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    • 10. 发明申请
    • SYSTEMS AND METHODS FOR PHASE MEASUREMENTS
    • 用于相位测量的系统和方法
    • US20130265585A1
    • 2013-10-10
    • US13715475
    • 2012-12-14
    • David FeldJonathan FeldAlison Hearn
    • Christopher Fang-YenGabriel PopescuChanghuei YangAdam WaxRamachandra DasariMichael Feld
    • G01B9/02
    • G01B9/02091A61B5/14532A61B5/1455A61B5/7232G01B9/02002G01B9/02007G01B9/02011G01B9/02057G01B9/02063G01B9/02067G01B9/02069G01B9/02071G01B9/02072G01B9/02078G01B9/02083G01B9/0209G01B2290/45G01B2290/60G01B2290/70G01J9/04G01N21/45
    • Preferred embodiments of the present invention are directed to systems for phase measurement such as for imaging small biological objects with light. These embodiments can be applied to the fields of, for example, cellular physiology and neuroscience. These preferred embodiments are based on principles of phase measurements and imaging technologies. The scientific motivation for using phase measurements and imaging technologies is derived from, for example, cellular biology at the sub-micron level which can include, without limitation, imaging origins of dysplasia, cellular communication, neuronal transmission and implementation of the genetic code. Light based techniques with nanometer resolution enable the cellular machinery to be studied in its native state. Thus, preferred embodiments of the present invention include systems based on principles of interferometry and/or phase measurements and are used to study cellular physiology. These systems include principles of low coherence interferometry (LCI) using optical interferometers to measure phase, or light scattering spectroscopy (LSS) wherein interference within the cellular components themselves is used, or in the alternative the principles of LCI and LSS can be combined to result in systems of the present invention.
    • 本发明的优选实施例涉及用于相位测量的系统,例如用于利用光成像小生物物体。 这些实施方案可以应用于例如细胞生理学和神经科学领域。 这些优选实施例基于相位测量和成像技术的原理。 使用相位测量和成像技术的科学动机源于例如亚微米级别的细胞生物学,其可以包括但不限于成像发育异常起源,细胞通讯,神经元传播和遗传密码的实现。 具有纳米分辨率的基于光的技术使得能够以其天然状态研究细胞机械。 因此,本发明的优选实施例包括基于干涉测量和/或相位测量的原理的系统,并且用于研究细胞生理学。 这些系统包括使用光学干涉仪来测量相位的低相干干涉测量(LCI)原理,或使用其中使用细胞部件本身内部的干扰的光散射光谱(LSS),或者替代地,LCI和LSS的原理可以组合以产生 在本发明的系统中。