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1. 发明申请

US20120302892A1 PORTABLE OPTICAL FIBER PROBE-BASED SPECTROSCOPIC SCANNER FOR RAPID CANCER DIAGNOSIS 审中-公开
标题翻译：便携式光纤基于探针的光谱扫描仪用于快速诊断
公开(公告)号：US20120302892A1
公开(公告)日：2012-11-29
申请号：US13338920
申请日：2011-12-28
申请人： Niyom Lue , Michael Feld , Ishan Barman , Narahara Chari Dingari , Ramachandra Dasari , David Feld , Alison Hearn , Jonathan Feld
发明人： Niyom Lue , Michael Feld , Ishan Barman , Narahara Chari Dingari , Ramachandra Dasari , David Feld , Alison Hearn , Jonathan Feld
IPC分类号： A61B6/00
CPC分类号： A61B5/0091 , A61B5/0068 , A61B5/0071 , A61B5/0075 , A61B5/0084 , A61B5/0086 , A61B5/42 , A61B5/4312 , G01N21/64 , G01N2021/4742 , G01N2021/656 , G01N2201/0639
摘要： A multimodal probe system for spectroscopic scanning of tissue for disease diagnosis. The system can use diffuse reflectance spectroscopy, fluorescence spectroscopy and Raman spectroscopy for the detection of cancerous tissue, such as tissue margin assessment.
摘要翻译：用于疾病诊断的组织光谱扫描的多模式探针系统。该系统可以使用漫反射光谱，荧光光谱和拉曼光谱法检测癌组织，如组织边缘评估。

2. 发明申请

US20120035442A1 PORTABLE RAMAN DIAGNOSTIC SYSTEM 有权
标题翻译：便携式拉曼诊断系统
公开(公告)号：US20120035442A1
公开(公告)日：2012-02-09
申请号：US13167445
申请日：2011-06-23
申请人： Ishan Barman , Narahara Chari Dingari , Ramachandra Dasari , Michael Feld , Chae-Ryon Kong , David Feld , Alison Hearn , Jonathan Feld
发明人： Ishan Barman , Narahara Chari Dingari , Ramachandra Dasari , Michael Feld , Chae-Ryon Kong , David Feld , Alison Hearn , Jonathan Feld
IPC分类号： A61B5/1455
CPC分类号： A61B5/14532 , A61B5/1455 , A61B5/4312 , A61B5/444 , A61B2560/0223 , G01J3/0208 , G01J3/0216 , G01J3/0218 , G01J3/0272 , G01J3/44 , G01N21/65 , G01N2201/129
摘要： The present invention further relates to the selection of the specific filter combinations, which can provide sufficient information for multivariate calibration to extract accurate analyte concentrations in complex biological systems. The present invention also describes wavelength interval selection methods that give rise to the miniaturized designs. Finally, this invention presents a plurality of wavelength selection methods and miniaturized spectroscopic apparatus designs and the necessary tools to map from one domain (wavelength selection) to the other (design parameters). Such selection of informative spectral bands has a broad scope in miniaturizing any clinical diagnostic instruments which employ Raman spectroscopy in particular and other spectroscopic techniques in general.
摘要翻译：本发明还涉及特定过滤器组合的选择，其可以提供足够的信息用于多变量校准以提取复杂生物系统中的精确分析物浓度。本发明还描述了引起小型化设计的波长间隔选择方法。最后，本发明提出了多种波长选择方法和小型化分光设备设计以及从一个域（波长选择）到另一个域（设计参数）映射的必要工具。信息谱带的这种选择在使得特别采用拉曼光谱和其他光谱技术的任何临床诊断仪器的小型化方面具有广泛的范围。

3. 发明授权

US09662047B2 Portable raman diagnostic system 有权
公开(公告)号：US09662047B2
公开(公告)日：2017-05-30
申请号：US13167445
申请日：2011-06-23
申请人： Ishan Barman , Narahara Chari Dingari , Ramachandra Dasari , Michael Feld , Jonathan Feld , David Feld , Alison Hearn , Chae-Ryon Kong , Jeon Woong Kang
发明人： Ishan Barman , Narahara Chari Dingari , Ramachandra Dasari , Michael Feld , Chae-Ryon Kong , Jeon Woong Kang
IPC分类号： A61B5/1455 , A61B5/145 , G01J3/02 , G01J3/44 , G01N21/65 , A61B5/00
CPC分类号： A61B5/14532 , A61B5/1455 , A61B5/4312 , A61B5/444 , A61B2560/0223 , G01J3/0208 , G01J3/0216 , G01J3/0218 , G01J3/0272 , G01J3/44 , G01N21/65 , G01N2201/129
摘要： The present invention further relates to the selection of the specific filter combinations, which can provide sufficient information for multivariate calibration to extract accurate analyte concentrations in complex biological systems. The present invention also describes wavelength interval selection methods that give rise to the miniaturized designs. Finally, this invention presents a plurality of wavelength selection methods and miniaturized spectroscopic apparatus designs and the necessary tools to map from one domain (wavelength selection) to the other (design parameters). Such selection of informative spectral bands has a broad scope in miniaturizing any clinical diagnostic instruments which employ Raman spectroscopy in particular and other spectroscopic techniques in general.

4. 发明授权

US09433351B2 Tri modal spectroscopic imaging 有权
标题翻译：三态光谱成像
公开(公告)号：US09433351B2
公开(公告)日：2016-09-06
申请号：US13464578
申请日：2012-05-04
申请人： Chung-Chieh Yu , Condon Lau , Stephen Fulghum , Christopher Fang-yen , Ramachandra Dasari , Michael Feld , David Feld , Alison Hearn , Jonathan Feld
发明人： Chung-Chieh Yu , Condon Lau , Stephen Fulghum , Christopher Fang-yen , Ramachandra Dasari , Michael Feld
IPC分类号： A61B6/00 , A61B5/00 , G01J3/02 , G01J3/10 , G01J3/32 , G01N21/47 , G01N21/49
CPC分类号： A61B5/0059 , A61B5/0066 , G01J3/02 , G01J3/0224 , G01J3/0229 , G01J3/10 , G01J3/32 , G01N21/4738 , G01N21/49 , G01N2021/4733
摘要： The present invention relates to a spectroscopic imaging system using autofluorescence and reflectance images to diagnose tissue. A preferred embodiment of the invention uses a plurality of light sources to illuminate a tissue region to provide the fluorescence and reflectance images, respectively.
摘要翻译：本发明涉及使用自发荧光和反射图像诊断组织的光谱成像系统。本发明的优选实施例使用多个光源照射组织区域以分别提供荧光和反射图像。

5. 发明申请

US20120259228A1 TRI MODAL SPECTROSCOPIC IMAGING 审中-公开
标题翻译： TRI模式光谱成像
公开(公告)号：US20120259228A1
公开(公告)日：2012-10-11
申请号：US13464578
申请日：2012-05-04
申请人： Chung-Chieh Yu , Condon Lau , Stephen Fulghum , Christopher Fang-yen , Ramachandra Dasari , Michael Feld , David Feld , Alison Hearn , Jonathan Feld
发明人： Chung-Chieh Yu , Condon Lau , Stephen Fulghum , Christopher Fang-yen , Ramachandra Dasari , Michael Feld , David Feld , Alison Hearn , Jonathan Feld
IPC分类号： A61B6/00 , A61B18/20
CPC分类号： A61B5/0059 , A61B5/0066 , G01J3/02 , G01J3/0224 , G01J3/0229 , G01J3/10 , G01J3/32 , G01N21/4738 , G01N21/49 , G01N2021/4733
摘要： The present invention relates to a spectroscopic imaging system using autofluorescence and reflectance images to diagnose tissue. A preferred embodiment of the invention uses a plurality of light sources to illuminate a tissue region to provide the fluorescence and reflectance images, respectively.
摘要翻译：本发明涉及使用自发荧光和反射图像诊断组织的光谱成像系统。本发明的优选实施例使用多个光源照射组织区域以分别提供荧光和反射图像。

6. 发明授权

US10451402B2 Single shot full-field reflection phase microscopy 有权
公开(公告)号：US10451402B2
公开(公告)日：2019-10-22
申请号：US13358254
申请日：2012-01-25
申请人： Zahid Yaqoob , Wonshik Choi , Toyohiko Yamauchi , Michael Feld , David Feld , Alison Hearn , Jonathan Feld
发明人： Zahid Yaqoob , Wonshik Choi , Toyohiko Yamauchi , Michael Feld
IPC分类号： G01B9/04 , G01N21/45 , G01B9/02 , G02B27/10 , G02B27/50 , G03H1/04 , G03H1/00
摘要： The present invention relates to a full-field reflection phase microscope. In a preferred embodiment, the invention can combine low-coherence interferometry and off-axis digital holographic microscopy (DHM). The reflection-based DHM provides highly sensitive and a single-shot imaging of cellular dynamics while the use of low coherence source provides a depth-selective measurement. A preferred embodiment of the system uses a diffraction grating in the reference arm to generate an interference image of uniform contrast over the entire field-of-view albeit low-coherence light source. With improved path-length sensitivity, the present invention is suitable for full-field measurement of membrane dynamics in live cells with sub-nanometer-scale sensitivity.

7. 发明申请

US20120307035A1 SINGLE-SHOT FULL-FIELD REFLECTION PHASE MICROSCOPY 审中-公开
标题翻译：单镜全场反射相显微镜
公开(公告)号：US20120307035A1
公开(公告)日：2012-12-06
申请号：US13358254
申请日：2012-01-25
申请人： Zahid Yaqoob , Wonshik Choi , Toyohiko Yamauchi , Michael Feld , David Feld , Alison Hearn , Jonathan Feld
发明人： Zahid Yaqoob , Wonshik Choi , Toyohiko Yamauchi , Michael Feld , David Feld , Alison Hearn , Jonathan Feld
IPC分类号： H04N7/18
CPC分类号： G01B9/04 , G01B9/02032 , G01B9/02047 , G01B9/02064 , G01B9/0207 , G01B9/02084 , G01B9/02091 , G01N21/45 , G02B27/1086 , G02B27/50 , G03H1/0443 , G03H2001/005 , G03H2001/0456 , G03H2001/0467 , G03H2222/24
摘要： The present invention relates to a full-field reflection phase microscope. In a preferred embodiment, the invention can combine low-coherence interferometry and off-axis digital holographic microscopy (DHM). The reflection-based DHM provides highly sensitive and a single-shot imaging of cellular dynamics while the use of low coherence source provides a depth-selective measurement. A preferred embodiment of the system uses a diffraction grating in the reference arm to generate an interference image of uniform contrast over the entire field-of-view albeit low-coherence light source. With improved path-length sensitivity, the present invention is suitable for full-field measurement of membrane dynamics in live cells with sub-nanometer-scale sensitivity.
摘要翻译：本发明涉及全场反射相位显微镜。在优选实施例中，本发明可以组合低相干干涉测量和离轴数字全息显微镜（DHM）。基于反射的DHM提供高灵敏度和单次成像的细胞动力学，而使用低相干源提供深度选择性测量。该系统的优选实施例使用参考臂中的衍射光栅来产生在整个视场内虽然具有低相干光源的均匀对比度的干涉图像。随着路径长度灵敏度的提高，本发明适用于具有亚纳米级灵敏度的活细胞膜动力学的全场测量。

8. 发明申请

US20140361148A1 SYSTEM AND METHOD FOR HILBERT PHASE IMAGING 审中-公开
标题翻译：用于HILBERT相位成像的系统和方法
公开(公告)号：US20140361148A1
公开(公告)日：2014-12-11
申请号：US14301187
申请日：2014-06-10
申请人： Jonathan Feld , David Feld , Alison Hearn
发明人： Gabriel Popescu , Ramachandra Dasari , Michael Feld
IPC分类号： H01L27/146 , G01N33/49 , G06K9/00 , G01N15/10
CPC分类号： H01L27/14601 , G01N15/10 , G01N15/1475 , G01N21/453 , G01N33/49 , G01N2015/0073 , G01N2015/008 , G01N2015/145 , G01N2015/1454 , G01N2015/1497 , G06K9/00134
摘要： Hilbert phase microscopy (HPM) as an optical technique for measuring high transverse resolution quantitative phase images associated with optically transparent objects. Due to its single-shot nature, HPM is suitable for investigating rapid phenomena that take place in transparent structures such as biological cells. A preferred embodiment is used for measuring biological systems including measurements on red blood cells, while its ability to quantify dynamic processes on the millisecond scale, for example, can be illustrated with measurements on evaporating micron-size water droplets.
摘要翻译：希尔伯特相位显微镜（HPM）作为用于测量与光学透明物体相关的高横向分辨率定量相位图像的光学技术。由于其单次性质，HPM适用于调查在诸如生物细胞的透明结构中发生的快速现象。优选的实施例用于测量生物系统，包括对红血细胞的测量，而其量化毫秒级别的动态过程的能力可以用蒸发微米级水滴的测量来说明。

9. 发明申请

US20150177133A1 TOMOGRAPHIC PHASE MICROSCOPY 有权
标题翻译： TOMOGRAPHIC相显微镜
公开(公告)号：US20150177133A1
公开(公告)日：2015-06-25
申请号：US14490242
申请日：2014-09-18
申请人： Alison Hearn , David Feld , Jonathan Feld
发明人： Wonshik Choi , Ramachandra Dasari , Christopher Fang-Yen , Michael Feld
IPC分类号： G01N21/45 , G01N21/64
CPC分类号： G01N21/45 , G01N21/51 , G01N21/6458 , G01N21/6486 , G01N2021/458 , G01N2201/061 , G01N2201/105 , G01N2201/12
摘要： The present invention relates to systems and methods for quantitative three-dimensional mapping of refractive index in living or non-living cells, tissues, or organisms using a phase-shifting laser interferometric microscope with variable illumination angle. A preferred embodiment provides tomographic imaging of cells and multicellular organisms, and time-dependent changes in cell structure and the quantitative characterization of specimen-induced aberrations in high-resolution microscopy with multiple applications in tissue light scattering.
摘要翻译：本发明涉及使用具有可变照明角度的移相激光干涉显微镜在生活或非活细胞，组织或生物体中定量三维映射折射率的系统和方法。优选的实施方案提供细胞和多细胞生物的层析成像，以及在组织光散射中具有多种应用的高分辨率显微镜中细胞结构的时间依赖性变化和样品诱导的像差的定量表征。

10. 发明申请

US20130265585A1 SYSTEMS AND METHODS FOR PHASE MEASUREMENTS 有权
标题翻译：用于相位测量的系统和方法
公开(公告)号：US20130265585A1
公开(公告)日：2013-10-10
申请号：US13715475
申请日：2012-12-14
申请人： David Feld , Jonathan Feld , Alison Hearn
发明人： Christopher Fang-Yen , Gabriel Popescu , Changhuei Yang , Adam Wax , Ramachandra Dasari , Michael Feld
IPC分类号： G01B9/02
CPC分类号： G01B9/02091 , A61B5/14532 , A61B5/1455 , A61B5/7232 , G01B9/02002 , G01B9/02007 , G01B9/02011 , G01B9/02057 , G01B9/02063 , G01B9/02067 , G01B9/02069 , G01B9/02071 , G01B9/02072 , G01B9/02078 , G01B9/02083 , G01B9/0209 , G01B2290/45 , G01B2290/60 , G01B2290/70 , G01J9/04 , G01N21/45
摘要： Preferred embodiments of the present invention are directed to systems for phase measurement such as for imaging small biological objects with light. These embodiments can be applied to the fields of, for example, cellular physiology and neuroscience. These preferred embodiments are based on principles of phase measurements and imaging technologies. The scientific motivation for using phase measurements and imaging technologies is derived from, for example, cellular biology at the sub-micron level which can include, without limitation, imaging origins of dysplasia, cellular communication, neuronal transmission and implementation of the genetic code. Light based techniques with nanometer resolution enable the cellular machinery to be studied in its native state. Thus, preferred embodiments of the present invention include systems based on principles of interferometry and/or phase measurements and are used to study cellular physiology. These systems include principles of low coherence interferometry (LCI) using optical interferometers to measure phase, or light scattering spectroscopy (LSS) wherein interference within the cellular components themselves is used, or in the alternative the principles of LCI and LSS can be combined to result in systems of the present invention.
摘要翻译：本发明的优选实施例涉及用于相位测量的系统，例如用于利用光成像小生物物体。这些实施方案可以应用于例如细胞生理学和神经科学领域。这些优选实施例基于相位测量和成像技术的原理。使用相位测量和成像技术的科学动机源于例如亚微米级别的细胞生物学，其可以包括但不限于成像发育异常起源，细胞通讯，神经元传播和遗传密码的实现。具有纳米分辨率的基于光的技术使得能够以其天然状态研究细胞机械。因此，本发明的优选实施例包括基于干涉测量和/或相位测量的原理的系统，并且用于研究细胞生理学。这些系统包括使用光学干涉仪来测量相位的低相干干涉测量（LCI）原理，或使用其中使用细胞部件本身内部的干扰的光散射光谱（LSS），或者替代地，LCI和LSS的原理可以组合以产生在本发明的系统中。

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