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1. 发明授权

US08404491B2 Luminescent chemical sensor integrated with at least one molecular trap 有权
标题翻译：与至少一个分子陷阱集成的发光化学传感器
公开(公告)号：US08404491B2
公开(公告)日：2013-03-26
申请号：US12916299
申请日：2010-10-29
申请人： Zhiyong Li , Michael Josef Stuke , Shih-Yuan Wang , Huei Pei Kuo
发明人： Zhiyong Li , Michael Josef Stuke , Shih-Yuan Wang , Huei Pei Kuo
IPC分类号： G01N21/76
CPC分类号： G01N33/5438 , B82Y15/00 , G01N21/648 , G01N21/658 , Y10T436/25
摘要： A luminescent chemical sensor integrated with at least one molecular trap. The luminescent chemical sensor includes at least one molecular trap and at least one metallic-nanofinger device integrated with at least one molecular trap. The molecular trap includes a plurality of electrodes that trap at least one analyte molecule. The metallic-nanofinger device includes a substrate, and a plurality of nanofingers coupled with the substrate. A nanofinger of the plurality includes a flexible column, and a metallic cap coupled to an apex of the flexible column. At least the nanofinger and a second nanofinger of the plurality of nanofingers are to self-arrange into a close-packed configuration with the analyte molecule. A method for using, and a chemical-analysis apparatus including the luminescent chemical sensor are also provided.
摘要翻译：与至少一个分子阱集成的发光化学传感器。发光化学传感器包括至少一个分子阱和至少一个与至少一个分子陷阱集成的金属纳米酮装置。分子阱包括捕获至少一种分析物分子的多个电极。金属纳米装置包括衬底和与衬底耦合的多个纳米器件。多个纳米针板包括柔性柱和联接到柔性柱的顶点的金属帽。至少纳米角蛋白和多个纳米针的第二纳米梳理器将自分配成与分析物分子紧密堆积的构型。还提供了使用方法和包括发光化学传感器的化学分析装置。

2. 发明申请

US20110188033A1 MOLECULE DETECTION USING RAMAN LIGHT DETECTION 失效
标题翻译：使用拉曼光检测的分子检测
公开(公告)号：US20110188033A1
公开(公告)日：2011-08-04
申请号：US12696853
申请日：2010-01-29
申请人： Min Hu , Alexandre M. Bratkovski , Jingjing Li , Huei Pei Kuo , Zhiyong Li , Fung Suong Ou , Michael Josef Stuke , Michael Renne Ty Tan , Shih-Yuan Wang , Wei Wu
发明人： Min Hu , Alexandre M. Bratkovski , Jingjing Li , Huei Pei Kuo , Zhiyong Li , Fung Suong Ou , Michael Josef Stuke , Michael Renne Ty Tan , Shih-Yuan Wang , Wei Wu
IPC分类号： G01J3/44
CPC分类号： G01J3/44
摘要： An apparatus for detecting at least one molecule using Raman light detection includes a substrate for supporting a sample containing the at least one molecule, a laser source for emitting a laser beam to cause Raman light emission from the at least one molecule, a modulating element for modulating a spatial relationship between the laser beam and the substrate at an identified frequency to cause the Raman light to be emitted from the at least one molecule at the identified frequency, at least one detector for detecting the Raman light emitted from the at least one molecule, and a post-signal processing unit configured to process the detected Raman light emission at the identified frequency to detect the at least one molecule.
摘要翻译：用于使用拉曼光检测检测至少一个分子的装置包括用于支撑含有至少一个分子的样品的基底，用于发射激光束以产生来自至少一个分子的拉曼光发射的激光源，以识别的频率调制激光束和衬底之间的空间关系，以使所述拉曼光以所识别的频率从所述至少一个分子发射;至少一个检测器，用于检测从所述至少一个分子发射的拉曼光以及后信号处理单元，被配置为处理所识别的频率处的所检测的拉曼光发射以检测所述至少一个分子。

3. 发明申请

US20120107948A1 LUMINESCENT CHEMICAL SENSOR INTEGRATED WITH AT LEAST ONE MOLECULAR TRAP 有权
标题翻译： LUMINESCENT化学传感器与最少的一个分子轨迹集成
公开(公告)号：US20120107948A1
公开(公告)日：2012-05-03
申请号：US12916299
申请日：2010-10-29
申请人： Zhiyong LI , Michael Josef Stuke , Shih-Yuan Wang , Huei Pei Kuo
发明人： Zhiyong LI , Michael Josef Stuke , Shih-Yuan Wang , Huei Pei Kuo
IPC分类号： G01N21/75 , G01N33/48 , C40B60/00 , G01N1/00
CPC分类号： G01N33/5438 , B82Y15/00 , G01N21/648 , G01N21/658 , Y10T436/25
摘要： A luminescent chemical sensor integrated with at least one molecular trap. The luminescent chemical sensor includes at least one molecular trap and at least one metallic-nanofinger device integrated with at least one molecular trap. The molecular trap includes a plurality of electrodes that trap at least one analyte molecule. The metallic-nanofinger device includes a substrate, and a plurality of nanofingers coupled with the substrate. A nanofinger of the plurality includes a flexible column, and a metallic cap coupled to an apex of the flexible column. At least the nanofinger and a second nanofinger of the plurality of nanofingers are to self-arrange into a close-packed configuration with the analyte molecule. A method for using, and a chemical-analysis apparatus including the luminescent chemical sensor are also provided.
摘要翻译：与至少一个分子阱集成的发光化学传感器。发光化学传感器包括至少一个分子阱和至少一个与至少一个分子陷阱集成的金属纳米酮装置。分子阱包括捕获至少一种分析物分子的多个电极。金属纳米装置包括衬底和与衬底耦合的多个纳米器件。多个纳米针板包括柔性柱和联接到柔性柱的顶点的金属帽。至少纳米角蛋白和多个纳米针的第二纳米梳理器将自分配成与分析物分子紧密堆积的构型。还提供了使用方法和包括发光化学传感器的化学分析装置。

4. 发明授权

US08208137B2 Molecule detection using Raman light detection 失效
标题翻译：使用拉曼光检测的分子检测
公开(公告)号：US08208137B2
公开(公告)日：2012-06-26
申请号：US12696853
申请日：2010-01-29
申请人： Min Hu , Alexandre M. Bratkovski , Jingjing Li , Huei Pei Kuo , Zhiyong Li , Fung Suong Ou , Michael Josef Stuke , Michael Renne Ty Tan , Shih-Yuan Wang , Wei Wu
发明人： Min Hu , Alexandre M. Bratkovski , Jingjing Li , Huei Pei Kuo , Zhiyong Li , Fung Suong Ou , Michael Josef Stuke , Michael Renne Ty Tan , Shih-Yuan Wang , Wei Wu
IPC分类号： G01J3/44
CPC分类号： G01J3/44
摘要： An apparatus for detecting at least one molecule using Raman light detection includes a substrate for supporting a sample containing the at least one molecule, a laser source for emitting a laser beam to cause Raman light emission from the at least one molecule, a modulating element for modulating a spatial relationship between the laser beam and the substrate at an identified frequency to cause the Raman light to be emitted from the at least one molecule at the identified frequency, at least one detector for detecting the Raman light emitted from the at least one molecule, and a post-signal processing unit configured to process the detected Raman light emission at the identified frequency to detect the at least one molecule.
摘要翻译：用于使用拉曼光检测检测至少一个分子的装置包括用于支撑含有至少一个分子的样品的基底，用于发射激光束以产生来自至少一个分子的拉曼光发射的激光源，以识别的频率调制激光束和衬底之间的空间关系，以使所述拉曼光以所识别的频率从所述至少一个分子发射;至少一个检测器，用于检测从所述至少一个分子发射的拉曼光以及后信号处理单元，被配置为处理所识别的频率处的所检测的拉曼光发射以检测所述至少一个分子。

5. 发明授权

US08687186B2 Nanowire-based systems for performing raman spectroscopy 有权
标题翻译：用于执行拉曼光谱的基于纳米线的系统
公开(公告)号：US08687186B2
公开(公告)日：2014-04-01
申请号：US13383387
申请日：2009-07-30
申请人： Shih-Yuan Wang , Jingjing Li , Huei Pei Kuo , David A. Fattal , Nobuhiko Kobayashi , Zhiyong Li
发明人： Shih-Yuan Wang , Jingjing Li , Huei Pei Kuo , David A. Fattal , Nobuhiko Kobayashi , Zhiyong Li
IPC分类号： G01J3/44
CPC分类号： G01N21/658 , B82Y15/00 , G01J3/44
摘要： Embodiments of the present invention are directed to nanowire-based systems for performing surface-enhanced Raman spectroscopy. In one embodiment, a system comprises a substrate having a surface and a plurality of tapered nanowires disposed on the surface. Each nanowire has a tapered end directed away from the surface. The system also includes a plurality of nanoparticles disposed near the tapered end of each nanowire. When each nanowire is illuminated with light of a pump wavelength, Raman excitation light is emitted from the tapered end of the nanowire to interact with the nanoparticles and produce enhanced Raman scattered light from molecules located in close proximity to the nanoparticles.
摘要翻译：本发明的实施方案涉及用于进行表面增强拉曼光谱的基于纳米线的系统。在一个实施例中，系统包括具有设置在表面上的表面和多个锥形纳米线的基板。每个纳米线具有远离表面的锥形端。该系统还包括设置在每个纳米线的锥形端附近的多个纳米颗粒。当每个纳米线被泵浦波长的光照射时，拉曼激发光从纳米线的锥形端发射以与纳米颗粒相互作用，并从位于紧邻纳米颗粒的分子产生增强的拉曼散射光。

6. 发明申请

US20110228266A1 SUBSTRATE FOR SURFACE ENHANCED RAMAN SCATTERING (SERS) 有权
标题翻译：表面增强拉曼散射基板（SERS）
公开(公告)号：US20110228266A1
公开(公告)日：2011-09-22
申请号：US13129571
申请日：2008-11-17
申请人： Huei Pei Kuo , Jing Tang , Fung Suong Ou , Zhiyong Li , Shih-Yuan Wang
发明人： Huei Pei Kuo , Jing Tang , Fung Suong Ou , Zhiyong Li , Shih-Yuan Wang
IPC分类号： G01J3/44 , B05D5/06 , B05D3/10 , B05D3/00 , C23C16/44 , B82Y40/00 , B82Y20/00
CPC分类号： B82Y20/00 , G01N21/658
摘要： A substrate for Surface Enhanced Raman Scattering (SERS). The substrate comprises at least one nanostructure protruding from a surface of the substrate and a SERS active metal over the at least one nanostructure, wherein the SERS active metal substantially covers the at least one nanostructure and the SERS active metal creates a textured layer on the at least one nanostructure.
摘要翻译：用于表面增强拉曼散射（SERS）的衬底。衬底包括从衬底的表面突出的至少一个纳米结构和在至少一个纳米结构上的SERS活性金属，其中SERS活性金属基本上覆盖至少一个纳米结构，并且SERS活性金属在其上形成纹理化层至少一个纳米结构。

7. 发明申请

US20150241355A1 APPARATUS FOR PERFORMING SPECTROSCOPY HAVING A PARABOLIC REFLECTOR AND SERS ELEMENTS 审中-公开
标题翻译：用于执行具有抛物面反射器和元件元件的光谱的装置
公开(公告)号：US20150241355A1
公开(公告)日：2015-08-27
申请号：US14406653
申请日：2012-07-31
申请人： Shih-Yuan Wang , Gary Gibson , Zhiyong Li , Alexandre M. Bratkovski , Steven Barcelo , Ansoon Kim , Mineo Yamakawa , Zhang-Lin Zhou , Huei Pei Kuo
发明人： Shih-Yuan Wang , Gary Gibson , Zhiyong Li , Alexandre M. Bratkovski , Steven Barcelo , Ansoon Kim , Mineo Yamakawa , Zhang-Lin Zhou , Huei Pei Kuo
IPC分类号： G01N21/65 , A61F2/02 , A61F2/82 , G02B5/10
CPC分类号： G01N21/658 , A61F2/02 , A61F2/82 , G01N2201/068 , G02B5/10 , Y10T29/49826
摘要： According to an example, an apparatus for performing spectroscopy includes a parabolic reflector and a plurality of surface-enhanced Raman spectroscopy (SERS) elements spaced from the parabolic reflector and positioned substantially at a focal point of the parabolic reflector. The parabolic reflector is to reflect Raman scattered light emitted from molecules in a near field generated by the plurality of SERS elements to substantially increase the flux of the Raman scattered light emitted out of the apparatus.
摘要翻译：根据一个实例，用于执行光谱学的装置包括抛物面反射器和与抛物面反射器间隔开并且基本上位于抛物面反射器的焦点的多个表面增强拉曼光谱（SERS）元件。抛物面反射器是反射由多个SERS元件产生的近场中的分子发射的拉曼散射光，以大大增加从该装置发出的拉曼散射光的通量。

8. 发明授权

US08472018B2 Grating for multiple discrete wavelengths of Raman scattering 有权
标题翻译：用于多个离散波长的拉曼散射的光栅
公开(公告)号：US08472018B2
公开(公告)日：2013-06-25
申请号：US12847982
申请日：2010-07-30
申请人： Michael J. Stuke , Michael R. T. Tan , Alexandre M. Bratkovski , Min Hu , Huei Pei Kuo , Jingjing Li , Zhiyong Li , Fung Suong Ou , Shih-Yuan Wang , Wei Wu
发明人： Michael J. Stuke , Michael R. T. Tan , Alexandre M. Bratkovski , Min Hu , Huei Pei Kuo , Jingjing Li , Zhiyong Li , Fung Suong Ou , Shih-Yuan Wang , Wei Wu
IPC分类号： G01J3/44
CPC分类号： G01N21/65 , G01N21/658
摘要： Systems and methods employ a layer having a pattern that provides multiple discrete guided mode resonances for respective couplings of separated wavelengths into the layer. Further, a structure including features shaped to enhance Raman scattering to produce light of the resonant wavelengths can be employed with the patterned layer.
摘要翻译：系统和方法采用具有图案的层，该图案为分离的波长的各个耦合提供到层中提供多个离散的引导模式谐振。此外，可以使用包括成形为增强拉曼散射以产生谐振波长的光的特征的结构与图案化层。

9. 发明申请

US20120026493A1 GRATING FOR MULTIPLE DISCRETE WAVELENGTHS OF RAMAN SCATTERING 有权
标题翻译：用于拉曼散射的多个分辨波长的光刻
公开(公告)号：US20120026493A1
公开(公告)日：2012-02-02
申请号：US12847982
申请日：2010-07-30
申请人： Michael J. Stuke , Michael R.T. Tan , Alexandre M. Bratkovski , Min Hu , Huei Pei Kuo , Jingjing Li , Zhiyong Li , Fung Suong Ou , Shih-Yuan Wang , Wei Wu
发明人： Michael J. Stuke , Michael R.T. Tan , Alexandre M. Bratkovski , Min Hu , Huei Pei Kuo , Jingjing Li , Zhiyong Li , Fung Suong Ou , Shih-Yuan Wang , Wei Wu
IPC分类号： G01J3/44
CPC分类号： G01N21/65 , G01N21/658
摘要： Systems and methods employ a layer having a pattern that provides multiple discrete guided mode resonances for respective couplings of separated wavelengths into the layer. Further, a structure including features shaped to enhance Raman scattering to produce light of the resonant wavelengths can be employed with the patterned layer.
摘要翻译：系统和方法采用具有图案的层，该图案为分离的波长的各个耦合提供到层中提供多个离散的引导模式谐振。此外，可以使用包括成形为增强拉曼散射以产生谐振波长的光的特征的结构与图案化层。

10. 发明申请

US20120013903A1 NANOWIRE LIGHT CONCENTRATORS FOR PERFORMING RAMAN SPECTROSCOPY 审中-公开
标题翻译：用于执行拉曼光谱的纳米级光集中器
公开(公告)号：US20120013903A1
公开(公告)日：2012-01-19
申请号：US13258391
申请日：2009-07-30
申请人： Huei Pei Kuo , Shih-Yuan Wang , David A. Fattal , Jingjing Li , Nobuhiko Kobayashi , Zhiyong Li
发明人： Huei Pei Kuo , Shih-Yuan Wang , David A. Fattal , Jingjing Li , Nobuhiko Kobayashi , Zhiyong Li
IPC分类号： G01J3/44 , B82Y20/00 , B82B1/00
CPC分类号： G01N21/658
摘要： Embodiments of the present invention are directed to systems for performing surface-enhanced Raman spectroscopy. In one embodiment, a system (100, 400, 600, 800, 900, 950) for performing Raman spectroscopy comprises a substrate (102) substantially transparent to a range of wavelengths of electromagnetic radiation and a plurality of nanowires (104, 602) disposed on a surface of the substrate. The nanowires are substantially transparent to the range of wavelengths of electromagnetic radiation. The system includes a material disposed on each of the nanowires. The electromagnetic radiation is transmitted within the substrate, into the nanowires, and emitted from the ends of the nanowires to produce enhanced Raman scattered light from molecules located on or in proximity to the material.
摘要翻译：本发明的实施例涉及用于进行表面增强拉曼光谱的系统。在一个实施例中，用于执行拉曼光谱的系统（100,400,600,800,900,950）包括对电磁辐射的波长范围基本上透明的基底（102）和设置的多个纳米线（104,602）在基板的表面上。纳米线对于电磁辐射的波长范围基本上是透明的。该系统包括设置在每个纳米线上的材料。电磁辐射在衬底内传输到纳米线中，并从纳米线的端部发射，以产生来自位于材料上或附近的分子的增强的拉曼散射光。

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