , Fung Suong Ou , Michael Josef Stuke , Michael Renne Ty Tan , Shih-Yuan Wang , Wei Wu
IPC分类号： G01J3/44
CPC分类号： G01J3/44
摘要： An apparatus for detecting at least one molecule using Raman light detection includes a substrate for supporting a sample containing the at least one molecule, a laser source for emitting a laser beam to cause Raman light emission from the at least one molecule, a modulating element for modulating a spatial relationship between the laser beam and the substrate at an identified frequency to cause the Raman light to be emitted from the at least one molecule at the identified frequency, at least one detector for detecting the Raman light emitted from the at least one molecule, and a post-signal processing unit configured to process the detected Raman light emission at the identified frequency to detect the at least one molecule.
摘要翻译：用于使用拉曼光检测检测至少一个分子的装置包括用于支撑含有至少一个分子的样品的基底，用于发射激光束以产生来自至少一个分子的拉曼光发射的激光源，以识别的频率调制激光束和衬底之间的空间关系，以使所述拉曼光以所识别的频率从所述至少一个分子发射;至少一个检测器，用于检测从所述至少一个分子发射的拉曼光以及后信号处理单元，被配置为处理所识别的频率处的所检测的拉曼光发射以检测所述至少一个分子。

5. 发明申请

US20140036262A1 ELECTRONIC AND PLASMONIC ENHANCEMENT FOR SURFACE ENHANCED RAMAN SPECTROSCOPY 审中-公开
标题翻译：表面增强拉曼光谱的电子和等离子体增强
公开(公告)号：US20140036262A1
公开(公告)日：2014-02-06
申请号：US13562567
申请日：2012-07-31
申请人： Shih-Yuan Wang , Gary Gibson , Zhiyong Li , Alexandre M. Bratkovski , Huei Pei Kuo , Zhang-Lin Zhou , R Stanley Williams
发明人： Shih-Yuan Wang , Gary Gibson , Zhiyong Li , Alexandre M. Bratkovski , Huei Pei Kuo , Zhang-Lin Zhou , R Stanley Williams
IPC分类号： G01J3/44
CPC分类号： G01N21/658
摘要： An apparatus for surface enhanced Raman spectroscopy includes a substrate, a nanostructure and a plasmonic material. The nanostructure and the plasmonic material are integrated together to provide electronic and plasmonic enhancement to a Raman signal produced by electromagnetic radiation scattering from an analyte.
摘要翻译：用于表面增强拉曼光谱的装置包括底物，纳米结构和等离子体激元材料。将纳米结构和等离子体激元材料集成在一起，以对由分析物的电磁辐射散射产生的拉曼信号提供电子和等离子体增强。

6. 发明申请

US20140029002A1 ADJUSTABLE INTERSURFACE SPACING FOR SURFACE ENHANCED RAMAN SPECTROSCOPY 审中-公开
标题翻译：表面增强拉曼光谱的可调节的表面间距
公开(公告)号：US20140029002A1
公开(公告)日：2014-01-30
申请号：US13561561
申请日：2012-07-30
申请人： Shih-Yuan Wang , Zhiyong Li , Alexandre M. Bratkovski , Gary Gibson , Huei Pei Kuo , Zhang-Lin Zhou , Steven J. Barcelo , Ansoon Kim , R Stanley Williams
发明人： Shih-Yuan Wang , Zhiyong Li , Alexandre M. Bratkovski , Gary Gibson , Huei Pei Kuo , Zhang-Lin Zhou , Steven J. Barcelo , Ansoon Kim , R Stanley Williams
IPC分类号： G01J3/44
CPC分类号： G01N21/658 , B82Y15/00
摘要： A sensor for surface enhanced Raman spectroscopy (SERS) sensor includes surfaces and an actuator to adjust an intersurface spacing between the surfaces to contain an analyte and allow the analyte to be released from containment.
摘要翻译：用于表面增强拉曼光谱（SERS）传感器的传感器包括表面和致动器，以调节表面之间的表面间隔，以包含分析物并允许分析物从容纳物释放。

7. 发明授权

US08559003B2 Electrically driven devices for surface enhanced raman spectroscopy 有权
标题翻译：用于表面增强拉曼光谱的电驱动装置
公开(公告)号：US08559003B2
公开(公告)日：2013-10-15
申请号：US13384456
申请日：2009-09-17
申请人： Huei Pei Kuo , Shih-Yuan Wang , Min Hu , Zhiyong Li , Alexandre M. Bratkovski
发明人： Huei Pei Kuo , Shih-Yuan Wang , Min Hu , Zhiyong Li , Alexandre M. Bratkovski
IPC分类号： G01J3/44
CPC分类号： G01N21/658 , B82Y15/00 , B82Y30/00
摘要： An electrically driven device for surface enhanced Raman spectroscopy includes a first electrode, a substrate positioned proximate to the first electrode, a plurality of cone shaped protrusions formed integrally with or on a substrate surface, a Raman signal-enhancing material coated on each protrusion, and a second electrode positioned relative to the first electrode at a predetermined distance. Each of the protrusions has a tip with a radius of curvature ranging from about 0.1 nm to about 100 nm. The second electrode is positioned relative to the first electrode such that the electrodes together produce an electric field when a voltage bias is applied therebetween. The electric field has a field distribution that creates a stronger field gradient at a region proximate to the tips than at other portions of the substrate.
摘要翻译：用于表面增强拉曼光谱的电驱动装置包括第一电极，靠近第一电极定位的基板，与基底表面一体地形成的多个锥形突起，涂覆在每个突起上的拉曼信号增强材料，以及相对于第一电极以预定距离定位的第二电极。每个突起具有具有约0.1nm至约100nm范围的曲率半径的尖端。第二电极相对于第一电极定位，使得当在其之间施加电压偏置时，电极一起产生电场。电场具有场分布，其在靠近尖端的区域处产生比在衬底的其它部分更强的场梯度。

8. 发明申请

US20120113419A1 NANOWIRE-BASED SYSTEMS FOR PERFORMING RAMAN SPECTROSCOPY 有权
标题翻译：用于执行拉曼光谱的基于纳米级的系统
公开(公告)号：US20120113419A1
公开(公告)日：2012-05-10
申请号：US13383387
申请日：2009-07-30
申请人： Shih-Yuan Wang , Jingjing Li , Huei Pei Kuo , David A. Fattal , Nobuhiko Kobayashi , Zhiyong Li
发明人： Shih-Yuan Wang , Jingjing Li , Huei Pei Kuo , David A. Fattal , Nobuhiko Kobayashi , Zhiyong Li
IPC分类号： G01J3/44 , B82Y99/00
CPC分类号： G01N21/658 , B82Y15/00 , G01J3/44
摘要： Embodiments of the present invention are directed to nanowire-based systems for performing surface-enhanced Raman spectroscopy. In one embodiment, a system comprises a substrate (102) having a surface and a plurality of tapered nanowires (104) disposed on the surface. Each nanowire has a tapered end directed away from the surface. The system also includes a plurality of nanoparticles (110) disposed near the tapered end of each nanowire. When each nanowire is illuminated with light of a pump wavelength, Raman excitation light is emitted from the tapered end of the nanowire to interact with the nanoparticles and produce enhanced Raman scattered light from molecules located in close proximity to the nanoparticles.
摘要翻译：本发明的实施方案涉及用于进行表面增强拉曼光谱的基于纳米线的系统。在一个实施例中，系统包括具有表面的基板（102）和设置在表面上的多个锥形纳米线（104）。每个纳米线具有远离表面的锥形端。该系统还包括在每个纳米线的锥形端附近设置的多个纳米颗粒（110）。当每个纳米线被泵浦波长的光照射时，拉曼激发光从纳米线的锥形端发射以与纳米颗粒相互作用，并从位于紧邻纳米颗粒的分子产生增强的拉曼散射光。

9. 发明授权

US08687186B2 Nanowire-based systems for performing raman spectroscopy 有权
标题翻译：用于执行拉曼光谱的基于纳米线的系统
公开(公告)号：US08687186B2
公开(公告)日：2014-04-01
申请号：US13383387
申请日：2009-07-30
申请人： Shih-Yuan Wang , Jingjing Li , Huei Pei Kuo , David A. Fattal , Nobuhiko Kobayashi , Zhiyong Li
发明人： Shih-Yuan Wang , Jingjing Li , Huei Pei Kuo , David A. Fattal , Nobuhiko Kobayashi , Zhiyong Li
IPC分类号： G01J3/44
CPC分类号： G01N21/658 , B82Y15/00 , G01J3/44
摘要： Embodiments of the present invention are directed to nanowire-based systems for performing surface-enhanced Raman spectroscopy. In one embodiment, a system comprises a substrate having a surface and a plurality of tapered nanowires disposed on the surface. Each nanowire has a tapered end directed away from the surface. The system also includes a plurality of nanoparticles disposed near the tapered end of each nanowire. When each nanowire is illuminated with light of a pump wavelength, Raman excitation light is emitted from the tapered end of the nanowire to interact with the nanoparticles and produce enhanced Raman scattered light from molecules located in close proximity to the nanoparticles.
摘要翻译：本发明的实施方案涉及用于进行表面增强拉曼光谱的基于纳米线的系统。在一个实施例中，系统包括具有设置在表面上的表面和多个锥形纳米线的基板。每个纳米线具有远离表面的锥形端。该系统还包括设置在每个纳米线的锥形端附近的多个纳米颗粒。当每个纳米线被泵浦波长的光照射时，拉曼激发光从纳米线的锥形端发射以与纳米颗粒相互作用，并从位于紧邻纳米颗粒的分子产生增强的拉曼散射光。

10. 发明申请

US20110228266A1 SUBSTRATE FOR SURFACE ENHANCED RAMAN SCATTERING (SERS) 有权
标题翻译：表面增强拉曼散射基板（SERS）
公开(公告)号：US20110228266A1
公开(公告)日：2011-09-22
申请号：US13129571
申请日：2008-11-17
申请人： Huei Pei Kuo , Jing Tang , Fung Suong Ou , Zhiyong Li , Shih-Yuan Wang
发明人： Huei Pei Kuo , Jing Tang , Fung Suong Ou , Zhiyong Li , Shih-Yuan Wang
IPC分类号： G01J3/44 , B05D5/06 , B05D3/10 , B05D3/00 , C23C16/44 , B82Y40/00 , B82Y20/00
CPC分类号： B82Y20/00 , G01N21/658
摘要： A substrate for Surface Enhanced Raman Scattering (SERS). The substrate comprises at least one nanostructure protruding from a surface of the substrate and a SERS active metal over the at least one nanostructure, wherein the SERS active metal substantially covers the at least one nanostructure and the SERS active metal creates a textured layer on the at least one nanostructure.
摘要翻译：用于表面增强拉曼散射（SERS）的衬底。衬底包括从衬底的表面突出的至少一个纳米结构和在至少一个纳米结构上的SERS活性金属，其中SERS活性金属基本上覆盖至少一个纳米结构，并且SERS活性金属在其上形成纹理化层至少一个纳米结构。

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